My baby sister, River has ASA she is doing well but can't have much protein at all. She is 11 months old and standing almost walking. Please wish her luck in life knowing she might not have the life we anticipated for her 💖
You probably dont care but if you guys are stoned like me during the covid times then you can watch pretty much all of the new series on instaflixxer. Have been streaming with my brother for the last couple of weeks =)
@@arjunforest3097 this comment is literally talking about my sister who could potentially die and you talk about getting high? Damn. But an update: she still has ASA but is doing very good, she is a healthy baby girl who is walking and lives to swim. She is 2 years old now and is starting to talk 💖
i wonder why he doesn't have a lot more views, but anyways i rlly liked the way that you explain things! Also, your drawings and organization makes me jealous hahaha Congrats and Thanks! :)
try to become hyperammonemia patient than go to him for treatment and during the course of treatment you can get a proposal from him ... although its a risky route to take ... :)
@@Byrial it was not on a serious note .. frankly speaking my 3 years old child is going through the same condition and he was in hospital 2 days ago .. . but some time we have to laugh out our challenges . It gives us strength and motivation to to stay firm and keep fighting . if you are been heart I apologize from the depth of my heart.. I am really sorry ..
Beautiful explanation. Had fatigue and brainfog for 3 years sudden onset. Was deficient in Ornithine, Citrulline and BCAAs, but had hight Arginine. Amino Acid therapy helped a bit. Still have brain fog but docs cant figure out the cause since my organs look fine, my liver too. I dont have OTC deficiency (23and me showed that), so we don't know what caused the amino acid deficiency despite a high protein diet. Taking BCAA help me not to lose weight. Don't know if I should take glutamine, my docs know nothing about that.
Do you have high ammonia? In that case i wouldnt take glutamine obviously. Im not sure if an ornithine deficiency is a strong indication of elevated ammonia.
Cool lecture. A doubt why are we getting rid of glyine> How does hyperammonemia lead to a rise in glycine levels.. is it just that are trying to get rid of the amino acid pool in the body or just that we have a mechanism of excretion of hippurate so we make use of glycine
Great presentation and leaves me curious why nitric oxide wasn't part of this cycle. Also is Urea another possible way to treat a cycle defect and why is Glycine a problem? And what about Keto Acids binding to Ammonium for safe removal?
Adding exogenous arginine for arginosuccinase deficiency makes no sense. Given your explanation, adding ornithine would make sense. Furthermore, you must mention the vitamin, mineral cofactors.
Hey I know you posted this a year ago but I just had the same thought. You couldn't because arginine is needed to combine with water to form urea (from what I understand)
من اجل نزوه لا تتجاوز بضع لحظات يولد انسان ليشقى من ستين الى سبعين عام 😃الامور قد تبدو عبث ولكنها سنة الحياه ، فى بداية الامر حيوان منوى من الاب يندمج مع حيوانه منويه من الام 😁ثم تحدث عدة انقسامات وتحوارت شكليه وتمايزات جسديه فى رحم الام طيلة 9 اشهر ليولد طفلا ضعيفا هشا ثم يكتسب من بعد ضعف قوه واخيرا فى النهايه من بعد قوة ضعفا على النمط التالى طفل ضعيف >شاب مغرور بقوته >واخيرا كهل عجوز لو طبقنا هذا على واحده من اهم موجبات الحياه للإنسان لكانت مثالا مطابقا لحياتنا اولا الحيوان المنوى هو الCO2 والحيوانه هى الNH4 😁يندمجا معا ليتكون الطفل الCarbamoyl phosphate يتمايز ويكبر داخل رحم الام حتى يكتمل تمام يخرج الى الحياه وهى (cytoplasm ) على هيئه citrulline هذه المرحله كلها داخل رحم الام وهى ال mitochondrial matrex 😉اما بدايه الحياه تاخذ الام هذا الطفل الرضيع الضعيف ال citrulline وتغذيه بالaspartate حتى ينضج ويصبح فى سن ما قبل البلوغ اى قبل الاعتماد على النفس وهى الargininosuccinate حيث كلمة argi تعنى ما وكلمة nino قبل وsuccinate تعنى البلوغ وهذا من معجم اللغة الزومبيه الوجيز 😂يريد الطفل المميز اى القادر على تميز الاشياء ان يتحرر من سطوة والديه الى اكتشاف قدراته ومهاراته وهى فترة المراهقه فيفقد حنان والديه على هيئة fumarate ليصبح شابا ناضجا فى ريعان شبابه اسمهarginine ثم بعد الشباب يفقد قوته وهى الماء H2O ومن الماء الحياه فاذا فقد فقدت الحياه يدخل الماء على الشاب العفى Arginine ويتركه وهو عجوز كهل وهو ornithine ويعطيه ولدا اسمه الurea ليعيد دورة حياة ابيه هذا كله فى الcytoplasm ويقولون فى الامثال لفى بينا يا urea دوخينا يا urea خدينا يمين شويه خدينا شمال شويه وادينا عايشين يا urea 😂وشكرا 😃
My baby sister, River has ASA she is doing well but can't have much protein at all. She is 11 months old and standing almost walking. Please wish her luck in life knowing she might not have the life we anticipated for her 💖
You probably dont care but if you guys are stoned like me during the covid times then you can watch pretty much all of the new series on instaflixxer. Have been streaming with my brother for the last couple of weeks =)
@Arjun Forest yup, have been using Instaflixxer for months myself =)
@@arjunforest3097 this comment is literally talking about my sister who could potentially die and you talk about getting high? Damn.
But an update: she still has ASA but is doing very good, she is a healthy baby girl who is walking and lives to swim. She is 2 years old now and is starting to talk 💖
@@izzyawe5799 these guys are probably just spam, just ignore them. Also congrats on your sister's health!
You breakdown complex reactions in such a way that it no longer fells complex.
HATS OFF for the effort you put for that.👍👏
Finally what I have been looking for. I can't thank you enough for this. Liked and subscribed.
i wonder why he doesn't have a lot more views, but anyways i rlly liked the way that you explain things! Also, your drawings and organization makes me jealous hahaha Congrats and Thanks! :)
YOU ARE JUST THE BEST AND ONLY THE BEST IN EXPLAINATION
Doctor's comment: excellent explanation, very comprehensive, and well organized.
Fan girl comment: How do I marry you and your brain?! 😍😳😛
try to become hyperammonemia patient than go to him for treatment and during the course of treatment you can get a proposal from him ... although its a risky route to take ... :)
@@khalidyar I didnt laugh as i actualy excperienced hyperammonemia, but people are allowed to make fun of anything imo.
@@Byrial it was not on a serious note .. frankly speaking my 3 years old child is going through the same condition and he was in hospital 2 days ago .. . but some time we have to laugh out our challenges . It gives us strength and motivation to to stay firm and keep fighting . if you are been heart I apologize from the depth of my heart.. I am really sorry ..
Let her get your number 👩⚕️
Midway through the lecture i was thinking; i am sure someone is thinking what im thinking and... sure enough! ( i’m two years late but still! Haha)
Best presentation, simple , concise and to the point..Thank you ❣
very well done,Alhumdullilah you explained it fully and indeed it is conceptual.
you are excellent . we need people like you.
Very beautiful explanation.
Thank you very much.
Thank you sir for ur invaluably simple explanation.
You are making med studs life easier, can u pls make a video regarding microsomal oxidation?📹
Excellent video !
very nice...well expounded and comprehensive lecture.thumbs up 👍👏
I dont know how to thank you enough
Great vid keep up the stella work you star
Beautiful explanation. Had fatigue and brainfog for 3 years sudden onset. Was deficient in Ornithine, Citrulline and BCAAs, but had hight Arginine. Amino Acid therapy helped a bit. Still have brain fog but docs cant figure out the cause since my organs look fine, my liver too. I dont have OTC deficiency (23and me showed that), so we don't know what caused the amino acid deficiency despite a high protein diet. Taking BCAA help me not to lose weight. Don't know if I should take glutamine, my docs know nothing about that.
Do you have high ammonia? In that case i wouldnt take glutamine obviously. Im not sure if an ornithine deficiency is a strong indication of elevated ammonia.
Also, 23 and me is not a sensitive enough genetic test for this kind of condition
I got hyperammonemia from depakote (valproic acid, seizure medication) and almost died from it. Epic experience.
You are a genius!!! Thank you
So what does it take to make, lets say the carbomoyl phosphate synthelase enzyme work? Any minerals etc that support this function?
Probably not because its a genetic defect
Cool lecture. A doubt why are we getting rid of glyine> How does hyperammonemia lead to a rise in glycine levels.. is it just that are trying to get rid of the amino acid pool in the body or just that we have a mechanism of excretion of hippurate so we make use of glycine
Nice sir!
Great presentation and leaves me curious why nitric oxide wasn't part of this cycle. Also is Urea another possible way to treat a cycle defect and why is Glycine a problem? And what about Keto Acids binding to Ammonium for safe removal?
Sir I have a question related to clinical significance of urea cycle ! So can I add these disorder that you have added in this video ? Help me
very nice sir......but u should zoom on the writhing so that we can see whats written......please write a bit larger......(sorry 4 my bad eng)
just full screen and watch in hd
how does the body get rid of excess arginosuccinate?
By converting it to Arginine through the arginase succinate enzyme?
Adding exogenous arginine for arginosuccinase deficiency makes no sense. Given your explanation, adding ornithine would make sense. Furthermore, you must mention the vitamin, mineral cofactors.
Why high level of glutamine is sought in bodybuilding industry then? It needs to be corrected.
how do you reverse a fatty liver?
stop the cause i.e stop drinking.
i don't drink alcohol maybe a few times a year socially small amounts i think it's from red meat
you should go speak with your primary care physician.
For argininosuccinase deficiency, can we treat the patient by using ornithine replacement instead of arginine?
Hey I know you posted this a year ago but I just had the same thought. You couldn't because arginine is needed to combine with water to form urea (from what I understand)
Does this mean excess glutamine is adverse to our body?
Yes! "Excess" is the operative word.
2:48 reaction
Thats my nightmare right now 💔😥😥😥😥😥😥😥😥
is hyper ammonium fully curable if diagnosed in infants
Yes with a liver transplant
very graet
Arginine supplement does help with Ornithine Transcarbamylase Deficiency, apparently*
No, why do you need arginine supplement ?
@@Eye-it-azz ask Google
Could someone Translate this in danish???? 🙏🙏🙏💖
Respect
why I did not find you earlier 😭
🙏🙏🙏
من اجل نزوه لا تتجاوز بضع لحظات يولد انسان ليشقى من ستين الى سبعين عام 😃الامور قد تبدو عبث ولكنها سنة الحياه ، فى بداية الامر حيوان منوى من الاب يندمج مع حيوانه منويه من الام 😁ثم تحدث عدة انقسامات وتحوارت شكليه وتمايزات جسديه فى رحم الام طيلة 9 اشهر ليولد طفلا ضعيفا هشا ثم يكتسب من بعد ضعف قوه واخيرا فى النهايه من بعد قوة ضعفا على النمط التالى طفل ضعيف >شاب مغرور بقوته >واخيرا كهل عجوز لو طبقنا هذا على واحده من اهم موجبات الحياه للإنسان لكانت مثالا مطابقا لحياتنا اولا الحيوان المنوى هو الCO2 والحيوانه هى الNH4 😁يندمجا معا ليتكون الطفل الCarbamoyl phosphate يتمايز ويكبر داخل رحم الام حتى يكتمل تمام يخرج الى الحياه وهى (cytoplasm ) على هيئه citrulline هذه المرحله كلها داخل رحم الام وهى ال mitochondrial matrex 😉اما بدايه الحياه تاخذ الام هذا الطفل الرضيع الضعيف ال citrulline وتغذيه بالaspartate حتى ينضج ويصبح فى سن ما قبل البلوغ اى قبل الاعتماد على النفس وهى الargininosuccinate حيث كلمة argi تعنى ما وكلمة nino قبل وsuccinate تعنى البلوغ وهذا من معجم اللغة الزومبيه الوجيز 😂يريد الطفل المميز اى القادر على تميز الاشياء ان يتحرر من سطوة والديه الى اكتشاف قدراته ومهاراته وهى فترة المراهقه فيفقد حنان والديه على هيئة fumarate ليصبح شابا ناضجا فى ريعان شبابه اسمهarginine ثم بعد الشباب يفقد قوته وهى الماء H2O ومن الماء الحياه فاذا فقد فقدت الحياه يدخل الماء على الشاب العفى Arginine ويتركه وهو عجوز كهل وهو ornithine ويعطيه ولدا اسمه الurea ليعيد دورة حياة ابيه هذا كله فى الcytoplasm ويقولون فى الامثال لفى بينا يا urea دوخينا يا urea خدينا يمين شويه خدينا شمال شويه وادينا عايشين يا urea 😂وشكرا 😃
Saleem Abutaleb واضح انك شربان شي 😂🥃
Plx made this lecture in Urdu