Why Electrostatics Rules the Life of a Cell with Robijn Bruinsma
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- Опубликовано: 19 авг 2024
- Physics recognizes four fundamental interactions: Gravity, Electromagnetism, and the Strong and Weak Interactions. For life at the level of cells, just one interaction matters: electrostatics. The basic electrostatic force has a very simple form, similar to Newton’s Law of Gravitation but at the level of the cell, a zoo of complex physical interactions is encountered: “aqueous” electrostatics, the hydrophobic interaction, the hydrophilic interaction, and the van der Waals interaction. The talk will discuss how all these interactions emerge from the basic electrostatic interaction by the combined effects of entropy and quantum mechanics. This emergent form of electrostatics provides us with fundamental insights into the organization of cells, into the workings of important biomolecules like DNA and proteins, it tells us how nervous signals get transmitted, and how an important part of our immune system works.
Robijn Bruinsma is Emeritus Professor of Physics and Astronomy at the University of California, Los Angeles (UCLA) where he specializes in the application of physics to cell and molecular biology. He has a B.S. in Physics from the Vrije Universiteit, Amsterdam (1974), an M.S. in Physics from Utrecht University (1976), and a Ph.D. in Physics (1976) from the University of Southern California where his thesis advisor was Kazumi Maki. He conducted postdoctoral research at Harvard University (1979-1980), before moving to Brookhaven National Laboratory as a Research Associate (1980-1982). Bruinsma was then a Visiting Scientist at the IBM T. J. Watson Research Center (1982-1984) before moving to UCLA in 1984. His current research focus is the self-assembly of viruses in particular of HIV. Bruinsma has received the Pierre et Marie Curie Visiting Professorship of the City of Paris Industrial Physics and Chemistry Higher Educational Institution (ESPCI) (1994) and the Rothschild Foundation Fellowship (1996). He has also been named Fellow of the American Physical Society (2001), a Distinguished Lecturer of the Collège de France (1999), received the Hans Fischer Fellowship of the Technical University Munich (2011), and was a Simons Fellow (2016).
This lecture was originally recorded on Wednesday, July 10, 2024 at the Aspen Center for Physics.
Note: The videos featured in this lecture do have sound, and we apologize that it did not make it into the recording. Please find the original recordings, with sound, here:
Simulation of water freezing into ice
• Simulation of water fr...
Molecular Visualizations of DNA (2003) Drew Berry wehi.tv
• Molecular Visualizatio...
This is one of the best science lecture/explanations, I think Dr. Richard Feynman PhD would enjoy this as well. Another example of this system which we can observe and identify of matter, is almost magically configured, but the actual physical process is a result of the atomic characteristics. I like the dry humor that Robin Bruinsma's uses to highlight the configuration.
I didn't understand a lot of this but hoped some of it might rub off on me. That's why I listened to the whole lecture and questions. I loved the water part. And how the molecules attract even when they don't. And the twist pushes out the water. At 75 and no formal training in this stuff or any science I can only play with the ideas. Thanks for the lecture.
We are so glad you enjoyed it! Thank you!
one of my favorite things about biology is how it can be visualised or imagined.. if u havent watched them yet, those wehi videos of cgi cell stuff are great. and these days there's even more, just gotta find them with the right search terms (maybe like "cell biology visualization simulation") but im sure u know how finicky search is these days. it just fills me with awe how a second is such a long time for the wiggling molecule cities that qre our cells😮
Outstanding explanation of the molecular geometry of water and ice! I now know why ice floats! Awesome!!!!!!
Loved seeing this, and I loved this guy's energy
Thank you!
Great lecture but ruined by the poor sound. I think there’s an AI service that will clean up the sound. Politely suggest you do that and repost. Thanks :)
Hi! We actually did use the "Enhance Audio" feature in Premiere Pro. Unfortunately, it didn't help much. We are working on upgrading our system. Thank you for your patience!
@@AspenPhysicsthis is still so much better than previous!!
Really enjoyed this presentation, thank you for sharing your time and work, peace
what if they just talk that way huh 😄
What part does electromagnetic radiation play in all of this? Could it serve as a coupling or synchronization mechanism, perhaps? Or a cellular signal priming mechanism?
C6H12 is cyclohexane, hexane is C6H14.
As I listen to Nick Lane and Michael Levin, I am disappointed that even they do not see the relationship between genetic information and bioelectricity. This presentation is "correct,' but what does it lead to? I saw a structured water device by a metaphysician I respect, and was forced to suss out what it actually does to the water. He didn't offer mechanism of action and a proof of concept experiment. Here is the basis for a deterministic gene drive. It does start with the water.
The structured water device is a plastic tube wound 12 times (8+4) around a 2" X 2"X 1" block magnet. As the water passes around the inertial plane of the magnet under fluid flow conditions (Navier-Stokes for genetics anyone?), it undergoes PH perturbations due to magnetic-geometric displacement of the cis-trans hydrogen bonds (2 sets of 3) in the water molecules. If you line the tube with PH sensors, there is nothing to debate. The memory of a biological system is in the sequencing of the hydrogen bonds in the water, as the water is the substrate of biology. 12 turns around the magnet = a linear resequencing of the water. Another of his devices is 6 turns (3+3) around the top and bottom of a giant cylinder magnet. I would favor a solenoid of 6 ring magnets because the magnetic fields work on both sides of the tube at once. But who's counting?
A juicy Sci-Fi tidbit: the film Unforgettable with Ray Liotta posited that one could experience the memories of another person by injecting their cerebrospinal fluid. That was 1996. I forget the year, but the paper I read on the neural signaling mechanism on the inside of the spinal canal really didn't shock me. It's PH fluctuations. Ain't that some shit.
The math of genetics looks binary to us face noise making apes, because of 4 base pairs. But proteins are built on 3 digit codons, the first of which is deterministic. If you follow those cis-trans bond PH signatures up through the tree of life, you will find that the embedded +/-uncertainty of protein folding falls into place. We have Knuth's idea of complexity on the brain, the real thing is done in 3D. AlphaFold, meh.
Can u give a reference to this water device? I’d like to read for myself thanks
@@zakaminzada4737 ruclips.net/video/I4iOOeIzdSQ/видео.html
ruclips.net/video/eWmr2T-_hM8/видео.html
People don't often understand Ken. I simply say that if you line the tube of the device with PH sensors, you will see the perturbations. He never explicitly says what the device actually does to the water.
A gene drive would be based on manipulating the fields around the fluid flow tube and "extruding" pieces of functional code. The "hard" part is building a math out of biology. With computer controlled electromagnetic fields, it would be doable. Starts with the water. I might post a video soon, but only after I work out some of the basics in my head. I'll have to look at the shape and charge/orientation of some basic molecules and look for the PH signatures.
You might also be interested in Gerald Pollack's work on the electrostatics of water. The presenter is right about physicists not understanding water. I do hope this offers a first principles building block for the work of Lane and Levin.
@@zakaminzada4737 Also, if you slow down the molecular activity in water by freezing it around a magnet, you will see some interesting things.
ruclips.net/video/HY0rZZV7x6A/видео.html
Source?
One thing I will say though, our world is obsessed with binary and dualism. In reality, though, everything is related to the number 3. No surprise those in the know worship the triangle (pyramid).
@WalterSamuels Unfourtunately you'll have to search my comments. I'v been trying to explain to the top computer scientists what they're doing wrong. A reliable 0-1-2 gate digital computer would be NP complete. Look for my comments on Demystify Sci, Alexander Unzicker and NJWildberger videos. Wildberger is a pure math rebel who calls bs on infinities in math. Unzicker is a rebel physicist. Anastasia seems to get the 3D computation problem. We never finished electrostatics to make 3d read-write electronic devices. We stacked binary to oblivion.
greetings from southern Brasil