Thanks for watching this episode with Dr. Richard Johnson! If you're finding it valuable, please vote by hitting the LIKE button on the video. This lets me know what type of guests to book for upcoming shows. Thanks! -Jesse 💙
I have been on Keto for 8 months with one meal per month that includes sugary carbs like baked potato, tortilla chips, tortillas. I am 63 years old. My body is fat adapted now and that may be why i do not crave sweets! It is so exciting to me that i went from eating family size bags of m&ms, dove chocolate, donuts, pastries, cake and enormous amounts of cookies daily (all of 2023 and before) then started Keto Jan 1st 2024 and as of today, have lost 70lbs and no longer crave sweets.
Liver and other intestinal meat in a meatloaf or sausage will do your system a lot of good. With homemade olive oil mayonnaise, with some algae oil for omega 3's.
🎯 Key points for quick navigation: 00:28 *🍬 Allulose, a sweetener less sweet than sugar, can help manage postprandial glucose and stimulate GLP-1, potentially aiding weight loss.* 02:47 *🐻 Animals like bears naturally regulate weight; they eat more to store fat before winter, a biologically driven process linked to survival instincts.* 04:34 *🍔 A switch in our bodies triggers fat storage by reducing ATP production, making us feel tired and hungry, driven particularly by fructose from sugars and carbs.* 11:49 *🍭 Allulose, unlike other low-calorie sweeteners, doesn't activate the fat storage switch, stimulates GLP-1, and shows promise in managing weight and blood sugar levels.* 14:57 *🏥 GLP-1 agonists like semaglutide help weight loss but have side effects and weight regain issues; allulose offers a milder alternative with potential health benefits.* 23:46 *🕒 Allulose acts quickly (half-life of about 2 hours), ideal for managing blood sugar by taking before meals to reduce glucose spikes.* 25:49 *🩸 Allulose significantly lowers postprandial blood glucose levels, potentially reducing risk factors for conditions like Alzheimer's.* 28:02 *🍫 Taking 10 grams of allulose with a meal effectively dampens blood glucose spikes, particularly beneficial for those with mild to moderate insulin resistance.* 31:15 *🧠 GLP1 agonists like allulose may inhibit glucagon production, which helps in controlling blood glucose levels after meals.* 33:28 *⚙️ The "switch" mechanism driven by fructose metabolism in mitochondria can lead to ATP depletion, oxidative stress, and potentially facilitate cancer cell growth.* 41:59 *🚫 Fructose-induced mitochondrial damage and ATP depletion contribute to insulin resistance, promoting fat storage and metabolic dysregulation in obesity.* 48:19 *🏋️♂️ Exercise and nutrients like epicatechin can help regenerate damaged mitochondria, even in individuals who have been overweight for an extended period.* 52:55 *🍫 Dark chocolate, especially with allulose, contains epicatechin which supports muscle growth and mitochondrial function.* 54:19 *🚴♂️ Phase two exercises like brisk walking or biking at a lactate threshold are ideal (30-75 minutes, 3 times a week) for stimulating mitochondria.* 58:33 *🍔 Processed foods high in sugar and salt, soft drinks, and high glycemic foods like french fries contribute significantly to metabolic syndrome and weight gain.* 01:02:55 *🧂 Salt increases the conversion of glucose to fructose in the body, exacerbating metabolic issues, especially in conjunction with high carbohydrate intake.* 01:13:30 *🥔 Carbohydrates, especially with added salt, significantly increase the conversion of glucose to fructose, impacting metabolic health differently in those with metabolic syndrome.* 01:18:51 *🍺 Alcohol consumption can trigger glucose conversion to fructose, similar to salt and uric acid.* 01:22:03 *💧 Staying well hydrated can mitigate the effects of salt-triggered glucose-to-fructose conversion.* 01:23:11 *📉 Serum sodium levels slightly above normal range (138-142) increase risks for aging, obesity, and diabetes.* 01:24:42 *🥩 Low-carb diets like keto or carnivore are effective for weight loss and reducing fructose generation from glucose.* 01:29:47 *🧠 Alzheimer's disease is increasingly recognized as a metabolic disease linked to insulin resistance and high fructose levels in the brain.* 01:37:50 *🍲 Umami-rich foods can elevate uric acid levels, which amplify the effects of other foods in causing obesity.* Made with HARPA AI
Thank you again Jessie, you are like a surgeon who cuts right to the meaning of what is spoken by your guest, he recognizes your talent for explaining to your listeners the very heart of his work. I love learning from you! God bless you.
There is only ONE proper way to lose weight (fat, not lean mass): get the insulin levels down. Cut the sugars and starches. Simple, cheap, but maybe not easy. But would you rather spend tens of 1000s of dollars on dangerous drugs?
You are correct for 99% of the people right now. If you are a real athlete or workout the equivalent of running 6+ miles per day, you will want an insulin spike within an hour after your workout. This greatly enhances recovery from workouts. During the other 23 hours, even athletes probably store more fat than desired if insulin rises.
It's easy... eat a couple pounds of fatty red meat per day as your base diet, and cut the carbs. Once adapted, you've just trained your body to be a fat burning machine. It works..
Exactly. I did that, lost 35kgs and reversed my type 2 diabetes. I also fast weekly which I find incredibly useful. I'm not on any medications which doesn't help big pharma and the mainstream medical system who would profit from treating sick people. My approach saves me money!
It's definitely not easy to tell yourself "no" all day, but I lost 40 lbs, and my A1C is within normal range now. My cholesterol is still high. I was 200lbs and now 158-160 lbs. I'm proud of myself. I use allulose in my coffee exclusively(65 yrs old)
@@TinaandPokey Well done. My story is similar. It sure requires discipline but the benefits 'outweigh the disadvantages. I found intermittent fasting great for curbing hunger pains. It took a little while to become fat adapted but I can't live without my fasting now
The movie was My cousin Vinny 😊. Just received my bag of allulose yesterday after watching you and doctor ben bikman talking about it . I do sugar-free and low carb and I love to bake so this is perfect for me . I do need to talk to my sisters since one is diabetic and1 is on ozanpic . When I had cancer I cut out all sugars thank you for your information and really enjoy your podcast Jesse . Have a beautiful day guys 😊😊
4 months ago metobolic video. At end here is the slide the dr shows Reduce. Sugar. Salt. Starchy carbs. Alcohol. Seed oils. Processed meat. Fruit juice. Do. Hydrate take omega 3. Vit b c d. Natural fruits. Allulose. Vegetables. Dairy. Keto foods. Olive oil. Dark chocolate. Coffee. Diets include. Keto. Paleo. Intermittent fasting. Vegan. Mediterranean. His book. I believe his diet is 50% carbs 25% protein 25% fat. There ya go😊
I do a mostly carnivore diet with fasting and will say that utilizing Allulose at the end of a meal keeps me out of the kitchen the rest of the evening. I've never thought about using it before, but maybe if weight loss slows, I'll do just that. It also tastes amazing, closest thing to sugar I've ever had.
Sounds like allulose would be perfect to mix in with my home made milk kefir, which tastes very tart. I like to eat that after dinner because that is said to improve sleep.
@anybodyoutthere3208 use it in a homemade drink, tea, lemonade, throw a few strawberries or raspberries in the blender w lemon & allulouse and add water ice make a WONDERFUL lemonade. Also, make a keto dessert using allulouse (my personal fav is keto CHEESECAKE!!) you will get a very nice dose of allulouse. Look up keto dessert recipies online. Use HEALTHY oils (coconut & avocado for cooking, olive oil for no cooking).
When bears start eating more, they only eat the skin of the salmon where most of the fat and Omegas are. They discard the meat which is then food for other critters down stream.
Carnivore is certainly a long term proposition. There are many testimonies out there. Much prefer to spend money on meat than additives. Great interview, Jesse.
36:21 "so the mitochondria use oxygen and this other system gets turned on and that's the system that drives cancer. So when you activate this pathway you block the production of energy from the Mitochondria from the factories but there is this other system that takes over which uh cancers low because cancers often grow with in areas with low oxygen and now they here's this energy being made in the absence of oxygen. So tumor cells love it and we actually showed that cancer cells love sugar. Others have shown that if you feed sugar to animals with cancer it can stimulate metastases for Christ sake so it's like bad news to eat a lot of sugar when you have cancer"
Why any more than fructose would be considered the same? I don't trust ANY publicly acclaimed health"experts" any more. We're on our own, sifting through the info. God willing that we individually seek AND find.
The worst for me is sugar alcohols where at one point I woke up, called in sick, and spent the day in bed with liver pains and body aches. Allulose, disrupts me badly also, not with liver pain, but with severe gas and intestinal bloat. IMO anything that gives off warnings like that just cant be good for the body and is a hidden negative. Its not like say Splenda where I drank for 25 yrs and the whole time wondered if it had any negative effect. Oh you say its bad for us....ok I then stopped a yr ago. Allulose instead was like I purchased a massive bag of it and that bag went rather fast. Second bag and halfway thru I was like well this is not making me feel well and I dumped it all down the toilet, expensive dump!
Dark chocolate is high in oxalates. Vitamin C supplements also break down into oxalates. I would like to see doctors at least mention this when they recommend these as well as spinach , nuts, and seeds.Oxalates accumulate in the body causing pain, urinary tract damage, etc.
I’ve followed health, nutrition, fitness and emerging science for years now but this caught my attention when you talked about uric acid which has always been high for me. Very interesting discussion!
False hope. I went to several stores and they didn’t have it so I ordered it online. Supposed to get here Monday (today is Wednesday). The waiting is killing me lol 🙄
I am back to starch/meat diet. Reason why I keep going off carnivore is I cant seem to rid myself of carb cravings to the point of excessive thoughts all day. At one point 2 days ago my brain was filled with crispy egg rolls. It was turning over in my mind and all the memories of my most delicious egg rolls bites in my life were flooding my mind, as egg rolls being my favorite food LOL. Anyway, with talk about how carbohydrates being what causes the switch where less ATP is produced causing sluggishness and overeating and even more its pointed towards fructose being the "main" culprit I wonder why low to zero fuctose diets are not recommended. Fructose is everywhere. I was eating a normal diet but with good foods and went from feeling ok to getting severe joint pains all over my body. Breakfast was a bowl of these wheat biscuits with bananas and blue berries and milk. Lunch was pasta with meat sauce etc etc. I came to find that the hidden sugar was not really hidden but was at around 150gms per day. Sugar, which is half fructose is hidden everywhere nowadays. fruits of course but also bread and pasta sauce, hot sauce and whatever its everywhere!
Ozempic actually ruined my metabolic system. I had reduced my A1C to 5.6 on a keto diet..... For one year..but weight loss stalled for 9 months. I got discouraged and gave up. Over the next 4 years I was mostly low carb and the weight loss stayed off except for 20 pounds. My A1C started to climb but was very gradual. Dr wanted me on ozempic. I took it for one year with little to no weight loss or lowering A1C. I expressed my concern and she kept saying up the dose, but it never worked and then she said reduce your meals to only one a day....!😮 I was already low carb and thought...HOW stupid is that. Guess what, I gave it up and decided to do a keto diet again....but now my metabolic system is so screwed up that keto does not work the same and my A1C is up at 8.9....never was ever that high....never...in 14 years.
I hope you are well and attentive to thyself - for these are some questions asked to the universe at this point in lineartime - the why, does it seem or why is it like this. Here you need to focus on a little spoken about isssue that is affecting everyhing - LPS - if you wish you can find more detail on the net and then you will find solutions.
I experience marked appetite suppression with Allulose. 1.5 Tbsp in a drink before meals...tastes exactly like sugar to me (although I dont eat sugar) my food intake is lowered 40-50%...feel full for 4 to 6 hours. Doesnt effect my wife that much, but it works on her too.
Dr Johnson is also a nephrologist. I would love to hear from him what he would suggest to people like me who has chronic kidney disease stage 3 and is on a renal diet to preserve kidney function. The diet is comprised of little or no animal protein and mostly of complex carbs. I don’t touch sugar, junk food or processed foods but 3 times a day, after each meal, my CGM shows that my glucose levels rise to very unhealthy levels. I’ve followed online advise on how to combine and prepare my foods but haven’t had successful results. My mother had Alzheimer’s and this terrifies me. Please bring on someone who could discuss this dilemma. There are supposedly 37 million people in the US who have CKD and most of them don’t know they have it. Thank you.
Might be caused by eating high oxalate foods. Spinach, nuts, seeds, dark chocolate, beets, potatoes, tea, almond products, chard, turmeric, kiwifruit are all high. Also vitamin C supplement breaks down into oxalate. Oxalates bind with minerals making them unavailable for absorption plus they form sharp crystals that damage the kidneys, cause joint pain, fibromyalgia, and sometimes urinary stones. I read about a woman who swopped lots of cashews for potato chips and seriously damaged her kidneys within a month. See Sally K Norton videos for more information. If you are eating a lot of oxalates, you need to reduce them slowly or can have dumping symptoms.
Goid lord, shut up. You have an absurd one track mind. I know you feel knowledgeable because you learned about oxylates, but it's not the answer to everything
Stay away from all sugars.... During the pandemic i went alittle crazy with erythritol and i got heart palpitations, then few years later studies came out saying causes heart disease.
Fascinating insight! Love how nutrition, nature, evolution and our ancestral past ties together to make sense and help guide is towards holistic health!
I seen the topic of LSP as the next big topic given that we need to seek and find. Thank for the good show, host, I made my person notes as comments, this is for my person use.
Maybe I miss it but I didn’t hear him mention the ultimate healthy food, fatty red meat. If not what a shame. Is it fear of upsetting somebody that people like this stop short of calling it out.
Great interview! When you get near normal body composition (not weight), at that point, you cannot continue to live off of ketones without having a mechanism to replenish your body fat stores. I think the paranoia that can occur towards fructose can be overblown if you think you can exercise full control of your own body. Not likely. Hibernating animals benefit greatly from living off their fat, so it's not a death sentence. But they do live in a cyclic manner. There's going to be automatic systems that work despite our limited understanding of the system. Moderation is still going to be key. Varied diet and fasting patterns are integral to that, but people, including me, want a simple (albeit boring) one stop solution to living healthy. Not going to happen.
I use allulose in my coffee every morning with my heavy cream and I am currently eating my Greek yogurt mixed with 10 G of allulose frozen berries and frozen blueberries and mini chocolate chips
I have been saying this for 10 years since I first saw Dr. Johnson on the Mercola RUclips channel. We know the main reason we gain body fat is as a survival mechanism. Johnson's work on fructose literally proves why we like sugar so much. We get addicted because our bodies are telling us to eat as much fruit as possible in the fall because the extra fat may mean the difference between starving to death, or gaining enough fat to survive until spring. Fructose is the true, main reason we get fat because we are eating extracted fructose year-round to prepare for a famine that's never going to come... Fructose causes obesity, insulin resistance, metabolic syndrome and diabetes. I write about this in my book, which features lots of Richard Johnson's research, called "Cavemen Weren't Fat."
What about people who live around the equator and don’t experience the fall season because it stays warm all year round? What do they do with all that plentiful fruit?
Neanderthal people (the 1st cavemen) in my opinion were going into hibernation mode during wintertime so they had to build fat in their bodies. it was not only a survival mechanism but it was also a way to regulate their body's temperature while staying inactive for longer periods of time. They were able to store fat in their stomach, but also in their calves, their hands, their nose, their ears and their eyes. All parts in therir bodies was constructed to keep heat at a maximum level; it was very convenient when it gets cold but unbearable during summertime. I also believe the depression gene comes from Neanderthals, b/c their bodies was able to shut down completely with a slow metabolism during wintertime.
@@stevenrix7277 That is a nice idea, but in every instance when you overfeed healthy humans carbs, their metabolism speeds up to account for it and burns it off. Winter fat storage is part of the process of torpor and is mainly caused by eating autumnal foods high in Linoleic Acid
Wonderful podcast here. I have a question: since even protein can elevate post prandial blood glucose, with a concomitant rise in insulin, for a short time - and since in healthy individuals this is normal, is there a downside to suppressing this with 10 g. of allulose? Do we really want to suppress natural and normal release of insulin?
European think different. In the USA they think, just get started. If there appear problems, we can stop sales. In Europe, we check first if there might be problems, in order not to risk the health of citizens due to sales interests.
This polyol pathway might explain the higher risk for lung cancer in IPF (an interstitial lung disease). In a patient dx’d with both diseases late in cancer progression it may shed light on which came first. Unfortunately not actionable for the terminal cancer patient, but possibly quite valuable for first degree relatives who also have pulmonary fibrosis. But this raises questions for me too. I have elevated uric acid, just about 2 mg/dl above normal. I also eat a fairly well controlled low carb-keto diet and avoid starches and sugar. I have heard that ketone bodies and uric acid compete for excretion and that this can explain my higher uric acid. But it also concerns me that I may need to lower carbohydrate intake even further to avoid activating the polyol-fructose-uric acid pathway. Is there a way to know which is responsible for the elevation of uric acid? My thinking is that since my carbs come mostly from high fiber sources, the slow metabolism of the carbohydrate would meditate the endogenous production of fructose.
Fructose works the same way, not regarding by which process it was produced. Fruit sugar has the effect, at least with me, that you get hungrier the more you eat. You should turn more to berries and nuts. Better tasting and less dangerous.
Could you provide some clarification? Isn't the liver the primary organ responsible for fructose metabolism? When you mention mitochondria, are you specifically referring to the mitochondria within liver cells?
at 45 minutes into listening - so i am seeing this mean we may have loads of energry in our fat, but we still low on the active form of energry, becuase manything are broken to move the stored energry into active energry(ATP).. and this is a liver issue. Why? Why cant a liver do it conversion job correctly.
what's he selling? he goes through quite a bit of context and information about the product, and he's transparently called out his consultancy with a couple companies, yet he's not selling any of their products.
I do not think I need any of these diet things. Being 68@6 foot ,, 160 lbs and being Carnivore I dont have to monitor anything except my protein intake which is why I eat really fatty meat.
@@Roberto-cg2gr Oh, that too! I also learned that EXOGENOUS BHB also helps. I gave some capsules to a relative with CKD, and doctors noted an improvement. 🙂
Do the bears really “know” they want/need to gain fat? Or is this when fruits are available and like us eating the fruits causes them to also eat more than they need and then they get fat at just the right time. The bears who got the fattest survived more often over the winter, and so on and so on. No thinking or planning by beats necessary, just survival of the “fattest”. Oops! I mean “fittest”. 😂
12:30 No, the reason you joined the company is NOT because you're 'very, very curious'. The reason you joined the company is becuse you're 'very, very' keen to make a buck. Be honest!
Interesting! Yeah, I’m with you even though I’ve never tried it. I’d rather just skip “foods” with added sugar, grains and seed oils and enjoy eating whole real foods. Next challenge: reducing the amount of fruit I eat. Only managed 2 days, so far. 😆
To say that something tastes horrible seems off to me. You find it horrible tasting, but others don’t. Clearly, others don’t, including myself. My best use is to add it to artificial sweetener or sugar. It seems to take up some of the sweetness slack, so I use less of the others. Knowing that it has the GLO-1 effect makes it attractive.
I got some and it isn't sweet at all to me and has a funny taste. I have had yogurt with it and the sweetness in it obviously comes from the stevia in it, not the allulose.
Wow!!! THANK YOU, VERY MUCH!!!!, for all of this EXTREMELY INTERESTING, and HELPFUL information!!!["SHARED"] (IMHO: Dr. Johnson's voice sounds much like Dr. David Perlmutter's!)
@@splorch Well, I still won't be jumping on it - anything novel has to be tried and tested for at least 25 yrs... we all saw what happned to the new "flu remedy"...
@AdventuresWithQuinn when you eat a piece of fruit or anything with table sugar, honey or high fructose corn syrup, 50% (or more - HFC) is fructose. Plus, as Jesse mentions, your body can make fructose out of certain foods you eat. In light of these observations, your criticism about "fructose not being found in isolation" is meaningless.
@@Ge1Ri4 +50% fructose is not 100% fructose. Your body can make fructose via the polyol pathway, but again you basically never ingest 100% glucose. Mixed sugars at ingestion fundamentally changes the way they are metabolized. The mouse models the book is based on made for a great read, but there is no repeatability shown in humans in real life.
@@JesseChappus Your body can make fructose via the polyol pathway, but again you basically never ingest 100% glucose. Mixed sugars at ingestion fundamentally changes the way they are metabolized. The mouse models the book is based on made for a great read, but there is no repeatability shown in humans in real life.
Thanks for watching this episode with Dr. Richard Johnson! If you're finding it valuable, please vote by hitting the LIKE button on the video. This lets me know what type of guests to book for upcoming shows. Thanks! -Jesse 💙
Jesse...What about Nu-Salt, potassium chloride, does that activate the 'switch' with carbs to fructose as salt does?
Read Dr. Johnsons great book!
😂❤
Is Dr. Johnson's meal plan included in this book?
@@mudpiedays No, its not.
I have been on Keto for 8 months with one meal per month that includes sugary carbs like baked potato, tortilla chips, tortillas.
I am 63 years old. My body is fat adapted now and that may be why i do not crave sweets! It is so exciting to me that i went from eating family size bags of m&ms, dove chocolate, donuts, pastries, cake and enormous amounts of cookies daily (all of 2023 and before) then started Keto Jan 1st 2024 and as of today, have lost 70lbs and no longer crave sweets.
Sorry, but keto is LOW CARB vegetables, NOT STARCHY vegetables, but you have a good start to go keto/ carnivore.
way to go, bro! you're doing great. don't worry about Ketoan fanatics.
Lol. Shut up @@darlin1951
One cheat day a week is doable, if you change sugar for monk fruit sugar with erythritol, you can eat a lot more sweet stuff without consequences
Liver and other intestinal meat in a meatloaf or sausage will do your system a lot of good. With homemade olive oil mayonnaise, with some algae oil for omega 3's.
🎯 Key points for quick navigation:
00:28 *🍬 Allulose, a sweetener less sweet than sugar, can help manage postprandial glucose and stimulate GLP-1, potentially aiding weight loss.*
02:47 *🐻 Animals like bears naturally regulate weight; they eat more to store fat before winter, a biologically driven process linked to survival instincts.*
04:34 *🍔 A switch in our bodies triggers fat storage by reducing ATP production, making us feel tired and hungry, driven particularly by fructose from sugars and carbs.*
11:49 *🍭 Allulose, unlike other low-calorie sweeteners, doesn't activate the fat storage switch, stimulates GLP-1, and shows promise in managing weight and blood sugar levels.*
14:57 *🏥 GLP-1 agonists like semaglutide help weight loss but have side effects and weight regain issues; allulose offers a milder alternative with potential health benefits.*
23:46 *🕒 Allulose acts quickly (half-life of about 2 hours), ideal for managing blood sugar by taking before meals to reduce glucose spikes.*
25:49 *🩸 Allulose significantly lowers postprandial blood glucose levels, potentially reducing risk factors for conditions like Alzheimer's.*
28:02 *🍫 Taking 10 grams of allulose with a meal effectively dampens blood glucose spikes, particularly beneficial for those with mild to moderate insulin resistance.*
31:15 *🧠 GLP1 agonists like allulose may inhibit glucagon production, which helps in controlling blood glucose levels after meals.*
33:28 *⚙️ The "switch" mechanism driven by fructose metabolism in mitochondria can lead to ATP depletion, oxidative stress, and potentially facilitate cancer cell growth.*
41:59 *🚫 Fructose-induced mitochondrial damage and ATP depletion contribute to insulin resistance, promoting fat storage and metabolic dysregulation in obesity.*
48:19 *🏋️♂️ Exercise and nutrients like epicatechin can help regenerate damaged mitochondria, even in individuals who have been overweight for an extended period.*
52:55 *🍫 Dark chocolate, especially with allulose, contains epicatechin which supports muscle growth and mitochondrial function.*
54:19 *🚴♂️ Phase two exercises like brisk walking or biking at a lactate threshold are ideal (30-75 minutes, 3 times a week) for stimulating mitochondria.*
58:33 *🍔 Processed foods high in sugar and salt, soft drinks, and high glycemic foods like french fries contribute significantly to metabolic syndrome and weight gain.*
01:02:55 *🧂 Salt increases the conversion of glucose to fructose in the body, exacerbating metabolic issues, especially in conjunction with high carbohydrate intake.*
01:13:30 *🥔 Carbohydrates, especially with added salt, significantly increase the conversion of glucose to fructose, impacting metabolic health differently in those with metabolic syndrome.*
01:18:51 *🍺 Alcohol consumption can trigger glucose conversion to fructose, similar to salt and uric acid.*
01:22:03 *💧 Staying well hydrated can mitigate the effects of salt-triggered glucose-to-fructose conversion.*
01:23:11 *📉 Serum sodium levels slightly above normal range (138-142) increase risks for aging, obesity, and diabetes.*
01:24:42 *🥩 Low-carb diets like keto or carnivore are effective for weight loss and reducing fructose generation from glucose.*
01:29:47 *🧠 Alzheimer's disease is increasingly recognized as a metabolic disease linked to insulin resistance and high fructose levels in the brain.*
01:37:50 *🍲 Umami-rich foods can elevate uric acid levels, which amplify the effects of other foods in causing obesity.*
Made with HARPA AI
Thank you.
👍😘
Thanks! Next time without bold text, please.
cool 👍
CAUTION Allulose is BAD NEWS, Folks it's a man made substitute, just as dangerous as all the other artificial, bad side effects
Thank you again Jessie, you are like a surgeon who cuts right to the meaning of what is spoken by your guest, he recognizes your talent for explaining to your listeners the very heart of his work. I love learning from you! God bless you.
Fabulous interview, Jesse!! You really did your homework.
Thank you! I always do ;)
Thanks Jesse, another great conversation with dr Johnson. 👍👏👏
There is only ONE proper way to lose weight (fat, not lean mass): get the insulin levels down. Cut the sugars and starches. Simple, cheap, but maybe not easy. But would you rather spend tens of 1000s of dollars on dangerous drugs?
You are correct for 99% of the people right now. If you are a real athlete or workout the equivalent of running 6+ miles per day, you will want an insulin spike within an hour after your workout. This greatly enhances recovery from workouts. During the other 23 hours, even athletes probably store more fat than desired if insulin rises.
It's easy... eat a couple pounds of fatty red meat per day as your base diet, and cut the carbs. Once adapted, you've just trained your body to be a fat burning machine. It works..
Exactly. I did that, lost 35kgs and reversed my type 2 diabetes. I also fast weekly which I find incredibly useful. I'm not on any medications which doesn't help big pharma and the mainstream medical system who would profit from treating sick people. My approach saves me money!
It's definitely not easy to tell yourself "no" all day, but I lost 40 lbs, and my A1C is within normal range now. My cholesterol is still high. I was 200lbs and now 158-160 lbs. I'm proud of myself. I use allulose in my coffee exclusively(65 yrs old)
@@TinaandPokey Well done. My story is similar. It sure requires discipline but the benefits 'outweigh the disadvantages. I found intermittent fasting great for curbing hunger pains. It took a little while to become fat adapted but I can't live without my fasting now
The movie was My cousin Vinny 😊. Just received my bag of allulose yesterday after watching you and doctor ben bikman talking about it . I do sugar-free and low carb and I love to bake so this is perfect for me . I do need to talk to my sisters since one is diabetic and1 is on ozanpic . When I had cancer I cut out all sugars thank you for your information and really enjoy your podcast Jesse . Have a beautiful day guys 😊😊
4 months ago metobolic video. At end here is the slide the dr shows
Reduce. Sugar. Salt. Starchy carbs. Alcohol. Seed oils. Processed meat. Fruit juice.
Do. Hydrate take omega 3. Vit b c d. Natural fruits. Allulose. Vegetables. Dairy. Keto foods. Olive oil. Dark chocolate. Coffee.
Diets include. Keto. Paleo. Intermittent fasting. Vegan. Mediterranean. His book. I believe his diet is 50% carbs 25% protein 25% fat.
There ya go😊
Thank you! Have a great day!
No way will 50% carbs work. Zero carb is the way to go. 20% protein and the remainder fat.
thank you pumpkin
I do a mostly carnivore diet with fasting and will say that utilizing Allulose at the end of a meal keeps me out of the kitchen the rest of the evening. I've never thought about using it before, but maybe if weight loss slows, I'll do just that. It also tastes amazing, closest thing to sugar I've ever had.
What do you put it in after dinner ? How do you use it
Sounds like allulose would be perfect to mix in with my home made milk kefir, which tastes very tart. I like to eat that after dinner because that is said to improve sleep.
@anybodyoutthere3208 use it in a homemade drink, tea, lemonade, throw a few strawberries or raspberries in the blender w lemon & allulouse and add water ice make a WONDERFUL lemonade. Also, make a keto dessert using allulouse (my personal fav is keto CHEESECAKE!!) you will get a very nice dose of allulouse. Look up keto dessert recipies online. Use HEALTHY oils (coconut & avocado for cooking, olive oil for no cooking).
Just such a great informative discussion! Thank you so much for the great questions and having a a guest that broke it down!❤
A Brilliant discussion that provides nidus for further research into multiple preventive health aspects.🎉
Allulose is great! I use it in place of sugar all the time. I love it.
Awesome interview! 🎉 Thanks! 😃
When bears start eating more, they only eat the skin of the salmon where most of the fat and Omegas are. They discard the meat which is then food for other critters down stream.
Carnivore is certainly a long term proposition. There are many testimonies out there. Much prefer to spend money on meat than additives. Great interview, Jesse.
36:21 "so the mitochondria use oxygen and this other system gets turned on and that's the system that drives cancer. So when you activate this pathway you block the production of energy from the Mitochondria from the factories but there is this other system that takes over which uh cancers low because cancers often grow with in areas with low oxygen and now they here's this energy being made in the absence of oxygen. So tumor cells love it and we actually showed that cancer cells love sugar. Others have shown that if you feed sugar to animals with cancer it can stimulate metastases for Christ sake so it's like bad news to eat a lot of sugar when you have cancer"
In Europe, allulose is still considered to be a carcinogen
😮
The easies way to become healthy is to do the opposite than doctors say.
This is no joke unfortunately!
Why any more than fructose would be considered the same? I don't trust ANY publicly acclaimed health"experts" any more. We're on our own, sifting through the info. God willing that we individually seek AND find.
The worst for me is sugar alcohols where at one point I woke up, called in sick, and spent the day in bed with liver pains and body aches. Allulose, disrupts me badly also, not with liver pain, but with severe gas and intestinal bloat. IMO anything that gives off warnings like that just cant be good for the body and is a hidden negative. Its not like say Splenda where I drank for 25 yrs and the whole time wondered if it had any negative effect. Oh you say its bad for us....ok I then stopped a yr ago. Allulose instead was like I purchased a massive bag of it and that bag went rather fast. Second bag and halfway thru I was like well this is not making me feel well and I dumped it all down the toilet, expensive dump!
Dark chocolate is high in oxalates. Vitamin C supplements also break down into oxalates. I would like to see doctors at least mention this when they recommend these as well as spinach , nuts, and seeds.Oxalates accumulate in the body causing pain, urinary tract damage, etc.
I’ve followed health, nutrition, fitness and emerging science for years now but this caught my attention when you talked about uric acid which has always been high for me. Very interesting discussion!
Last time I asked for Allulose in Canada, I was told that it has not been approved here yet. I bought it in the States!
Amazon USA will ship it to Canada.
@@kennettle
Good tip, thanks
And as long as it shows to be healthy, it never WILL be approved 🤨!
I like cyclamate sweetener. Not approved in USA!
YOU CAN ORDER IT FROM CANADA! 😂😂😂
Stopped using allulose after pain near bladder and heard another person commenting on allulose giving then UTI
ALL sugars are poison
Messes me up to point where I flushed an expensive amount of it down toilet.
I’m vegan, 5’8 126lbs don’t really exercise other than walking my dog and I eat what I please when I want in quantities that satisfy me!
I’m going to get some Allulose tomorrow morning 👍🏼👍🏼🙏🏼🙏🏼
False hope. I went to several stores and they didn’t have it so I ordered it online. Supposed to get here Monday (today is Wednesday). The waiting is killing me lol 🙄
I am back to starch/meat diet. Reason why I keep going off carnivore is I cant seem to rid myself of carb cravings to the point of excessive thoughts all day. At one point 2 days ago my brain was filled with crispy egg rolls. It was turning over in my mind and all the memories of my most delicious egg rolls bites in my life were flooding my mind, as egg rolls being my favorite food LOL. Anyway, with talk about how carbohydrates being what causes the switch where less ATP is produced causing sluggishness and overeating and even more its pointed towards fructose being the "main" culprit I wonder why low to zero fuctose diets are not recommended.
Fructose is everywhere. I was eating a normal diet but with good foods and went from feeling ok to getting severe joint pains all over my body. Breakfast was a bowl of these wheat biscuits with bananas and blue berries and milk. Lunch was pasta with meat sauce etc etc. I came to find that the hidden sugar was not really hidden but was at around 150gms per day. Sugar, which is half fructose is hidden everywhere nowadays. fruits of course but also bread and pasta sauce, hot sauce and whatever its everywhere!
Ozempic actually ruined my metabolic system. I had reduced my A1C to 5.6 on a keto diet..... For one year..but weight loss stalled for 9 months. I got discouraged and gave up. Over the next 4 years I was mostly low carb and the weight loss stayed off except for 20 pounds. My A1C started to climb but was very gradual. Dr wanted me on ozempic. I took it for one year with little to no weight loss or lowering A1C. I expressed my concern and she kept saying up the dose, but it never worked and then she said reduce your meals to only one a day....!😮
I was already low carb and thought...HOW stupid is that.
Guess what, I gave it up and decided to do a keto diet again....but now my metabolic system is so screwed up that keto does not work the same and my A1C is up at 8.9....never was ever that high....never...in 14 years.
Oh and I forgot to mention...my Uric acid is over 500 and I am repeatedly having painful gout. So yeah.
I hope you are well and attentive to thyself - for these are some questions asked to the universe at this point in lineartime - the why, does it seem or why is it like this. Here you need to focus on a little spoken about isssue that is affecting everyhing - LPS - if you wish you can find more detail on the net and then you will find solutions.
Go carnivore for a while to get back to where you were!
..... when your A1c is better, go back on keto and don't give up, keep working on it!
I experience marked appetite suppression with Allulose. 1.5 Tbsp in a drink before meals...tastes exactly like sugar to me (although I dont eat sugar) my food intake is lowered 40-50%...feel full for 4 to 6 hours.
Doesnt effect my wife that much, but it works on her too.
Are there any side effect of allulose?????
Dr Johnson is also a nephrologist. I would love to hear from him what he would suggest to people like me who has chronic kidney disease stage 3 and is on a renal diet to preserve kidney function. The diet is comprised of little or no animal protein and mostly of complex carbs. I don’t touch sugar, junk food or processed foods but 3 times a day, after each meal, my CGM shows that my glucose levels rise to very unhealthy levels. I’ve followed online advise on how to combine and prepare my foods but haven’t had successful results. My mother had Alzheimer’s and this terrifies me. Please bring on someone who could discuss this dilemma. There are supposedly 37 million people in the US who have CKD and most of them don’t know they have it. Thank you.
I’m no scientist.. but have you listened to Dr Jason Fung on kidney disease?.. good luck!😊
Might be caused by eating high oxalate foods. Spinach, nuts, seeds, dark chocolate, beets, potatoes, tea, almond products, chard, turmeric, kiwifruit are all high. Also vitamin C supplement breaks down into oxalate. Oxalates bind with minerals making them unavailable for absorption plus they form sharp crystals that damage the kidneys, cause joint pain, fibromyalgia, and sometimes urinary stones.
I read about a woman who swopped lots of cashews for potato chips and seriously damaged her kidneys within a month.
See Sally K Norton videos for more information. If you are eating a lot of oxalates, you need to reduce them slowly or can have dumping symptoms.
Goid lord, shut up. You have an absurd one track mind. I know you feel knowledgeable because you learned about oxylates, but it's not the answer to everything
Sadly, Health Canada has not approved Allusole. So it's not available here
you should still be able to purchase it online... it's not outlawed, just not approved for sale (in Canada).
Stay away from all sugars.... During the pandemic i went alittle crazy with erythritol and i got heart palpitations, then few years later studies came out saying causes heart disease.
Fascinating insight! Love how nutrition, nature, evolution and our ancestral past ties together to make sense and help guide is towards holistic health!
I seen the topic of LSP as the next big topic given that we need to seek and find. Thank for the good show, host, I made my person notes as comments, this is for my person use.
Maybe I miss it but I didn’t hear him mention the ultimate healthy food, fatty red meat. If not what a shame. Is it fear of upsetting somebody that people like this stop short of calling it out.
Spot on
Love my red fatty meats
Never felt better!!
Great interview!
When you get near normal body composition (not weight), at that point, you cannot continue to live off of ketones without having a mechanism to replenish your body fat stores.
I think the paranoia that can occur towards fructose can be overblown if you think you can exercise full control of your own body. Not likely.
Hibernating animals benefit greatly from living off their fat, so it's not a death sentence. But they do live in a cyclic manner. There's going to be automatic systems that work despite our limited understanding of the system.
Moderation is still going to be key. Varied diet and fasting patterns are integral to that, but people, including me, want a simple (albeit boring) one stop solution to living healthy. Not going to happen.
I use allulose in my coffee every morning with my heavy cream and I am currently eating my Greek yogurt mixed with 10 G of allulose frozen berries and frozen blueberries and mini chocolate chips
What about Nu-Salt, potassium chloride, does that activate the 'switch' with carbs to fructose as salt does?
I have been saying this for 10 years since I first saw Dr. Johnson on the Mercola RUclips channel. We know the main reason we gain body fat is as a survival mechanism. Johnson's work on fructose literally proves why we like sugar so much. We get addicted because our bodies are telling us to eat as much fruit as possible in the fall because the extra fat may mean the difference between starving to death, or gaining enough fat to survive until spring.
Fructose is the true, main reason we get fat because we are eating extracted fructose year-round to prepare for a famine that's never going to come...
Fructose causes obesity, insulin resistance, metabolic syndrome and diabetes.
I write about this in my book, which features lots of Richard Johnson's research, called "Cavemen Weren't Fat."
This is what the book said but unfortunately is not practically correct.
What about people who live around the equator and don’t experience the fall season because it stays warm all year round? What do they do with all that plentiful fruit?
Neanderthal people (the 1st cavemen) in my opinion were going into hibernation mode during wintertime so they had to build fat in their bodies. it was not only a survival mechanism but it was also a way to regulate their body's temperature while staying inactive for longer periods of time. They were able to store fat in their stomach, but also in their calves, their hands, their nose, their ears and their eyes. All parts in therir bodies was constructed to keep heat at a maximum level; it was very convenient when it gets cold but unbearable during summertime. I also believe the depression gene comes from Neanderthals, b/c their bodies was able to shut down completely with a slow metabolism during wintertime.
@@stevenrix7277 Hi. What about the cave men in year round warm climates with year round fruit available?
@@stevenrix7277 That is a nice idea, but in every instance when you overfeed healthy humans carbs, their metabolism speeds up to account for it and burns it off.
Winter fat storage is part of the process of torpor and is mainly caused by eating autumnal foods high in Linoleic Acid
Wonderful podcast here. I have a question: since even protein can elevate post prandial blood glucose, with a concomitant rise in insulin, for a short time - and since in healthy individuals this is normal, is there a downside to suppressing this with 10 g. of allulose? Do we really want to suppress natural and normal release of insulin?
Is sea salt, Himalayan bad for you? Or is it only iodized salt?
Why is it not allowed in Europe? their food tends to be better than ours (hell, any country is probably far better than usa foods)
European think different. In the USA they think, just get started. If there appear problems, we can stop sales. In Europe, we check first if there might be problems, in order not to risk the health of citizens due to sales interests.
This polyol pathway might explain the higher risk for lung cancer in IPF (an interstitial lung disease). In a patient dx’d with both diseases late in cancer progression it may shed light on which came first. Unfortunately not actionable for the terminal cancer patient, but possibly quite valuable for first degree relatives who also have pulmonary fibrosis.
But this raises questions for me too. I have elevated uric acid, just about 2 mg/dl above normal. I also eat a fairly well controlled low carb-keto diet and avoid starches and sugar. I have heard that ketone bodies and uric acid compete for excretion and that this can explain my higher uric acid. But it also concerns me that I may need to lower carbohydrate intake even further to avoid activating the polyol-fructose-uric acid pathway. Is there a way to know which is responsible for the elevation of uric acid? My thinking is that since my carbs come mostly from high fiber sources, the slow metabolism of the carbohydrate would meditate the endogenous production of fructose.
Please have a research on how eating eggs stimulate GLP1
Really appreciate your words from the Word. However, why is financial help theconly prayer asked here?
Sadly both Blue Oak epicatechin and Urolithin A are outrageously expensive.
This is banned in Canada & Europe as a possible carcinogen. 🙈
What fructose does he mean??? From processed food only or fruit also??
Fructose works the same way, not regarding by which process it was produced. Fruit sugar has the effect, at least with me, that you get hungrier the more you eat. You should turn more to berries and nuts. Better tasting and less dangerous.
My body doesn't accept animals protein. How do I apply this method
Could you provide some clarification? Isn't the liver the primary organ responsible for fructose metabolism? When you mention mitochondria, are you specifically referring to the mitochondria within liver cells?
So does the drop in ATP mean - that we are robbing the other non-liver cells from their Phosphase groups to help out the liver?
at 45 minutes into listening - so i am seeing this mean we may have loads of energry in our fat, but we still low on the active form of energry, becuase manything are broken to move the stored energry into active energry(ATP).. and this is a liver issue. Why? Why cant a liver do it conversion job correctly.
So i conclude that even if the liver is taking the hit, all the donor cells of the P will take an impact effect.
compounds like epicatechin from raw cocoa beans or high dark chocolate is good to help the mitrochondia.
The craving for Alcopop is same for Sugar - aka me and my father-
All fructose problematic??? Including that from whole fruits & honey???
I’m always skeptical watching these podcasts when they’re are selling something.
what's he selling? he goes through quite a bit of context and information about the product, and he's transparently called out his consultancy with a couple companies, yet he's not selling any of their products.
Dr. Robert Lustig has also mentioned allulose in the reduction of insulin. This isn't the first doctor I've heard talk about it.
My Cousin Vinny. It was Alabama, not Louisiana.
Sounds like he's describing the 'Randle Cycle'
There are already epicatechin supplements.
I do not think I need any of these diet things. Being 68@6 foot ,, 160 lbs and being Carnivore I dont have to monitor anything except my protein intake which is why I eat really fatty meat.
controlling basal insulin is more important than postprandial insulin spikes
Exactly. See my question above.
Right so, but what shall you do, when the liver produces sugar independently to raise sugars ?
I'm sure if you stay on RUclips long enough you will hear many "experts" saying the spikes kill you
Please ask Dr Rick Johnson to have a research on GKI of less than 2 to cure CKD
There's info on BHB that helps CKD! See Thomas DeLauer on RUclips.
@@MissDeb-jq6nz
Jason Fung have a video on fasting helping CKD. Fasting increases BHB
@@Roberto-cg2gr Oh, that too! I also learned that EXOGENOUS BHB also helps. I gave some capsules to a relative with CKD, and doctors noted an improvement. 🙂
@@MissDeb-jq6nz
Looking for a published research on GKI of less than 2 to cure or reverse CKD
Do the bears really “know” they want/need to gain fat? Or is this when fruits are available and like us eating the fruits causes them to also eat more than they need and then they get fat at just the right time. The bears who got the fattest survived more often over the winter, and so on and so on. No thinking or planning by beats necessary, just survival of the “fattest”. Oops! I mean “fittest”. 😂
Kind of goes without saying.
Eat only bacon, beef, butter, and eggs. Easiest weight loss diet ever.
Anyone posting a summary?
There's one above.
We do not hiber Nate !
it destroys the-pancreas
Are you saying that ozempic destroys the pancreas?
Every processed food has high fructose corn syrup
Obviously not true
12:30 No, the reason you joined the company is NOT because you're 'very, very curious'. The reason you joined the company is becuse you're 'very, very' keen to make a buck. Be honest!
You can be both. Even scientists have to eat. Seems like a dude who knows his stuff.
Very interesting about Alzhiemers.
Allulose taste horrible. I would rather never eat sweets again than to have to eat that stuff. 🤮
Individual differences apply. Benefits outweigh taste. Pinch your nose maybe
If only I were you!!😢
Interesting! Yeah, I’m with you even though I’ve never tried it. I’d rather just skip “foods” with added sugar, grains and seed oils and enjoy eating whole real foods. Next challenge: reducing the amount of fruit I eat. Only managed 2 days, so far. 😆
To say that something tastes horrible seems off to me. You find it horrible tasting, but others don’t. Clearly, others don’t, including myself. My best use is to add it to artificial sweetener or sugar. It seems to take up some of the sweetness slack, so I use less of the others. Knowing that it has the GLO-1 effect makes it attractive.
I got some and it isn't sweet at all to me and has a funny taste. I have had yogurt with it and the sweetness in it obviously comes from the stevia in it, not the allulose.
Wow!!! THANK YOU, VERY MUCH!!!!, for all of this EXTREMELY INTERESTING, and HELPFUL information!!!["SHARED"]
(IMHO: Dr. Johnson's voice sounds much like Dr. David Perlmutter's!)
♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥♥
hmmmmm: Why is allulose banned in Europe? Allulose is banned in Europe and Canada, possible carcinogen.
It's not banned in Europe - it's in the approval process, which was delayed by covid. Approval might come this year
@@splorch Well, I still won't be jumping on it - anything novel has to be tried and tested for at least 25 yrs... we all saw what happned to the new "flu remedy"...
@@laurelledubois What does that mean?
His book "why we get fat" was a whole book based on fructose metabolism - but no one eats fructose in isolation so it's meaningless
His book is brilliant! It doesn't need to be in isolation plus glucose can be converted to fructose in the body. Watch and have your mind blown :)
@AdventuresWithQuinn when you eat a piece of fruit or anything with table sugar, honey or high fructose corn syrup, 50% (or more - HFC) is fructose. Plus, as Jesse mentions, your body can make fructose out of certain foods you eat. In light of these observations, your criticism about "fructose not being found in isolation" is meaningless.
@@Ge1Ri4
+50% fructose is not 100% fructose.
Your body can make fructose via the polyol pathway, but again you basically never ingest 100% glucose.
Mixed sugars at ingestion fundamentally changes the way they are metabolized.
The mouse models the book is based on made for a great read, but there is no repeatability shown in humans in real life.
@@JesseChappus
Your body can make fructose via the polyol pathway, but again you basically never ingest 100% glucose. Mixed sugars at ingestion fundamentally changes the way they are metabolized.
The mouse models the book is based on made for a great read, but there is no repeatability shown in humans in real life.
@@AdventuresWithQuinn We do eat almost 100 percent glucose when you eat the white part of a potato or the white part of rice.