Receptor Pharmacology (Part 03) = G Protein Coupled Receptor | Pharmacology of G-Protein Receptors

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Pharmacology is all about the study of drug and their effect on the body along with the body responsible for the drug taken. The drug gives its action mainly through the receptor.
Receptors are the macromolecule or binding site located at the surface or inside the cell. They are used to recognize the signal or drug molecule and initiate the biological response. The biological response is generally given by any drug using any of these mechanisms- (1) Enzyme (2) Ion channels (3) Transport (4) Receptor. In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell. When such chemical signals bind to a receptor, they cause some form of cellular/tissue response, e.g. a change in the electrical activity of a cell. A receptor is a protein which binds to a specific molecule. The molecule it binds is known as the ligand. A ligand may be any molecule, from inorganic minerals to organism-created proteins, hormones, and neurotransmitters. The ligand binds to the ligand-binding site on the receptor protein. When this binding happens, the receptor undergoes a conformational change. This change shapes slightly alters the protein’s function. From this, a number of things can happen. The conformational change in the receptor can cause the receptor to become an enzyme and actively combine or separate certain molecules
GPCRs play a role in an incredible array of functions in the human body, and an increased understanding of these receptors has greatly affected modern medicine. In fact, researchers estimate that between one-third and one-half of all marketed drugs act by binding to GPCRs. G proteins are specialized proteins with the ability to bind the nucleotides guanosine triphosphate (GTP) and guanosine diphosphate (GDP). Some G proteins, such as the signalling protein Ras, are small proteins with a single subunit. However, the G proteins that associate with GPCRs are heterotrimeric, meaning they have three different subunits: an alpha subunit, a beta subunit, and a gamma subunit. Two of these subunits - alpha and gamma - are attached to the plasma membrane by lipid anchors.
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Pharmacology chapter # 02 drug receptor interactions pdf file is available or not? If available then plz give me. It is very confusing and difficult to learn over book.
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Safa Yaqoob Apart from notes, this video will help you - What is Receptor? Different types of Receptors in Pharmacology. Simple explaination with examples ruclips.net/video/udp-nbKHSy0/видео.html

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