Convergent Total Synthesis of Cyclopamine

An organic chemistry minilecture on the 'Convergent Total Synthesis of (-)-Cyclopamine' by Manolis Sofiadis, Dongmin Xu, Anthony J. Rodriguez, Benedikt Nissl, Sebastian Clementson, Nadia Nasser Petersen and Phil S. Baran* Highlights include an Asymmetric Allylic Alkylation, a radical Halocyclisation and a challenging Ring Closing Metathesis to form a tetrasubstituted olefin.
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References:
10.26434/chemrxiv-2023-tf81r (This work)
Phytochemistry 1968, 7, 303-306 (Isolation)
Org. Lett. 2008, 10, 2, 289-292 (Cu H Reductant)
Angew. Chem. Int. Ed. 2006, 45,497-500 (LaCl3.2LiCl)
Nat. Synth. 2022, 1, 641-648 (Asymmetric Allylic Alkylation)
Chem. Eur. J. 2007, 13, 8029-8036 (Grubbs Catalyst)
J. Org. Chem. 2016, 81, 10707-10714 (LiDBB reagent)

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[@exuma7524]

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