Thank you so much for creating these excellent slides and explaining this metabolic pathway so clearly. I learned a LOT and took a page of notes to help me pack it into my brain. On to part 2!
I have been googling this topic all day and despite reading numerous medical journals and articles, and everyone's definition of lactic acidosis, lactic acid, and lactate are all different. I am in the medical field. This is something that actually could make sense. Thank you I owe you my life. electroneutrality in the plasma nice. so basically it should be called lactate + hydrogen ion acidosis, not lactic acidosis
The principle of electroneutrality is interesting, but my question is if we know that physical exercise tests the blood lactate from where the hydrogen ions come from to maintain this balance?
Lactic acid has a hydrogen ion and would disassociate into lactate and the hydrogen ion. Decreased pH in the blood is due to the maintenance of electroneutrality (balance of cations and anions lactate is an anion). Exercise throws it out of balance. Cations need to be added to balance it out (hydrogen ions- and thua the pH drops).
The body is mostly composed of H2O, so during high intensity exercise (e.g., anaerobic conditions), the O2 supply directly coming from respiration decreases and therefore the body takes O2 from water releasing H+ to the blood stream and tissue?…just a thought
I’m a bit confused and haven’t been in a chemistry class for awhile if anyone could help. If hydrogen ions are increased in order to maintain balance from increased lactate, why does the PH level drop instead of returning to neutral? Do hydrogen ions just have a greater affect on ph than lactate at their stabilized amounts?
Yes, I think it is because the introduction of H+ by glycolysis makes the solution more acidic than lactate can buffer the release of H+. This describes what I think you’re getting at in the paragraph after Table 1: journals.physiology.org/doi/full/10.1152/physiol.00033.2017
The hydrogen cations are increased to help maintain electro neutrality not to maintain PH balance. I think that is what you are confusing. The effect of increasing hydrogen cations to maintain electro neutrality is a lowering of PH
First of all, thank you for such a great and informative video. Are there any researches you can provide for the theory which concludes that after glycolysis, "lactate" is produced, not lactic acid ?
When they are bound to proteins, they do not have any effect on plasma pH. After detaching, they can influence plasma pH as we measure plasma pH by concentration of H+ and OH-
My favourite biochemistry channel, thank you 🙏 the concept of SID is not undisputed
Thank you so much for creating these excellent slides and explaining this metabolic pathway so clearly. I learned a LOT and took a page of notes to help me pack it into my brain. On to part 2!
Thank you!
I add baking soda pre intense exersize... amazing difference! Thanks for the clarity here!
I have been googling this topic all day and despite reading numerous medical journals and articles, and everyone's definition of lactic acidosis, lactic acid, and lactate are all different. I am in the medical field. This is something that actually could make sense. Thank you I owe you my life. electroneutrality in the plasma nice. so basically it should be called lactate + hydrogen ion acidosis, not lactic acidosis
Oh where is the next video! Can’t wait to watch it!
Thanks! I'm working on it now and should have it up within 1 week.
Excellent !! Clear as a bell
The principle of electroneutrality is interesting, but my question is if we know that physical exercise tests the blood lactate from where the hydrogen ions come from to maintain this balance?
From the dissociazione of water
Thank you, this is exactly what I was wondering about
Wonderful explanation!
thanks a lot , it was very helpful
Thank YOU!!!
Lactic acid has a hydrogen ion and would disassociate into lactate and the hydrogen ion.
Decreased pH in the blood is due to the maintenance of electroneutrality (balance of cations and anions lactate is an anion). Exercise throws it out of balance. Cations need to be added to balance it out (hydrogen ions- and thua the pH drops).
So it does decrease pH, just not the method that we thought.
so where does the extra [H+] come from? hydrogen ions just hanging around in the blood, maybe on plasma proteins? Thanks :)
Yes, H+ come mostly from plasma proteins.
@@CatalystUniversity Doesn't come from ATP Hyrdolysis?
@@CatalystUniversity Great video. I'm eager to know what research papers support this position that the H+ comes from plasma proteins. Thanks.
The body is mostly composed of H2O, so during high intensity exercise (e.g., anaerobic conditions), the O2 supply directly coming from respiration decreases and therefore the body takes O2 from water releasing H+ to the blood stream and tissue?…just a thought
I’m a bit confused and haven’t been in a chemistry class for awhile if anyone could help. If hydrogen ions are increased in order to maintain balance from increased lactate, why does the PH level drop instead of returning to neutral? Do hydrogen ions just have a greater affect on ph than lactate at their stabilized amounts?
Yes, I think it is because the introduction of H+ by glycolysis makes the solution more acidic than lactate can buffer the release of H+.
This describes what I think you’re getting at in the paragraph after Table 1:
journals.physiology.org/doi/full/10.1152/physiol.00033.2017
pH just refers to the amount of H+ in solution. It doesn't measure Cations vs Anions. It only measures Hydrogens. It's a bit misleading
The hydrogen cations are increased to help maintain electro neutrality not to maintain PH balance. I think that is what you are confusing. The effect of increasing hydrogen cations to maintain electro neutrality is a lowering of PH
First of all, thank you for such a great and informative video. Are there any researches you can provide for the theory which concludes that after glycolysis, "lactate" is produced, not lactic acid ?
May H+ cane from water dissociati in?
isn't this from Peter Stewart's research that is sort of not completely accepted?
If the H+ come from blood plasma proteins is used to produce electroneutrality, why the PH drops then?
When they are bound to proteins, they do not have any effect on plasma pH. After detaching, they can influence plasma pH as we measure plasma pH by concentration of H+ and OH-
The more I learn, the more I realize how much of what I thought I knew is incorrect :/
dale gringo poné las fórmulas