Thanks for this short presentation. I’ve been reading literature that confirms this and seeing so many videos describing something different. I almost argued with someone to say, No, it is not lactic acid that causes metabolic acidosis. I relented and decided to stay out of that fight.
Dr said lactate is good. I kept hearing that lactate was bad. They said the quicker we can get rid of it, the better we can perform. This explanation reminds me of why so many people struggle with education.
Good video, Dr. Galpin. When trying to build muscle mass, here is what seperates the men from the boys, the women from the girls...motivation and pain tolerance. When you can achieve your anaerobic/lactate threshold, and push that red line up each time, you will activate the maximum amount of motor units in a muscle cell, both red and white fibers. Maximum intensity for 1-2 minutes, right to the edge of the glycolictic pathway. Each time you force the nervous system to continue sending neurons to the neuromuscular junction when it doesn't really want to, you increase the excitation threshold, and can tolerate more discomfort each time. I have found drop sets are the best way to do this, because you can really punish the muscles, but protect the connective tissues by giving them a break on each successive drop. This is also the best way to achieve the possibility of hyperplasia.💪☺
Thank you for this explanation! Been arguing with fellow massage therapists about “lactic acid build up” and wanted to use this video to show them but it’s way too long. need a 30 second version.
Good video. But I would disagree about the statement that pyruvate becomes lactate in the absence of O2. Even at rest or low intensity exercise we produce lactate when we have more than enough O2. Lactate production is required to generate NAD molecule, NAD is needed for the glycolysis to keep working.
I watched this with hope that I would understand "lactate" more but ended up with more confusing as I there are more jargons mentioned here. It's not your fault at all Dr.Andy but it's mine as my knowledge/education is so limited. I supposed I need to investigate more what those jargons such as ATP, Pyruvate etc means, once understood them I should come back and watch this clip more. Thank you.
Dr Galpin a lactate question if you will help. I measure my lactate monthly on my zone 2 training for mitochondrial biogenesis. I keep it 1.7-1.9 mmole for 90 minutes 4 days a week. However, I donate blood every 2 months, the gift of life, and have noticed after donating blood my lactate, at same wattage and heart rate is ridiculously high. How long should it take to arrive at a legitimately accurate level? Your knowledge on Bioenergetics is inspiring. Thank you for sharing!
great piece of the big puzzle. the question for me is which kind of hormonal effect it has regarding hunger. how does it affect grehlin, glucagon production, glp-1, .... etc.
Hi, I"ve been watching Dr. Heiser's videos for more than a year now. I've learned much from Dr. Heiser and have been blessed by his approach to the Word. I wanted to take the certificate course but need to ask how.
Thanks for the great video. I know this was specifically a lactate topic however could you expand and add other fuel sources such as free fatty acids and ketones into the mix please. I always wonder how non glucose fuel sources impact lactate buffering and using lactate as fuel.
Thank you. I need this explanation for a research topic. It's using TENS to decrease the pain sensation felt from lactic acid so one can supposedly increase repetitions. Some people stop with the pain, some tolerate the burning sensation and only stop if the muscle really fails. If TENS does work, then it might decrease the pain felt from the lactic acid
It isn't just the pain that stops further contractions it's also the fact that the increased acidity in the cell inhibits the enzymes involved in the different energy creating processes, and if I recall correctly it also messes with calcium's ability to bind to tropomin
Hi! I never said lactate is the cause of all diseases, or any disease. Rather, lactic acidosis (lactate fermentation IN THE PRESENCE OF OXYGEN) is the most common mechanism of chronic diseases. While modern dr's focus on lactate for athletes, in the 1930's it was the focus for all sick patients to address. Unfortunately, that info disappeared after 1961.
So I heard from this that lactate isn't bad no matter how much you have in your body is that correct as it can be used for fuel? So what is lactic acidosis? I always heard that it was a bad thing and is it connected to lactate? Is lactate and lactic acid the same thing? I'm a bit confused. 😕
Is the accumulation of hydrogen ions in your body that actually causes the problems and the acidosis. We measure lactate because it is easier to measure and is directly proportional to the amount of H+ in your body.
Great video Andy. I’ve found your videos through Andrew Huberman’s podcast, and it’s a great educational experience. I was wondering though, if lactate acts as a buffer to help increase endurance, what exactly is carnosyn beta alanine doing then if it’s supposed to increase endurance?
Does lactate concentration increase as a direct result of not being able to take in and circulate enough oxygen for aerobic metabolism? In other words the more out of breath you become the more lactate accumulates?
My son 3.5months old he have Lactate plasma issue 10.7 . Now he is not able to speak🗣 and he is not identifying if say anything he is not able to understand. My docter said it is genetic problem come from mother she said it is not curable. Please suggest it is curable? What step s we need to take to improve my baby
Why does the body acidify when we are using anaerobic metabolism? And how does that relate to transportation of Co2 in the form of HCO3 and hyperventilation and exhaliation of Co2? I know the body hyperventilates to deacidify itself during hard exercise (eg. ventilatory threshhold and respiratory compensation) but how is it all connected? Anybody smart out there who can help me? Thanks!
I would love to know why I feel so tired after compound exercise or high reps weights or calisthenics. Any ideas? I know a personal trainer who just said lift heavier with fewer reps but I want to improve endurance. My main hobby is hiking and I want to feel fitter, more able to keep going for longer without feeling awful the following 2 days.
You might be doing too much volume at the intensity you train at, or not resting enough. Completely anecdotal since im not you, but since i usually tend to train too hard and too much in a single session i often felt fatigued. So i tallied up the volume and split it into more frequent sessions with the same weekly total volume. Quality of reps went up strength went up, and my sense of fatigue went down and thus i could increase my activity levels more. Nothing but improvements for me. Also, a HR sensor like polar h10 is magical for gaining insight into the "intensity" your body is training at highly recommend it. In the end you are optimizing your body through training and a combination of selfassesment with qualitative and quantitative measures is one of the easiest ways to do that.
@@albertog507fat does not get turned into glucose. It is the only macronutrient that does not turn to glucose. protein can turn into glucose. Fat will not though. I am trying to understand if a zero carb diet will stop excess lactate since lactate is observed in high concentrations in the brain in mental disorders.
So, I'm not a scientist. But can you clarify if any of these molecules of pyruvate are related to ketones? I'm having a hard time understanding what ketones are.
Laura Villegas they're related in that they're both energy molecules. Both glucose and fatty acids need oxaloacetate in order to enter the krebs cycle...when oxaloacetate is low, these substrates go to the liver instead to be turned into ketone bodies, which return out into the body to be used as fuel. Ketones are advantageous over fatty acids because they can be used by the brain
Out of curiosity, is it lactate which is produced or is it lactic acid which is produced which is subsequently rapidly dissociated to a lactate and H+?
@@joecanti5944 lactate is produced. Under aerobic conditions lactate can be converted by to glucose by the liver. Under anaerobic conditions, this doesn't happen fast enough and lactates is sent to and accumulates in the blood stream (lactate threshold). But in the blood stream you also have free floating hydrogen ions that also accumulates and lower the PH. The lactate will bond with with the hydrogen ions to form lactic acid. You can look at lactate and lactic acid definitions: lactic has an hydrogen ion that lactate doesn't have. This hydrogen comes from ATP hydrolysis that put free hydrogen ions in the blood stream. Also during aerocib conditions these free hydrogens are picked up by oxygen to from water (H2O) which is not acidic. That's with you last longer when aerobic
I know this question will probably not get pickup , but does that mean , hydogen ions are only a problem when they don't get pickedup by the pyruvate?? Free floating ions? How does this happen?
The only way hydrogen ions won't be a problem is if it's picked up by bicarbonate buffers or by oxygen to form water H2O. Bicarbonate buffers are limited and sometimes you don't have enough oxygen available (anaerobic metabolism) so hydrogen builds and tend to mix with lactate to form lactic acid. Hydrogen or lactic acid are both acid and will lower the PH and impede energy production. Hydrogen with bicarbonate and hydrogen with oxygen is not acidic
@@condicionamentofisico4655 lactate is not acid. Lactate can take hydrogen ions to prevent muscles from being acidic. It then forms lactic acid but that doesn't make your muscle more acidic What does is when you go through anaerobic metabolism. Here NADH loses an hydrogen ions that is picked up by lactate to form lactic acid. But you also have hydrogen ions generated in atp hydrolysis and this one can not be picked up by lactate and stays in the muscle. Your muscle then becomes more and more acidic, forcing you to stop
This is misleading. First of all, it's pyruvic acid (not simply pyruvate) that's produced by glycolysis. In the absence of sufficient oxygen to support pyruvate metabolism in mitochondria (via the TCA cycle and the respiratory chain), pyruvic acid is converted to lactic acid. This step is essential to re-generate NAD from NADH, otherwise glycolysis would grind to a halt. So lactate is not pyruvate plus a proton. And lactate isn't acting as a buffer. For every lactate formed from anaerobic glycolysis, a proton (H+ ion) is also formed.
because they depend on this system 2:54 to produce energy, its the best system for long time length effort, in the other side like those who run for 100 meters they depending on anaerobic system.
The big question is If i am fat adapted and eat less than 10% carbs for my 3-4 hours bike ride, will i have a higher lactate threshold than carbs addicted athletes?
![Felix "Unfair" | [Stray Kids : SKZ-PLAYER]](http://i.ytimg.com/vi/Oswujxm2Ag0/mqdefault.jpg)
"Don't blame it for all your weak ass endurance." Priceless.
Dr. Andy, you just gave the BEST explanation I've ever heard! Thanks so much for sharing. Following now!
My professor included this video on our module this week. I was so stoked to my know my professor knows about you, lol.
Your way of explaining things is just so damn beautiful honestly - massive thank you
Finally someone that doesn't make me fall asleep. THANK YOU.
Thanks for this short presentation. I’ve been reading literature that confirms this and seeing so many videos describing something different. I almost argued with someone to say, No, it is not lactic acid that causes metabolic acidosis. I relented and decided to stay out of that fight.
Dr said lactate is good. I kept hearing that lactate was bad. They said the quicker we can get rid of it, the better we can perform. This explanation reminds me of why so many people struggle with education.
Very good explanation. I got answer what I wondered for long time.
Good video, Dr. Galpin. When trying to build muscle mass, here is what seperates the men from the boys, the women from the girls...motivation and pain tolerance. When you can achieve your anaerobic/lactate threshold, and push that red line up each time, you will activate the maximum amount of motor units in a muscle cell, both red and white fibers. Maximum intensity for 1-2 minutes, right to the edge of the glycolictic pathway. Each time you force the nervous system to continue sending neurons to the neuromuscular junction when it doesn't really want to, you increase the excitation threshold, and can tolerate more discomfort each time. I have found drop sets are the best way to do this, because you can really punish the muscles, but protect the connective tissues by giving them a break on each successive drop. This is also the best way to achieve the possibility of hyperplasia.💪☺
nice
tbh you deserve way more subscribers, so much instructive videos
That is the first explanation I’ve really understood Andy! Thank you!
Physiotherapy student here. This explanation is great, thank you!!
You sir are a gem to society. May your brain forever remain intelligent
Me siento feliz de haber hecho la búsqueda que me trajo a este video
Thank you for this explanation! Been arguing with fellow massage therapists about “lactic acid build up” and wanted to use this video to show them but it’s way too long. need a 30 second version.
Understood. Better lecturer than uni lecturers
Good video. But I would disagree about the statement that pyruvate becomes lactate in the absence of O2. Even at rest or low intensity exercise we produce lactate when we have more than enough O2. Lactate production is required to generate NAD molecule, NAD is needed for the glycolysis to keep working.
I watched this with hope that I would understand "lactate" more but ended up with more confusing as I there are more jargons mentioned here. It's not your fault at all Dr.Andy but it's mine as my knowledge/education is so limited. I supposed I need to investigate more what those jargons such as ATP, Pyruvate etc means, once understood them I should come back and watch this clip more. Thank you.
You just saved me. I understand so much now
Dr Galpin a lactate question if you will help. I measure my lactate monthly on my zone 2 training for mitochondrial biogenesis. I keep it 1.7-1.9 mmole for 90 minutes 4 days a week. However, I donate blood every 2 months, the gift of life, and have noticed after donating blood my lactate, at same wattage and heart rate is ridiculously high. How long should it take to arrive at a legitimately accurate level? Your knowledge on Bioenergetics is inspiring. Thank you for sharing!
Enjoy your vids Andy. Minor detail: Pyruvate actually picks up 2 protons to become lactate.
Yes one from NADH and one from the ATP hydrolysis
thanks, Mr. Science
This made sense and helped a great deal. Thank you!!
Heya Doctor! Thanks a lot for this very easy to follow session, much appreciated!
Great video, the easiest way to explain it and lactate is a good thing, hallelujiah
great piece of the big puzzle. the question for me is which kind of hormonal effect it has regarding hunger. how does it affect grehlin, glucagon production, glp-1, .... etc.
Thats powerful and interesting session
Great video. Thanks!
Hi, I"ve been watching Dr. Heiser's videos for more than a year now. I've learned much from Dr. Heiser and have been blessed by his approach to the Word. I wanted to take the certificate course but need to ask how.
Wow, awesome. What an explanation.👍🏻❤️🙏🏿😀
Thanks for the great video. I know this was specifically a lactate topic however could you expand and add other fuel sources such as free fatty acids and ketones into the mix please. I always wonder how non glucose fuel sources impact lactate buffering and using lactate as fuel.
Great insight on pyruvate to lactate (H+). Thanks!
amazing thank you!!!
Thank you. I need this explanation for a research topic. It's using TENS to decrease the pain sensation felt from lactic acid so one can supposedly increase repetitions. Some people stop with the pain, some tolerate the burning sensation and only stop if the muscle really fails. If TENS does work, then it might decrease the pain felt from the lactic acid
Sec Ad try Alpha-Stim instead
It isn't just the pain that stops further contractions it's also the fact that the increased acidity in the cell inhibits the enzymes involved in the different energy creating processes, and if I recall correctly it also messes with calcium's ability to bind to tropomin
Super helpful
What to do if you think you have lactic acidosis? I have burning muscles sometimes within seconds mainly in my arms and forearms.
Really helpful. Thanks Andy.
Nice video.... Followig you for a few years... Excelence
What is the other side of the ion that that H came from and what is it doing?
Fantastic!
what about ingesting lactic acid via some fermented products?
Hi Andy. Dr. Darren Schmidt speaks about lactic acidosis like the cause of all diseases. What is your opinion on this, how to prevent it? Many thanks
Regular respiratory alkalosis and tons of veggies = prevention of lactic acidosis.
Hi! I never said lactate is the cause of all diseases, or any disease. Rather, lactic acidosis (lactate fermentation IN THE PRESENCE OF OXYGEN) is the most common mechanism of chronic diseases. While modern dr's focus on lactate for athletes, in the 1930's it was the focus for all sick patients to address. Unfortunately, that info disappeared after 1961.
@@realfoodcures Thanks for actually finding this comment and clarifying!
So I heard from this that lactate isn't bad no matter how much you have in your body is that correct as it can be used for fuel? So what is lactic acidosis? I always heard that it was a bad thing and is it connected to lactate? Is lactate and lactic acid the same thing? I'm a bit confused. 😕
Is the accumulation of hydrogen ions in your body that actually causes the problems and the acidosis. We measure lactate because it is easier to measure and is directly proportional to the amount of H+ in your body.
When lactate metabolism is occurring in the brain, which space in the brain does the byproduct of water go?
Simple Video! :) Thank You
Just wondering what are levels of mg/dl or mmol/l for aerobic /treshold and max values?
Great video Andy. I’ve found your videos through Andrew Huberman’s podcast, and it’s a great educational experience. I was wondering though, if lactate acts as a buffer to help increase endurance, what exactly is carnosyn beta alanine doing then if it’s supposed to increase endurance?
😭😭😭😭😭😭😭😭❤️❤️❤️😭❤️❤️😭a
Does lactate concentration increase as a direct result of not being able to take in and circulate enough oxygen for aerobic metabolism?
In other words the more out of breath you become the more lactate accumulates?
the more H you accumulate, the more "out of breath" you become
I might sound really dumb but what is
The difference between lactate dehydrogenase and lactate plasma blood tests. Thank you.
So do you not make lactate if you burn fat or protein for fuel?
very helpful, thanks!
Hello, how it' s called the app where you can drag ? Thanks
My son 3.5months old he have Lactate plasma issue 10.7 . Now he is not able to speak🗣 and he is not identifying if say anything he is not able to understand. My docter said it is genetic problem come from mother she said it is not curable. Please suggest it is curable? What step
s we need to take to improve my baby
Would the Wim Hof method help?
awesmone doc, I a Triathlete and coach as well, i hav alot of problems with cramps so i have hear story here and there its nuts,, any suggestion
The biggest thing is experimentation. Keep trying as many different things as possible. Start with diet. Specifically carbs. Good luck!
how does this work if you're in ketosis?
Why does the body acidify when we are using anaerobic metabolism? And how does that relate to transportation of Co2 in the form of HCO3 and hyperventilation and exhaliation of Co2?
I know the body hyperventilates to deacidify itself during hard exercise (eg. ventilatory threshhold and respiratory compensation) but how is it all connected? Anybody smart out there who can help me? Thanks!
I would love to know why I feel so tired after compound exercise or high reps weights or calisthenics. Any ideas? I know a personal trainer who just said lift heavier with fewer reps but I want to improve endurance. My main hobby is hiking and I want to feel fitter, more able to keep going for longer without feeling awful the following 2 days.
You might be doing too much volume at the intensity you train at, or not resting enough. Completely anecdotal since im not you, but since i usually tend to train too hard and too much in a single session i often felt fatigued. So i tallied up the volume and split it into more frequent sessions with the same weekly total volume.
Quality of reps went up strength went up, and my sense of fatigue went down and thus i could increase my activity levels more. Nothing but improvements for me. Also, a HR sensor like polar h10 is magical for gaining insight into the "intensity" your body is training at highly recommend it. In the end you are optimizing your body through training and a combination of selfassesment with qualitative and quantitative measures is one of the easiest ways to do that.
Awesome
Hi Does it mean that if I am fat adapted and use fat as energy, less lactate is produced?
Yeow Mun Wong means go to the gym fat ass watching a video ain’t going to make u swoll also iron man dies in end game
I would also like to see this question answered!
To my understanding “Fat” or insulin, is just your bodies stored glucose.
@@albertog507fat does not get turned into glucose. It is the only macronutrient that does not turn to glucose. protein can turn into glucose. Fat will not though. I am trying to understand if a zero carb diet will stop excess lactate since lactate is observed in high concentrations in the brain in mental disorders.
So lactic acid has no role in creating an acidic environment within the exercising muscle? Its just the H+?
Get it at Galpin
Can vit c counter lactic acid?
You lost me just before ATP
zone angel iron man dies in end game
So, I'm not a scientist. But can you clarify if any of these molecules of pyruvate are related to ketones?
I'm having a hard time understanding what ketones are.
Laura Villegas they're related in that they're both energy molecules. Both glucose and fatty acids need oxaloacetate in order to enter the krebs cycle...when oxaloacetate is low, these substrates go to the liver instead to be turned into ketone bodies, which return out into the body to be used as fuel. Ketones are advantageous over fatty acids because they can be used by the brain
Great explanation! Thank you!
is not lactose a contributor to sore and or cramped muscles?
Lactose is a sugar in dairy. Lactate is not the same thing. And no, lactate doesn't make your muscles sore or cramp.
Out of curiosity, is it lactate which is produced or is it lactic acid which is produced which is subsequently rapidly dissociated to a lactate and H+?
Luke Olsen pretty sure it's lactate that's produced - but I also wanted to know the relationship with lactic acid...
@@joecanti5944 lactate is produced. Under aerobic conditions lactate can be converted by to glucose by the liver. Under anaerobic conditions, this doesn't happen fast enough and lactates is sent to and accumulates in the blood stream (lactate threshold). But in the blood stream you also have free floating hydrogen ions that also accumulates and lower the PH. The lactate will bond with with the hydrogen ions to form lactic acid. You can look at lactate and lactic acid definitions: lactic has an hydrogen ion that lactate doesn't have. This hydrogen comes from ATP hydrolysis that put free hydrogen ions in the blood stream.
Also during aerocib conditions these free hydrogens are picked up by oxygen to from water (H2O) which is not acidic. That's with you last longer when aerobic
Bless
Why does my chest burn when I'm running ?
Acid reflux.
Would this process be the reason you struggle for the first five minutes of your workout, but seems to get easier as it goes on?
Nate Iowa sane as when I beat my meat hard for the first five minutes but then gets easier the more I go on
wonders how eating yogurt with lactobacillus alters the lactate in blood that otherwise gets converted at the liver.
Lactose is not the same as lactate.
🙏
I'm not scientists but I sense something is missing in complete picture of understanding
I know this question will probably not get pickup , but does that mean , hydogen ions are only a problem when they don't get pickedup by the pyruvate?? Free floating ions? How does this happen?
The only way hydrogen ions won't be a problem is if it's picked up by bicarbonate buffers or by oxygen to form water H2O.
Bicarbonate buffers are limited and sometimes you don't have enough oxygen available (anaerobic metabolism) so hydrogen builds and tend to mix with lactate to form lactic acid. Hydrogen or lactic acid are both acid and will lower the PH and impede energy production.
Hydrogen with bicarbonate and hydrogen with oxygen is not acidic
@@nsn27 So , lactate is not acid right ? he "come up" to prevent acidosis an earlier "fatigue" ; so muscle dont turn in latic acid > lactate.
@@condicionamentofisico4655 lactate is not acid.
Lactate can take hydrogen ions to prevent muscles from being acidic. It then forms lactic acid but that doesn't make your muscle more acidic
What does is when you go through anaerobic metabolism. Here NADH loses an hydrogen ions that is picked up by lactate to form lactic acid. But you also have hydrogen ions generated in atp hydrolysis and this one can not be picked up by lactate and stays in the muscle. Your muscle then becomes more and more acidic, forcing you to stop
👍🏻
A build up of lactic acid without the removal causes muscles to cramp up. To combat this muscle fatigue is to use carnosine.
It's prevents a build up of lactic acid but not entirely. Giving the muscles a faster time to recover.
Lactate and glucose are components of sweat.
This is misleading. First of all, it's pyruvic acid (not simply pyruvate) that's produced by glycolysis. In the absence of sufficient oxygen to support pyruvate metabolism in mitochondria (via the TCA cycle and the respiratory chain), pyruvic acid is converted to lactic acid. This step is essential to re-generate NAD from NADH, otherwise glycolysis would grind to a halt. So lactate is not pyruvate plus a proton. And lactate isn't acting as a buffer. For every lactate formed from anaerobic glycolysis, a proton (H+ ion) is also formed.
Why do athletes produce less lactate than normal people
because they depend on this system 2:54 to produce energy, its the best system for long time length effort, in the other side like those who run for 100 meters they depending on anaerobic system.
You get an A from me.
What I want to hear is a sick/high sugar life style does is make YOU the cancer candidate without oxygen/exercise to burn these dirty calories.
uhhh I'm a THIRD year exercise physiology student. Where have you beeeeeen??
I blame lactate for my marital problems.
Andy, your hair has changed since this video, creatine side effect? Jk
👊😎
The big question is
If i am fat adapted and eat less than 10% carbs for my 3-4 hours bike ride, will i have a higher lactate threshold than carbs addicted athletes?
Maybe it will help if he uses less sarcasm
Dang life is weird
This is too academic, I am left clueless after I watched the whole video
Is this for people with degrees.,in medical sciences.