Chris thanks so much for answering my question, very cogent answer too. I'm trying keto and it's wrecking my sleep, so your explaining how carbs help get stuff into the brain is doubly illuminating.
Did you find a TIME OF DAY to ingest carbs that helps your sleep? (I am thinking oatmeal as a good last meal before sleep - ?). Too bad Chris did not relate ingestion of tryptophan containing foods (or supplementation), exercise or niacin? with daily clock of activities/ingestion.
I definitely identify with all of this. Anecdotally, melatonin causes depression in me-- especially over time. Tryptophan in the form of a 1000mg supplement + exercise+ carbs lifts my mood incredibly. I actually can't take my Tryptophan supplement before bed, because it's energizing as opposed to sedating. I've been told my B3/Niacin levels were consistently low (during former OATS test), so this connection could make sense as well. Thanks!
Interesting that you find Tryptophan supplementation before bed 'energizing'. I have also found taking tryptophan does nothing for my sleep. Oatmeal on the other hand . . . If I could 'do' dairy, I would think oatmeal and yogurt or milk would be an ideal sleeping pill. Also, at what time of day is exercise most useful for sleep optimization?
11:00 four things you need Tryptophan for: 1. making protein 2. making niacin 3. making serotonin 4. making Melatonin ...i.e. if taking Tryptophan makes a difference in one of those or things affected by those, EITHER youcare deficient in Tryptophan (from protein intake), failing to breakdown and digest protein, failing to absorb OR a lifestyle/diet factor like too nuch stress/not enough exercise is causing Tryptophan to not be broken down from protein or you are eating too much carbs, etc
@@sassuki What is your suggestion as to tryptophan containing foods (and which are best? Turkey or Oatmeal, for example?) and time of day for optimizing melatonin, especially as it relates to 24 hr sleep cycle? THANKS. (I am guessing you are not a fan of tryptophan supplementation, but if you are. . . I have tried such, and the tryptophan does not assist in quality of sleep for me. However after ingestion of dark eat of turkey I'm reduced to jello. However a temporary condition, it seems.) Anyway, I would be flattered if you would lay out (more than Chris did) When and How to up the tryptophan in my system? I have long had the impression that I am low . . . (history of insomnia beginning in my mid 20's. I am 62 now.) Thank you again. I have recently noticed your comments here, almost always compelling. Make that 'always'!
@@eugeniebreida1583 thanks, I do my best to help :) Best sources are all kinds of meat, chicken and fish, as well as cheese and legumes. The rest I answered in one of the other comments :)
1) Have a good run with these, Chris! They also sound better to me. 2) How does one regulate their body temperature down? I'm getting crazy every summer, while a ton of my female friends feel cold. I do keto/low carb, supplement some things, do daily pushups. The heat interrupts my sleep, although I try and help myself with it. It got me curious about body temperature regulation in general, but nobody talks about it, especially as clear and technical as you do. So I write this hoping I'll get lucky. :)
I'm not sure I have too much to offer here. It probably comes down to hormone balance, but I don't know too much about the mechanisms of how sex hormones impact it. An AC, EightSleep, and/or ChiliPad can be very useful for sleep.
@@chrismasterjohn Thanks for your response. The role of hormones of all stripes play a huge role here, it would be pretty impossible for you to cover . . . Of course with women it's important to know metabolic state (weight/bmi?), age (still ovulating?), and much more. As to sleep and overheating, ONE idea for Vospi would be: are sheets/quilt etc coverings BREATHING - or are you covered in synthetics (under which I myself find it impossible to sleep, as they ruin my skin's ability to respirate properly). Just a thought. Probably off the mark! (Also, I have my bedroom in my basement, for purposes of COOL AIR year round.)
@@chrismasterjohnregarding: "PPS" ...proton pump Stimulators... what stimulates stomach acid production? Why does it decline AT ALL with age to begin with?
@@chrismasterjohn 12:05 if any of these is true...i.e. lacking Tryptophan, then what else "should probably" be considered as lacking? / issues at the root? Low stomach acid production? Low digestive enzyme production? Vagus nerve impairment? Adrenal "lock" / vicious cycle?
I’m hoping this comment reaches you. I was researching the kynurenine pathway and was blown away by its impact on inflammation. There’s a few research studies suggesting that Vitamin B6/P5P helps reduce Kynurenie levels in the body however Tryptophan appears to be in the same pathway. With your expert opinion what would be the best ways to attack Kynurenine levels in the body? Feel free to make a video since I haven’t seen any one really break this down step by step.
@@zoetekauw9647 I realize my n=1 probably isn’t worth anything to you but I’ve experienced some undeniable cardiac side effects from taking 5htp for months at a time. Aside from that, it also uses up AAAD enzyme to make serotonin which competes with tyrosine to make dopamine so leads to NT imbalance
@@alexxxisbatman I've read about the mechanisms, but studies fail to consistently show the tangible adverse effects that these mechanisms imply (they may be counterbalanced with some yet to be identified other mechanism), which is consistent with the fact that the compound continues to be available without prescription. I don't know what else you may have been taking in conjunction with 5-htp, or whether you have any contraindications. You have my sympathy but realize that it is indeed an n=1. Irks me when these stories are parroted without circumspection and start to be taken at face value.
I am low in lithium , magnesium and zinc I was having depression and sleepless nights so I decided to have them all since I started taking my deficient vitamins I am doing very well no depression and feeling happier,but still struggling with falling to sleep Now I want to buy tryptophan for my sleep instead of sleeping aid which sometimes doesn’t even help me , can I take tryptophan with lithium, thank you for the informative video stay blessed 👍
Question: I eat canned cod liver once per week (About 75 grams of liver). It contains 7500 MCG Vit A + 5,4 grams omega 3. I know to much vitamin A from Animals can be harmfull. Can i eat it all at once or should i spread it across the week? Thanks!
I have used Melatonin and L tryptophan at night on occasion. I use tyrosine in the morning. Occasionally, I do a niacin flush, which I enjoy even though you warn against it I enjoy amateur biohacking and lost weight doing a ketogenic diet but transitioned to a zero carb zero sugar and very little to no fruit --- mostly carnivore diet. My transition has been a slow process. I eat alot of eggs sunnyside up with runny yolks and butter and unrefined coconut oil and red meat or beef. I have had eye surgery so I don't have to wear glasses. I use taurine (supplement) which is a protein from meat to protect my eyes against degeneration and it helps. I also use NAC, R lipoic and sometimes glutathione or a high dose MSM organic sulfur. Astaxanthin is good. Zinc, copper, magnesium, potassium. Himalayan salt. Purified water. Vitamin D. Vitamin k2mk7. Thymus gland extract. Lions Mane mushroom. Jarrows brand high quality B complex. Boron. Minerals Zero seed oils no lectins no inflammatory oils, no pepper, no inflammatory things.
Are you doing the anti inflammatory for purposes of reducing an autoimmune condition? I am attempting the same, although I have veggies on my list, and find that with my kind of arthritis the sat animal fats/beef seem to be off the table. Otherwise your list makes sense for me as well. Your thoughts?
@@eugeniebreida1583 I am a big AMATEUR biohacker and my ideas change over time. I like to experiment. I lost about 80 pounds doing a ketogenic diet and then transitioned to a ketogenic carnivore diet. I found that taurine benefits your eyes. I don't eat alot of chicken so I supplement with taurine instead. I don't always eat enough meat so I found it beneficial to supplement with tyrosine and acetly L carnitine and tryptophan. I don't always eat enough liver and thymus or thyroid gland and found it beneficial to supplement with gland extracts. Thymus gland is important as is decreases in size as people age and it is a source to modulate control T cells which fight viruses and cancer. Bone marrow is the primary source of T cells so in theory things that increase bone marrow would be helpful. Vitamin D, k2mk7, A, and minerals, magnesium, potassium, boron, manganese, copper, zinc etc. Consume bone broth and bone marrow. High quality B complex NAC and R version of lipoic acid. Direct sunshine. Exercise. Deep sleep. Honor the circadian rhythm. Eliminate grains and flour which block or interfere with nutrients. Eliminate sugar. Avoid lectins avoid glyphosate. Purified water Hot Epsom salt baths Direct sunshine preferably during the noon hour over more than 60% of my body Biohacks - rotating alternative days High dosage niacin flush, Serrapeptase and nattokinase, MSM organic sulfur, Sulforaphane, Red light therapy MSM in my eyes On skin mixed different options: Niacin or r lipoic acid or organic unrefined coconut oil or high quality beef tallow or * DMAE - *fatastic Other biohacks
Things are bad only when you overdose on them. Optimal tryptophan intake from food is up to 1,5g per day. So supplement only if you don't achieve the 1,5g.
@@sassuki how do you quantify that as a ratio for a certain weight slice of said fish/meat? Like, is the tryptophan you can derive from fish only 1.5g per slice of...how much weight ?
@@mazklassa9338 it is linked to how much protein you need per day for optimal health and muscle growth, which is about 1,6g per kg of bodyweight. Meaning you need about a pound of meat and fish per day, achieving around 1,5g of Tryptophan.
Very informative video! Healthline and other sources states that tryptophan supplements comes with a few risks... i want to use tryptophan since i’ve had a few great experiences on it. But i’m still skepticsl using it.. can you adress the risks of using it? I’ve heard that alot og people died using it in the 80’s or 90’s. Thank you
That was a badly manufactured supplement. Best way to get your tryptophan is food. One steak already covers the minimum daily requirements of Tryptophan
@@sassuki Ok, terrific. I try to eat a little meat with each of 2 or 3 meals . . . rarely steak (autoimmunity takes red meat off the menu), instead salmon, chicken thighs (turkey unavailable), occasional lamb (that may cause inflammation more than others listed, unfortunately). Will taking 3 - 4 ounces of meat 2 - 3 times a day cover it? IF I supplement w/tryptophan - what is ideal time of day? IF you were to rec a brand, any thoughts? The label on Source Naturals suggests 1 500 mg tab 3 x's day BETWEEN meals. Does this make sense? If so, it would be a large shift from past thinking, perhaps it would help me immensely? (I do think I am shy on tryptophan - essential amino acid, precurseor to kynurenines regulating immune system (have PsArth), converts to niacin (if needed), niacin supports innumerable metabolic systems, all of which are a little off kilter in my world (have begun supplementing with entire B-world). In conclusion, perhaps tryp supplements never worked w/me as I would take with food . . . If you have the time, any response/suggestions much appreciated.
@@eugeniebreida1583 I don't know how red meat is supposed to cause inflammation; all I hear is the opposite actually, but well, you know your body better. People on carnivore diets swear on it to resolve a multitude of health problems, including autoimmune conditions 🤔 Anyway, best time to emphasize tryptophan is dinner, as it seems to have a short half-life. I personally take a small protein shake (with just 15g powder) if my dinner didn't have enough meat or fish, and it helps me just like a regular steak to sleep like a baby. I usually do 8 to 9 hours straight then. According to the label it does provide about 400mg of Tryptophan per 15g serving. The recommended dosage of Source Natural sounds weird to me at least. You can hardly do more than 1,5g per day from food; how come they recommend this amount 3 times a day?! Doesn't make sense to me. If you ask me, a 500mg supplement is all you need if your dinner was average. Brands I don't know. As said, when I supplement, I take a protein shake, as I want complete protein.
@@sassuki Thanks much! Am currently in process of reading your many replies (thanks for all). Meanwhile, just as to this one, what Brand is your shake?? (hmm : ). ). And perhaps I mis-typed, Source Recs 500 mg 3x's/day - 1500 total. So, it is a bit high, but not off the charts?? (Do not worry, I don't take it, at one time had tried ONE 500mg here and there, as I said, it seemed to have no effect, or ill effect, on sleep.) As to the inflammation, perhaps I just can't dig my head out of the saturated fat sand . . . but I have VERY high cholesterol, my understanding is eating more sat fat than I already do will be more likely to make it even higher, than lowering it. Correct? (am quite worried about arteries, as my PsA is attacking capillaries along with everything else.). Ideas?? Meanwhile I had lamb as the featured calories in my large breakfast/lunch today - incentivized by the video's guest. Yes, agreed, Tryptophan seems to have quite a short half-life. I hope its knock-on effects last a lot longer! Cheers.
@@eugeniebreida1583 I use the Multipower protein at the moment. Tastes best to me. 3x 500mg is fine if you are low on protein, but then again, I would rather increase my protein intake then as a whole rather than taking separate amino acids. Optimal protein intake is 1,6g/kg bodyweight per day. Cholesterol is a very controversial topic. What I hear a lot is anything between 200 and 300 is a grey zone, and not necessarily bad if the HDL and Triglycerides are fine; and that carbs are the main driver for high cholesterol, much more than fat. You may look into the Niacin form of vitamin B3, which is very effective in regulating cholesterol, but high doses cause flashing for most people, which might be irritating for many. Dr. Hoffer was regularly giving 3x (1g of Niacin + 1g of Vitamin C) per day for cholesterol. You may want to read about that (I think he has a book about this co-authored with Dr. Saul)
Since supplementing with tryptophan my nitric oxide levels have raised... what are your thoughts on that. Also can you take to much tryptophan or not really
You get 1 to 1,5g per day if you eat optimal amounts of protein (400 to 500g of fish or meat). So 500 to 1000mg supplementation is enough if your food intake is suboptimal.
I would say it's not natural to "supplement" melatonin, because it is a hormone, so not something you get from food, so nothing to supplement. For me taking melatonin for a jet lag is like taking an aspirin for a headache. And that should be the end of it. Supplementing melatonin is wrong. Tryptophan is the way to go, which is readily available in food anyway. One steak provides the minimum daily requirements of Tryptophan.
A large, one pound steak! Thanks . . . I will try to get 3-4 ounces of meats down the hatch 3 times a day. A pain, but will be worth it. Need my Tryptophan! (And completely agree concerning the use of exogenous melatonin. Although scientifically I believe studies confirm it is anti-inflammatory in nature, it is best supplied by Nature - endogenously.)
@@sassuki Thanks. I bet each of us likes to come up with more than the minimum. Again . . . steak!! Really, you should check out forums full of artheropathies (of all types) and the diets intelligent people are following. I am open minded, but would love to see a forum of folks struggling with these sorts of autoimmunity who are thriving on fatty meats, eggs (typ. cause immune responses in this type of disease), or heaven forbid, cheese/milk products. I would be in heaven if eggs and dairy were on my menu. (And I would be able to gain back weight lost to my choice of 'non-inflammatory- foods. I am open minded and all ears to learn another path. Or I would not be here with Chris MasterJohn . . . whose pronouncements I have been mulling for a few years . . . Any diet recommendations for reducing inflammation which you can find science for? (If you are interested in helping me . . . I am definitely appreciative of following your injections to the discussion, I am hardly laying down a challenge!) Thanks once again. (Psoriatic Arthritis is eating away at my being).
@@eugeniebreida1583 you may be a candidate for a carnivore diet after all :D I personally don't think much of it, as I love bread and pasta, but well, I don't have your condition! Look up Dr. Shawn Baker and Dr. Paul Saladino. What I hear a lot from people like these is that mixing meat and vegetables is the problem for them, and not meat per se. But then again, you know your body best, and I never experimented with it, so I can't make any concrete recommendations here.
because if you are taking pure melatonin your body get used to it and therefore you will need more because you are disrupting natural melatonin production
Chris thanks so much for answering my question, very cogent answer too. I'm trying keto and it's wrecking my sleep, so your explaining how carbs help get stuff into the brain is doubly illuminating.
Did you find a TIME OF DAY to ingest carbs that helps your sleep? (I am thinking oatmeal as a good last meal before sleep - ?). Too bad Chris did not relate ingestion of tryptophan containing foods (or supplementation), exercise or niacin? with daily clock of activities/ingestion.
I definitely identify with all of this. Anecdotally, melatonin causes depression in me-- especially over time. Tryptophan in the form of a 1000mg supplement + exercise+ carbs lifts my mood incredibly. I actually can't take my Tryptophan supplement before bed, because it's energizing as opposed to sedating. I've been told my B3/Niacin levels were consistently low (during former OATS test), so this connection could make sense as well. Thanks!
Interesting that you find Tryptophan supplementation before bed 'energizing'. I have also found taking tryptophan does nothing for my sleep. Oatmeal on the other hand . . .
If I could 'do' dairy, I would think oatmeal and yogurt or milk would be an ideal sleeping pill.
Also, at what time of day is exercise most useful for sleep optimization?
Look into the teachings of neurosurgeon Jack Kruse and you won’t have to worry about that stuff anymore. It’s way more simple than all that
Yeah looking forward to your book... I ordered it at least a month ago !!!!
I ordered it more than a year ago!
11:00 four things you need Tryptophan for:
1. making protein
2. making niacin
3. making serotonin
4. making Melatonin
...i.e. if taking Tryptophan makes a difference in one of those or things affected by those, EITHER youcare deficient in Tryptophan (from protein intake), failing to breakdown and digest protein, failing to absorb OR a lifestyle/diet factor like too nuch stress/not enough exercise is causing Tryptophan to not be broken down from protein or you are eating too much carbs, etc
well said! thank you for providing this info in a clear way without all of the science jargon I can't understand.
Thank you. And again Thank you for all you do to educate xxxxxx
I think you should have mentioned that melatonin declines as we age, especially after mid 40s, and that it is a very powerful antioxidant.
More of a reason to optimize your tryptophan intake.
@@sassuki What is your suggestion as to tryptophan containing foods (and which are best? Turkey or Oatmeal, for example?) and time of day for optimizing melatonin, especially as it relates to 24 hr sleep cycle?
THANKS. (I am guessing you are not a fan of tryptophan supplementation, but if you are. . . I have tried such, and the tryptophan does not assist in quality of sleep for me. However after ingestion of dark eat of turkey I'm reduced to jello. However a temporary condition, it seems.)
Anyway, I would be flattered if you would lay out (more than Chris did) When and How to up the tryptophan in my system? I have long had the impression that I am low . . . (history of insomnia beginning in my mid 20's. I am 62 now.)
Thank you again. I have recently noticed your comments here, almost always compelling. Make that 'always'!
@@eugeniebreida1583 thanks, I do my best to help :)
Best sources are all kinds of meat, chicken and fish, as well as cheese and legumes.
The rest I answered in one of the other comments :)
1) Have a good run with these, Chris! They also sound better to me.
2) How does one regulate their body temperature down? I'm getting crazy every summer, while a ton of my female friends feel cold. I do keto/low carb, supplement some things, do daily pushups.
The heat interrupts my sleep, although I try and help myself with it.
It got me curious about body temperature regulation in general, but nobody talks about it, especially as clear and technical as you do.
So I write this hoping I'll get lucky. :)
I'm not sure I have too much to offer here. It probably comes down to hormone balance, but I don't know too much about the mechanisms of how sex hormones impact it. An AC, EightSleep, and/or ChiliPad can be very useful for sleep.
@@chrismasterjohn Thanks for your response. The role of hormones of all stripes play a huge role here, it would be pretty impossible for you to cover . . . Of course with women it's important to know metabolic state (weight/bmi?), age (still ovulating?), and much more.
As to sleep and overheating, ONE idea for Vospi would be: are sheets/quilt etc coverings BREATHING - or are you covered in synthetics (under which I myself find it impossible to sleep, as they ruin my skin's ability to respirate properly). Just a thought. Probably off the mark! (Also, I have my bedroom in my basement, for purposes of COOL AIR year round.)
@@chrismasterjohnregarding: "PPS" ...proton pump Stimulators... what stimulates stomach acid production?
Why does it decline AT ALL with age to begin with?
@@chrismasterjohn 12:05 if any of these is true...i.e. lacking Tryptophan, then what else "should probably" be considered as lacking? / issues at the root? Low stomach acid production? Low digestive enzyme production? Vagus nerve impairment? Adrenal "lock" / vicious cycle?
I’m hoping this comment reaches you. I was researching the kynurenine pathway and was blown away by its impact on inflammation. There’s a few research studies suggesting that Vitamin B6/P5P helps reduce Kynurenie levels in the body however Tryptophan appears to be in the same pathway.
With your expert opinion what would be the best ways to attack Kynurenine levels in the body? Feel free to make a video since I haven’t seen any one really break this down step by step.
i like 5-htp in the morning. it also lowers the effect of grehlin. i like it a lot
Causes cardiac fibrosis without EGCG or green tea extract
@@alexxxisbatman This is a persistent myth.
@@zoetekauw9647 I realize my n=1 probably isn’t worth anything to you but I’ve experienced some undeniable cardiac side effects from taking 5htp for months at a time. Aside from that, it also uses up AAAD enzyme to make serotonin which competes with tyrosine to make dopamine so leads to NT imbalance
@@alexxxisbatman I've read about the mechanisms, but studies fail to consistently show the tangible adverse effects that these mechanisms imply (they may be counterbalanced with some yet to be identified other mechanism), which is consistent with the fact that the compound continues to be available without prescription. I don't know what else you may have been taking in conjunction with 5-htp, or whether you have any contraindications. You have my sympathy but realize that it is indeed an n=1. Irks me when these stories are parroted without circumspection and start to be taken at face value.
Are Tryptophan and L-tryptophan clearly different (based obviously on the presence/absence of the prefix letter "L")?
I am low in lithium , magnesium and zinc I was having depression and sleepless nights so I decided to have them all since I started taking my deficient vitamins I am doing very well no depression and feeling happier,but still struggling with falling to sleep
Now I want to buy tryptophan for my sleep instead of sleeping aid which sometimes doesn’t even help me , can I take tryptophan with lithium, thank you for the informative video stay blessed 👍
I don’t know whether tryptophan interacts with lithium.
I was given 4000 mg of l tryptophan due to sleep apnea! It is working well as long as I take a carb with it
Question: I eat canned cod liver once per week (About 75 grams of liver). It contains 7500 MCG Vit A + 5,4 grams omega 3. I know to much vitamin A from Animals can be harmfull. Can i eat it all at once or should i spread it across the week?
Thanks!
I have used Melatonin and L tryptophan at night on occasion. I use tyrosine in the morning. Occasionally, I do a niacin flush, which I enjoy even though you warn against it
I enjoy amateur biohacking and lost weight doing a ketogenic diet but transitioned to a zero carb zero sugar and very little to no fruit --- mostly carnivore diet. My transition has been a slow process. I eat alot of eggs sunnyside up with runny yolks and butter and unrefined coconut oil and red meat or beef.
I have had eye surgery so I don't have to wear glasses. I use taurine (supplement) which is a protein from meat to protect my eyes against degeneration and it helps. I also use NAC, R lipoic and sometimes glutathione or a high dose MSM organic sulfur. Astaxanthin is good. Zinc, copper, magnesium, potassium. Himalayan salt. Purified water. Vitamin D. Vitamin k2mk7. Thymus gland extract. Lions Mane mushroom. Jarrows brand high quality B complex. Boron. Minerals
Zero seed oils no lectins no inflammatory oils, no pepper, no inflammatory things.
Are you doing the anti inflammatory for purposes of reducing an autoimmune condition? I am attempting the same, although I have veggies on my list, and find that with my kind of arthritis the sat animal fats/beef seem to be off the table. Otherwise your list makes sense for me as well.
Your thoughts?
@@eugeniebreida1583 I am a big AMATEUR biohacker and my ideas change over time. I like to experiment. I lost about 80 pounds doing a ketogenic diet and then transitioned to a ketogenic carnivore diet.
I found that taurine benefits your eyes. I don't eat alot of chicken so I supplement with taurine instead. I don't always eat enough meat so I found it beneficial to supplement with tyrosine and acetly L carnitine and tryptophan. I don't always eat enough liver and thymus or thyroid gland and found it beneficial to supplement with gland extracts. Thymus gland is important as is decreases in size as people age and it is a source to modulate control T cells which fight viruses and cancer. Bone marrow is the primary source of T cells so in theory things that increase bone marrow would be helpful. Vitamin D, k2mk7, A, and minerals, magnesium, potassium, boron, manganese, copper, zinc etc. Consume bone broth and bone marrow. High quality B complex
NAC and R version of lipoic acid.
Direct sunshine. Exercise. Deep sleep. Honor the circadian rhythm. Eliminate grains and flour which block or interfere with nutrients. Eliminate sugar. Avoid lectins avoid glyphosate. Purified water
Hot Epsom salt baths
Direct sunshine preferably during the noon hour over more than 60% of my body
Biohacks - rotating alternative days
High dosage niacin flush,
Serrapeptase and nattokinase,
MSM organic sulfur,
Sulforaphane,
Red light therapy
MSM in my eyes
On skin mixed different options: Niacin or r lipoic acid or organic unrefined coconut oil or high quality beef tallow or * DMAE - *fatastic
Other biohacks
should i cycle collgen powder ??
but tryptophan restriction is said to activate anti aging pathways so I'm a bit leary of supplementing..
Things are bad only when you overdose on them. Optimal tryptophan intake from food is up to 1,5g per day. So supplement only if you don't achieve the 1,5g.
@@sassuki how do you quantify that as a ratio for a certain weight slice of said fish/meat? Like, is the tryptophan you can derive from fish only 1.5g per slice of...how much weight ?
@@mazklassa9338 it is linked to how much protein you need per day for optimal health and muscle growth, which is about 1,6g per kg of bodyweight. Meaning you need about a pound of meat and fish per day, achieving around 1,5g of Tryptophan.
Wouldn't supplementing melatonin will eventually down regulate the pathways that make melatonin in the body naturally?
I've heard and read this several times. For that reason I won't take it regularily, so I would like to know this as well.
@@loriscott9091 I've seen presentations that say no
@@dannyjonze Thank you!
@@user-cm9ef4fw7m Your name says it all
This sounds like something that can be person dependent. Klinghardt says 300 mg plus. Dr reiter is a melatonin researcher of over 30 years
Very informative video! Healthline and other sources states that tryptophan supplements comes with a few risks... i want to use tryptophan since i’ve had a few great experiences on it. But i’m still skepticsl using it.. can you adress the risks of using it? I’ve heard that alot og people died using it in the 80’s or 90’s. Thank you
That was a badly manufactured supplement. Best way to get your tryptophan is food. One steak already covers the minimum daily requirements of Tryptophan
@@sassuki Ok, terrific. I try to eat a little meat with each of 2 or 3 meals . . . rarely steak (autoimmunity takes red meat off the menu), instead salmon, chicken thighs (turkey unavailable), occasional lamb (that may cause inflammation more than others listed, unfortunately). Will taking 3 - 4 ounces of meat 2 - 3 times a day cover it?
IF I supplement w/tryptophan - what is ideal time of day? IF you were to rec a brand, any thoughts? The label on Source Naturals suggests 1 500 mg tab 3 x's day BETWEEN meals. Does this make sense?
If so, it would be a large shift from past thinking, perhaps it would help me immensely?
(I do think I am shy on tryptophan - essential amino acid, precurseor to kynurenines regulating immune system (have PsArth), converts to niacin (if needed), niacin supports innumerable metabolic systems, all of which are a little off kilter in my world (have begun supplementing with entire B-world).
In conclusion, perhaps tryp supplements never worked w/me as I would take with food . . .
If you have the time, any response/suggestions much appreciated.
@@eugeniebreida1583 I don't know how red meat is supposed to cause inflammation; all I hear is the opposite actually, but well, you know your body better. People on carnivore diets swear on it to resolve a multitude of health problems, including autoimmune conditions 🤔
Anyway, best time to emphasize tryptophan is dinner, as it seems to have a short half-life. I personally take a small protein shake (with just 15g powder) if my dinner didn't have enough meat or fish, and it helps me just like a regular steak to sleep like a baby. I usually do 8 to 9 hours straight then. According to the label it does provide about 400mg of Tryptophan per 15g serving.
The recommended dosage of Source Natural sounds weird to me at least. You can hardly do more than 1,5g per day from food; how come they recommend this amount 3 times a day?! Doesn't make sense to me. If you ask me, a 500mg supplement is all you need if your dinner was average. Brands I don't know. As said, when I supplement, I take a protein shake, as I want complete protein.
@@sassuki Thanks much! Am currently in process of reading your many replies (thanks for all). Meanwhile, just as to this one, what Brand is your shake?? (hmm : ). ).
And perhaps I mis-typed, Source Recs 500 mg 3x's/day - 1500 total. So, it is a bit high, but not off the charts?? (Do not worry, I don't take it, at one time had tried ONE 500mg here and there, as I said, it seemed to have no effect, or ill effect, on sleep.)
As to the inflammation, perhaps I just can't dig my head out of the saturated fat sand . . . but I have VERY high cholesterol, my understanding is eating more sat fat than I already do will be more likely to make it even higher, than lowering it. Correct? (am quite worried about arteries, as my PsA is attacking capillaries along with everything else.). Ideas??
Meanwhile I had lamb as the featured calories in my large breakfast/lunch today - incentivized by the video's guest.
Yes, agreed, Tryptophan seems to have quite a short half-life. I hope its knock-on effects last a lot longer!
Cheers.
@@eugeniebreida1583 I use the Multipower protein at the moment. Tastes best to me.
3x 500mg is fine if you are low on protein, but then again, I would rather increase my protein intake then as a whole rather than taking separate amino acids. Optimal protein intake is 1,6g/kg bodyweight per day.
Cholesterol is a very controversial topic. What I hear a lot is anything between 200 and 300 is a grey zone, and not necessarily bad if the HDL and Triglycerides are fine; and that carbs are the main driver for high cholesterol, much more than fat.
You may look into the Niacin form of vitamin B3, which is very effective in regulating cholesterol, but high doses cause flashing for most people, which might be irritating for many. Dr. Hoffer was regularly giving 3x (1g of Niacin + 1g of Vitamin C) per day for cholesterol. You may want to read about that (I think he has a book about this co-authored with Dr. Saul)
Since supplementing with tryptophan my nitric oxide levels have raised... what are your thoughts on that. Also can you take to much tryptophan or not really
Interesting. You can take too much of anything.
What's recommendation for tryptophan? I am taking a little less than 500 mg in the and that is already helping my depression
You get 1 to 1,5g per day if you eat optimal amounts of protein (400 to 500g of fish or meat). So 500 to 1000mg supplementation is enough if your food intake is suboptimal.
@@sassuki That would make the daily optimal intake . . .? . . . what? (and What are grams in ounces, hmm.)
@@eugeniebreida1583 I think 1 oz was 30g or so.
Yeah, 1,5g Tryptophan a day is optimal.
It just cut off in middle of livestream speech?
franks sign on your right ear?
I would say it's not natural to "supplement" melatonin, because it is a hormone, so not something you get from food, so nothing to supplement. For me taking melatonin for a jet lag is like taking an aspirin for a headache. And that should be the end of it. Supplementing melatonin is wrong. Tryptophan is the way to go, which is readily available in food anyway. One steak provides the minimum daily requirements of Tryptophan.
A large, one pound steak! Thanks . . . I will try to get 3-4 ounces of meats down the hatch 3 times a day. A pain, but will be worth it. Need my Tryptophan! (And completely agree concerning the use of exogenous melatonin. Although scientifically I believe studies confirm it is anti-inflammatory in nature, it is best supplied by Nature - endogenously.)
@@eugeniebreida1583 the minimum daily requirement for Tryptophan is 400mg, so even a small 150g steak is totally sufficient to get it
@@sassuki Thanks. I bet each of us likes to come up with more than the minimum. Again . . . steak!! Really, you should check out forums full of artheropathies (of all types) and the diets intelligent people are following.
I am open minded, but would love to see a forum of folks struggling with these sorts of autoimmunity who are thriving on fatty meats, eggs (typ. cause immune responses in this type of disease), or heaven forbid, cheese/milk products. I would be in heaven if eggs and dairy were on my menu. (And I would be able to gain back weight lost to my choice of 'non-inflammatory- foods.
I am open minded and all ears to learn another path. Or I would not be here with Chris MasterJohn . . . whose pronouncements I have been mulling for a few years . . .
Any diet recommendations for reducing inflammation which you can find science for? (If you are interested in helping me . . . I am definitely appreciative of following your injections to the discussion, I am hardly laying down a challenge!)
Thanks once again. (Psoriatic Arthritis is eating away at my being).
@@eugeniebreida1583 you may be a candidate for a carnivore diet after all :D
I personally don't think much of it, as I love bread and pasta, but well, I don't have your condition!
Look up Dr. Shawn Baker and Dr. Paul Saladino. What I hear a lot from people like these is that mixing meat and vegetables is the problem for them, and not meat per se. But then again, you know your body best, and I never experimented with it, so I can't make any concrete recommendations here.
Melatonin did absolutely nothing for me..5H L-Try... is making me having good sleep and dreams... GAba too...
Who else is here learning about Tryptophan/Melatonin/Serotonin and sleep in 2024 👇
I'm a Doctor.
You obviously haven't taken L-tryptophan
Thank you Chrissy-poo
because if you are taking pure melatonin your body get used to it and therefore you will need more because you are disrupting natural melatonin production