Not a pharmacologist, but pharmacokinetics is how the body affects the drugs (the liver enzymes turning the drugs into metabolites) whereas pharmacodynamics is how drugs affect the body (the mechanism of blocking pain) so I guess the video has a bit of both?
I'm not a pharmacologist, but I am a pharmacist. What I remember from school is that pharmacokinetics involves the ADME processes (absorption, distribution, metabolism, excretion), whereas pharmacodynamics involves the mechanism of action. You are right that there is a brief mention of mechanism. However, the video focuses more on how the drug molecules move after ingestion and less on how the medicine works (i.e. COX-1 and COX-2 inhibition). ...and I've officially nerded out on RUclips XD
WeArePharmers Yup, you really have nerded out but don't worry, you're in good company. Also, you're right. It does focus more on the pharmacokinetics side of it. Thanks.
Not a medical professional or student. Just a sick guy at home curious about how this works. Fantastically simple explanation. I'm sure there is more nuance I'm gonna miss but this answered my questions. Thanks for the video!
Has anyone got that feeling when they're stuck in the Ted Ed loop? LIke, it's so hard ignore a Ted Ed vid in your recommendations and when you click it and finish it, there's always another one waiting for you in the side column. I've already got 2 hours of watching Ted Ed alone... But anyways, thank you so much Ted Ed for answering so many of our biggest questions.
This is honestly one of the best (and well explained/simple) videos I think I have ever watched. The animation is excellent and the narration is superb. I now understand how the body processes medicine more clearly now. Thank you.
I'm so thankful for this video! I Study medicine and had been trying to process a pharmacology lecture on this topic just now. SO glad I saw this before going to bed
knocknockify Alchohol is technically a poison, so while its in your system your liver is working like crazy. So it can't process your medicine at the same rate it would when you're sober and you could easily overdose.
knocknockify It depends on the drugs you're taking! Consuming alcohol with paracetamol, whose metabolites are toxic, for example, would result in even more toxicity to the liver. But in the case of hypnotic drugs like valium, its respiratory depression effect will be likely be multiplied if taking with alcohol, and that might be fatal. So tl;dr - Alcohol will make what's already bad worse ;)
Thankyou so much, I've been on medication for my epilepsy for years and it felt like magic. Which I wasn't particularly thrilled with for something so important, so it's nice to know how it works.
Really good explanation, explained the pharmacodynamics in an easy to understand way. During this special period, countless medical workers and scientists have made significant contributions to the world. worthy of respect
I’m currently on acne medication. I need to consume 11 amount of pills a day. I wondered how do the pills work in my body. Now I understand. Thank you!!
Such an exciting time to go into healthcare, I hope personalized medicine comes to fruition in the UK and helps us care for patients better as early as possible! :)
I don't know if I'm the only one but the reason I'm watching this it's because I sprained my ankle and I took an Advil pill and now I'm watching this to see what it's doing in my body
Those affect the levels of neurotransmitters during synaptic transmission. eg, people with depression generally have low serotonin levels meaning a low rate of fire for that neuron and so by blocking the selective re uptake molecules that reabsorb serotonin using SSRIs (selective serotonin re uptake inhibitors), the concentration increases and reverses the low serotonin levels, and in turn some of the symptoms. For ADD, adderal and other drugs can be used that block different re uptake molecules that are associated with Dopamine which helps with motivation and concentration.
I'm having a migraine then i took one pill of paracetamol then I went to sleep,I don't know either with my sleep or that pill that stop myself from the pain.
Aleena there is no cure at the moment. Different people have different reactions to some of the “potentially helpful” drugs on the market and some have had great success changing small things like dietary changes or adding yoga to the routine (I can’t help but wonder if they had through chronic migraines or just tension headaches Simply because I haven’t been that lucky). It sucks. I take triptans, lay in the dark hoping to sleep it off. .. & life passes by. Ugh Fingers crossed they come up with something and I am sorry to hear you have them too.
Dear people that' reading this, we don't know each other but I wish you all the best in life don't ever blam yourself, accept things and a key for happy life.....
And that's why the doctor recommends you to rest after taking the medicine! The lesser the heart rate, slower the blood will flow through the liver in a given time and therefore slower it will remove the medicine out of your body increasing it's effectiveness. Eureka!!
They are absorbed by your organism in the same way, but vitamins don't act the same way as medication, they have diverse roles in your organism such as becoming enzymes or maintaining your immune system.
Pharmacokinetics focuses mainly on what the body does to the drug. To summarize its steps, remember ADME, Administration, distribution, metabolism, excretion.
dude, i was so scared of taking pills and stuff, it feels like putting poisen or unknown chemicals into your body, but now i know its not that bad, thanks.
As far as I know , the APIs of Ibuprofen molecule converting to inactive metabolites is termed as 1st pass metabolism. But why some molecule gets converted to inactive while some escape?. How the molecules manage to escape 1st pass metabolism in liver?
Initially it was very tough to understand for me ,after seeing this video , because it is followed simple way to understand the process thanks for keeping this video❤️
Probably the best and simplest explanation of pharmacodynamics I've ever seen. Brilliant. Thanks.
Fizan Ahmed ikr, I just took a pharmacology course and watching this is like a mini abstract
Wouldn't this be considered more pharmacokinetics than pharmacodynamics?
Not a pharmacologist, but pharmacokinetics is how the body affects the drugs (the liver enzymes turning the drugs into metabolites) whereas pharmacodynamics is how drugs affect the body (the mechanism of blocking pain) so I guess the video has a bit of both?
I'm not a pharmacologist, but I am a pharmacist. What I remember from school is that pharmacokinetics involves the ADME processes (absorption, distribution, metabolism, excretion), whereas pharmacodynamics involves the mechanism of action.
You are right that there is a brief mention of mechanism. However, the video focuses more on how the drug molecules move after ingestion and less on how the medicine works (i.e. COX-1 and COX-2 inhibition).
...and I've officially nerded out on RUclips XD
WeArePharmers Yup, you really have nerded out but don't worry, you're in good company. Also, you're right. It does focus more on the pharmacokinetics side of it. Thanks.
So much respect for doctors, scientists, and just modern medicine for their contribution to the world 👏🏼
All praise to the lord who gave us this kinda intelligent complicated system in our body
And still we can't cure common cold. Greek and Herbal medicine are much more effective.
p7
@@musicmaniac257 maybe theres no direct treatment because of the many kinds of viruses that cause it
😯
Not a medical professional or student. Just a sick guy at home curious about how this works. Fantastically simple explanation. I'm sure there is more nuance I'm gonna miss but this answered my questions. Thanks for the video!
What are/was sick with?
@@reagan_ruth7117 I had Covid back when it first started. Was a mean bugger lol.
@@KennethSee covid? bro i forgot it was a thing 3 years ago
@@nickjunior9862 Yep! I got alpha while traveling in Asia during winter 2019. Laid me flat for like a week and a half haha
Me too 🤣🤣
I fucking love how you guys turn complex subjects like this into simple and interesting animated videos
Is it designed to cure a disease, read the instructions on the label, age and diet could be blame💊
I learned way more in this 4 minute video than I did doing two years of biology in high school
That’s not true
@@bunysparks3494 That's because he had chosen letters.
Really?
@@zhaohuiwang67 probably not
Facx 😹😹
Has anyone got that feeling when they're stuck in the Ted Ed loop? LIke, it's so hard ignore a Ted Ed vid in your recommendations and when you click it and finish it, there's always another one waiting for you in the side column. I've already got 2 hours of watching Ted Ed alone... But anyways, thank you so much Ted Ed for answering so many of our biggest questions.
Lmfao this was posted 44 seconds ago and someone already disliked it.... calm down bruh you haven't even watched the video 😂😂
savage hater XD
e
Senaca Gardipee no he/she must have mistaken it for a fistbump button.
These people would dislike nudes from Scarlett Johansson....grumpy cats or Ron Swansons :P :D
This was posted 4 months ago tho xd
My poor, poor liver
You seem to be in the comments of every science video on RUclips 😂. Great videos btw!
I see you everywhere
Dr.StickFigure ubiquitous one
( ͡◉ ͜ʖ ͡◉) My poor, poor puss
you again
dude i didn't know my liver was a pachinko machine............
Yes
Haha
My brain is a slot machine
It always lose no matter what cost
hahaha
Is this an Alvamajo pureya reference?
This is honestly one of the best (and well explained/simple) videos I think I have ever watched. The animation is excellent and the narration is superb. I now understand how the body processes medicine more clearly now. Thank you.
I'm so thankful for this video! I Study medicine and had been trying to process a pharmacology lecture on this topic just now. SO glad I saw this before going to bed
rand kubaysi 9i9090
I am also thank you for the complete comments 😂
If you are interested in getting adderall, Percocet, oxycodone, Xanax visit our website/ buymedpharmacy.com
My GCSE Biology exam is tomorrow, great video but I'm still panicking. Loved the animation.
Quazi Irtiza Good Luck :)
Thanks :)
Quazi Irtiza All the best ! :)
If you love science, then the biology test shouldn't be to hard. But still, good luck!
Emma Baker What's GCSE???
how about a video on how vaccination works?
Darsh Jalan They introduce a weakened form of whatever illness the vaccine is for and your body's immune system learns how to fight it.
anonymous yeah but still it would be good to see a more detailed version of your answer. Thanks for that by the way:)
Darsh Jalan No problem.
It doesn't. *grabs popcorn*
D1visor so then how does it work?
This channel provides me with information that I didn't really seek for, but I'm grateful nonetheless to have known it now.
Watching it as a pharmacy student, all I have to say is: great video for everyone to understand the basics! Well done guys 💯
The visuals and the concise explanation with examples made it easy to understand even for the non-experts. It was great.
I have so much respect for all of the medical professionals who save lives and educate their patients every day! God Bless them all!
How does alcohol affects this process? I see warnings not to take medicines with alcohol
knocknockify Alchohol is technically a poison, so while its in your system your liver is working like crazy. So it can't process your medicine at the same rate it would when you're sober and you could easily overdose.
uh alcohol is actually a sin so idk
How is alcohol a sin...? Jesus literally turned water into wine once.
knocknockify It depends on the drugs you're taking! Consuming alcohol with paracetamol, whose metabolites are toxic, for example, would result in even more toxicity to the liver. But in the case of hypnotic drugs like valium, its respiratory depression effect will be likely be multiplied if taking with alcohol, and that might be fatal. So tl;dr - Alcohol will make what's already bad worse ;)
Alcohol is processed in the liver the same way as medicine. Taking medicine while consuming alcohol can overwork and damage your liver.
The animation, the music, her voice is so soothing! Amazing job!
This is why I love animated , simplified stuff for complex subjects like these , everybody gets it.
Amazing explanation. No one ever said me my body goes through so much trouble for my life and I'm so ungrateful.
Alhamdulillah ya Rab❤️
I find it fascinating the people who created this and proved it worked and be able to explain it step by step
This is one of the best explanatory animations I've seen on anything. Great job.
One of TED-Ed's the best illustrations, despite its simplicity. Thanks to everyone who's behind this great educational channel.
can you do a video on how inuslin works? like when diabetics take shots? i think that'd be so cool ☺
Jacob Braxton that would be fun to watch in a little animation
along with a video about Celiac disease and how it affects the body when those allergens enter the body. that'd be interesting to see. 👍
Insulin video would be awesome! I have PCOS and insulin resistance and something about that area would be cool
i read it muslim instead of insulin
Watch "nucleus media diabetes" it might help you :)
By far,the best channel on RUclips.Every concept,every video gives you something new to learn and cherish
Calm down its not the best channel you are so childish i bet when you see people open a door you are amaze and in awe 😂
Thankyou so much, I've been on medication for my epilepsy for years and it felt like magic. Which I wasn't particularly thrilled with for something so important, so it's nice to know how it works.
Absolutely brilliant animation. I worked in pharmaceutical industry all my life. Still learned something!
I *LOVE* this animation
Me too
It reminds me of the pinball counting animation from Sesame Street
Really good explanation, explained the pharmacodynamics in an easy to understand way. During this special period, countless medical workers and scientists have made significant contributions to the world. worthy of respect
I’ve been wondering this forever. How amazing! A very well made video.
I'm a pharmacy student, n won't go away without watching it even though I've already studied about it
Watching this with a sore throat, imagining how will the medicines help me out
I’m currently on acne medication. I need to consume 11 amount of pills a day. I wondered how do the pills work in my body. Now I understand. Thank you!!
It was the simplest explanation of medicine reaction I have ever seen....and probably indelible as well....thank you so much
the intelligible illustration of the video is totally amazing，I cannot find other who is better than ted's
I was searching for this information for several days and I have found it here, thank you so much 😊
And now I know, the inside of my liver looks like an arcade game. Thanks Ted-Ed, for sharing your wisdom.
watching this as i am on antibiotics every 8 hours, want to know what happens then. thank you! been learning a lot from ted! :)
that was very informative and simple. Ted Ed you've done it again
Thank you for the explanation and the illustration. They're very clear and informative.
The animation makes this so much easier to understand, thank you!
The way the animator truly represented the amazingly well-oganized incredible machine the human body is was just sublime to me.
The most educational English content even seen on RUclips(English is my second language)
what a lovely animation
The fantastic animation made it super easy for me to understand how medicines work.
Such an exciting time to go into healthcare, I hope personalized medicine comes to fruition in the UK and helps us care for patients better as early as possible! :)
this video is so beautifully made and the music is peaceful
Great information and animations
This video required several days of editing 👍 thanks for that 🤗
Omg i love this, this video popped up just when I needed a simple pharmacokinetic video to study with 😩
Whoever drew every scene of this video. IT LOOKS SO AMAZING!!! BRAVO!👏👏👏👏👏👏👏👏👏❤️❤️❤️
I don't know if I'm the only one but the reason I'm watching this it's because I sprained my ankle and I took an Advil pill and now I'm watching this to see what it's doing in my body
Woah! LOL
This is very helpful. And love ur animation concept
Must say this , the animation is really brilliant and very useful way to understand pharmodynamics......
This was something I have always wondered about, thanks for providing an answer!
This specific topic was something which I was waiting for since ages. Thanks
What about drugs that affect your brain like to help ADD? (Ex: Concerta)
thenaynaycat it's slow release and has a tougher inner shell so it dissolves in the system slower
Those affect the levels of neurotransmitters during synaptic transmission. eg, people with depression generally have low serotonin levels meaning a low rate of fire for that neuron and so by blocking the selective re uptake molecules that reabsorb serotonin using SSRIs (selective serotonin re uptake inhibitors), the concentration increases and reverses the low serotonin levels, and in turn some of the symptoms. For ADD, adderal and other drugs can be used that block different re uptake molecules that are associated with Dopamine which helps with motivation and concentration.
thenaynaycat it's better if you don't take it
Pwner 1775 lol no
Gluten does it! celiac.com
Now this is a worthy explanation, worth my time.
Am I the only one who ACTUALLY *ENJOYS* the taste of medicine???
ZeckDoesStuff yes
I like the taste of uncoated aspirin a little
The simplest way to explain pharmacodynamics.... Brilliant job 🌼
love the animation
Probably the best video on 💊....seems like I have travelled through my body along with the medicine . ANIMATION IS GREAT.
The Music Is like Im Going on a mall...
The details and the design in our body is a masterpiece
3:22 I don't think Slenderman needs a painkiller
1:10
Forgot to mention that some medication, their metabolites are as active as the original form.
I'm having a migraine then i took one pill of paracetamol then I went to sleep,I don't know either with my sleep or that pill that stop myself from the pain.
Naddy Kim u rare
Naddy Kim both! But Sleep is king! PS-sorry you have migraines. I have them too, chronically. Therefore I sleep my life away :(
@@mulliganstew72 how do you get rid of chronic migraine?
Aleena there is no cure at the moment. Different people have different reactions to some of the “potentially helpful” drugs on the market and some have had great success changing small things like dietary changes or adding yoga to the routine (I can’t help but wonder if they had through chronic migraines or just tension headaches Simply because I haven’t been that lucky). It sucks. I take triptans, lay in the dark hoping to sleep it off. .. & life passes by. Ugh Fingers crossed they come up with something and I am sorry to hear you have them too.
If you are interested in getting adderall, Percocet, oxycodone, Xanax visit our website/ buymedpharmacy.com
Thank you for an easy to follow and understand answer!
The animation and music is an amazing art on its own....
DAMN. THIS WAS ONE OF THE BEST VIDEOS BY TEDEX
0:14 it all happened to me when you just said them.
Thanks for the simple presentation
2D has probably learned more about his life watching this than he will in his entire life-time.
Ingenius genius channels, illustration, explanation & sounaffects is eye friendly and digestable learning
Dear people that' reading this, we don't know each other but I wish you all the best in life don't ever blam yourself, accept things and a key for happy life.....
This channel the best thing happened to the world
And that's why the doctor recommends you to rest after taking the medicine! The lesser the heart rate, slower the blood will flow through the liver in a given time and therefore slower it will remove the medicine out of your body increasing it's effectiveness.
Eureka!!
Lol so you probably aatch Horrid Henry
I've always wondered where does the medicine knows where to go. Fascinating.
Is this the same for vitamin and cod fish tablets
Rimsha Khalid no
They are absorbed by your organism in the same way, but vitamins don't act the same way as medication, they have diverse roles in your organism such as becoming enzymes or maintaining your immune system.
If you are interested in getting adderall, Percocet, oxycodone, Xanax visit our website/ buymedpharmacy.com
Best explanation of médecin absorption on RUclips
That means painkillers are just stopping symptoms temporarily, not curing the actual problem,
@@yonce3431 him
True but maybe we get cured quicker when wd do not have the pain
More Videos pls.. About medicines and Dialsease.. Pls simplify it so the Normal or common persons can understand it FULLy
the animation on this reminds me of the pinball/countdown cartoon from Seasame Street.
Found this video extremely useful and satisfying. Thank you
Whoa. I loved the animation on this video!,
Pharmacokinetics focuses mainly on what the body does to the drug. To summarize its steps, remember ADME, Administration, distribution, metabolism, excretion.
Make a video on how good bacteria fights bad bacteria
Short, simple and informative. I love it.
3:40 I can see that happening
Thanks sie
dude, i was so scared of taking pills and stuff, it feels like putting poisen or unknown chemicals into your body, but now i know its not that bad, thanks.
Sublime explanation and graphics which simplifies the complex processes👌🏻👌🏻👌🏻👌🏻
As far as I know , the APIs of Ibuprofen molecule converting to inactive metabolites is termed as 1st pass metabolism. But why some molecule gets converted to inactive while some escape?. How the molecules manage to escape 1st pass metabolism in liver?
I loved the animation. It's like that hand drawn old school animation from the 80's.
Does medicine affect in your body permanently or it will go away after a few days?
Continue to share worthwhile lessons
2017 was 7 years ago?!??
Yes
DAMNNNNNNNNN
It’s gonna be 8
Initially it was very tough to understand for me ,after seeing this video , because it is followed simple way to understand the process thanks for keeping this video❤️
No one cares. Who asked you're such a useless organism.
Holy fuck this animtion is amazing