That’s sounds great. I believe GLP-1 has helped my anxiety (GAD). Please do a video on GLP-1’s & mental health!! Some literature says it causes depression & anxiety, yet in others it helps people with depression & anxiety. I believe like any medication, everyone handles everything differently. This helps me. And I hope more people dive into it so that the studies keep studying it. Believe it or not they are actually paying attention to influencers and doctors on social media so the studies are listening to you guys so I would love it if you guys go into that even if you did it just a little bit just brought some things to light because it’s so important. This drug helps with so many things other than diabetes and Chronic obesity not weight loss chronic obesity two different things and the word should be used chronic obesity, losing 10 pounds is not obesity so the proper terms should be used by all of these influencers and doctors online but trust me what you’re doing is helping more people than you ever know thank you.
I feel more mental clarity and less depression since starting 3 weeks ago. This has been a life saving drug for me for so many reasons. Lowering my comorbidities one by one. I can’t wait to get off my bp meds.
I suffer from severe insomnia and have relied on sleep meds for nearly 40 years. After fighting for much of 2024 to gain access to tirzepatide, I am pleased to have finally accomplished that feat. But - for the first 3 to 4 days after injection, I don't feel my sleep meds and I don't sleep. The tirzepatide completely blocks absorption of other medications in me. If I only had to go through this period of sleep deprivation once a month, as opposed to once a week, it would greatly boost the quality of my life. I wish I had been born at least 50 years later, since I know my life expectancy will not allow me to see the many exciting obesity treatments coming down the pike. It's an exciting time to be alive, especially if one is young enough to see these innovations come to fruition and become accessible to everyone.
The fasting community is going to have a whole fit when Dr. Fung comes out in support of GLP1s. He’s a nephrologist and said he turned to fasting with his patients to see if it could reduce kidney disease. His ultimate goal was to get people off of dialysis (but it didn’t work with that).
Most doctors don’t realize that obesity is a disease. It’s not surprising as some doctors blame patients for their blood pressure and cholesterol numbers. It’s like telling an alcoholic to just say no to alcohol. Yes, some patients can improve their health, but many can’t due to their hereditary. Let’s hope we get a more enlightened medical profession.
Thank you for the information. I have been on Trizepatide since Nov 6th, and lost 7.5lbs, Happy for the lost and realize if I don't keep my proteins up my loss seems to slow. Or it's also my body making adjustments to the loss. Have a great week.
Regarding the meds not working for everyone, I’m very interested in the topic of cycling that has been popping up here and there. Other peptides (like Sermorelin) are prescribed to be cycled (5 days on/2 days off or 3 months on/1 month off), so the thought is that maybe GLP-1s could be more effective if cycled, too. The problem is that if you come off of them, you could rebound, or for a T2D like me, you would lose blood glucose control. SO… if we had a different drug to switch to, would that keep our bodies from getting immune (for lack of a better term) to the meds and keep them from becoming ineffective? That’s the emerging question I see around the GLP-1 streets lately. 🤔
CD: yes i have sen several conversations on this - all anecdotal and most of them coming from the world of GNC/Supplements/peptides. I have not seen anything from the academic research world but it may be worth a shot assuming your docto is working with you and managing closely.
@@thedownsized yeah. As you know, I have a ways to go before maintenance, and I’m still on 5.0, so I personally won’t be needing that anytime soon, but it’s an interesting idea.
LD: I’ve done carb cycling and calorie cycling. I heard someone say that our receptors get flooded with the glp-1 at some point, so taking a break would help them reset. Definitely need to research this.
Thing is, GLP-1s do not seem to become ineffective. Rather, ppl just THINK they do, because they cannot keep losing more and more weight on them forever. 😢 But what they’re missing is that there is a powerful countervailing force to weight-loss: *your own biology.* 🧬 Your body does not like you losing weight… especially losing LOTS of weight. It thinks you’re starving to death. 😯 So in response to weight loss, it: - Increases your hunger hormones - Decreases your satiety hormones - Slows your metabolism. And the MORE weight you lose, the STRONGER your biology ‘fights back’ against the weight-loss. 💥 🥊 At some point, your biology’s response is going to be SO STRONG that even the top dose of a GLP-1 med is being fought to a standstill. But your receptors are still fine. Not every drug causes a down-regulation response. Doubt this? Well, both Lilly and Novo have run maintenance trials for Tirzepatide and Semaglutide. In those, ppl were put on the meds for awhile, and experienced a lot of weight loss. THEN, they were split into two groups for maintenance for a year…. a ‘non-medication’ group and a medication group. Results: Non-med group ppl gained most of the weight back. Meds group KEPT IT OFF… and even lost a bit more. ✅ If your receptors were cooked, then why would the meds keep on working well? 🤷🏻♀️ The peptides ppl are likely over-generalizing. While there may possibly be a few outlier folks who respond well to cycling GLP-1s (‘cuz everybody is different, and a few are VERY different), I would not bet on it as a good practice for the average person. But ppl are certainly free to experiment, assuming their doctor is on board. 👩⚕️ I just sure wouldn’t do it if I was diabetic or had other very significant co-morbidities that were being helped by the GLP-1. And I feel like cycling kinda trades on hope. Say you have 40 percent of your body weight to lose to get to a ‘normal’ weight. Unless you’re a super-responder, you’re likely NOT going to get to your goal via a GLP-1 med alone. But cycling holds out the promise that you can. So ppl are going to be ATTRACTED to the concept… even though there’s no real scientific evidence to back up the practice with GLP-1s. 🤨
@@cloakster honestly: For most people it stops working because they do not adjust what they eat and dring to their decreased BMR. Happens with and without injections. The idea that some receptors might turn resistant is valid though. Happens with many other receptors too (insulin, leptin, …). And would explain why ballanced insulin production is still working for DT2 patients but food noise and slowed digestion effects decrease.
I think many of the insurance companies are betting that when someone needs a knee replacement, stroke treatment, etc. if will be in the future and the patient will be covered by someone else's insurance, so they have trouble justifying the short-term high $$$ in a particular policy year.
Love the updates! and conversation on the up coming medications! The hope is with more options everyone can find a medication that works for them 🙏🏼One shot a month! I’m with Laraine sign me up! Thank you for the info! ❤💉
I am on 10mg I have 1and a half months left of the 10mg but my dr has moved me up to the 12.5mg should I finish the 10mg before I start the 12.5mg I did take one of the 12.5mg and it worked so much better for me but I don’t want to waste any of my meds ❤😊
You Believe every clinical trial and expert that is positive for GLP-1. You believe every Super-responder no matter how miraculous the weight loss. Yet, you question/doubt clinical trials and experts that conclude 10-20% will not respond or will have the same weight loss of other diets. People are spending hundreds of dollars for this medication so the expectation is that they will do better than traditional changes (many have zero costs). You repeatedly question and doubt the commitment of anyone that is not achieving their goals. Sounds like they weren’t committed in WW either. Why are there so many RX for high blood pressure - because they work for some and not for others.
LD: I often question many of the trials for GLP-1's, good and bad. I don't want people to be discouraged from even trying a GLP-1. I thought the 20% number sounded high. I have spent hundreds of dollars on many diets - Nutrisystem, Jenni Craig, Physicians Weight Loss, WW, ect and low dollars on other diets - Cabbage Soup diet, Carb Addicts diet, Hollywood Diet, 17 Day Diet, and never found that the cost correlated with the success. I do think that for some people it will be as easy as just take the shot and you will lose weight. For others just taking the shot will not be enough, and other factors like protein intake, water, exercise, ect will make the difference. I look forward to the day when many more GLP-1 drugs will be available - like a once a month shot! And people can work with their Dr. to find the GLP-1 that works best for them.
That’s sounds great. I believe GLP-1 has helped my anxiety (GAD). Please do a video on GLP-1’s & mental health!! Some literature says it causes depression & anxiety, yet in others it helps people with depression & anxiety. I believe like any medication, everyone handles everything differently. This helps me. And I hope more people dive into it so that the studies keep studying it. Believe it or not they are actually paying attention to influencers and doctors on social media so the studies are listening to you guys so I would love it if you guys go into that even if you did it just a little bit just brought some things to light because it’s so important. This drug helps with so many things other than diabetes and Chronic obesity not weight loss chronic obesity two different things and the word should be used chronic obesity, losing 10 pounds is not obesity so the proper terms should be used by all of these influencers and doctors online but trust me what you’re doing is helping more people than you ever know thank you.
I feel more mental clarity and less depression since starting 3 weeks ago. This has been a life saving drug for me for so many reasons. Lowering my comorbidities one by one. I can’t wait to get off my bp meds.
CD: we have discussed this in a number of the past news segments covering research as it was released
I definitely feel a mental health benefit. I'm wondering if it's related in some way to having more even blood sugar -- no dips, etc.
I suffer from severe insomnia and have relied on sleep meds for nearly 40 years. After fighting for much of 2024 to gain access to tirzepatide, I am pleased to have finally accomplished that feat. But - for the first 3 to 4 days after injection, I don't feel my sleep meds and I don't sleep. The tirzepatide completely blocks absorption of other medications in me. If I only had to go through this period of sleep deprivation once a month, as opposed to once a week, it would greatly boost the quality of my life. I wish I had been born at least 50 years later, since I know my life expectancy will not allow me to see the many exciting obesity treatments coming down the pike. It's an exciting time to be alive, especially if one is young enough to see these innovations come to fruition and become accessible to everyone.
Oh wow! Sleep is so important- I’m sorry you have to go through that. Hopefully the next generations of these meds will be better for you ❤️
@@sallysmack9372 would NEVER want to grow up in this day and age! NEVER.
@@Rogue_1987 I get that. I'm speaking only in terms of the advances in science.
The fasting community is going to have a whole fit when Dr. Fung comes out in support of GLP1s. He’s a nephrologist and said he turned to fasting with his patients to see if it could reduce kidney disease. His ultimate goal was to get people off of dialysis (but it didn’t work with that).
Most doctors don’t realize that obesity is a disease. It’s not surprising as some doctors blame patients for their blood pressure and cholesterol numbers. It’s like telling an alcoholic to just say no to alcohol. Yes, some patients can improve their health, but many can’t due to their hereditary. Let’s hope we get a more enlightened medical profession.
Most doctors should realize it by now… considering that the AMA declared obesity a disease back in 2013.
But yeah, there are always dead-enders. 🤦🏽
Thank you for the information. I have been on Trizepatide since Nov 6th, and lost 7.5lbs, Happy for the lost and realize if I don't keep my proteins up my loss seems to slow. Or it's also my body making adjustments to the loss. Have a great week.
Thanks for watching
Regarding the meds not working for everyone, I’m very interested in the topic of cycling that has been popping up here and there. Other peptides (like Sermorelin) are prescribed to be cycled (5 days on/2 days off or 3 months on/1 month off), so the thought is that maybe GLP-1s could be more effective if cycled, too. The problem is that if you come off of them, you could rebound, or for a T2D like me, you would lose blood glucose control. SO… if we had a different drug to switch to, would that keep our bodies from getting immune (for lack of a better term) to the meds and keep them from becoming ineffective? That’s the emerging question I see around the GLP-1 streets lately. 🤔
CD: yes i have sen several conversations on this - all anecdotal and most of them coming from the world of GNC/Supplements/peptides. I have not seen anything from the academic research world but it may be worth a shot assuming your docto is working with you and managing closely.
@@thedownsized yeah. As you know, I have a ways to go before maintenance, and I’m still on 5.0, so I personally won’t be needing that anytime soon, but it’s an interesting idea.
LD: I’ve done carb cycling and calorie cycling. I heard someone say that our receptors get flooded with the glp-1 at some point, so taking a break would help them reset. Definitely need to research this.
Thing is, GLP-1s do not seem to become ineffective.
Rather, ppl just THINK they do, because they cannot keep losing more and more weight on them forever. 😢
But what they’re missing is that there is a powerful countervailing force to weight-loss: *your own biology.* 🧬
Your body does not like you losing weight… especially losing LOTS of weight. It thinks you’re starving to death. 😯
So in response to weight loss, it:
- Increases your hunger hormones
- Decreases your satiety hormones
- Slows your metabolism.
And the MORE weight you lose, the STRONGER your biology ‘fights back’ against the weight-loss. 💥 🥊
At some point, your biology’s response is going to be SO STRONG that even the top dose of a GLP-1 med is being fought to a standstill. But your receptors are still fine. Not every drug causes a down-regulation response.
Doubt this? Well, both Lilly and Novo have run maintenance trials for Tirzepatide and Semaglutide.
In those, ppl were put on the meds for awhile, and experienced a lot of weight loss.
THEN, they were split into two groups for maintenance for a year…. a ‘non-medication’ group and a medication group.
Results: Non-med group ppl gained most of the weight back. Meds group KEPT IT OFF… and even lost a bit more. ✅
If your receptors were cooked, then why would the meds keep on working well? 🤷🏻♀️
The peptides ppl are likely over-generalizing. While there may possibly be a few outlier folks who respond well to cycling GLP-1s (‘cuz everybody is different, and a few are VERY different), I would not bet on it as a good practice for the average person.
But ppl are certainly free to experiment, assuming their doctor is on board. 👩⚕️
I just sure wouldn’t do it if I was diabetic or had other very significant co-morbidities that were being helped by the GLP-1.
And I feel like cycling kinda trades on hope.
Say you have 40 percent of your body weight to lose to get to a ‘normal’ weight. Unless you’re a super-responder, you’re likely NOT going to get to your goal via a GLP-1 med alone.
But cycling holds out the promise that you can. So ppl are going to be ATTRACTED to the concept… even though there’s no real scientific evidence to back up the practice with GLP-1s. 🤨
@@cloakster honestly: For most people it stops working because they do not adjust what they eat and dring to their decreased BMR. Happens with and without injections.
The idea that some receptors might turn resistant is valid though. Happens with many other receptors too (insulin, leptin, …). And would explain why ballanced insulin production is still working for DT2 patients but food noise and slowed digestion effects decrease.
... and now I want to buy Amgen for Christmas!
Thanks guys always so much information ❤
I think many of the insurance companies are betting that when someone needs a knee replacement, stroke treatment, etc. if will be in the future and the patient will be covered by someone else's insurance, so they have trouble justifying the short-term high $$$ in a particular policy year.
CD: I think you are correct
Love the updates! and conversation on the up coming medications! The hope is with more options everyone can find a medication that works for them 🙏🏼One shot a month! I’m with Laraine sign me up! Thank you for the info! ❤💉
Thank you 😊
You're welcome 😊
Good evening!!
I am on 10mg I have 1and a half months left of the 10mg but my dr has moved me up to the 12.5mg should I finish the 10mg before I start the 12.5mg I did take one of the 12.5mg and it worked so much better for me but I don’t want to waste any of my meds ❤😊
CD: I would personally take the rest of the ten. But talk to your doctor
Thank you I was thinking the same thing because I don't want to waste my meds ❤@@thedownsized
You should finish the 10mg
Thank you @@Sansann84
You Believe every clinical trial and expert that is positive for GLP-1. You believe every Super-responder no matter how miraculous the weight loss. Yet, you question/doubt clinical trials and experts that conclude 10-20% will not respond or will have the same weight loss of other diets. People are spending hundreds of dollars for this medication so the expectation is that they will do better than traditional changes (many have zero costs). You repeatedly question and doubt the commitment of anyone that is not achieving their goals. Sounds like they weren’t committed in WW either. Why are there so many RX for high blood pressure - because they work for some and not for others.
LD: I often question many of the trials for GLP-1's, good and bad. I don't want people to be discouraged from even trying a GLP-1. I thought the 20% number sounded high.
I have spent hundreds of dollars on many diets - Nutrisystem, Jenni Craig, Physicians Weight Loss, WW, ect and low dollars on other diets - Cabbage Soup diet, Carb Addicts diet, Hollywood Diet, 17 Day Diet, and never found that the cost correlated with the success.
I do think that for some people it will be as easy as just take the shot and you will lose weight. For others just taking the shot will not be enough, and other factors like protein intake, water, exercise, ect will make the difference.
I look forward to the day when many more GLP-1 drugs will be available - like a once a month shot! And people can work with their Dr. to find the GLP-1 that works best for them.