@@sidharthsk3807 Gene Editing will destroy religion, bring human enlightnment and will help solve racism, worthless nature of human breeding, so on so on.
@@Ivan.A.Churlyuski Nazi eugenics was completely different. The methods, the motives, the outcomes. Completely different. Thats like comparing 18th century surgery with modern surgery. CRISPR Cas9 technology has the ability to change the world. If we have the ability to cure an illness, would you not agree we have a responsibility to do so?
While I understand people who are scared of "designed babies" my main objection to their objections is logical. Few people today still object Transplantology despite obvious countless controversies, procedures that are by definition defying integrity of human beings often go even worse for patients not to mention fueling criminal activity and human trafficking! Personally I found therefore Germline CRISPR if carefully planed on well understood genes Far LESS controversial! Than already existing other medical technologies. And it's doubtlessly better to eliminate the cause of illnesses and sufferings than to ineptly treat their symptoms. He Jiankui is a real hero of Humanity The Gagarin of XXI Century! Pity that while Gagarin was worshipped by people throughout the world regardless of cold war affiliations Chinese Stasi got He arrested right after his conference were he presented flawless germ therapy results!
Current western scientific community reacts to this as people from medieval times when they were told that Sun is not moving around Earth, but it's the opposite. Shame on ethical parasites.
I’m surprised, given what happened to Dr. He that (a) the video is still up; and (b) despite that, there haven’t been more views. Im not saying he was okay to proceed with the gene editing but this maybe the single biggest event in the 21st century so far!
The reason why this topic isn't more talked about is probably because there is an actual lack of evidence of the experiment actually working and creating such a breakthrough, as claimed by the researchers. The research team was anonymous, the experimental process (reportedly) wasn't documented properly, and no external research committee has reviewed and verified the research process and its results.
@@volkanaksoy6313 Yeah like history will remember that or that he was the first human to venture into where no human dare venture. Bdw I think he'll be back home by this Christmas & it's upon history to judge on what he did.
Dr. He claimed “before returning Lulu and Nana to Grace’s womb, we checked how the gene surgery went by whole genome sequencing. The results indicated the surgery worked safely, as intended. Grace’s pregnancy was normal, which we monitored closely by ultrasounds and blood tests. After birth, we again deep sequenced Lulu and Nana’s whole genomes. This verified the gene surgery worked safely: no gene was changed except the one to prevent HIV infection.” As far as I know (sorry, I am not a specialist in this field so I might have misunderstood) the whole genome sequencing to find one nucleotide change requires substantial numbers of cells to normalize the mis-reading of the sequence. How can he get such substantial number of embryonic cells before returning the embryo into mother’s body? And what was the "reference" genome to check if there are potential changes of the sequence?
@@xavierrodriguez2463 Then do you think Dr. He got substantial number (say, it should not be less than 10 thousands) of embryonic cells for the whole genome sequence? During the period of incubation, do you think he maintained the embryo to put into the womb? Honestly, I think it is very unlikely. Anyway, now the authority of China can take substantial cells to test for the whole genome sequence. Does someone knows the results?
Gene editing is one way to cure disease, but not at this stage. CRISPR-CAS9 is still premature with high risk, this is illegal in China and is a huge ethical issue in science world
Nidhogg I think the social impact will be more concerning. Rich people would pay big money to ensure their offsprings have a competitive edge, while average people remain “inferior”. This will create a bigger problem than income inequality, as people assume their future is hopeless and their children will be enslaved by a superior “species”. We still don’t know the long term effect, maybe With enough modified gene in the pool human will lost the ability to reproduce, and there’s no way you can stop it since people are paying so much for something that can be done easily at a local underground lab.
Nidhogg When you talk about humanity. Think again what is humanity. When the gene editing technology still has high risk and unpredictable outcomes, you can not use on human embryos to born a human. More serious issue is that if you editing the genes (one or amount of) you can not even define the baby is still homo sapiens or not, how can you speak humanity any more? This is ethics issue. Gene editing is not a normal technology as you mentioned plastic or rocket thing. Think Again，why this is not legal in US or China, if it’s better for your so called humanities.
Nidhogg Apparently, you’re still unclear about this technology and its risk. Gene editing is one way to cure disease for sure but not at this stage. This experiment is no different from what nazi did in German or China during WWII. Think this in a different way, if you want to have a baby, do you agree with perform this unpredictable surgery on him or her? Do you want to add the risk for cancer or other diseases for your baby? I believe you don’t want to do that anymore. See this called humanities, regardless you are a scientist or a religion one, you will make this decision as a human, nothing about evolution.
@@yudax5057 You are talking like the rich people don't already have more range of experimental treatments available than the common person. This is nothing new. Somewhere this kind of experiment has already been done behind closed doors.
He failed to achieve his goal, neither of the babies is immune to HIV and both of them have a version of the CCR5 gene that has never before been seen that may compromise their ability to fight infection. He broke various Chinese laws (including gathering informed consent from the parents, you see he didn't inform them of the danger, and illegally practicing medicine) all to do something we already can do, prevent the passage of HIV to offspring
J Barr Yet, as far as we know, everything is fine since nobody will release his work and/or follow-up and are instead fining and throwing him in jail. People and scientists are claiming it didn’t work, but nobody has presented any evidence whatsoever.
@@maxmilian3229 it doesn't matter if it worked or not. Genetic manipulation has proven to be completely unreliable and caused exponentially more problems than the 1 or 2 they have resolved
Sofia & Hamza he failed. And future generation are in danger . This girls one days will have kids and create a generation full of problems or who know what else they will show .
J. Trenche how do you know everything is fine ? We will only know when this twins appear and check how they are doing ! No one know what is their genetic material .
This actually could be fake, just to raise awareness for the controversy around human genome editing. There are some red flags: 1, There is no paper or preprint 2, Hospital doesn't know about the existence of the babies and 3, I fail to understand why you would knockout a receptor to which HIV binds if the dad is the one with the HIV. Isn't the HIV removed from the sperm when you do the IVF treatment? 4, Whole genome sequencing before and after editing is a very good idea, however it is very very hard to make 100% sure CRISPR did not aspecifically target something. Variant calling and other bam analyses would detect changes in the DNA if the depth is good enough, however if for some reason the CRISPR-cas9 creates or inserts DNA that does not align to the human genome, then it will go undetected with those analyses. You could write some scripts to check changes in the unmapped or align against other genomes like virusses and transposons that are not known transposable elements, but I doubt that they did that.
I rather hope this is faked news!!!! as a biologist I can't even be calm to bla all this arguments like you! He did years of search in a good lab in the US he knew all of these!!! He ONLY wanted to do experiments with NO ethics and moral!! this is evil!!! so ashamed as a Chinese!!!WTF....
Yeah, he is really experienced and he knows what he is talking about. But it still keeps the possibility open that it might just be a publicity stunt. He thought really good about it, but somethings just doesn't make sense. By the way, that I think it's fake, doesn't mean that it is not possible. On the contrary, it is very much possible. @@xuanwang1870
The homosexualisation of the young is an important element in the globalist plan to reduce fertility. This innovation will reduce the costs of future generations migrating their sexuality to pleasure-oriented, non-reproductive outlets.
@@GM4ThePeople If I understand your point, you think that they want to engineer ppl to be gay? Idk if ppl want that, but too me that sounds really hard. They think homosexuality has more to do with epigenetics than with genetics, which makes it a lot harder to modify. But still, changing the whole mechanism of something is really hard. For example, what they claimed to have done here, is disabling one gene, which is easy. But when you want to change something like the way an eye functions or the when someone gets angry, there are so many processes involved. You would first need to map tens of genes involved in the cascade and then know how they work and know how you can change them for the better. It is soo many information and right now we do not even know what most genes exactly do, let alone in which cascade they belong and how they exactly function. Now because homosexuality is even more complicated than that, I do not think that we will live to see that ppl can engineer sexuality.
Because we have no idea how a person with a conditional 1000 iq will feel, will we be able to detect a new mental illness in them, if there is one? And in general, will he or she be a human being in the usual sense of the word? And there are many more factors that, at the very least, should make us take gene editing more seriously.
While I understand people who are scared of "designed babies" my main objection to their objections is logical. Few people today still object Transplantology despite obvious countless controversies, procedures that are by definition defying integrity of human beings often go even worse for patients not to mention fueling criminal activity and human trafficking! Personally I found therefore Germline CRISPR if carefully planed on well understood genes Far LESS controversial! Than already existing other medical technologies. And it's doubtlessly better to eliminate the cause of illnesses and sufferings than to ineptly treat their symptoms. He Jiankui is a real hero of Humanity The Gagarin of XXI Century! Pity that while Gagarin was worshipped by people throughout the world regardless of cold war affiliations Chinese Stasi got He arrested right after his conference were he presented flawless germ therapy results!
These experiments are highly controversial and we don't know the final results. As I know he is in prison at the present time in China due that he violated China's regulations. I think he tried to help science but did not realize that this technology may be used for different uses.
The funny thing is, that the guy KNEW about the papers on supermemory mice with the deleted CCR5 gene. The edit was made not only to make the children immune to HIV. It was partially done to make some sort of supermemory superhumans. xd
The Biggest mistake that He and his team made was that he went very public about his experiments. Given the ease of using CRISPR-cas9 technology, it's clear that there are many experiments already under way that we don't know about.
I don't understand what he did wrong, aside from practicing illegally. He made GMO children? Should be fine for people who approve of GMOs. He modified embryos? Pro-choice people dismiss potential for the future of that embryo in favor of the parent's choice. Therefore he did not "harm" the children, just as how you cannot "harm" the fetus by killing it. I don't get why people are being so hypocritical about this and saying it's wrong.
What a wonderful achievement from this humble, humanitarian. Gene editing surgery that prevents HIV is not 'enhancement'. The decision to commit to this surgery was an ethical choice. The surgery allows an 'at risk' parent to enjoy guilt-free fatherhood, knowing he will not pass this debilitating disease to his children. "The surgery reproduces a natural genetic variation shared by more than 100 million people of primarily European origin that confers strong resistance to initial HIV-1 infection and disease progression." So, NOT 'enhancement', simply a brave step forward using surgical skills to edit out disease. He Jiankui has gifted this happy couple with two healthy children. Congratulations, He Jiankui, for your courage in making this possible.
@@colenewaltersmusicandother9330 Like so many other wonderful benefits to mankind that have come from modern medicine, children will no longer have to suffer from a (now preventable) range of disabilities and disease. With the potential for making children's lives free from pain and suffering, this is a truly amazing medical breakthough.
@@Zizzyyzz legality doesn’t always equal morality Assuming this isn’t a stunt and he actually created designer babies, this is an amazing advancement in technology.
@@waspoppin4784 Lol what? What he did WAS unethical in so many ways. First, he obtained false consent from the parents by deceiving them (told them it was some vaccine program). Also, he effectively did a procedure on humans that's barely been tried with animals; in medicine, you never try out a therapy on humans until you understand the safety, efficacy, and mechanism/rationale of the individual steps of the procedure. Also, even if gene editing was a common thing, there are far less risky procedures that would be tried before turning to editing of the embryo; for example, editing bone marrow stem cells in HIV infected patients so that you're not messing around with all the cells of a human body. Gene therapy holds enormous promise, but it has to be developed more responsibly and cautiously than this.
"A Chinese court has sentenced He Jiankui, the biophysicist who announced that he had created the world’s first gene-edited babies, to three years in prison for *“illegal medical practice”,* and handed down shorter sentences to two colleagues who assisted him. The punishments put to rest speculation over whether the Chinese government would bring criminal charges for an act that shocked the world, and are likely to deter others from similar behaviour, say Chinese scientists."
Natural and not too scary death to the actually pretty normal governors! Let the Emperor's fate be slightly uncomfortable! We, small and humble part of the people of Empire, are sorry but have to make some protesting noise!
So instead of letting the people who are more genetically disposed to sleeping around, not being careful thus getting HIV and naturally eliminating themselves from the gene pool you would rather encourage their behavior and even give them increased resistance to these diseases? Do you even think about the long term consequences that this will leave on the society?
I'm against the fact that he was jailed in China. Parents had already given their consent so it's wrong what was done to this doctor. I hope it was a deletion mutation. So, no other genes were alerted. Well, those girls were never followed up for their progress, so it's unknown what happened to their health.
Dude is crazy. One of the biggest problems with CRISPR is creating perfect guide RNA so that the CRISPR system doesnt run around trying to modify all DNA sequences that are slightly similar. Off targets are the biggest problem and could cause HUGE issues. This shit doesnt seem right to me
Perhaps the rush to be first is more short-sighted arrogance than anything else. Plenty of people know how to do this, including the people that invented it at Harvard, Berkley, and a handful of other labs including one in Shanghai. The issue wasn't that it couldn't be done, but should it be done. It is a very different thing playing with a child who has no say in how they will be born, and working with an adult that can give consent. Plus there is no consideration of the additional generations this experiment affects. There is so much we don't know about our DNA, and the collateral damage this technique may cause to other genes that are dormant, but we may need in human kind's future evolution.
So with the argument about "consent", should we stop circumcising babies? What about implementing religion or giving them a name they didn't choose? So, let's ignore that issue. We can never predict the effects of our actions. We didn't foresee the climate impact of industrialization, but you wouldn't be typing on a tiny computer that fits in your pocket if we didn't pursue it. So let's ignore "considering the future effects" cause we can't predict that. And technology naturally affects our species' evolution. Discovering fire and using it to cook your food, is the same technological advancement as using CRISPR. So let's ignore that argument too.
@@kevinsundelin8639 It's tough to say. There may be obvious short-term benefits like this experiment here. However, among scientists in the field we are concerned about long-term effects of gene-editing. We aren't sure if there are any unintended consequences of editing certain genes in or out or whether this technology is as precise as we wish it to be. Combining that with how much we don't understand about the whole system we're manipulating and it could be dangerous in the long run.
@@MrTRANnysaurus exactly, this video brings up the same things you are speaking of. I can't believe all the positive comments in here about this. ruclips.net/video/_YpACFaK0O4/видео.html
Thanks for your reply @@boukmann1791! I looked in multiple articles online and searched in published papers and apparently circumcision prevents UTI on babies. Circumcision is a good thing. The only bad thing is, kids don't have a say on the matter. It's like feeding your kids/babies vegetables. You know the benefits of it, but they dont. What do you say to that? And also, it's hard to predict the effects of our action. Did you know we don't know how analgesics work? Yet Tylenol is over the counter. Look it up! The effects of 5g is still being debated, and it's coming gonna be on your next mobile devices. We can halt technological progress until we're 100% sure it's only gonna be for good, but we will never move forward.
For those self righteous and out right religious people crying out at this man for trying to play god , this man is a hero . His research and experiments paved the way for a better future in mankind .
The project has not been reported to the Chinese medical management department. The incident has attracted the attention of the government and relevant scholars have been investigated.
But is this true? As in the description they say results are not yet published. So, I'm confused if this is legit or a hoax. What does your media say about it? Can you tell me about it :)
@@kiranrenduchintala4178China’s national media “People’s Daily” issued an article condemning this behavior, which is very regrettable. This may be true. The scientists involved in the trial have been investigated because the experiment was illegal and has not been reviewed by the medical research department. This scientist is simply a madman.
@@jasonkiu3029 I honestly don't know what to think of it. Something good came out of it but it still need to be studied. It is indeed unfortunate and illegal human experiment for sure. There is also a recent surge of biohackers doing the same since the CRISPR kit is relatively cheap.
@@kiranrenduchintala4178 What "good" are you referring to? Is it the fact that supposedly the girls will be resistant to HIV? What a ridiculous reason to do this - there is NO reason good enough - don't be naive.
The ethical problem which arises with wanting to raise your Childs IQ via Gen editing is that you deem someone unworthy of living or at the least less valuable, if they do not fulfill your/societies expectations of intelligence. Why should it matter, if your child is of average or high intelligence. It should and cannot determine a persons worth. Having an high IQ does not automatically promise success, happiness, health or any other factor you would believe would come with above average cognitive abilities
i am fully support your actions about this, i may cause controversies at first, but over time people will understand that the life is changing so does the diseases and this medical treatment will come in front to prevent any of this diseases. Keep up the good work sir!
@@skaffen i had not thought of that. We usually fixate on one thing and his was to prevent the children from contracting HIV. Which was a very very low percentage since the mother hasn't contacted it. I would like to see studies on prevention of cancer or muscular dystrophy things that could be performed on concenting adults.
All you have to do is look at genetically modified food crops to understand the inevitable outcome of manipulation. Humans have prospered for over 200,000yrs, often while the demise of a few benefitted the many, yet selfishness and acedimic arrogance is full steam ahead to derail evolution.
If this treatment uses for disable person's it will a god gift for them . Because they have to face unlimited hurdles in their routine life.This treatment have to use and also approved for only those persons who really needs it.Stopping the miss used of it, its a realy one hope for disable people's , who r many amount in world.
Dear He Jiankui, Happy Birthday! I salute you because you have changed the history of our world. Your name will be remembered for hundreds and thousands of years to come, while the names of kings and presidents will be forgotten in History. And that is for a simple reason. Before 2018 A.D. the Natural history of Life was dictated by accidental mutations in live organisms. If one out of a millions mutations was successful, the organism had progressed. A better, more survivable form of life was passing on their new genes onward to the new generations. That is, obviously, called Evolution, and was discovered by Charles Darvin. But with you, He Jiankui, everything has changed. The occurred Philosophical Jump is that a form of life (Human) had changed its genes not by Accidental Mutation but by a Conscious Mutation! That where the Quantity of billions of years of Evolution made a Jump into a new Quality. That is huge. That is named Revolution. We, your contemporaries, cannot see your greatness today, as it was many times in history. Many criticize you, condemn, and even sentenced you for what it will be a common practice very soon, maybe during our lifetime. Blessed to be your contemporary. You have my utmost Respect.
Let's be honest people: early or late some arrogant and self-centered scientist would do something like this. Let's hope this don't backfire us in the future.
I think generally, the science community is too afraid to use it cause it's too cheap and too easy. Which I don't understand. They worked so hard for thousands of years trying to figure out how to be God and when they figured it out, they freak out.
Dear He Jiankui and team, thank you so much for this first bold step. I would like to reassure you than you have done a truly great thing, beyond the results but by having the courage and bravery to proceed with giving Lulu and Nana a chance at a healthy and normal life. Ofcourse, you will be criticized but please do remember that all great pioneers and innovators face skecptisim, being called crazy and sometimes worse at some point in their lives. Thank you and I wish you, your family and team a beautiful life ahead.
I can remember back to around the mid 90's when they first cloned the Sheep: "Dolly" Immediately after they were successful, two Italian doctors sought permission to clone Human Beings. They were refused. But who's to say that they didn't sneak off some place and do it anyway. I mean, when the W.H.O ordered all doctors and pathologist not to perform Post Mortems / Autopsies on C.O.V.I.D-19 deaths. Italian doctors and German Doctors didn't listen to the orders, and then they came out and spoke openly of their findings.
@@blackboxbs8642 They found that things just didn't add up. And then they were warned not to talk about anything else that they may have found. They said C.O.V.I.D_19 Wasn't nearly as dangerous as we were being told. They speculated that it had to be man made.
This doctor was sentenced to 3 years in prison. This was unethical and illegal. We've had lots of that going on all over the world these past few years.
In this very specific case (of "Lulu and Nana"), there is a reliable method to ensure whether their DNA was harmed inadvertently in any areas other than that intended (the CCR5 "HIV-infection" gene). It is not clear whether Dr. He followed this method or not - he was unclear in his presentation. It could be proven safe in this specific case IF he did ALL of the following: 1) he sequenced the zygote's ("Lulu / Nana"'s) entire DNA before introducing the gene-splicing modification (the "Original" DNA), 2) After introducing the gene-splicing modification, he sequenced the entire DNA (the "Modified" DNA). 3) Do a full comparative analysis of the differences between the "Original" DNA and the "Modified" DNA -- effectively subtract/compare the two full sequences of DNA looking for any/all variations. 4) Ensure that the ONLY variations in the "Modified" DNA are to the CCR5 region. If his lab was able to demonstrate step 4, with high statistical significance and precision, then we can be sure the girls will be safe from unintended genetic harm. We then will have to wait and see if they will be immune to HIV-1 infection. (though, they may not be immune to other forms of HIV). This explanation provided by Dr. He's lab was very important to understanding what was done and why. However, this is only a verbal statement. We need his statements to be verified through independent means: a) is it true that the genetic father of "Lulu and Nana" is HIV-positive b) does the genetic father have the HIV-1 variant? c) Can other labs also sequence "Lulu and Nana"'s DNA to confirm the sequencing done by Dr. He's lab was correctly done and is reproducible/confirmed Though this is a controversial area, scientists can implement proper stringent controls to ensure such work, on individual cases, are done with sufficient controls to ensure safety (societal and individual).
To be really sure about this method, it needs statistics of at least a hundred of children. But society sucks, and doing so illegally would be impossible, since no one would see any profit.
still don't understand why he picked HIV, its very bad and all but we do have treatments that allows affected individual to live an almost okish life..... i am just shocked by his courage.... even though at the end of the day, he doesn't seem to provide a solid solution to HIV.... and now because he modified the germline cell, if lulu and nana were to have kids, their kids could inherit that artificial mutation....... kinda explains why the scientific community would have bad blood towards this
If this is true, I’m ganna be excited asf. In ancient times, a person made this special glass that could not be easily broken and could be reshaped easily. He presented it to a king but was put to death not long after. Humanity lost many great innovations to greed and selfishness. Don’t let it happen again
This is not new actually scientists trying to do this more than 10 years ago but the strict regulations require them to destroy the embryo after 14 days and nobody was allowed to use human cells to do experiments like this. But they actually started doin g animals a while ago
I understand your sentiment but it has been discovered that He did not work correctly with the Crispr gene editing. Not only are Lulu and Nana not protected against HIV but *are* careless science experiments with unknown outcomes for themselves and future generations they may birth.
Unfortunately it didn't work and might even caused them to be more susceptible to other illness. It was super complicated but if you read the newer info about them, it's scary and sad.
Are the twins now immune to HIV? If so, can they pass those genes onto their children? If so, doesn't that mean eventually humanity will be immune to HIV if their genes manage to spread into future generations? If they each had 2 children and the average birth rate of their subsequent offspring was 2, then we would have over 2 billion humans born with HIV immunity after 30 generations.
Yes, this was so-called germline editing, so in principle the trait of immunity to HIV as we know it will be passed on to any offspring. Other than that, remember that the human species first has to manage to survive before you can get to your 30 generations. It's also possible that the HIV virus no longer exists by then.
Your decisions to conduct this experiment and release no data to peer-review are unethical and you've done irreparable damage to the science of gene-editing. Thanks, He Lab! Suchy sweethearts you are !
To me, this man is a hero. If you want to achieve big scientific breakthroughs, you need to be bold. Sanctimonious bioethicists love to express "outrage and shock" at this type of work, but what have they done? They love to lecture, debate, and discuss ethical issues endlessly while admonishing people like He Jiankui for actually daring to get things done. Think about a world with less disease, longer lifespans, and smarter, happier people. If that strikes you as dystopian, then you're very small-minded. What's the matter, anyway? Are you just jealous that when this treatment becomes available to babies of the future, you won't be one of the recipients? Boohoo. Don't hold back human progress!
The problems being: one, there is no breakthrough and two, it’s not ethical. The technique has been used for years and close to being patented, just look it up. Nothing new was gained by applying it to human. What he did was imposing unknown and unnecessary risks on disadvantaged couples and their children.
True. The fact that so many people are antiprogress and anti science is ridiculous. I bet none of them have seen a family member suffer from an incurable disease which could be easily prevented with this technology.
coco oh you sweet summer child. Read a little and you will find that a lot of the “anti-progress” people are scientists themselves who understand the risks and condemn the inhumane treatment done in the name of progress.
Every time someone brings up ethics it seems they are speaking about anything but ethics. Ignoring the whining from the bio-"ethicists", this was still somewhat premature.
There in the hands of people that will stop at nothing to achieve a super human that can take over the world when they see no need for week people. The past history of splitting genes is evolving. Just saying. That’s what I see. Follow the money.
We must research and be wise to always consider science. I'm a biomedical student and I think if we can use science for the good, we are right. I respect all the religious and ethic's views, but if people think science is "playing God", we shoudn't ever have discovered peniciline. Think about it.
It's a great news about gene tharaphy!!!! One more question when are you doing other desiess like muscular dystrophy I'm also a muscular dystrophy patent.....
When I first read of Crispr my initial comment was, "OMG, the Chinese are going to start playing God and Frankenstein". It was a moment I wish I'd been wrong. Fast forward articles by those in the know we learn that He *did not* perform the Crispr editing correctly! Not only are Lulu and Nana not protected from contracting HIV but they are scientific freak shows with no known or even speculated outcomes on their health and future generations. This is the first time I'm angered by the label, Made In China...
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Very brave of him to do this, if his intentions were genuine I support it. I wouldn't mind having super humans around, if we can all somehow accept that our next generation baby's will be a lot better in everything.
Lulu has genetic mosaicism so she still produces some of the CCR5 protein. Jiankui progressed unsupported and I’m vanity for a disease that could be prevented through sperm screening, which he already did.
we already have autustics, been around for many years, superior in many ways: deeper concentration skills, sharper logical thinking, honesty way more difficult to corrupt, etc.(while inferior in social scenarios and processing senses stimulation) but ....are bullied.
except that they may not have the immunity to HIV at all and also their CCR5 versions are possibly the only two versions in the world as they are made up but they are still able to be passed down by reproducing. Do you have any clue what this could mean? This is the greatest example to why we should be twice as cautious with this genetic engineering.
@CogentPhilosopher So what? it has to be done, there is ALWAYS something in any area that we are ignorant, and he made this for that family not for you, so piss off
It´s not that easy, because one thing He Jiankuil did´nt mention is that CRISPR did not work as planed and the babies suffered genetic mosaicism for CCR5 (the gene he talks about in the video).
I am quite indecisive whether this could be the dawn of a utopian (i.e. fatal trait removal, ethical enhancement) or a dystopian (e.g. Auxley's Brave New World's alpha/beta/.../epsilon-castes) society for humankind. Possibly somewhere between the two extremes, but it's both inspiring and frightening.
The CCR5 gene he edited (or rather disabled) is correlated with memory and intelligence. It is absent in the Chinese population, but prevalent in northern Europe.
A world first for Prof He Jiankui. Many world firsts have come and gone. Some have propelled humanity to greatness, others not so. You claim good intentions but we'll let history be the judge. Perhaps some day down the road, this will all be behind us and you'll have the Nobel in your hand. I hope and pray that the Lulu and Nana will be there when that day comes.
He's a pioneer. There's going to be many scary new technologies coming soon. We have to prepare and take control of them as soon as we can, ignoring it won't help us
@@sinem2493 Nah y’all don’t know how this thing works. Multiple genes determine someone’s IQ. Not to mention, we don’t know which genes are responsible for that.
@@Zizzyyzz It were politicians who have no knowledge of science , they ruled it unethical or illegal . there were literally no scientist related to this field to judge , so better not judge a fish by its ability to climb a tree
If you support this guy, then you clearly did not look at the full extent of the risks and implications of his experiment. 1) The experiment was not approved, first of all. 2) He did not inform the parents of the risks. 3) He created frameshift null mutations because the CCR5 alleles were not created in the twin girls. As a result of this, one of them is mosaic (this means that it was genetically different from the twins, which can cause disease in the future) and the girls may still susceptible to HIV. 4) The scientific basis for the study is weak: it is very rare for fathers to pass HIV down to daughters. It's difficult to say, but there might be other mutations and genes altered that might impact the girls in the future. Please be aware of the conflict in ethics and safety of this study.
@@Zizzyyzz Yes. My genetics professor ranted about him in class, which is how I found out about what he did. It's just frustrating how people who don't understand genetics and the full extent of the issues he caused keep supporting him.
I strongly approve of this as it benefits future generations because they will not need to worry about as many diseases or debilitating illnesses thus improving the human race
Just watch this video again in 10 years.
Why
I WANT TO WATCH IT NOW UOU CANT STOP ME
@@Triggered_Carefree they mean there migt not be the same reaction and maybe they'll be actually praising hin
@@norannegm4527 yes, he will be appreciated..
@@sidharthsk3807 Gene Editing will destroy religion, bring human enlightnment and will help solve racism, worthless nature of human breeding, so on so on.
How do we know that Nana and Lulu are the first? That they may be the succesfull ones is ok but we don't know how many times they tried and failed.
So the firsf
Adam and first designer baby
It’s like we’ve collectively forgotten the deeds of Nazi Germany.
@@Ivan.A.Churlyuski Nazi eugenics was completely different. The methods, the motives, the outcomes. Completely different. Thats like comparing 18th century surgery with modern surgery. CRISPR Cas9 technology has the ability to change the world. If we have the ability to cure an illness, would you not agree we have a responsibility to do so?
Wouldn’t it be like comparing to 1940’s surgery? Why go back to the 1700’s?
Congratulations, you have taken a huge leap. Not being afraid of the controversial talk and making a stand, you have paved a way for humanity!
a way to nobody knows where... May heaven help us!😥
While I understand people who are scared of "designed babies" my main objection to their objections is logical. Few people today still object Transplantology despite obvious countless controversies, procedures that are by definition defying integrity of human beings often go even worse for patients not to mention fueling criminal activity and human trafficking!
Personally I found therefore Germline CRISPR if carefully planed on well understood genes Far LESS controversial! Than already existing other medical technologies.
And it's doubtlessly better to eliminate the cause of illnesses and sufferings than to ineptly treat their symptoms.
He Jiankui is a real hero of Humanity
The Gagarin of XXI Century!
Pity that while Gagarin was worshipped by people throughout the world regardless of cold war affiliations Chinese Stasi got He arrested right after his conference were he presented flawless germ therapy results!
Current western scientific community reacts to this as people from medieval times when they were told that Sun is not moving around Earth, but it's the opposite. Shame on ethical parasites.
its a haram leap
@@sbfzsbfzshutup not everyone believes in god if god didn’t want this he wouldn’t make it available for us to do
Кто от ALI? Ставь лайк, посмотрим сколько нас!
Клоунада ради лайков?
@@קירילמ Причем тут клоунада? Просто будет инфа сколько пришло его аудитории
Неожиданно
яатутопия
@@surigarro я с обеих
I’m surprised, given what happened to Dr. He that (a) the video is still up; and (b) despite that, there haven’t been more views. Im not saying he was okay to proceed with the gene editing but this maybe the single biggest event in the 21st century so far!
agree
The reason why this topic isn't more talked about is probably because there is an actual lack of evidence of the experiment actually working and creating such a breakthrough, as claimed by the researchers. The research team was anonymous, the experimental process (reportedly) wasn't documented properly, and no external research committee has reviewed and verified the research process and its results.
@@anonymousstacker2044 because if he would of announced his research before hand, he would be told not to do it already beforehand.
Publish the bam files. You can't make the claim 'safe' without 3rd party validation.
Maybe it could have consequences, we'll just have to see what happens!
@@lepmuhangpa well, the doctor leading the research got arrested.
@@volkanaksoy6313 Oh shit
@@volkanaksoy6313 Yeah like history will remember that or that he was the first human to venture into where no human dare venture. Bdw I think he'll be back home by this Christmas & it's upon history to judge on what he did.
Dr. He claimed “before returning Lulu and Nana to Grace’s womb, we checked how the gene surgery went by whole genome sequencing. The results indicated the surgery worked safely, as intended. Grace’s pregnancy was normal, which we monitored closely by ultrasounds and blood tests. After birth, we again deep sequenced Lulu and Nana’s whole genomes. This verified the gene surgery worked safely: no gene was changed except the one to prevent HIV infection.”
As far as I know (sorry, I am not a specialist in this field so I might have misunderstood) the whole genome sequencing to find one nucleotide change requires substantial numbers of cells to normalize the mis-reading of the sequence. How can he get such substantial number of embryonic cells before returning the embryo into mother’s body?
And what was the "reference" genome to check if there are potential changes of the sequence?
The cell multiplied before it was put back into the womb, as embryos often do.
@@xavierrodriguez2463 Then do you think Dr. He got substantial number (say, it should not be less than 10 thousands) of embryonic cells for the whole genome sequence? During the period of incubation, do you think he maintained the embryo to put into the womb? Honestly, I think it is very unlikely. Anyway, now the authority of China can take substantial cells to test for the whole genome sequence. Does someone knows the results?
@@frog-wi3ys Yes. Disaster. He and two colleagues were sent to prison over this.
@@Zizzyyzz at least he tried
@@kaylithdalix...to be a mad scientist. This experiment made no sense; much like Fraudchi's.
Gene editing is one way to cure disease, but not at this stage. CRISPR-CAS9 is still premature with high risk, this is illegal in China and is a huge ethical issue in science world
Nidhogg I think the social impact will be more concerning. Rich people would pay big money to ensure their offsprings have a competitive edge, while average people remain “inferior”. This will create a bigger problem than income inequality, as people assume their future is hopeless and their children will be enslaved by a superior “species”. We still don’t know the long term effect, maybe With enough modified gene in the pool human will lost the ability to reproduce, and there’s no way you can stop it since people are paying so much for something that can be done easily at a local underground lab.
Nidhogg When you talk about humanity. Think again what is humanity. When the gene editing technology still has high risk and unpredictable outcomes, you can not use on human embryos to born a human. More serious issue is that if you editing the genes (one or amount of) you can not even define the baby is still homo sapiens or not, how can you speak humanity any more? This is ethics issue. Gene editing is not a normal technology as you mentioned plastic or rocket thing. Think Again，why this is not legal in US or China, if it’s better for your so called humanities.
Nidhogg Apparently, you’re still unclear about this technology and its risk. Gene editing is one way to cure disease for sure but not at this stage. This experiment is no different from what nazi did in German or China during WWII. Think this in a different way, if you want to have a baby, do you agree with perform this unpredictable surgery on him or her? Do you want to add the risk for cancer or other diseases for your baby? I believe you don’t want to do that anymore. See this called humanities, regardless you are a scientist or a religion one, you will make this decision as a human, nothing about evolution.
@@yudax5057 You are talking like the rich people don't already have more range of experimental treatments available than the common person. This is nothing new. Somewhere this kind of experiment has already been done behind closed doors.
@Ruijun Wu Yes, I think He Jiankui is biomedically and biogenetically naive; and bioethically irresponsible! 😲👎
I still don't know what's wrong with what he did and why he was sentenced to 3 years in jail
He failed to achieve his goal, neither of the babies is immune to HIV and both of them have a version of the CCR5 gene that has never before been seen that may compromise their ability to fight infection. He broke various Chinese laws (including gathering informed consent from the parents, you see he didn't inform them of the danger, and illegally practicing medicine) all to do something we already can do, prevent the passage of HIV to offspring
J Barr Yet, as far as we know, everything is fine since nobody will release his work and/or follow-up and are instead fining and throwing him in jail. People and scientists are claiming it didn’t work, but nobody has presented any evidence whatsoever.
@@maxmilian3229 it doesn't matter if it worked or not. Genetic manipulation has proven to be completely unreliable and caused exponentially more problems than the 1 or 2 they have resolved
Sofia & Hamza he failed. And future generation are in danger . This girls one days will have kids and create a generation full of problems or who know what else they will show .
J. Trenche how do you know everything is fine ? We will only know when this twins appear and check how they are doing ! No one know what is their genetic material .
This actually could be fake, just to raise awareness for the controversy around human genome editing. There are some red flags: 1, There is no paper or preprint 2, Hospital doesn't know about the existence of the babies and 3, I fail to understand why you would knockout a receptor to which HIV binds if the dad is the one with the HIV. Isn't the HIV removed from the sperm when you do the IVF treatment? 4, Whole genome sequencing before and after editing is a very good idea, however it is very very hard to make 100% sure CRISPR did not aspecifically target something. Variant calling and other bam analyses would detect changes in the DNA if the depth is good enough, however if for some reason the CRISPR-cas9 creates or inserts DNA that does not align to the human genome, then it will go undetected with those analyses. You could write some scripts to check changes in the unmapped or align against other genomes like virusses and transposons that are not known transposable elements, but I doubt that they did that.
I rather hope this is faked news!!!! as a biologist I can't even be calm to bla all this arguments like you! He did years of search in a good lab in the US he knew all of these!!! He ONLY wanted to do experiments with NO ethics and moral!! this is evil!!! so ashamed as a Chinese!!!WTF....
Yeah, he is really experienced and he knows what he is talking about. But it still keeps the possibility open that it might just be a publicity stunt. He thought really good about it, but somethings just doesn't make sense. By the way, that I think it's fake, doesn't mean that it is not possible. On the contrary, it is very much possible. @@xuanwang1870
The homosexualisation of the young is an important element in the globalist plan to reduce fertility. This innovation will reduce the costs of future generations migrating their sexuality to pleasure-oriented, non-reproductive outlets.
@@GM4ThePeople If I understand your point, you think that they want to engineer ppl to be gay? Idk if ppl want that, but too me that sounds really hard. They think homosexuality has more to do with epigenetics than with genetics, which makes it a lot harder to modify. But still, changing the whole mechanism of something is really hard. For example, what they claimed to have done here, is disabling one gene, which is easy. But when you want to change something like the way an eye functions or the when someone gets angry, there are so many processes involved. You would first need to map tens of genes involved in the cascade and then know how they work and know how you can change them for the better. It is soo many information and right now we do not even know what most genes exactly do, let alone in which cascade they belong and how they exactly function. Now because homosexuality is even more complicated than that, I do not think that we will live to see that ppl can engineer sexuality.
@@DDieDDes No, you did not understand my point.
Where are LuLu and NaNa now?
That's what i would like to know!
Dead
@@bampoeky3963 really???
@@lifelif2813 Nobody knows.
In Professor Xavier's school.
“Your scientists were so preoccupied with whether or not they could, they never stopped to think if they should.”
Trust me if you master this skills they'll come calling for help.
No, enhancing IQ should not be banned. Why would we want people to be stupid?
We already have the resources to make every person smart. It's just that capitalist forces keep people uneducated
@handsfortoothpicks This is the truth unfortunately. No true politician wants people who can't be controlled.
Both good points imo
Because we have no idea how a person with a conditional 1000 iq will feel, will we be able to detect a new mental illness in them, if there is one? And in general, will he or she be a human being in the usual sense of the word?
And there are many more factors that, at the very least, should make us take gene editing more seriously.
This type of treatment opens a chance for normal life to many childrens and kids! Keep it like that Hi Jiankui! Massive step forward for a human!
like covid china will alwys create catastrophie to world
While I understand people who are scared of "designed babies" my main objection to their objections is logical. Few people today still object Transplantology despite obvious countless controversies, procedures that are by definition defying integrity of human beings often go even worse for patients not to mention fueling criminal activity and human trafficking!
Personally I found therefore Germline CRISPR if carefully planed on well understood genes Far LESS controversial! Than already existing other medical technologies.
And it's doubtlessly better to eliminate the cause of illnesses and sufferings than to ineptly treat their symptoms.
He Jiankui is a real hero of Humanity
The Gagarin of XXI Century!
Pity that while Gagarin was worshipped by people throughout the world regardless of cold war affiliations Chinese Stasi got He arrested right after his conference were he presented flawless germ therapy results!
@@kusumpal1558 Covid is one big speculation
I was feeling bad as a Chinese student in BME and I am feeling desperate after seeing these comments in both Chinese and English.
Sounds dangerous, where are the girls.
@@tentimesful Shenzhen, China
@伟峰 陈 ???怎么
you are not the only one
@冯时熙 They will be found by the Chinese Social Credit system.
These experiments are highly controversial and we don't know the final results. As I know he is in prison at the present time in China due that he violated China's regulations. I think he tried to help science but did not realize that this technology may be used for different uses.
The funny thing is, that the guy KNEW about the papers on supermemory mice with the deleted CCR5 gene. The edit was made not only to make the children immune to HIV. It was partially done to make some sort of supermemory superhumans. xd
Wrong!
Genesis 3:5
The Biggest mistake that He and his team made was that he went very public about his experiments.
Given the ease of using CRISPR-cas9 technology, it's clear that there are many experiments already under way that we don't know about.
有个评论说得好，在技术上没有任何突破，被突破的只有科研人员的底线。
There's technically no breakthrough, only the bottom line broken.
@@user-Chinano12345要谈论这个问题的话，这个实验一旦拉开了活体实验的序幕，谁才是行动力最强的阶层？不是那些受困于先天不平等，各方面资源都紧张的阶层，而是有权有势的财阀、政客，利用自己手上的资源来进行资助、为所有的违规操作大开方便之门却对外秘而不宣；而他们也会成为最先受益的人，随心所欲地打造他们的完美后代。我看不到你说的公平世界如何发生，我对可能已经悄然进行的social polarization感到无比担忧。凡事没有最好只有更好，技术可以治疗疾病、可以预防疾病、可以改善容貌，甚至增强各项身体素质，那具体点来说呢？肤色可以修改吗？智力可以无尽开发吗？谁是决定表型优劣的权威？谁又能保证所有人拥有公平的“修改权”？到那个时候想起来遵守规范制定法律，不怕晚了？
@@user-Chinano12345 我从来没有反对过gene editing, 甚至我实验室还在做cas9 delivery相关研究，可能并不触及gene editing本身，但也轮不到你一个把基因编辑等同于测序，从而觉得编辑后代就几百美金的人来指责我门外汉。制毒跟制药的技术基础还一模一样呢，是一回事吗？是的，测序不贵，全测序都商品化了你看学界有联名声讨吗？编辑一个后代可不是做几个测序就完了，你尊敬的贺老师做了近60页的ppt还没把这整个实验讲明白呢，你知道他花了多少钱，他又知道你已经替他制订了薄利多销的市场战略了吗？我也不是经济学专业人士，就是顺便修了个二学位罢了。我们来讲讲市场经济下现实的不公平，很多药物，比如抗癌药的价格就让很多家庭难以负担，而药的价格是由实际的生产成本决定的吗？不是，我们还要回收前面十几年的研发成本，而法律也必须予以支持，专利制度正是从市场角度保护创新力。所以无论是因为这项技术的灰色发展无法面向大众，又或者单纯从市场经济考虑，它必将在相当一段时期里受到某种程度的垄断，这期间造成的社会效益会有人为之买单吗？另外，我的观点也并非科幻小说里来，我甚至没有阅读过相关题材的小说。有关基因疗法的伦理问题有相当多的研究文献，内行人请多少看一眼。
@@user-Chinano12345 你想象中未来要做一个转基因后代就跟现在卖卖美瞳跟假发差不多，那天可能会来，但我们的担忧更多是着眼于眼下的。所有反对这个实验的科学家，不是在反对基因编辑本身，这一点你要认清。所有的争议在于此刻能不能、该不该进行活体实验。技术本身存在太多风险，我看过整个报告，实验设计上勉强能说尽可能降低了两个孩子身上脱靶的问题，但这不等同于这两个孩子及她们的后代(如果有的话)没有承担其它的风险。这个技术真正成熟还有很多要做的，而我们不觉得争个一朝一夕而让普通人去承担这些风险是科学进步的需要。你说我不懂经济不懂市场，我可能学得不精，但是经济学在我眼里是理解人性的学科，你说伦理是垃圾，因为人性本身就很肮脏，你说限制应用于显性的外部缺陷，这不就是一种约束？要么基于法律，要么基于道德，绝不可能基于市场经济。经济学的基础就是需求与供给，只要有人不再满足于平均的各项指征，就会产生需求，就是一种商机，除非你哪天把人类逐利的本能编辑一下，否则哪怕是黑市交易，都会有人去做，毕竟成本不高啊？
@@user-Chinano12345 研发的成本不只是成功的成本，还有失败的成本，一个成功的药物背后是无数次的淘汰。而进入活体实验，我们需要承担的不只是时间和金钱的成本，中间出现的人为导致缺陷的个体甚至群体，不需要有人为之负责么？还是也可以直接“淘汰”？跟你讲到这里我真的茅塞顿开，为什么做测序出身的贺老师胆子这么大。大概伦理在你们眼里真的什么都不是。
@@user-Chinano12345 到现在还觉得这是宗教伦理问题，举国皆醉你俩独醒真的蛮孤独的。建议你去Nature看看专业的评论跟投票结果，看看昨天HK的峰会上有多少老外给他鼓掌叫好。他在美国的PhD导师现在也被调查了，你觉得是宗教迫害吗？
This guy got arrested for doing not permited lab-experiments and "unethical" changes
It's bullshit. He should be given a medal
@@cassuso4902 he should be given a medal though
Good too bad there's a thousand more brilliantly $tupid people like him... Wuhan *ahem*.
Humanity First!
its stupid and incredible at the same time...
If you have the ability to stop babies from being born with a disease and don’t do it.. you’re a scumbag. I’m glad he didn’t care what people thought.
I don't understand what he did wrong, aside from practicing illegally. He made GMO children? Should be fine for people who approve of GMOs. He modified embryos? Pro-choice people dismiss potential for the future of that embryo in favor of the parent's choice. Therefore he did not "harm" the children, just as how you cannot "harm" the fetus by killing it. I don't get why people are being so hypocritical about this and saying it's wrong.
Here's why you shouldn't skip your ethics class at college:
What a wonderful achievement from this humble, humanitarian. Gene editing surgery that prevents HIV is not 'enhancement'. The decision to commit to this surgery was an ethical choice. The surgery allows an 'at risk' parent to enjoy guilt-free fatherhood, knowing he will not pass this debilitating disease to his children. "The surgery reproduces a natural genetic variation shared by more than 100 million people of primarily European origin that confers strong resistance to initial HIV-1 infection and disease progression." So, NOT 'enhancement', simply a brave step forward using surgical skills to edit out disease. He Jiankui has gifted this happy couple with two healthy children. Congratulations, He Jiankui, for your courage in making this possible.
Agreed 👍🏻
You have no idea what is about to come.
@@colenewaltersmusicandother9330 Like so many other wonderful benefits to mankind that have come from modern medicine, children will no longer have to suffer from a (now preventable) range of disabilities and disease. With the potential for making children's lives free from pain and suffering, this is a truly amazing medical breakthough.
@Karen Z Nonsense!
Onde esta lulu e nana hoje?
Anybody else notice the irony in "He" being the pronoun used when refering to God?
Thanks for your service!
He served prison over this "service".
@@Zizzyyzz legality doesn’t always equal morality
Assuming this isn’t a stunt and he actually created designer babies, this is an amazing advancement in technology.
@@waspoppin4784 So was Covid-19.
@@Zizzyyzz what are you talking about?
@@waspoppin4784 Lol what? What he did WAS unethical in so many ways. First, he obtained false consent from the parents by deceiving them (told them it was some vaccine program). Also, he effectively did a procedure on humans that's barely been tried with animals; in medicine, you never try out a therapy on humans until you understand the safety, efficacy, and mechanism/rationale of the individual steps of the procedure. Also, even if gene editing was a common thing, there are far less risky procedures that would be tried before turning to editing of the embryo; for example, editing bone marrow stem cells in HIV infected patients so that you're not messing around with all the cells of a human body. Gene therapy holds enormous promise, but it has to be developed more responsibly and cautiously than this.
"A Chinese court has sentenced He Jiankui, the biophysicist who announced that he had created the world’s first gene-edited babies, to three years in prison for *“illegal medical practice”,* and handed down shorter sentences to two colleagues who assisted him. The punishments put to rest speculation over whether the Chinese government would bring criminal charges for an act that shocked the world, and are likely to deter others from similar behaviour, say Chinese scientists."
Natural and not too scary death to the actually pretty normal governors!
Let the Emperor's fate be slightly uncomfortable!
We, small and humble part of the people of Empire, are sorry but have to make some protesting noise!
This is such an awesome kernel patch.
that crashes whenever your run your favorite app
So instead of letting the people who are more genetically disposed to sleeping around, not being careful thus getting HIV and naturally eliminating themselves from the gene pool you would rather encourage their behavior and even give them increased resistance to these diseases? Do you even think about the long term consequences that this will leave on the society?
@@rohacha9iin40 I am not a Christian.
Humanity will never be the same once CRISPR becomes main stream
Great news for now. I hope it never turn into the beginning of the end.
2020 Welcome to the ENDING!
If true, this is the beginning of something bigger and even worse
I'm against the fact that he was jailed in China. Parents had already given their consent so it's wrong what was done to this doctor. I hope it was a deletion mutation. So, no other genes were alerted. Well, those girls were never followed up for their progress, so it's unknown what happened to their health.
Dude is crazy. One of the biggest problems with CRISPR is creating perfect guide RNA so that the CRISPR system doesnt run around trying to modify all DNA sequences that are slightly similar. Off targets are the biggest problem and could cause HUGE issues. This shit doesnt seem right to me
Perhaps the rush to be first is more short-sighted arrogance than anything else. Plenty of people know how to do this, including the people that invented it at Harvard, Berkley, and a handful of other labs including one in Shanghai. The issue wasn't that it couldn't be done, but should it be done. It is a very different thing playing with a child who has no say in how they will be born, and working with an adult that can give consent. Plus there is no consideration of the additional generations this experiment affects. There is so much we don't know about our DNA, and the collateral damage this technique may cause to other genes that are dormant, but we may need in human kind's future evolution.
So even in this case, where these children were born without HIV, you wouldn't even consider any benefits from this?
So with the argument about "consent", should we stop circumcising babies? What about implementing religion or giving them a name they didn't choose? So, let's ignore that issue. We can never predict the effects of our actions. We didn't foresee the climate impact of industrialization, but you wouldn't be typing on a tiny computer that fits in your pocket if we didn't pursue it. So let's ignore "considering the future effects" cause we can't predict that. And technology naturally affects our species' evolution. Discovering fire and using it to cook your food, is the same technological advancement as using CRISPR. So let's ignore that argument too.
@@kevinsundelin8639 It's tough to say. There may be obvious short-term benefits like this experiment here. However, among scientists in the field we are concerned about long-term effects of gene-editing. We aren't sure if there are any unintended consequences of editing certain genes in or out or whether this technology is as precise as we wish it to be. Combining that with how much we don't understand about the whole system we're manipulating and it could be dangerous in the long run.
@@MrTRANnysaurus exactly, this video brings up the same things you are speaking of.
I can't believe all the positive comments in here about this. ruclips.net/video/_YpACFaK0O4/видео.html
Thanks for your reply @@boukmann1791! I looked in multiple articles online and searched in published papers and apparently circumcision prevents UTI on babies. Circumcision is a good thing. The only bad thing is, kids don't have a say on the matter. It's like feeding your kids/babies vegetables. You know the benefits of it, but they dont. What do you say to that?
And also, it's hard to predict the effects of our action. Did you know we don't know how analgesics work? Yet Tylenol is over the counter. Look it up! The effects of 5g is still being debated, and it's coming gonna be on your next mobile devices. We can halt technological progress until we're 100% sure it's only gonna be for good, but we will never move forward.
Keep up the great work!
if the father signed a consent form and the baby is ok whats wrong? he didn't do anything wrong but try to help somebody in need
For those self righteous and out right religious people crying out at this man for trying to play god , this man is a hero . His research and experiments paved the way for a better future in mankind .
This will destroy humanity
The project has not been reported to the Chinese medical management department. The incident has attracted the attention of the government and relevant scholars have been investigated.
But is this true? As in the description they say results are not yet published. So, I'm confused if this is legit or a hoax. What does your media say about it? Can you tell me about it :)
@@kiranrenduchintala4178 Indeed. Chinese state-owned media has confirmed the two babies were born.
@@kiranrenduchintala4178China’s national media “People’s Daily” issued an article condemning this behavior, which is very regrettable. This may be true. The scientists involved in the trial have been investigated because the experiment was illegal and has not been reviewed by the medical research department. This scientist is simply a madman.
@@jasonkiu3029 I honestly don't know what to think of it. Something good came out of it but it still need to be studied. It is indeed unfortunate and illegal human experiment for sure. There is also a recent surge of biohackers doing the same since the CRISPR kit is relatively cheap.
@@kiranrenduchintala4178 What "good" are you referring to? Is it the fact that supposedly the girls will be resistant to HIV? What a ridiculous reason to do this - there is NO reason good enough - don't be naive.
This man is doing great work, but what's wrong with couple wanting their children to have a higher IQ or w/e?
The ethical problem which arises with wanting to raise your Childs IQ via Gen editing is that you deem someone unworthy of living or at the least less valuable, if they do not fulfill your/societies expectations of intelligence. Why should it matter, if your child is of average or high intelligence. It should and cannot determine a persons worth. Having an high IQ does not automatically promise success, happiness, health or any other factor you would believe would come with above average cognitive abilities
i am fully support your actions about this, i may cause controversies at first, but over time people will understand that the life is changing so does the diseases and this medical treatment will come in front to prevent any of this diseases. Keep up the good work sir!
Lol by changing DNA we will predispose ourselves to diseases we have no idea of, and that we were protected from until then.
@@skaffen i had not thought of that. We usually fixate on one thing and his was to prevent the children from contracting HIV. Which was a very very low percentage since the mother hasn't contacted it. I would like to see studies on prevention of cancer or muscular dystrophy things that could be performed on concenting adults.
he went to jail. breaking news.
All you have to do is look at genetically modified food crops to understand the inevitable outcome of manipulation. Humans have prospered for over 200,000yrs, often while the demise of a few benefitted the many, yet selfishness and acedimic arrogance is full steam ahead to derail evolution.
He was sentenced to three years in prison. His two colleagues who assisted him with this were given lighter terms.
If this treatment uses for disable person's it will a god gift for them . Because they have to face unlimited hurdles in their routine life.This treatment have to use and also approved for only those persons who really needs it.Stopping the miss used of it, its a realy one hope for disable people's , who r many amount in world.
我觉得法律上的触犯是次要的，法律本来就是一个规范，是以前制定的，某种程度上落后的。但是关键在于，这个实验到底是在验证CRISP技术应用于人的胚胎干细胞，还是真的为了对抗艾滋病做贡献，因为此次基因编辑婴儿实验是将CCR5修改为CCR5Δ32，CCR5Δ32确实是对HIV-1有较强的抗性，但HIV有两种类型，即HIV-1和HIV-2，而且HIV-1又存在多种亚型和亚型变种。也就是说此，此次经过基因编辑的婴儿虽然承受着一系列不确定的风险，但在理论上并不能完全免疫HIV。
Dear He Jiankui, Happy Birthday!
I salute you because you have changed the history of our world. Your name will be remembered for hundreds and thousands of years to come, while the names of kings and presidents will be forgotten in History.
And that is for a simple reason. Before 2018 A.D. the Natural history of Life was dictated by accidental mutations in live organisms. If one out of a millions mutations was successful, the organism had progressed. A better, more survivable form of life was passing on their new genes onward to the new generations. That is, obviously, called Evolution, and was discovered by Charles Darvin.
But with you, He Jiankui, everything has changed. The occurred Philosophical Jump is that a form of life (Human) had changed its genes not by Accidental Mutation but by a Conscious Mutation!
That where the Quantity of billions of years of Evolution made a Jump into a new Quality. That is huge. That is named Revolution.
We, your contemporaries, cannot see your greatness today, as it was many times in history. Many criticize you, condemn, and even sentenced you for what it will be a common practice very soon, maybe during our lifetime.
Blessed to be your contemporary.
You have my utmost Respect.
Кто от канала ALI?
Finally someone brave enough to do it
I hope you're being ironic. That dude's a narcissistic scam scientist craving for worldwide attention.
Let's be honest people: early or late some arrogant and self-centered scientist would do something like this. Let's hope this don't backfire us in the future.
I think generally, the science community is too afraid to use it cause it's too cheap and too easy. Which I don't understand. They worked so hard for thousands of years trying to figure out how to be God and when they figured it out, they freak out.
Dear He Jiankui and team, thank you so much for this first bold step. I would like to reassure you than you have done a truly great thing, beyond the results but by having the courage and bravery to proceed with giving Lulu and Nana a chance at a healthy and normal life. Ofcourse, you will be criticized but please do remember that all great pioneers and innovators face skecptisim, being called crazy and sometimes worse at some point in their lives. Thank you and I wish you, your family and team a beautiful life ahead.
x2
I'm aghast at the level of ignorance and lack of reflectiveness you are displaying by posting this comment.
I can remember back to around the mid 90's when they first cloned the Sheep: "Dolly" Immediately after they were successful, two Italian doctors sought permission to clone Human Beings. They were refused. But who's to say that they didn't sneak off some place and do it anyway. I mean, when the W.H.O ordered all doctors and pathologist not to perform Post Mortems / Autopsies on C.O.V.I.D-19 deaths. Italian doctors and German Doctors didn't listen to the orders, and then they came out and spoke openly of their findings.
what did they find?
@@blackboxbs8642 They found that things just didn't add up. And then they were warned not to talk about anything else that they may have found. They said C.O.V.I.D_19
Wasn't nearly as dangerous as we were being told. They speculated that it had to be man made.
@@B1N4RYGH0ST so what about the vaccine? should one take it? what is their end goal? kill people who took vaccines or kill those who didn't?
This doctor was sentenced to 3 years in prison. This was unethical and illegal. We've had lots of that going on all over the world these past few years.
@@Zizzyyzz why unethical tho? The doctor had good intentions.
In this very specific case (of "Lulu and Nana"), there is a reliable method to ensure whether their DNA was harmed inadvertently in any areas other than that intended (the CCR5 "HIV-infection" gene). It is not clear whether Dr. He followed this method or not - he was unclear in his presentation.
It could be proven safe in this specific case IF he did ALL of the following:
1) he sequenced the zygote's ("Lulu / Nana"'s) entire DNA before introducing the gene-splicing modification (the "Original" DNA),
2) After introducing the gene-splicing modification, he sequenced the entire DNA (the "Modified" DNA).
3) Do a full comparative analysis of the differences between the "Original" DNA and the "Modified" DNA -- effectively subtract/compare the two full sequences of DNA looking for any/all variations.
4) Ensure that the ONLY variations in the "Modified" DNA are to the CCR5 region.
If his lab was able to demonstrate step 4, with high statistical significance and precision, then we can be sure the girls will be safe from unintended genetic harm. We then will have to wait and see if they will be immune to HIV-1 infection. (though, they may not be immune to other forms of HIV).
This explanation provided by Dr. He's lab was very important to understanding what was done and why. However, this is only a verbal statement. We need his statements to be verified through independent means:
a) is it true that the genetic father of "Lulu and Nana" is HIV-positive
b) does the genetic father have the HIV-1 variant?
c) Can other labs also sequence "Lulu and Nana"'s DNA to confirm the sequencing done by Dr. He's lab was correctly done and is reproducible/confirmed
Though this is a controversial area, scientists can implement proper stringent controls to ensure such work, on individual cases, are done with sufficient controls to ensure safety (societal and individual).
Of course not. They already have problems because of unintended consequences. BBC did an article about it.
To be really sure about this method, it needs statistics of at least a hundred of children. But society sucks, and doing so illegally would be impossible, since no one would see any profit.
Where is this guy now?
Jail unfortunately
This is absolutely wrong and unethical.
Only the BOLD will be remembered in History.
Only the bold😂😂 .. lets just hope he will release the methodology of this study . I am curious .
Only the idiots
And may those who died in his experiments rest in peace even if we can't remember any of them.
yes, but not always for the right reasons.
@Robert Owen maybe we can live on with this technique
time is precious...play in 2x
In 2x it sounds like he is speaking Chinese
Don’t play god. Humans don’t deserve it.
Anyone know what happened to Lulu and Nana?
I want to know how they're doing now too
They died
@@zensation22 Source?
@@zensation22 yeah source??
still don't understand why he picked HIV, its very bad and all but we do have treatments that allows affected individual to live an almost okish life..... i am just shocked by his courage.... even though at the end of the day, he doesn't seem to provide a solid solution to HIV.... and now because he modified the germline cell, if lulu and nana were to have kids, their kids could inherit that artificial mutation....... kinda explains why the scientific community would have bad blood towards this
ruclips.net/video/h0n5WjcUKfE/видео.html
Steve says the father of Lulu and Nana had HIV himself, and he wanted his twins to be HIV resistant.
If this is true, I’m ganna be excited asf. In ancient times, a person made this special glass that could not be easily broken and could be reshaped easily. He presented it to a king but was put to death not long after. Humanity lost many great innovations to greed and selfishness. Don’t let it happen again
This is not new actually scientists trying to do this more than 10 years ago but the strict regulations require them to destroy the embryo after 14 days and nobody was allowed to use human cells to do experiments like this. But they actually started doin g animals a while ago
As someone who is HIV+ 25 years and counting, my hat is off to you... Heal the world one gene edit at a time! Godspeed ❤
I understand your sentiment but it has been discovered that He did not work correctly with the Crispr gene editing. Not only are Lulu and Nana not protected against HIV but *are* careless science experiments with unknown outcomes for themselves and future generations they may birth.
@@mizera_mykle fetal cell farming think bigger
Unfortunately it didn't work and might even caused them to be more susceptible to other illness. It was super complicated but if you read the newer info about them, it's scary and sad.
@@gratefulfortoday8310 Care to share links to new info?
@@gratefulfortoday8310 What reputable source do you have for this information?
《Gattaca》is becoming reality now, but in the movie, we still belive in miracle
Where is it published?
These girls will be the most talked about, stalked, and tested girls in human history. All eyes will be on them yet they are innocent.
doing a biology project bout it
Which class
Are the twins now immune to HIV? If so, can they pass those genes onto their children? If so, doesn't that mean eventually humanity will be immune to HIV if their genes manage to spread into future generations? If they each had 2 children and the average birth rate of their subsequent offspring was 2, then we would have over 2 billion humans born with HIV immunity after 30 generations.
Mathematically speaking, yes. That means humanity are all genetically modified organisms (GMO) in the very near future 🤔
Yes, this was so-called germline editing, so in principle the trait of immunity to HIV as we know it will be passed on to any offspring. Other than that, remember that the human species first has to manage to survive before you can get to your 30 generations. It's also possible that the HIV virus no longer exists by then.
Your decisions to conduct this experiment and release no data to peer-review are unethical and you've done irreparable damage to the science of gene-editing. Thanks, He Lab! Suchy sweethearts you are !
Peer review is a such a bs process holding society back. Its needs to die.
I don't think they are in anyway concerned with ethics or ethical behavior. They did more damage than good to the science. That is very true.
Эх.. ведь это эволюция дошла до самомодорнизации
So whats next?
Please, Tell me, where is the Brazilian people talking about this issue??????
Nem sinal disso no Brasil, pessoal preocupado com futebol e natal agora
É triste, cara... ver que não temos sequer letramento científico pra compreender o que tem sido feito com nossa própria espécie.
Can you gene edit my kid to become a Giga Chad?
But they failed they are actualy worst off
He put this video on youtube to get more potential clients like you!
To me, this man is a hero. If you want to achieve big scientific breakthroughs, you need to be bold. Sanctimonious bioethicists love to express "outrage and shock" at this type of work, but what have they done? They love to lecture, debate, and discuss ethical issues endlessly while admonishing people like He Jiankui for actually daring to get things done. Think about a world with less disease, longer lifespans, and smarter, happier people. If that strikes you as dystopian, then you're very small-minded. What's the matter, anyway? Are you just jealous that when this treatment becomes available to babies of the future, you won't be one of the recipients? Boohoo. Don't hold back human progress!
The problems being: one, there is no breakthrough and two, it’s not ethical. The technique has been used for years and close to being patented, just look it up. Nothing new was gained by applying it to human. What he did was imposing unknown and unnecessary risks on disadvantaged couples and their children.
True. The fact that so many people are antiprogress and anti science is ridiculous. I bet none of them have seen a family member suffer from an incurable disease which could be easily prevented with this technology.
coco oh you sweet summer child. Read a little and you will find that a lot of the “anti-progress” people are scientists themselves who understand the risks and condemn the inhumane treatment done in the name of progress.
Every time someone brings up ethics it seems they are speaking about anything but ethics.
Ignoring the whining from the bio-"ethicists", this was still somewhat premature.
There in the hands of people that will stop at nothing to achieve a super human that can take over the world when they see no need for week people. The past history of splitting genes is evolving. Just saying. That’s what I see. Follow the money.
Thank you Professor for daring to take this first,important step towards better future.
We must research and be wise to always consider science. I'm a biomedical student and I think if we can use science for the good, we are right. I respect all the religious and ethic's views, but if people think science is "playing God", we shoudn't ever have discovered peniciline. Think about it.
What are you doing research for? For the well-being of human beings or for your own celebrity?
It's a great news about gene tharaphy!!!!
One more question when are you doing other desiess like muscular dystrophy I'm also a muscular dystrophy patent.....
Gene therapy can also quickly recover nerve damage
Thanks for taking this step! We are exited to see your progress!
ironic
When I first read of Crispr my initial comment was, "OMG, the Chinese are going to start playing God and Frankenstein".
It was a moment I wish I'd been wrong.
Fast forward articles by those in the know we learn that He *did not* perform the Crispr editing correctly! Not only are Lulu and Nana not protected from contracting HIV but they are scientific freak shows with no known or even speculated outcomes on their health and future generations.
This is the first time I'm angered by the label, Made In China...
"First time"?
Why was he arrested again?
Please dont leave any comment and do not open any discussion about this video.
If you really want to do something report it.
you can find the "report button" on the below part of the video on the right.
next to "share" and "save"
Very brave of him to do this, if his intentions were genuine I support it.
I wouldn't mind having super humans around, if we can all somehow accept that our next generation baby's will be a lot better in everything.
The Boys intensifies
I wouldn't say "genuine intentions" with shtty ways, how many ppl lied to finish his insecure experiment? The parents, the gin doctors...
Lulu has genetic mosaicism so she still produces some of the CCR5 protein.
Jiankui progressed unsupported and I’m vanity for a disease that could be prevented through sperm screening, which he already did.
we already have autustics, been around for many years, superior in many ways: deeper concentration skills, sharper logical thinking, honesty way more difficult to corrupt, etc.(while inferior in social scenarios and processing senses stimulation) but ....are bullied.
except that they may not have the immunity to HIV at all and also their CCR5 versions are possibly the only two versions in the world as they are made up but they are still able to be passed down by reproducing. Do you have any clue what this could mean? This is the greatest example to why we should be twice as cautious with this genetic engineering.
You have my support from the United States. Keep up the good work.
@CogentPhilosopher So what? it has to be done, there is ALWAYS something in any area that we are ignorant, and he made this for that family not for you, so piss off
grow a race of w40k space marines instead
Maybe it could have consequences, we'll just have to see what happens!
how are the girls doing today?
It's easy to find out. You just have to take a DNA sample from the babies and test whether the gene is changed.
It´s not that easy, because one thing He Jiankuil did´nt mention is that CRISPR did not work as planed and the babies suffered genetic mosaicism for CCR5 (the gene he talks about in the video).
I dont believe he do this for his own interests.
mlices black yes, for his benefits! He is the ceo of many companies!
@@chineseboy1986 No? *They* did it for scientific research and advancement
I am quite indecisive whether this could be the dawn of a utopian (i.e. fatal trait removal, ethical enhancement) or a dystopian (e.g. Auxley's Brave New World's alpha/beta/.../epsilon-castes) society for humankind. Possibly somewhere between the two extremes, but it's both inspiring and frightening.
The CCR5 gene he edited (or rather disabled) is correlated with memory and intelligence. It is absent in the Chinese population, but prevalent in northern Europe.
A world first for Prof He Jiankui. Many world firsts have come and gone. Some have propelled humanity to greatness, others not so. You claim good intentions but we'll let history be the judge. Perhaps some day down the road, this will all be behind us and you'll have the Nobel in your hand. I hope and pray that the Lulu and Nana will be there when that day comes.
你改掉的这些基因除了保证不感染艾滋，能否保证这两个小朋友正常享受到疫苗的保护？如果生病了，她们的身体能不能使用现在人类通用的药物和治疗手段？她们的寿命会不会因此缩短？你们有想过怎么对她们负责吗？改变基因会影响到的其他方面不管是对她们自己的个体还是整个人类你们到底没有考虑过？
这两个婴儿以后的人生吧，她们都没有选择，永远都在被人检查当中，不管是为了她们本身的健康，整个人类的安全，还是验实改造的结果。艾滋病的父亲还有其他人都决定了她们以后的人生，我们现在还在提倡思想自由，连这个基本的自由从一开始就已经被侵犯了。
He's a pioneer.
There's going to be many scary new technologies coming soon. We have to prepare and take control of them as soon as we can, ignoring it won't help us
Can I have a boy running like usain bolt and thinking like einstein?
If you're in the rich/upper class , of course u can.
@@sinem2493 Nah y’all don’t know how this thing works. Multiple genes determine someone’s IQ. Not to mention, we don’t know which genes are responsible for that.
3:52 I think this is really important
so if i want my child to be good looking im a bad parent?
@@godcomplex8251 At some point of genetical modification, it isnt your kid anymore
I support you sir from the bottom of my heart 💜
He went to prison. Two of his colleagues were punished as well. This was illegal and unethical.
Nothing is illegal or unethical, it's science
@@shreeverma8473 And yet it was ruled unethical and illegal. You scare me.
@@Zizzyyzz It were politicians who have no knowledge of science , they ruled it unethical or illegal . there were literally no scientist related to this field to judge , so better not judge a fish by its ability to climb a tree
@@shreeverma8473 I can't understand you. Please use better translation software. Thank you.
He's now released from prison
Siapa yg kesini gara² abis nonton video kokbisa??
If you support this guy, then you clearly did not look at the full extent of the risks and implications of his experiment.
1) The experiment was not approved, first of all.
2) He did not inform the parents of the risks.
3) He created frameshift null mutations because the CCR5 alleles were not created in the twin girls. As a result of this, one of them is mosaic (this means that it was genetically different from the twins, which can cause disease in the future) and the girls may still susceptible to HIV.
4) The scientific basis for the study is weak: it is very rare for fathers to pass HIV down to daughters.
It's difficult to say, but there might be other mutations and genes altered that might impact the girls in the future. Please be aware of the conflict in ethics and safety of this study.
He went to prison over it. So, yeah.
@@Zizzyyzz Yes. My genetics professor ranted about him in class, which is how I found out about what he did. It's just frustrating how people who don't understand genetics and the full extent of the issues he caused keep supporting him.
@@marim.8743 Lotsa sheeple. 🐏🐑
I strongly approve of this as it benefits future generations because they will not need to worry about as many diseases or debilitating illnesses thus improving the human race
this is going to be interesting on the long run
any updates ?
Its not a new matter www.nature.com/news/three-parent-baby-claim-raises-hopes-and-ethical-concerns-1.20698, incase you missed the news.