Ron Research Update, March 29, 2021
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- Опубликовано: 5 сен 2024
- Research update from Ron Davis March 29, 2021
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Summary by Ben Howell (ME/CFS advocate and patient):
-Intro from Ron. Ron's sole focus is ME/CFS.
-Working on treatments/cure.
-Metabolic Trap idea. This is where critical enzyme gets trapped in it's function.
-Difficult to test in human cells, testing in bakers yeast. Have great technology for this.
-Have taken bakers yeast + put in critical gene that gets trapped (function gets trapped) + that is IDO1 gene.
-IDO1 converts tryptophan (in diet) to kynurenine.
- Kynurenine v. important-regulates immune system, can suppress inflammation etc.
- Placing gene into yeast can control it, but it makes the same protein that is made in humans.
- Many human genes will work in yeast and vice versa.
- Yeast doesn't really have this level of pathway so kynurenine can be used to make NAD.
- NAD is chemical compound that is extensively used in metabolism of organisms, human + yeast.
- In humans NAD used in ~400 chemical reactions, really essential.
- Required for production of energy in mitochondria.
- What they have done is make kynurenine in yeast with this enzyme + require it to make NAD.
- Yeast has multiple ways to make NAD so have removed all genes involved in the production of NAD.
- So ONLY way yeast can make NAD is to have this pathway on.
- If they trigger the metabolic trap, will shut down the enzymatic activity of ido1 then it can't kynurenine, and it can't make NAD. If can't make NAD, won't grow.
-One problem is don't want yeast to consume tryptophan by any other pathway.
-Looked into yeast, all genes have been sequenced + understand their function, found several genes that consume tryptophan for other purposes.
-Have removed these genes.
-This new developed yeast is now suitable for a test.
-Grew on low tryptophan, cells grew fine.
-If raise tryptophan concentration, high level of tryptophan can inhibit enzyme.
-This is very strange.
-Here is an enzyme (IDO1) that converts tryptophan to kynurenine. Would guess that if raised tryptophan would simply make more kynurenine.
-Not true-the high tryptophan inhibits the enzyme and can't make kynurenine.
-If it can't make kynurenine can't grow-so if raise concentration of tryptophan gets to point where it stops growing.
-As long as you leave tryptophan in at a high level, can't grow.
-If you then wash out the high level of tryptophan + put in low level of tryptophan, starts growing again.
-OR if leave high level of tryptophan but give yeast kynurenine (required for NAD) starts growing again even in presence of high tryptophan and absence of activity of enzyme.
-Why are they doing all this? One is to test the Metabolic Trap-something you can do in a test tube-does it work in a cell?
-This experiment shows it CAN work in a cell. It's yeast, but can still work in a cell.
- This is a possibility what is happening in humans.
-There is another reason to do this. Now have system where can shut down the enzyme in metabolic trap + the only way cell can grow is to get rid of tryptophan.
-Human cells not quite the same, it's not growth, it's making kynurenine which is critical factor.
-If this true in human cells, only way to make kynurenine would be to get rid of the tryptophan. The only way to get rid of tryptophan is to convert it to kynurenine.
-That's why it's called a trap, you get into it, you can't get out.
-However if they can find compound-that will 'block the block'-the inhibition that tryptophan has over the enzyme/IDO1 this then will reactivate IDO1, IDO1 will consume the tryptophan and cells will produce kynurenine.
-That's the stage are at at the moment with yeast.
-Fairly simple to do with yeast. Put in high tryptophan + can add drug(s) at different concentrations + look for growth.
- Have a robot that can do all of this, can do 96 at a time + have 3 robots, can do this with different concentrations of drugs.
-Can set up + leave to do experiments. Robot can do lots of experiments! Is being set up now.
-Unfortunately it's an old robot, needs some repairs + is in the process of repair.
-Getting help + are going to get fixed. So is just about ready to start doing drug screens.
-Have all FDA-approved drugs in their freezer. Have already screened all those drugs for their effect on yeast + know concentration that has some effect.
- Ron excited about this, has no idea what the probability is but is optimistic. Lots of things to try at lots of different concentrations.
-Also, if it works out + don't find any FDA-approved drugs, will start screening herbal extracts.
-Wants to have something patients can take + a new compound would take updated approval + take years to do. Doesn't want to do that.
-Optimistic can find something. If metabolic trap is real they have something can treat it with.
-Next thing is move to human cells. In process of doing that.
-Ron says thank you.
My daughter has been ill with ME/CFS for 13 years and is getting worse. So yes, time is something we don't have. Thank you.
Very exciting stuff. I’m 66 and have had ME/CFS since March 1980. I really only have 1 doctor who cares, and another who at least stays quiet when I discuss it... the rest ignore me. I’ve endured so much medical gaslighting throughout the years... I would not wish this living death on anyone.
@Get Skilled Or Die Trying I was 25, had just had my 3rd child 9 months earlier, and had two other children, aged 5 & 3.
@Get Skilled Or Die Trying I am with Barbara. 1989 then a long remission but came back with a vengence around 2007. Living dead is a perfect description. Thankful I can get out of bed once again but I still wander around exhausting myself by trying to navigate through the day.
We have to hang in there. Now that there are "long haulers" from co-vid, the pace of research is stepping up. I think if it helps them, it will help us.
Well said
Truly superman. Dr. Davis and Team- you have thousands of people rooting you on in your work, including me. Don't get discouraged. You are some of the most brilliant minds on earth and we know you can do this!
I was lying here writing a goodbye email to myself and then I received this email OMG I hope and pray that we have have a treatment soon thankyou
It is a cruel world we live in where a man who is nearly 80 has to work this hard for a cure for a crippling disease, when CFS and many other diseases could be cured if we as a society just gave up funding one generation of an iphone.
Thank you so much for taking the time to update us. I'm rooting for you all, what you are doing is amazing.
I have had ME for 4 years, it's severe, my life has changed beyond recognition, and i long for a cure or treatment for all us sufferers.
Much love.
Thank you so much Professor Davis (and Ashley for setting all of this up)! As always, it's fascinating to listen to these updates. And it brings so much hope. Thank you.
THANK YOU!!! Thank you for seeing us, keeping this going thru a Pandemic, ALL. OF. IT. 🥰 (& thank you on behalf of those of us too sick right now to say it themselves). Keep going team - keep going! 🙌🏼🙌🏼
Thank you for your endless commitment to helping us. I love how you explain what you're doing and why it's important. I want to share my admiration for you and your family and say once again, thank you. 🙏
Wow! so exciting a possible breakthrough. I know your son suffers from ME/CFS and unfortunately, my daughter is on about the same level as he appears to be. Thank you for the update!
Thank you so much Dr. Davis and team!
Thank you so much for these updates! Every time I hear you talk about continued progress on the metabolic trap theory, it brings tears to my eyes. I got sick in 2018 and I've followed this theory with you the whole way, hoping you wouldn't prove it wrong. Knowing that you haven't, and that the studies are continuing to progress, gives me so much hope!
Same 2018 june. Horrible disease losing my 20s now :(
Thank you. I want to cry every time I watch these video updates. I’ve had me/cfs since i was 14. 20 years of swimming upstream and no support. I’m so thankful for you.
Big Thanks from the UK. I have been ill for 30 years and can’t wait to get some life back as a consequence of the treatment produced by your research.
Thank you I am from UK and have severe ME
Thank you from Spain. I have MECFS
These updates give me hope for a cure for my boyfriend one day! Thank you so much for all you and your team do 💛
So happy to hear about Whitney’s improvement, he’s going in the right direction now. Brought a (happy) tear to my eye. Thank you so much for your dedication to this field of studies. You give us all hope and help to validate the seriousness of our disease.
I genuinely mean this that you're my hero!! We're so blessed to have someone as talented and driven as yourself along with Dr Phair to make such amazing progress. Keep marching on :)
These latest pieces of research being done, this included, are sounding so much more promising than anything has before, like we're actually finding genuinely helpful things out now about this awful condition. I have severe ME and it's been a rough couple of years with it recently. Thank you for everything you have done, for being so dedicated in the search for genuinely useful answers for your son and all of us out here. You are a good man! Good luck with the latest studies. 💚
Thank you Ron Davies. You gave me hope.
Not all hero's wear capes, thank you for all that you do, from New Zealand
Watching from NZ too!
Thank you so much. I have two children who have suffered from ME/CFS & POTS through most of childhood through today, decades later. Truly looking forward to hearing more progress you make-it is the most encouraging news so far in this very long journey. We all know both of the kids could actively pursue their dreams and have a life once we can get the ME/CFS & POTS better controlled. We are so grateful our daughter is being treated at Stanford’s CFS program.
Thank you Ron and Team you give hope to millions 🙏
Thank you from all of us who are in need of help. You are amazing
Hi Dr. Davis… I believe we may be relatives. I suffer from Fibromyalgia SFN Gastroparesis POTS and Chronic Migraines, but I strongly believe I have ME/CFS. I live on the East Cost and have seen so many dictora who do not believe in this syndrome. Thank you for your tireless research to help others all over the world who suffer as your son has suffered. I am related to Davis from all over the east coast, but mainly DE, MD, VA and PA… many who spread out to TX, CA, FL. I swear there has to be a genetic link somewhere for ME/CFS. Wishing you and your dedicated colleagues success in your research. I hope I live to see a treatment or at least that my kids will… thank you.
Thank you so much Ron Davis and team! You have an incredible mind. I had very severe ME and was bed bound for 3 years - there were many times when all that kept me going was the hope you and your work gave me and I can't thank you enough for that
Excellent update. Ron and his team are a real treasure.
How frequent updates can we expect?
Thank you for bringing hope for ME sufferers.
Definitely need more updates with hope as I’m close to giving up
Thank you for all your research and giving patients hope! 💙💜🧡🙏
God bless you, Ron!
We can't thank you enough for your dedication and hard work ~ This sounds like a wonderful break-through. I have faith that you will find a cure or treatment to get us out of our beds and able to enjoy life again. Blessings to you, your wife and Whitney.!.
Thank you so so much for everything you do for us all Dr Ron. x
Please make sure you take care of yourself as well Prof! Thank you so much for your commitment to this
That is so exciting! Thank you very much for your extensive research!
Thank you so much for the update. This is big news, and a big project! I was touched by this update. Again, thank you.
God bless you and your team.
Really clearly explained for non-science people with an ME brain to understand. Thank you for taking the time to do these videos - I'd struggle to be able to understand this by reading. Keep up the great work!
Thank you so much for all of your hard work, and for explaining your research to us. I, for one, am so very grateful.
Sounds exciting! I wish you received more funding
Thank you!
Emilie From france
Thank you for your hard work. You give us hope!
THANK YOU 🙏 RON and TEAM!!!
Thank you so much Dr Davis and your whole team for your extensive work ... I also bought your book and will hopefully learn and understand more... although Biology and Chemistry are not my fortés... but I am interested in being healed from ME!! Thank you again!
What is the book please?
@@GodsChild145 The Puzzle Solver:A Scientist's Desperate Quest to Cure the Illness that Stole His Son is a book by Tracie White with scientist Ronald W. Davis about Davis's efforts to cure his son Whitney Dafoe, who has very severe myalgic encephalomyelitis, also called chronic fatigue syndrome
@@GodsChild145 The Puzzle Maker by Ron Davis & a collaboratrice...
God bless you and your family, you’ll have breakthrough soon! Thank you for all your hard work.
If someone rich is reading this please fund research into CFS. I am deeply afraid right now
Thanks for the update! It helps us to be optimistic.
Very interesting thank you. I showed high tryptophan on an oat test a couple of years ago. For a short while in previous months I had been taking l-tryptophan for sleep and at other times amitriptyline. Over the last 3 years I've become completely bed-bound.
I appreciate your updates. I don't understand all of it, but it's encouraging to know what you're working on. It makes it easier to keep up hope than when we're only told, "We're working on it and we'll let you know in a few years if we come up with anything." Thank you.
Come on yeast, you got this! 🙏🏼
Thank you for helping us. 🙏
Thank you for sharing this progress and all the work you do!
Great update thank you!
Sir, here is a link to description of decompression sickness, and here are some excerpts:
"While DCS can affect anyone moving from high altitudes to low altitudes, such as hikers and those who work in aerospace and aviation flights, it’s most common in scuba divers."
(So, as you can see, this sickness can affect hikers and people flying in planes.)
"Common symptoms DCS may include:
fatigue, weakness, pain in muscles and joints, headache, lightheadedness or dizziness, confusion, vision problems, such as double vision, stomach pain, chest pain or coughing, shock, vertigo.
"More uncommonly, you may also experience:
muscle inflammation, itching, rash, swollen lymph nodes, extreme fatigue."
"For severe cases, there may also be long-term neurological effects."
WHAT IS DECOMPRESSION SICKNESS: "If you move from an area of high pressure to low pressure, nitrogen gas bubbles can form in the blood or tissues. The gas is then released into the body if the outside pressure is relieved too quickly. This can lead to obstructed blood flow and cause other pressure effects."
"Experts classify decompression sickness with symptoms affecting the skin, musculoskeletal, and lymphatic systems as type 1. Type 1 is sometimes called the bends.
"In type 2, a person will experience symptoms affecting the nervous system. Sometimes, type 2 is called the 'chokes'"
"The treatment for more serious cases of DCS involves recompression therapy, which is also known as hyperbaric oxygen therapy."
I pray you will try the hyperbaric oxygen therapy for your son. There is nothing to lose, and it may lead YOU to groundbreaking discoveries to help others with ME/CFS.
Thankyou! 🙏❤️❤️❤️🤗
Thank you so much!
THX Mr. Ron Davis !
Much appreciated!!
This kind of functioning reminds me to what happened to the Lorenzo's Oil. That movie made me understand better the metabolic trap
Prof. Davis,
Please allow me to suggest another hypothesis, one which I'm sure has not been looked at in this almost all encompassing but fruitless quest:
ME/CFS may be a result of the chronic exposure to the combination of
a) a highly concentrated dose of fluoride diffusing next to the brain stem.
b) dietary patterns of high carbohydrate intake.
a) is also known as: twice daily teeth brushing for 2 minutes (rat studies show F diffuses across the mucuous layer). We evolved with F in the water, not swishing 1000ppm of it (1500ppm for Europeans, who also happen to have a proportionally higher incidence of Fibromyalgia).
F in the brain is known to cause inflammation.
(Taurine affords neuroprotection against F).
b) is diabetes, insulin resistance, high blood sugar, and has a high comorbidity with ME/CSF, with the diagnosed cases, and probably much higher if pre-diabetic cases are included.
I have me/cfs since many years and im in such bad shape that pain clinics cant help me untill i first get better. I cant get out of bed and i cant function at all. But i found a good treatment that works wonders - cannabis. Not joking. Cbd doesnt do the trick on its own but cbd and thc together gives GREAT relief and it gives energy. Im just not legally allowed to use it medically in sweden yet... i also have fibromyalgia, ptsd and adhd and cannabis is helping for all of my symptoms making me a more functional beeing in all aspects. This treatment needs to be lifted up and everyone with me/cfs should be allowed to try medical cannabis. It makes hughe difference while looking for a cure.
Very interesting experiment, I can’t wait to hear about the results. I would really love Dr. Davis or Dr. Phair to give clear advice for people with ME/CFS whether or not they recommend taking Tryptophan or 5-HTP for sleep. I know they’ve weighed in on this before, but I would love a clearer explanation of what those supplements might do in a person with ME/CFS
5-htp bypasses the trytophan/kynurenic pathway and it catalysed to 5-ht by Tryptophan hydroxylase
@@wetelectronics238 Thanks for the information! I don’t have a science background so I don’t quite understand, but I appreciate the insight
You are a hero
Easier way to test it out is to stop eating muscle meats for a week and notices changes in how your body organizes itself (mood and sleep included). Then introduce it and have a substantial piece at one meal - how does your body respond to that? etc.
Also, look up - Eosinophilia-myalgia syndrome syndrome
Check out your estrogen/progesterone and B6 levels - this should give you a good idea of how your body handles tryptophan....
Thank you so much Ron! Good luck with everything
Very interesting theory. Especially given that many long covid patients with symptoms that effectively resemble me/CFS report benefits from niacin supplementation (increases NAD+). Your idea to screen for growth in yeast cells is a great idea, but I wonder if you could expedite the process by finding collaborators with similar microtitre spectrophotometers (would also be good for reproducibility). Have you thought about setting up an enzyme assays that uses NAD as readout (also very easy to measure with microtitre spectrophotometer. Here the advantage is that screens can be done much more rapidly (minutes as opposed to yeast growth that takes many hours to observe) and as a bonus the enzyme kinetics of kynurenine can be determined.
do you know the name brand or where these patients got the NAD??
@@dawnlinder2484 It is the flushing form that people are using. I tried it also along with the rest of the naicin supplement stack but I did not see any benefit, and it actually made me feel sick and one time it caused me to vomit! I was taking 100mg per day but broken up into 25mg. So I guess not everyone can tolerate it.
Ron wants to do it in vivo first. Then he will proceed to the enzyme essays. The latter is difficult because he does not have the personnel or the equipment and doesn’t have the funding. It is also difficult to just “get a collaborator”. The good scientists are usually busy with their own projects. He has managed to get quite a few good collaborators on some things though. Also the in vivo essay is a lot cheaper.
@@dawnlinder2484 see: nkalex.medium.com/the-team-of-front-line-doctors-and-biohackers-who-seem-to-have-solved-long-covid-5f9852f1101d
However, as noted in another reply not all long covid patients react well to Nicotinic acid (the flushing kind of niacin). So speak to your doctor before trying this.
@@johanvanheerden1141 I am not a long hauler covid-19 patient. I have had ME and Fibro for 33 years. So I am not new to this. I can only take methylated niacin because I have a gene mutation.
I hate going to the CFS subreddit. So depressing. I need to know this wont be forever. I am so terrified
Thank you SO much for your commitment to treating this horrible disease! You mention NAD. what about NAD as a benefit to patients?
Thank you so much Ron 👍👍👍👍👍👍😁😁👍👍👍
Block the block! Reactivate IDO1!
fuggin t-shirt right there
Thank you! 🙏🏼
Wouldnt elevated cerebral lactate in CFS suggest that NAD+ is functional but the redox balance between NAD+ and NADH are abnormal? Further if tryptophan is being caught in the kynurenic pathway does that mean that 5-ht conversion is low in CFS patients?
Thanks you very much!
Appreciate all the efforts. I would like to know if you are considering the hypothesis of the protective biological program, the protective response (as the hunkering in mammals and other species) related to the autonomic nervous system. I say it because is what makes most sense to me and many others, after years of research. Explanations of the context around the biochemistry technical stuff would be appreciated. Thank you so much!!
Thank you for the update.
Thx Ronny D!
I'd be really interested to know whether taking n a d h is safe if in relation to this. I feel it helped me at first but I'm not sure anymore. Also take B3 but if there's something going wrong I do wonder if taking me supplements is helping or hindering. Hopefully some advice will come out soon because many of us take these supplements. Hope the robot is fully functional again soon good luck
Just be sure the herbals are checked for high metals! Especially cadmium, mercury and lead like our grocery store dried herbs, even organic!
How can tryptophan build up if it's an essential aminoacid meaning we can only get it through food? Am I misunderstanding something?
Thanks a lot!!!
Has anyone tested effect of low tryptophan diet on me/cfs? I remember that acute tryptophan depletion was tested, but haven't seen anything on chronic.
From what I understand of the trap, even if you completely stop the input of tryptophan in your diet, it would take many several years (I want to say at least a decade, but I can't remember the specifics). But the problem with doing that is it's an essential amino acid, so it would be extremely dangerous to eliminate. With that in mind, a low tryptophan diet may never show any positive effects towards correcting the trap.
@@dougsouth Thank you!
The human body is a product of evolution. It is built specifically to work in the range of encountered environments. If you introduce changes in the environment faster than on the Evo scale (which we obviously are), any of these changes can completely break the human machine and it is somewhat pointless to try to reverse engineer the cause from the disfunction of the hyper-complex human body. It's like analysing the garbage spewed out by an algorithm when you send the wrong inputs. I mentioned the two imo biggest environment changes introduced below.
Have been following work of Peter Walter at UCSF in 'ISRIB' which he describes as rebooting the cells in TBI, Spinal Cord Injuries, Downs Syndrome symptoms, Diabetes, Hearing Loss, Prostate Cancer, Cognitive Impairment in mice reversed
Thank you!! Even though I’m very sick, thank you for not testing on animals, and on yeasts instead. As I don’t wish this disease on anyone, and that includes anyone who could suffer, including animals. I imagine ME/CFS would be very hard on an animal as they’d end constantly triggering severe PEM not knowing how to pace, and probably would end up starving to death which is suffering at its maximum. I’ll offer my body or cells instead.
Shouldn't supplementing kynurenine release you from the pathological feedback loop and cure the disease? According to the kynurenine trial at Uppsala the only guess they're making is that supplementing kynurenine maybe help against headache and brainfog if I remember it correctly? Not that it would resolve ME all together?
(The way I understand this theory: no) Elevated kynurenine can allow cells to function normally for some time. It will not (at least not directly) decrese the level of triptophan so the cell is still locked. To decrese tryptophan you need to process it somehow e.g with IDO1. IDO1 is blocked when there is too much tryptophan. Correct me if I am wrong.
@@aolchowik I thought that IDO1 gene had a mutation in ME/CFS and didn't work correctly and therefore IDO2 have to take care of transporting kynurenine from tryptophan and does so normally, but only to a cetrain extent. And that is before tryptophan levels reaches a certain level/threshold in conjunction with kynurenine at certain low amount where IDO2 eventually stops transporting kynurenine and the trap is engaged? I'm not correcting you. I'm no doctor nor scientist. But maybe I got it totally wrong then?
@@ChrisKadaver I'm not sure whether it was the IDO1 or the IDO2 enzyme, but the theory is that one processes tryptophan when the levels are 'low' and the other when they are 'high'. I believe it's the IDO1 that does the low. Basically one is active when the other is not. The problem is that IDO2 never kicks in when it should (high), but IDO1 shuts down because it's not meant to be active and then ... :/
Ideally you'd either find a way to activate the IDO2 or find some drug/herbal combination that will either engage IDO2 or reduce the tryptophan levels to the level where IDO1 kicks in again. Once we find that, assuming that this theory is correct, then we should be able to recover.
@@dougsouth Do they have also IDO2 cloned into yest ? I assumed that only IDO1 was cloned and " blocking the block" means looking for a drug that would stop IDO1 inhibition by tryptophan and allow IDO1 to work at high tryptophan concentrations.
@@aolchowik Good question. I just assumed it was a natural process in yeast, but brain fog may have filled in the wrong blanks. Now that you put it that way I think you are probably right. I'll just have to re-watch it when I've got the energy... I just going off of what I can remember reading about it in humans over 2 years ago now...
🙏🏻🙏🏻🙏🏻
Fascinating
Does anyone know metabolically if this relates to the positive effect seen on CFS supplementing with co-enzyme q10 and NADH?
Did the robot get fixed?
So I haver These happiness booster pills which consist of L-tryptophane niacin and vitamin B6 and B12. Is it counter productive to take tryptophan, or does it not matter ?
I would suggest looking at the many CFS recovery stories on yt and empirical knowledge from that source, instead of relying on having good engineers.
🙏
Thank you, Please test nutrients and herbs as well as drugs. Less side effects and often just as or more effective.
blocking the block sounds good! (I, or rather my overly sensitive ME-body that responds to supplements immediately, think the trap is actually B12 & iodine keeping eachother in balance so if one's low then the other one will be too due to the interaction between the pituitary gland & thyroid(?))
I took B12 years ago maybe 10 years ago and my B12 level is still over 2000. So this is out of balance correct
@@dawnlinder2484 wow, were those véry slow-release tablets!?
Has anyone found a way to alleviate PEM? Please reply :/
Ron would taking NAD Nasal or IV help us with CFS/ME?? I have taken vitamins in the past and have a hard time believing in whats in the capsule will actually help. Please let me know.
p.s. also hyperbaric oxygen therapy could be helpful
all downstream from VIRAL PERSISTENCE
Exactly.
@@safakhan3088 i was told his son worsened after taking Rituximab, an anti-viral for EBV, but bad for enterovirus. i don't know if that's true, but the person knows their me/cfs and is a doctor.
what i do know--with near certainty--that me/cfs is the result of a persistent pathogen and an out-of-control immune response.
@@gurpchirp Yeah, his son is in this state because of Rituximab. But RTXMB isn't good against EBV at all, several patients with EBV got much worse after it.
And yeah, thats what i think too. Latent infections provoking an unusual immunresponse
Jolly goodly. 1. I had me. Or a causation that was similar. Because as you ought to know there is no appropriate testing. 2 The term CFS is a spurious piece of dogs doings. So the term whilst being applied makes no sense. 3 Why have you not Don the enquiry into the history of its origin USA/UK culpability. And. 4 I don't get what you or why you are thinking that this is in any mysterious . Or hard to cure. On the point of the illness and Kiley cause ( various) thru lack of any current enquiry and secondly thru abhorrent misdiagnosis. Or as I call it bad guess syndrome. I had m.e for 16 years. I would still have it but for self enquiry and a disgust of what in the UK they call imaginary. Without any other definition being appropriate. ( Mental health ). Thus I took the approach of auto immune . And I also took the approach that was missing in say cancer treatments whereby there was no comprehension of long term destructive affects on the immune. Thus being given half baked things like steroids suck cause further weakness to the immune of a long term sufferer. Thus being both ineffective and damaging. So the long and the short of this is I cured myself using the obvious choice of naturals , whereby I was not further damaging a confused hyperthalamus. Which is why no chemical drugs have any use point or need. If the hyperthalamus is infected then you have bodily chaos of an anyhow effect. Thus no one grasps the basics. Thus move on regardless never seeing the blatantly obvious. Cut a long story short the cure is in parts. Rest 100% essential boost the gut biom. and build up the immune system without exhausting it . further. You then give the body the base essentials, some of which it can absurb others take time. Then when the body is strong enough you hit the end with natural interferons. That take out the causation. Then you rest for an age Whilst your body increases its defence mechanisms. The immune system is ther for a reason, m.e obscurity is down to. 2 reasons gov responsibility and a denial of the original source of infection. That's why I say start at the bloody begining and then you comprehend the subdefuge. Right I can now rest from my friend who keeps talking subjective shite . Don't worry a personal thing. Oxidative stress, glucose and mitochondrial stress. Auto immune states wrong waste gasses in the blood, tired bodily responses backed up by a constant immune. Come on fella I'm a bloody layman. Look at Ginkgo. Ginger. Garlic. Lemon juice , ginseng, the interferon is 3 herbals in combo. Don't forget you need an accompanying substance to transit the brain barrier , namely alcohol. So some stuff has to go in combo...same as malaria and the use of gin n tonic ( quinine). Isn't required in this case the quinine that is. But it can be swapped for even mo powerful viral killers. Etc and so on. .. Thus I am well apart from long term inflammation that has damage me left ventricle , blah blah blah.
I don't think that treating these downstream effects is going to work. You need to look for root causes and treat those. What if the so-called metabolic trap is a protective mechanism against further bodily damage from exertion? Treating it could precipitate severe relapse by giving a false sense of "energy" causing the patient to over exert. .
True....i'm still sure ME is a chronic infection of the CNS.
🙏💙
T H A N K - Y O U ! ! !
Hmmm. I think the Professor needs a new robot.