Why Should Postprandial Glucose Be Kept Under 140 mg/dL?
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- Опубликовано: 10 сен 2023
- Question: Why should postprandial blood glucose be kept under 140 milligrams per deciliter?
Short Answer: When blood glucose rises above 140 mg/dL, this is the approximate point at which it spills into the polyol pathway at a greater-than-normal rate, which represents a suboptimal state of metabolism that is likely to hurt antioxidant status and compromise detoxification pathways as well as the recycling of vitamin K and folate. It must be kept in mind that a healthy person will adapt to glycemic loads they consume regularly. Thus, a one-time spike above 140 mg/dL should never be used to conclude anything whatsoever. Only repeated spikes above this level with repeated consumption of the same glycemic load over several days to several weeks should be used as a cause for concern.
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How can I protect against oxalates?
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This snippet is from the April 12, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:
*What Causes Hypercholesterolemia and Does It Matter?
*How to Reverse Coronary Calcification?
*How to do a comprehensive nutritional screening
*How long after eating improperly cooked egg whites should I wait to take biotin?
*Is the extrusion process as harmful as some claim?
*How long can one fast before micronutrient deficiencies become an issue?
*Do B vitamins compete with each other for absorption?
*Why is thirst a symptom of diabetes?
*Do I agree with Peter Attia that ApoB should be driven as low as pharmacologically possible?
*During a fast, does the body break down muscle?
*How do you rest and refeed your brain?
*Why would someone have high RBC magnesium but low serum magnesium?
*GLA deficiency?
*Should we eat for our ethnicity?
*How convincing are polyphenol studies?
*Can coronary calcium be driven by oxalate?
*Citrulline for vasodilation
*How to reduce catabolism
*Rapid-fire run-through of orphaned questions from the submission contest, including a detailed look at Nadia’s thyroid numbers
Here’s a link to the full AMA: chrismasterjohnphd.substack.c...
The Lite episodes had perfect sound.
This is an amazing discovery for me, I've never thought of it this way before. Adaptation is just an automatic respose in our body, and is a hidden gem. Nobody really thought of such when it comes to diabete. Something we don't think about in our everyday life. We are full of fear. Chris, this is a masterpeice. Thank you. So now, can I assume to put myself on a regular sugar load,, but allow some outdoor activities like walkiing, something like what you're doing on this test, do you think my chart will show me similar as yours?
It's cool allows for some experimenting , & the reverse happens with low carb diets , insulin/carb resistance adaptation , so have to reintroduce slow in these cases
Im interested to hear updates on how your levels adapt to sucrose response if you try it (if there's also effect in diabetes with the insulin resistance factor)
Why is losing the adaptation a bad thing?
6:00 , glutathione inversely correlated , if >140 is lowering it that means less ability for cells & mitochondria to protect from oxidative stresors. I wonder if we get bigger or more sustained highs from glucagon&cortisol raising blood glucose , instead of being adapted to carbs? Or if it tends to be more stable lower
And how exactly does the adaptation work? Releasing more insulin?
higher reserves of preproinsulin and proinsulin levels must be it. not sure.
Bump
Sugar feeding mixed in water is a helpful way to get easily digested carbs / calories in digestive disorders ,
I was wondering what max at a time could be without spiking it too high. So tolerance adaptation should happen pretty fast , and sucrose is part fructose which doesn't spike blood glucose , so 40g sucrose would be easier for body to manage than that 40g test of glucose too
From this I'm gonna broadly assume 40g-60g of sucrose per 2 hours should be adaptable intake without going too high (in non diabetics at least) , but testing to confirm individual adaptation obviously best
Thanks
[Why under 140 is good on consistent basis 0:58 & 6:00 but not to be so concerned on occasion, allow it for adaptation 8:00]
Read a study where feeding mice 50% calories as sucrose increased intestinal cell proliferation (likely through increasing igf-1) , so could be good for gut repair
Did I miss something, was insulin checked during these glucose tests? If you adapt over time does that assume your insulin was constant for all 3 tests in your personal example? Then the further question would be is this an example of insulin sensitivity if your body adapts over time?
Exactly 😂
why do some people lose adaptation? can you make a video on all possible causes that lead to maladaptation? I am sure genetics play a role but what else could cause it? Thanks for sharing!
Likely yrs of lack of IR light thus no limited melatonin formation which results in mitochondrial damage so cell distress would be my guess. Oh and not enough vit c and vit e.
140... ssshht I keep under 120
So is this like a muscle - the more you use it in a sensible way, the better it becomes? Or is it like a rubber band - the more you stretch it back and forth, the more it becomes prone to some small internal damage and eventual snapping?
You need to test that because it could be either.
Your shit is good. Lots of reading for me to do. Are you on twitter ? We need you there
Dr. Chris are you going to adress the censorship that has been recently applied by RUclips on channels like yours? Are you considering sharing your content also somewhere else like rumble pls etc before the freedom of speach is completaly surpressed here by these bast...😢
I'm telling you, Chris is trolling us with the bad audio quality. wE hEaR yOu LoUd AnD cLeAr! Every video is a different setup and sounds off in a different way. The mic setup from 4 years ago sounded better.
Yes. Audio is shit. Yet it didn't bother me this time, my ears didn't choke on it. That number youtube shows to normalize to is -3 instead of the -9 or whatever it was last time. So for whatever reason, this was objectively and subjectively better.
Chris, I love your work, but please, do something about the sound quality. It's bordeline unbearable to listen to
Why do you think they eventually adapt to it? INSULIN! Does this overtime lead to insulin resistance if the system is progressively overloaded? Yes. What amount of carb foods does it take to overload the system? Probably varies from person to person.