I would have compared it to the Internet (ARPANET) of the 70s since we are just at the beginning of the revolution. We just need to make sure we don't become the world of Gattaca (movie).
I know this comment is not likely to be seen by anyone as this video was published a couple months ago, but I was not expecting to tear up while watching one of your videos. I have that exact mutation for LCA, and this gene therapy research is super exciting for me. Especially the guy who mentioned seeing a sunset for the first time in a couple of years, as that is something I want to do. Thanks for bringing this to my attention CF, I'm definitely going to try making some calls to this particular researcher and ask him about the progress they've made thus far and see if there is any opportunity for me to get in one of their clinical trials. (:
As a biotechnology student: great video! We need to keep researching, but simultanously think about the ethics. 😃 Curious to see what the future holds.
Yup. The fear is well placed, especially since it can disrupt the biochemical ecosystem within cells. That natural selection shaped over millions of years, & cause unforeseen consequences later in life.
I’m a huge technology optimist, I believe we should use it to its fullest capabilities wherever it initially seems “unnatural” or not. I’m for progress and innovation by almost any means. I love the lightning speed strides we’re making in tech, and none of it scares me. Not the AI, not the gene editing, not the “metaverse” and alternate digital realities, not even things like Elon Musks NeuraLink or the concept of being able to one day upload your consciousness. It all excites me and makes me extremely optimistic for the future.
There’s a reason it’s all happening so fast. Because it HAS TO. Same reason a deer is born almost able to stand from the get go. IT HAS TO. For survival reasons. But it also has to happen correctly. That’s what I have been working on my whole life but now no one listens….
My son (6yrs) progressively going blind. It's heartbreaking. He handles it better than his family. We've been waiting for good news. Thank you for this video
That's why I'm throwing money at this.,.If you want to help then your family are the right type of people to encourage others to invest in gene editing company's instead of charities that are supposed to fund cures but never do....(This company is called CRISPER but there are others and they will all contribute to curing diseases)... You could also research on reach out to company's about possible treatments (I find you can achieve more than asking doctors)
Can you try these below. I have a daughter who had sudden eyesight loss and Thank to God the Almighty, she is normal now. 1. Stop consuming all processed food, especially with high technology . 2. Go organic raw food or light cooking 3. drink plenty of free chemical water 4. Dont eat processed sugar at all, they arent sugar, they are poison, except they are simple processed, not ultra fine. 5. Be outdoor in the sun, especially morning sun and let him play and be active 6. no screen time at all 7. if you are a Theis believe in lord God, pray for Him. He is the absolute answer. He controls everything, as small as speckle dust.
I cannot even begin to fathom what it must feel like, for people who have been blind since birth (or shortly thereafter), to finally attain eyesight... It must be unimaginable.. Both the sensation of power, and scary in some way, because once you can see (or hear), there's no way to "turn it off", except closing your eyes. How can "we regular folk" imagine gaining a completely new sense we've never had before? And having it being opened permanently. It's so hard to imagine what that must be like.
It can take months or even years for their brains to learn how to use the visual information. To connect visual objects to the concept of those objects in the persons mind. Because, until then, they've had ideas about what these objects might be, but they didn't have any visual representation to base it on. Only by the other senses. Also, things like depth perception don't only happen because we have 2 eyes, but also because our brain knows how to use that information. When you can't see for long periods, your brain doesn't need to stimulate the parts of itself that deal with vision, so those parts of the brain don't grow, and can even atrophy over time. So, the visual stimulation is there, but a lot of these people have a hard time getting used to it. It can be overwhelming, and they might come into it slowly, a little at a time by wearing eye coverings and using their vision sparingly when they're curious about what something looks like. Some people come into it much more enthusiastically and get used to it more quickly. It all just depends on the person.
I remember watching a video on someone who was deaf, And they had an implant. When they could hear for the first time they cried, And so did I at their overwhelming joy and I'm not usually that emotional. Must be an incredible moment for these people to gain one of their major senses back, We all take basic things for granted. When I severely ripped a calf muscle and couldn't walk for 4 months, It made me appreciate things a lot more especially disabled people, Just trying to get up and go to the toilet or get a drink from fridge was a major effort and exhausting and that was just a muscle tear. Who would have thought a muscle you don't really notice or bother about could be so critical to basic tasks.
My father is colorblind. Its one of the more common ones that brown and green look similar to him. A company makes glasses that fix the error by doing some magic with the light. I got him a pair as a gift and the ass rejected them telling me not to waste my money. Do you know how furious I was? I put all this thought into getting him something that he never experienced in his life and he just slapped it away. Sadly he would have accepted a tshirt or tie, or cigars but I was really mad (and still am kind of) that he didn't even try them on.
Back in the late '80s I contacted an elderly customer to set up a service call. She was ecstatic because she had some sort of eye surgery a few days before and for the first time in her life could see. I wish I could describe her child like joy and wonder in everything around her.
Imagine shortening the curve towards progress by introducing AI to the Trials & Errors phase to identify potential caveats, and eliminate them before executing a CRISPR Procedure? My wife suffers with RP, so I will be on the lookout for progress there, and feel more hopeful that it will occur in a period where she can reap the benefits!
I'm am severely visually impaired myself after a generic disease caused my vision to plummet off a cliff a few years ago, just as I finished university. This really gives me hope, if I can get back even a small percentage of what I lost, I'll take it.
As someone who is visually impaired, this got be in the feels. Knowing there are big strides being made to improve this is incredible and that there could be a working solution out there, is mind blowing and life changing! So happy for those who took part and saw major life changes 💪😃
The thing that sucks is...once the study is over, these people no longer had access to the gene therapy, so they went blind again. :\ Imagine getting your vision back and then having it taken away.
I actually saw one of the Nobel scientists for this technology, Dr Emmanuelle Charpenier, in lecture at the Freie University in Berlin! This was before she even won. She's an amazing speaker. The dean said that she'll be one of the youngest who could win the Nobel when he introduced her. And she did. So happy for ALL OF THIS ❤️
Don’t get your hopes up just yet. Big Pharma will charge an exorbitant amount for this, as they always do. 99.99% of us wouldn’t be able to afford it. Let’s be honest here.
@@kovy689 Pharma's probably already have the tech, most likely already have the cure for cancer & other diseases but a cure doesn't make money. Patching people up temporary is a good income stream, if they actually cured people they would be out of business ( FACT )
@@DespaceMan Not probably, they already DO have the solution for most diseases know to man. They just safeguard it to maximize profits. And if that wasn’t enough, a bonus would be the the dozens “charities” acting like a cure doesn’t exist to further siphon cash from generous donors. I laugh every time some rich dude donates to a charity that already has a cure.
Excellent introduction to CRISPR - I appreciate your well thought out presentation of the incredibly aspirational and controversial topic. Thank you for adding to the public discourse as you have.
This is incredible! Ive been legally blind my entire life with a visual acuity of 6/96 (or 20/315 in feet). With that said there are still many who have it far worse and I still consider myself lucky to have the vision that I still have. But the limitations are massive. I'm unable to drive, I am very limited with my career choices ect. This could be absolutely massive in the coming years for millions of people around the world as this technology progresses. Not to mention the hundreds of millions of people affected within other medical fields. Fingers crossed 🤞
@@thesupreme1503 it is extremely rare for people to be completely blind to the point of no light perception. The USA classifies vision that is uncorrectable by conventional glasses worse than 20/200 as legally blind, or your field of view being less than 20°. But visual impairment is classified as starting 20/70.
As with any Tool it is always how you use it. Dynamite was invented for stone quarry works. It's not a question of the tool itself. It's always the ethical question what you wish reach and how. Not every how is responsibility.
And keeping it out of reach of idiots. The internet is a shining example of how poorly we have managed that. Spreading the stupid and making otherwise harmless idiots potentially dangerous to society (kids needlessly dying from measles springs to mind).
Yeah, every technology can be used for good or bad.. Hopefully people will use them for good thing, like for medical purpose.. (not for weird things.. sometimes people are too creative..)
Some say the end is near. Some say we'll see Armageddon soon. Certainly hope we will. I sure could use a vacation from this bullshit three-ring circus sideshow of freaks. Here in this hopeless fucking hole we call L.A. The only way to fix it is to flush it all away. Any fucking time. Any fucking day. Learn to swim, see you down in Arizona Bay. Fret for your figure And fret for your latte And fret for your lawsuit And fret for your hairpiece And fret for your Prozac And fret for your pilot And fret for your contract And fret for your car. It's a bullshit three-ring circus sideshow of freaks. Here in this hopeless fucking hole we call L.A. The only way to fix it is to flush it all away. Any fucking time. Any fucking day. Learn to swim, see you down in Arizona Bay. Some say a comet will fall from the sky. Followed by meteor showers and tidal waves. Followed by fault lines that cannot sit still. Followed by millions of dumbfounded dip shits. And some say the end is near. Some say we'll see Armageddon soon. Certainly hope we will I sure could use a vacation from this stupid shit, silly shit, stupid shit. One great big festering neon distraction, I've a suggestion to keep you all occupied. Learn to swim. Learn to swim. Learn to swim. 'Cause mom's gonna fix it all soon. Mom's comin' 'round to put it back the way it ought to be. Learn to swim. [repeat] Fuck L Ron Hubbard And fuck all his clones. Fuck all these gun-toting Hip gangster wannabes. Learn to swim. [repeat] Fuck retro anything. Fuck your tattoos. Fuck all you junkies And fuck your short memory. Learn to swim. [repeat] Fuck smiley glad-hands With hidden agendas. Fuck these dysfunctional Insecure actresses. Learn to swim. [repeat] 'Cause I'm praying for rain I'm praying for tidal waves I wanna see the ground give way. I wanna watch it all go down. Mom, please flush it all away. I wanna see it go right in and down. I wanna watch it go right in. Watch you flush it all away. Time to bring it down again. Don't just call me pessimist. Try and read between the lines. And I can't imagine why you wouldn't welcome any change, my friend. I wanna see it come down. Bring it down Suck it down. Flush it down. -Tool
I have a friend suffering from a similar condition, he started losing sights as a teenager, especially in low light conditions, and after that his field of vision reducing further and further, i really hope this treatment gets developped and accessible to more people in the next years/decade, i was really excited when i heard the news. I'm really stoked on genetic edition, probably more than the people working in the fields, yes, fix up our quirks, make us better, no need to suffer the effect of defects that managed to make it through the filter of natural selection.
@@nuggetonastick1804 tinnitus is the constant ringing in your ear that some people have. i personally got it from listening to too much loud music. since it cannot be transmitted, there is no vaccine.
Humans fear what they don't understand. New breakthroughs are always met with resistance. I think this technology is amazing and if properly implemented, will be used to treat many genetic diseases.
As a person who has aspirations to develop technologies of this sort in the future, this really makes me happy. One day we won’t treat symptoms but the very roots of the problems.
I researched CRISPR technology for my English research project and I’m so glad I did. This is pretty fascinating and I’m curious as to what improvements and advances (and, of course, downfalls) this technology will bring in the future.
Starting with the good, could help cure cancer. The bad, abusive parents who might know about this might try to wield another level of control on their children by threatening to mess up their genes or forcing them to undergo things that the child does not want.
This is absolutely amazing! I know how hard it can be when your eyes don't work properly as my eyes haven't been working together properly for many years. I've recently been having eye therapy and and the result has been absolutely amazing, especially with my studies at the moment. While I'm not blind I completely understand the difficulties and impact that eyesight has on peoples lives.
I have a theory (and hear me out) that mushrooms may be a major key to improving vision. Early studies have showed some promise and I have personally observed Paul Stamets’ mushroom stack to have noticeably improved my vision above 20/20 and had friends who wear contacts say they almost didn’t need them while on this special stack, among the other noticeable benefits. Color appears more vivid, everything become sharper, peripheral vision seems improved. I’ve done tests where I go to my favorite restaurant and can read the employee monitors from over 20 feet away, also notice extremely small bugs on the ground that I don’t think I would’ve before. I really hope more this and the numerous other benefits are more widely studied in the future. My city decriminalized all mushrooms at the start of the year and I have since began studying mycology, the benefits, and growing for personal use. It costs $50 and some good soil to have an unlimited supply of such a relatively easy to grow substance that has profound impacts on life. I’d really like to hear other’s who have tried the Stamets Stack thoughts on this! Very good video, excited to see where the future of gene editing takes us.
This is very powerful tech. Has the ability to do a lot of good or some insanely dark applications as well. Needs to continue to be strictly regulated.
For one with Stargardt's decease I am really exited for this technology, my condition isn't that bad yet, as I obviously can read and write still, but it is gonna get worse over time until I get legally blind, so this exites me greatly
Each technology is a tool. And it's up to us to decide how this tool is going to be used. Powerful tools such as CRISPR come with huge responsibility. We need to ensure that it's used with care
Currently, I am visually impaired on my right eye, and legally blind on my left eye. I was always visually impaired, but was able to see, to the point I got my driving license for motorcycles at 16. Unfortunately, when I was 19, a new disease appeared: Coats disease. This disease made me lose my left eye vision, and almost all vision on my right eye. My right eye, with glasses, is currently at 10% - but fortunately a good 10%, meaning, my vision is clear, average peripheral vision, but with some ghosting and with the help of magnifying glass, either physical or virtual. Seeing this innovations gives me two big hopes: 1) I might be able to see clearer, better, and maybe - just maybe - I can drive again, one of my biggest dreams! 2) My future children, if by chance get some visual disease from my genes, can be improved through this new techniques / technologies. This, along with the COVID-19 vaccines, prove that science is crucial for our quality of life!
Learning about CRISPR has been one of the most uplifting things ever. I used to have a lot of dark, depressing thoughts about dysgenic pressure, and how maybe the Nazis were right in that we needed some heavy hand to replace evolution now that we no longer had natural selection to clean up our gene pool, how religion was standing in the way of preventing our de-evolution as a species, how there might be some great war over designer babies and genetic engineering, etc. But seeing this technology in action gives me hope for the future.
@@aiistyt They should care because unregulated capitalism is creating oligarchy in usa, destroying our safety nets and the environment of our planet. Elon is considered a super genius even tho never invented anything, was born into better financial safety nets and now majority of Americans think he's self made and they can become like him.
@@Pyasa.shaitan But capitalism isn’t unregulated. As a diabetic i really wouldn’t care who solved it. As for Musk, you’re correct he wasn’t born poor but he is responsible for disrupting both the car & space industries.
@@aiistyt i mean with the way megacorps jacked up insulin prices to such an extreme degree, you should be concerned that corporate oligarchy is fucking everyone over! seriously man insulin was meant to be cheap and widely available
@@aiistyt Okay but what's the objective of all that disruption when majority of humanity can't afford them ? Climate change will affect poor countries the most, majority of them don't have access to tesla. If by disruption you mean taking advantage of your employees labor and marketing yourself as a super genius then no that's fraud.
I found this to be incredibly moving. Think about how long it took us to get here... and the ramifications are incalculable. I am incredibly hopeful for this technology, even if its deployment will be limited at first.
2 года назад
I love the progress in gene editing. Where ever did the breakthrough it is step forward in fixing other gene syndroms like my little girl have.
CRISPR is incredible and has virtually limitless applications. Ultimately it doesn't matter if some people are up in arms about it's ethical implications, nothing can stop the research now, it has too much promise to be stopped.
Frikkin amazing. They're hot on the trail of reversing aging aswell. Imagine never growing old and only dying through disease or an accident. Oink oink
This is very emotional for me because this isn’t just an advancement for blindness, but all genetically related diseases as well. God bless all of you, we’re lucky to have hope for the future.
I actually know a young woman who is a part of this amazing study….and we’re all so hopeful it will be successful and made available to all who need it. Amazing stuff!
To the *incredible person* that's seeing this, I wish you all the best in life❤ don't over blame yourself, accept things and go forward. Don't let others define what “success” is for you. Get up, learn the skills needed and get after it, all the keys to a happy life is in your hands. Keep pushing.
I think personally that within the decade we will see a change or series of changes just as revolutionary as software was for computing like with the invention of Microsoft Windows OS. Crispr could enable a suite of industries namely agriculture. It’s immediate use will be with cases of great urgency like trying to mitigate the negative socio-economic impact of climate change on crops that aren’t resistant to rising temperatures and increasingly turbulent climates. As well as preventing forest biomes from further deprecation due to human intervention like unwanted indirect deforestation, and nurturing species of trees on verge of becoming endangered where their presence in the environment is needed so that a healthy ecosystem is maintained. Another industry of immense commercial interest will perhaps be DNA computing when storing data on new forms of drives.
Like all new technology, it is scary to hypothesize possible futures that it will be abused (similar to internet when it was first coming around), but overall it's a fantastic development for humanity.
I was outraged when the Chinese scientist was reined in and imprisoned for gene editing. It goes to show how incredibly asinine the average person is in understanding biology if making babies more resistant to HIV, something already present in 10-20% of people if European ancestry is seen as wrong.
@@18890426 *Of European ancestry. The gene that He Jiankui inserted into those girls is already known to be present in Europeans, though I didn't think that the prevalence was 10% to 20%.
Inventors of CRISPR tech 1. Jennifer Doudna: Main researcher for applied use of CRISPR(white) 2. Emmanuelle Charpentier: CRISPR co-inventor of applied use(white) 3. Feng Zhang: the man who dared to move away from bacteria. Ground work for tech(Asian) 4. Francisco Mojica: ground work/discovered the existence of CRISPR sequence in bacteria(white) 5. Virginijus Šikšnys: ground work/one of the first to show how CRISPR works(white) 6. Stanley Qi: the pioneer of CRISPRa and CRISPRi(Asian) 7. David Liu: the one who introduced base-editor enzymes(Asian) 8. Matthew Porteus: the pioneer of cell-based CRISPR therapies(white) 9. Stephen Tsang: pioneer of ophthalmological genome surgery options(Asian) There is more but it's all based off the above break throughs.
@@christopherrapczynski204 if turned into a bio weapon through means of a man-made virus, the damage could be astronomical. It could be as simple as designing the cas-9 protein in a way that it replaces a commonly found and critical gene in all humans with gibberish.
Repairing a gene in a species is one thing. When we start splicing genes from other species that's where it becomes radically dangerous. There is literally no possibility of predicting the cumulative knockoff effects the more we do that. Covid-19 is a good example. I think we should have strong ethical guidelines that limit it to repairing broken genes not adding new genes.
I watch your channel heaps, But I just found this company doing stock market research on gene therapy and found this company is an extremely undervalued stock, This is the type of thing that can make you a billionaire but people are too busy gambling on the lottery instead of supporting this amazing research (Don't give money to charity to solve diseases, Buy stock in company's that have a financial reason to cure them)!!! I also have blindness in one eye and chronic heart failure and 20 years experience in the stock market🤷🏼♀️
I've been waiting for this forever, since I really want my blind brethren to see again, and if I ever were to lose my eyesight, I want to know that it could be fixed. Also could this make a person taller?
just wow..... i mean... it took 100's of years of science but Humans have now figured out how to fix blindness... we are amazing. this is amazing. we live in Harry Potter times. unbelievable and mind blowing. Another great episode
As someone who has vision problems for many years, this is so cool.. but I do agree we must approach w cautious but it also give me hope for the future when it comes to my vision.
Imagine treating someone, giving them eyesight for over a year, then choosing to let them go back to being blind and remain blind. I can only imagine how hard it must be to give someone the whole world back and then let it slowly be taken away.
I'm interested to see what the future holds for us, in my opinion it would be the greatest revolution in human history to be able to fix all the physical health issues we know today, no more cancer, no more glasses, no more of anything like it, how amazing would that be
As a plant scientist who has worked with CRISPR technology, I believe it has the potential to revolutionise medicine in the coming years. Of course, this is a new technology, and it will take some time to fully understand and overcome the challenges.
@@Farhanullah in case you haven't noticed humans can't be trusted with any technology. Have you looked out the window lately? The human race is fucked under the thumb of the human race. This technology is a curse and you will see why
I have retinitis pigmentosa, albeit a slow progressing form of the disorder. But if came between the use of CRISPR and the prospect of going blind, I would do the CRISPR procedure in a heartbeat. Unless you've walked in my shoes, you can't imagine how horrifying it is to be told by a doctor that you could eventually become blind.
There is no point in continuous suffering and living with limitations when there is an opportunity for development. Of course, like with anything, oversight is needed.
TG you don’t realize how different perceptions can be when your eye sights better than 20/20 and the rest of your families got bad eye sight pointing out things they can’t even see without glasses it’s incredible really whether it’s stars ⭐️ or rainbows 🌈 or auroras.
CRISPR IS probably like the Internet in the 80s. We don’t understand it yet but once we do there are infinite possibilities
CRISPIER than thou
unlike the net, one hopes that dank memes will not be produced.
@@DeconvertedMan dank genes
I would have compared it to the Internet (ARPANET) of the 70s since we are just at the beginning of the revolution. We just need to make sure we don't become the world of Gattaca (movie).
A lot of scope for abuse too, thanks to the evil out there in society.
Amid all the generally bad news in 2020/2021, this stands out as truly heartwarming
No….it actually is the worst of em all, think about bioterrorism as well!!
@@serotonin2222 Lol Resident Evil
Don't you trust the covid vax and it's makers? LOL! (NOT!).
@@keenanrobinson7239 boulder punching a***ole go brr
It does indeed
I know this comment is not likely to be seen by anyone as this video was published a couple months ago, but I was not expecting to tear up while watching one of your videos. I have that exact mutation for LCA, and this gene therapy research is super exciting for me. Especially the guy who mentioned seeing a sunset for the first time in a couple of years, as that is something I want to do. Thanks for bringing this to my attention CF, I'm definitely going to try making some calls to this particular researcher and ask him about the progress they've made thus far and see if there is any opportunity for me to get in one of their clinical trials. (:
hows everything going, are u getting this treatment?
Good luck! ✨
As a biotechnology student: great video! We need to keep researching, but simultanously think about the ethics. 😃 Curious to see what the future holds.
Yup. The fear is well placed, especially since it can disrupt the biochemical ecosystem within cells. That natural selection shaped over millions of years, & cause unforeseen consequences later in life.
I’m a huge technology optimist, I believe we should use it to its fullest capabilities wherever it initially seems “unnatural” or not. I’m for progress and innovation by almost any means. I love the lightning speed strides we’re making in tech, and none of it scares me. Not the AI, not the gene editing, not the “metaverse” and alternate digital realities, not even things like Elon Musks NeuraLink or the concept of being able to one day upload your consciousness. It all excites me and makes me extremely optimistic for the future.
There’s a reason it’s all happening so fast. Because it HAS TO. Same reason a deer is born almost able to stand from the get go. IT HAS TO. For survival reasons. But it also has to happen correctly. That’s what I have been working on my whole life but now no one listens….
This is huge! Great time to be alive.
Yeah it's all roses until China develop a gene-specific virus based on all the DNA that they've been collecting from all over the world.
.
@@01DOGG01 nice tinfoil hat :d
@@01DOGG01 They already did that remember?
I want to be put in cryogenesis and wake up in 100 years. It's going to be lit
My son (6yrs) progressively going blind. It's heartbreaking. He handles it better than his family. We've been waiting for good news. Thank you for this video
I wish the best for your son
Good Luck Todd
May God be with him and you. A number of us are following new approaches with cautious optimism
That's why I'm throwing money at this.,.If you want to help then your family are the right type of people to encourage others to invest in gene editing company's instead of charities that are supposed to fund cures but never do....(This company is called CRISPER but there are others and they will all contribute to curing diseases)... You could also research on reach out to company's about possible treatments (I find you can achieve more than asking doctors)
Can you try these below. I have a daughter who had sudden eyesight loss and Thank to God the Almighty, she is normal now.
1. Stop consuming all processed food, especially with high technology .
2. Go organic raw food or light cooking
3. drink plenty of free chemical water
4. Dont eat processed sugar at all, they arent sugar, they are poison, except they are simple processed, not ultra fine.
5. Be outdoor in the sun, especially morning sun and let him play and be active
6. no screen time at all
7. if you are a Theis believe in lord God, pray for Him. He is the absolute answer. He controls everything, as small as speckle dust.
I cannot even begin to fathom what it must feel like, for people who have been blind since birth (or shortly thereafter), to finally attain eyesight... It must be unimaginable.. Both the sensation of power, and scary in some way, because once you can see (or hear), there's no way to "turn it off", except closing your eyes.
How can "we regular folk" imagine gaining a completely new sense we've never had before? And having it being opened permanently. It's so hard to imagine what that must be like.
It can take months or even years for their brains to learn how to use the visual information. To connect visual objects to the concept of those objects in the persons mind. Because, until then, they've had ideas about what these objects might be, but they didn't have any visual representation to base it on. Only by the other senses. Also, things like depth perception don't only happen because we have 2 eyes, but also because our brain knows how to use that information.
When you can't see for long periods, your brain doesn't need to stimulate the parts of itself that deal with vision, so those parts of the brain don't grow, and can even atrophy over time. So, the visual stimulation is there, but a lot of these people have a hard time getting used to it. It can be overwhelming, and they might come into it slowly, a little at a time by wearing eye coverings and using their vision sparingly when they're curious about what something looks like.
Some people come into it much more enthusiastically and get used to it more quickly. It all just depends on the person.
I remember watching a video on someone who was deaf, And they had an implant. When they could hear for the first time they cried, And so did I at their overwhelming joy and I'm not usually that emotional.
Must be an incredible moment for these people to gain one of their major senses back, We all take basic things for granted.
When I severely ripped a calf muscle and couldn't walk for 4 months, It made me appreciate things a lot more especially disabled people, Just trying to get up and go to the toilet or get a drink from fridge was a major effort and exhausting and that was just a muscle tear. Who would have thought a muscle you don't really notice or bother about could be so critical to basic tasks.
My father is colorblind. Its one of the more common ones that brown and green look similar to him. A company makes glasses that fix the error by doing some magic with the light. I got him a pair as a gift and the ass rejected them telling me not to waste my money. Do you know how furious I was? I put all this thought into getting him something that he never experienced in his life and he just slapped it away. Sadly he would have accepted a tshirt or tie, or cigars but I was really mad (and still am kind of) that he didn't even try them on.
Back in the late '80s I contacted an elderly customer to set up a service call. She was ecstatic because she had some sort of eye surgery a few days before and for the first time in her life could see. I wish I could describe her child like joy and wonder in everything around her.
@@MrShwaggins change is hard and scary for some people. how can history get past people like us.
Imagine shortening the curve towards progress by introducing AI to the Trials & Errors phase to identify potential caveats, and eliminate them before executing a CRISPR Procedure? My wife suffers with RP, so I will be on the lookout for progress there, and feel more hopeful that it will occur in a period where she can reap the benefits!
I'm am severely visually impaired myself after a generic disease caused my vision to plummet off a cliff a few years ago, just as I finished university. This really gives me hope, if I can get back even a small percentage of what I lost, I'll take it.
As someone who is visually impaired, this got be in the feels. Knowing there are big strides being made to improve this is incredible and that there could be a working solution out there, is mind blowing and life changing! So happy for those who took part and saw major life changes 💪😃
How are you able to comment ?
@@asimgiri4269 I thought you were the same person 😂 you have the same photo in the snow with a beannie
@@ZZ-vl5nd 😂😂
The thing that sucks is...once the study is over, these people no longer had access to the gene therapy, so they went blind again. :\ Imagine getting your vision back and then having it taken away.
@@asimgiri4269 there are tools the visually impaired could use to surf the internet
I actually saw one of the Nobel scientists for this technology, Dr Emmanuelle Charpenier, in lecture at the Freie University in Berlin! This was before she even won. She's an amazing speaker. The dean said that she'll be one of the youngest who could win the Nobel when he introduced her. And she did. So happy for ALL OF THIS ❤️
Holly molly
@@venky3867 Holy Moly*
Don’t get your hopes up just yet. Big Pharma will charge an exorbitant amount for this, as they always do.
99.99% of us wouldn’t be able to afford it. Let’s be honest here.
@@kovy689 Pharma's probably already have the tech, most likely already have the cure for cancer & other diseases but a cure doesn't make money. Patching people up temporary is a good income stream, if they actually cured people they would be out of business ( FACT )
@@DespaceMan Not probably, they already DO have the solution for most diseases know to man. They just safeguard it to maximize profits.
And if that wasn’t enough, a bonus would be the the dozens “charities” acting like a cure doesn’t exist to further siphon cash from generous donors. I laugh every time some rich dude donates to a charity that already has a cure.
Excellent introduction to CRISPR - I appreciate your well thought out presentation of the incredibly aspirational and controversial topic. Thank you for adding to the public discourse as you have.
I’m a bio-technician, disabled from visual impairment from damage to my optic nerve. I will need to regrow my nerves. I’m hopeful 🥰👍
This is incredible! Ive been legally blind my entire life with a visual acuity of 6/96 (or 20/315 in feet). With that said there are still many who have it far worse and I still consider myself lucky to have the vision that I still have.
But the limitations are massive. I'm unable to drive, I am very limited with my career choices ect.
This could be absolutely massive in the coming years for millions of people around the world as this technology progresses. Not to mention the hundreds of millions of people affected within other medical fields.
Fingers crossed 🤞
How can you be illegally blind?
look at me being an asshole to a blind person I must be going to heaven
@@thesupreme1503 It is just classification of the level of blindness. There is not such thing as " illegally blind".
@@DarkGT hey man I feel u bro my visual acuity in feet is also 20/275 so I know what ur going thru
@@thesupreme1503 it is extremely rare for people to be completely blind to the point of no light perception. The USA classifies vision that is uncorrectable by conventional glasses worse than 20/200 as legally blind, or your field of view being less than 20°. But visual impairment is classified as starting 20/70.
@@frostman9661 ah nice thanks for the information
As with any Tool it is always how you use it. Dynamite was invented for stone quarry works. It's not a question of the tool itself. It's always the ethical question what you wish reach and how. Not every how is responsibility.
And keeping it out of reach of idiots. The internet is a shining example of how poorly we have managed that. Spreading the stupid and making otherwise harmless idiots potentially dangerous to society (kids needlessly dying from measles springs to mind).
Yeah, every technology can be used for good or bad.. Hopefully people will use them for good thing, like for medical purpose.. (not for weird things.. sometimes people are too creative..)
Some say the end is near.
Some say we'll see Armageddon soon.
Certainly hope we will.
I sure could use a vacation from this bullshit three-ring circus sideshow of freaks.
Here in this hopeless fucking hole we call L.A.
The only way to fix it is to flush it all away.
Any fucking time. Any fucking day.
Learn to swim, see you down in Arizona Bay.
Fret for your figure
And fret for your latte
And fret for your lawsuit
And fret for your hairpiece
And fret for your Prozac
And fret for your pilot
And fret for your contract
And fret for your car.
It's a bullshit three-ring circus sideshow of freaks.
Here in this hopeless fucking hole we call L.A.
The only way to fix it is to flush it all away.
Any fucking time. Any fucking day.
Learn to swim, see you down in Arizona Bay.
Some say a comet will fall from the sky.
Followed by meteor showers and tidal waves.
Followed by fault lines that cannot sit still.
Followed by millions of dumbfounded dip shits.
And some say the end is near.
Some say we'll see Armageddon soon.
Certainly hope we will
I sure could use a vacation from this stupid shit, silly shit, stupid shit.
One great big festering neon distraction,
I've a suggestion to keep you all occupied.
Learn to swim.
Learn to swim.
Learn to swim.
'Cause mom's gonna fix it all soon.
Mom's comin' 'round to put it back the way it ought to be.
Learn to swim. [repeat]
Fuck L Ron Hubbard
And fuck all his clones.
Fuck all these gun-toting
Hip gangster wannabes.
Learn to swim. [repeat]
Fuck retro anything.
Fuck your tattoos.
Fuck all you junkies
And fuck your short memory.
Learn to swim. [repeat]
Fuck smiley glad-hands
With hidden agendas.
Fuck these dysfunctional
Insecure actresses.
Learn to swim. [repeat]
'Cause I'm praying for rain
I'm praying for tidal waves
I wanna see the ground give way.
I wanna watch it all go down.
Mom, please flush it all away.
I wanna see it go right in and down.
I wanna watch it go right in.
Watch you flush it all away.
Time to bring it down again.
Don't just call me pessimist.
Try and read between the lines.
And I can't imagine why you wouldn't welcome any change, my friend.
I wanna see it come down.
Bring it down
Suck it down.
Flush it down.
-Tool
One of my biggest fears on this planet. Kudos and looking forward to the day when everyone can see without any problems.
As an Eye Doctor this is incredibly exciting!
I have a friend suffering from a similar condition, he started losing sights as a teenager, especially in low light conditions, and after that his field of vision reducing further and further, i really hope this treatment gets developped and accessible to more people in the next years/decade, i was really excited when i heard the news.
I'm really stoked on genetic edition, probably more than the people working in the fields, yes, fix up our quirks, make us better, no need to suffer the effect of defects that managed to make it through the filter of natural selection.
Now hoping to see a solution for tinnitus and hearing loss emerging
@@nuggetonastick1804 i think you're thinking of tetanus, tinnitus is not a virus or something.
@@owndampu1731 lol.
Hell yeah that would be great.
@@nuggetonastick1804 tinnitus is the constant ringing in your ear that some people have. i personally got it from listening to too much loud music. since it cannot be transmitted, there is no vaccine.
Hearing loss is due to physical damage at a scale far bigger than individual genes.
Humans fear what they don't understand. New breakthroughs are always met with resistance. I think this technology is amazing and if properly implemented, will be used to treat many genetic diseases.
Oh my god when that amazing man with cerebral palsy said he tried not to let it affect his work ethic… just want him to be happy. Touched my heart.
As a person who has aspirations to develop technologies of this sort in the future, this really makes me happy. One day we won’t treat symptoms but the very roots of the problems.
I researched CRISPR technology for my English research project and I’m so glad I did. This is pretty fascinating and I’m curious as to what improvements and advances (and, of course, downfalls) this technology will bring in the future.
Starting with the good, could help cure cancer. The bad, abusive parents who might know about this might try to wield another level of control on their children by threatening to mess up their genes or forcing them to undergo things that the child does not want.
@@rnbsteenstar Spot on.
Simply Amazing!Simply Amazing!Simply Amazing! Entire World and nations should support this Amazing research and way forward!
This is absolutely amazing! I know how hard it can be when your eyes don't work properly as my eyes haven't been working together properly for many years. I've recently been having eye therapy and and the result has been absolutely amazing, especially with my studies at the moment. While I'm not blind I completely understand the difficulties and impact that eyesight has on peoples lives.
@ghost mall Not trying to be snotty? So you're a natural.
can they reverse my failures with crispr
Mood 2021
9mm bullet can
@@vaidasspu You are very wise in your ways, master 🙏
@@vaidasspu that boy ain't right
@@-TK- that boy needs therapy
Seeing the man with the cerebral palsy being able to pick up the cup for the first time made me tear up, he looked so happy omg
I have a theory (and hear me out) that mushrooms may be a major key to improving vision. Early studies have showed some promise and I have personally observed Paul Stamets’ mushroom stack to have noticeably improved my vision above 20/20 and had friends who wear contacts say they almost didn’t need them while on this special stack, among the other noticeable benefits. Color appears more vivid, everything become sharper, peripheral vision seems improved. I’ve done tests where I go to my favorite restaurant and can read the employee monitors from over 20 feet away, also notice extremely small bugs on the ground that I don’t think I would’ve before. I really hope more this and the numerous other benefits are more widely studied in the future. My city decriminalized all mushrooms at the start of the year and I have since began studying mycology, the benefits, and growing for personal use. It costs $50 and some good soil to have an unlimited supply of such a relatively easy to grow substance that has profound impacts on life. I’d really like to hear other’s who have tried the Stamets Stack thoughts on this!
Very good video, excited to see where the future of gene editing takes us.
This is fantastic. Dagogo can you start adding chapters so we can start where we left when we come back?
It's 14 minutes long, just put it in 2× speed
@@julianbello8376 just get a plugin that does that
FINALLY a video about cutting edge medical technology
Thank you for everyone who is work in this field
Ive been watching you everyday for the past 2 weeks, ive been waiting for a new one!
This is very powerful tech. Has the ability to do a lot of good or some insanely dark applications as well. Needs to continue to be strictly regulated.
Positive use of science for a better life; just love it.
For one with Stargardt's decease I am really exited for this technology, my condition isn't that bad yet, as I obviously can read and write still, but it is gonna get worse over time until I get legally blind, so this exites me greatly
Also have stargardts. Would love to Share experiences. Couldnt find a way to message privately
@@skred3fr what would you like to ask about? I'm up for sharing
Each technology is a tool. And it's up to us to decide how this tool is going to be used. Powerful tools such as CRISPR come with huge responsibility. We need to ensure that it's used with care
I see it as a major breakthrough, Genetic engineering has always fascinated me . Although it may have it's downsides
These videos showcasing scientific breakthroughs are the reason I'm subscribed to your channel.
CRISP-R is *the future!* Someone should notify Roanoke Gaming about this!
Haha that channel (or references to it) seem to be everywhere i go on RUclips
@@jjcoola998 bots
The explanation of CRISPR at the start is really great and succinct, wonderfully edited, thanks.
Edit: Great caution advisory, I like it. 👍🏻
@@Kelly-vs8cm in English, this translates as, “After all, carrots are the best!” You into carrots?
I'm positively thrilled about this!
However, as a cancer patient I might be a bit biased. ;)
Understandable. I don't have anything like cancer or blindness but I am very excited to see this in action.
Currently, I am visually impaired on my right eye, and legally blind on my left eye.
I was always visually impaired, but was able to see, to the point I got my driving license for motorcycles at 16.
Unfortunately, when I was 19, a new disease appeared: Coats disease.
This disease made me lose my left eye vision, and almost all vision on my right eye.
My right eye, with glasses, is currently at 10% - but fortunately a good 10%, meaning, my vision is clear, average peripheral vision, but with some ghosting and with the help of magnifying glass, either physical or virtual.
Seeing this innovations gives me two big hopes:
1) I might be able to see clearer, better, and maybe - just maybe - I can drive again, one of my biggest dreams!
2) My future children, if by chance get some visual disease from my genes, can be improved through this new techniques / technologies.
This, along with the COVID-19 vaccines, prove that science is crucial for our quality of life!
Learning about CRISPR has been one of the most uplifting things ever. I used to have a lot of dark, depressing thoughts about dysgenic pressure, and how maybe the Nazis were right in that we needed some heavy hand to replace evolution now that we no longer had natural selection to clean up our gene pool, how religion was standing in the way of preventing our de-evolution as a species, how there might be some great war over designer babies and genetic engineering, etc. But seeing this technology in action gives me hope for the future.
Hope the credit goes to scientist for this innovative idea and not some billionaire.
I understand what you’re saying but I doubt people with sight problems will care
@@aiistyt
They should care because unregulated capitalism is creating oligarchy in usa, destroying our safety nets and the environment of our planet. Elon is considered a super genius even tho never invented anything, was born into better financial safety nets and now majority of Americans think he's self made and they can become like him.
@@Pyasa.shaitan But capitalism isn’t unregulated. As a diabetic i really wouldn’t care who solved it. As for Musk, you’re correct he wasn’t born poor but he is responsible for disrupting both the car & space industries.
@@aiistyt i mean with the way megacorps jacked up insulin prices to such an extreme degree, you should be concerned that corporate oligarchy is fucking everyone over! seriously man insulin was meant to be cheap and widely available
@@aiistyt
Okay but what's the objective of all that disruption when majority of humanity can't afford them ? Climate change will affect poor countries the most, majority of them don't have access to tesla. If by disruption you mean taking advantage of your employees labor and marketing yourself as a super genius then no that's fraud.
I love how science is trying to do such incredible things!
omfg, that is huge
Absolutely, papa flammy
I agree papa flammy
I found this to be incredibly moving. Think about how long it took us to get here... and the ramifications are incalculable.
I am incredibly hopeful for this technology, even if its deployment will be limited at first.
I love the progress in gene editing. Where ever did the breakthrough it is step forward in fixing other gene syndroms like my little girl have.
What's next - a Johnny Depp look-alike talking from a computer, healing other people and creating a hive mind?
have you heard of optogenetics and or Prime Editor? The latter is like Cripr but newer? Maybe worth looking into
Wow I’ve never heard of this!
I did! I even did a scoping review paper on this topic which was praised by my supervisor
CRISPR is incredible and has virtually limitless applications. Ultimately it doesn't matter if some people are up in arms about it's ethical implications, nothing can stop the research now, it has too much promise to be stopped.
"When science is on the march, nothing can stand in its way!" - Paul Bartel
Wow - amazing - hope this will be used greatly and safely to help many people.
Dagogo: "Cheers guys"
Me: (Is he gonna say it? IS HE GONNA SAY IT?!?)
Dagogo: "Have a good one"
Me: Ofcours he is! :)
Frikkin amazing. They're hot on the trail of reversing aging aswell. Imagine never growing old and only dying through disease or an accident.
Oink oink
This is very emotional for me because this isn’t just an advancement for blindness, but all genetically related diseases as well. God bless all of you, we’re lucky to have hope for the future.
I actually know a young woman who is a part of this amazing study….and we’re all so hopeful it will be successful and made available to all who need it. Amazing stuff!
To the *incredible person* that's seeing this, I wish you all the best in life❤ don't over blame yourself, accept things and go forward. Don't let others define what “success” is for you. Get up, learn the skills needed and get after it, all the keys to a happy life is in your hands. Keep pushing.
Finally all those girls will finally notice me!
I think there are so so many possibilities in science. People are afraid of change. Absolutely love this progress.
Mr Bing,
You wouldn't love the progress if you were the one been targeted to lose the right to live.
I think personally that within the decade we will see a change or series of changes just as revolutionary as software was for computing like with the invention of Microsoft Windows OS. Crispr could enable a suite of industries namely agriculture. It’s immediate use will be with cases of great urgency like trying to mitigate the negative socio-economic impact of climate change on crops that aren’t resistant to rising temperatures and increasingly turbulent climates. As well as preventing forest biomes from further deprecation due to human intervention like unwanted indirect deforestation, and nurturing species of trees on verge of becoming endangered where their presence in the environment is needed so that a healthy ecosystem is maintained. Another industry of immense commercial interest will perhaps be DNA computing when storing data on new forms of drives.
Like all new technology, it is scary to hypothesize possible futures that it will be abused (similar to internet when it was first coming around), but overall it's a fantastic development for humanity.
As long as it is as accessible as the Internet, I have faith that it'll be more good than bad
It will be abused, that is the issue with any progress we make. However the good things that come out outweigh this. This is why we progress.
I hope they make it affordable. Eyesight is a human right.
Hopefully it will become more affordable once the technique becomes more common.
These past few years will be talked about for ages to come as history keeps happening before our eyes every single day.
I hope this technology helps people with visual impairment. This will be absolutely great. If they make it really available to all perfect.
I was outraged when the Chinese scientist was reined in and imprisoned for gene editing. It goes to show how incredibly asinine the average person is in understanding biology if making babies more resistant to HIV, something already present in 10-20% of people if European ancestry is seen as wrong.
If Europeansancestry is seen as wrong? What do you mean by that ？
@@18890426 *Of European ancestry. The gene that He Jiankui inserted into those girls is already known to be present in Europeans, though I didn't think that the prevalence was 10% to 20%.
This reminds me of the first heart transplant and of the improvement of this procedure to it becoming a common procedure
Some of Best science and technology videos on the net very good
super low cost.......... american pharma company: that will be million dollars per shot please
Big Phama: *slaps patent on desk* now pay.
One doesn’t experience self-transcendence, the illusion of self only dissipates:🎈
Remember hearing about crispr 4 years ago. So happy it's moving forward.
Inventors of CRISPR tech
1. Jennifer Doudna: Main researcher for applied use of CRISPR(white)
2. Emmanuelle Charpentier: CRISPR co-inventor of applied use(white)
3. Feng Zhang: the man who dared to move away from bacteria. Ground work for tech(Asian)
4. Francisco Mojica: ground work/discovered the existence of CRISPR sequence in bacteria(white)
5. Virginijus Šikšnys: ground work/one of the first to show how CRISPR works(white)
6. Stanley Qi: the pioneer of CRISPRa and CRISPRi(Asian)
7. David Liu: the one who introduced base-editor enzymes(Asian)
8. Matthew Porteus: the pioneer of cell-based CRISPR therapies(white)
9. Stephen Tsang: pioneer of ophthalmological genome surgery options(Asian)
There is more but it's all based off the above break throughs.
As incredibly important as this technology is, it has the potential to make global thermonuclear war seem like a picnic by comparison
What?
@@christopherrapczynski204 if turned into a bio weapon through means of a man-made virus, the damage could be astronomical. It could be as simple as designing the cas-9 protein in a way that it replaces a commonly found and critical gene in all humans with gibberish.
Repairing a gene in a species is one thing. When we start splicing genes from other species that's where it becomes radically dangerous. There is literally no possibility of predicting the cumulative knockoff effects the more we do that. Covid-19 is a good example. I think we should have strong ethical guidelines that limit it to repairing broken genes not adding new genes.
I wonder if the military has not yet tried this yet, e.g. introducing cat eye gene to improve night vision of soldiers.
I watch your channel heaps, But I just found this company doing stock market research on gene therapy and found this company is an extremely undervalued stock, This is the type of thing that can make you a billionaire but people are too busy gambling on the lottery instead of supporting this amazing research (Don't give money to charity to solve diseases, Buy stock in company's that have a financial reason to cure them)!!!
I also have blindness in one eye and chronic heart failure and 20 years experience in the stock market🤷🏼♀️
I read an article about this already it's great you made a video about it it's pretty Kool 🔥🔥
I've been waiting for this forever, since I really want my blind brethren to see again, and if I ever were to lose my eyesight, I want to know that it could be fixed. Also could this make a person taller?
Yes😂😂
making an adult taller would be astronomically difficult but if embryos or babies were edited I think it would be possilbe
Why isn't this all over the news ? This is groundbreaking!
The sunset and sunrise can be seen for those who never seen before... we appreciate the continuously work of researchers around the globe.
just wow..... i mean... it took 100's of years of science but Humans have now figured out how to fix blindness... we are amazing. this is amazing. we live in Harry Potter times. unbelievable and mind blowing. Another great episode
As someone who is severely mentally disturbed, it makes me happy to think I might be helped yet
Where's the woman who says "You're watching Cold FusionTV?" That was the main highlight of mine from this channel
As someone who has vision problems for many years, this is so cool.. but I do agree we must approach w cautious but it also give me hope for the future when it comes to my vision.
I'm excited about this technology. I live for new advances in medicine
I hope this technology arrive soon everywhere
what we take for granted , it made me cry could barely type , thanks mate for restoring my fate in science a bit
Imagine treating someone, giving them eyesight for over a year, then choosing to let them go back to being blind and remain blind. I can only imagine how hard it must be to give someone the whole world back and then let it slowly be taken away.
"Increasing their quality of life"... Talk about an understatement :)
Finally, some great news!
Brilliant video!
I'm interested to see what the future holds for us, in my opinion it would be the greatest revolution in human history to be able to fix all the physical health issues we know today, no more cancer, no more glasses, no more of anything like it, how amazing would that be
Awesome video man, this made me cry 😭 I’m so happy for the benefit that it will do for those people that need help.
As a plant scientist who has worked with CRISPR technology, I believe it has the potential to revolutionise medicine in the coming years. Of course, this is a new technology, and it will take some time to fully understand and overcome the challenges.
How old are you 10?
@@joeschofield6971 33
@@Farhanullah in case you haven't noticed humans can't be trusted with any technology. Have you looked out the window lately? The human race is fucked under the thumb of the human race. This technology is a curse and you will see why
I miss that "you are watching coldfusion TV" opener. That was so cool
Yea, it got taken out by accident during editing. It'll be back next time.
I have retinitis pigmentosa, albeit a slow progressing form of the disorder. But if came between the use of CRISPR and the prospect of going blind, I would do the CRISPR procedure in a heartbeat. Unless you've walked in my shoes, you can't imagine how horrifying it is to be told by a doctor that you could eventually become blind.
This is like going to the library and learn the basics on a subject , but even better. Nice content
Very exciting to hear that they are doing clinical trials now!
There is no point in continuous suffering and living with limitations when there is an opportunity for development. Of course, like with anything, oversight is needed.
I'm so excited about this. The future looks bright
Amazing videos and music. Thank you for all you do!
TG you don’t realize how different perceptions can be when your eye sights better than 20/20 and the rest of your families got bad eye sight pointing out things they can’t even see without glasses it’s incredible really whether it’s stars ⭐️ or
rainbows 🌈 or auroras.