yes I want him to come back! So glad to see you address this! I’m a nurse been doing Keto- lost 120 pounds off 7 meds and have never felt better. It’s absolutely saved my life-and I was a non-believer and thought why not try it for a month. Have never quit !
Z dogg makes it very pretty clear on the front end that he is an entertainer, the first clue being that he goes by Z Dogg. If you'd prefer a more dead panned exploration of the material, both Peter Atila and Chris Kesser have hours and hours of material on cholesterol/ lipidology.
As a nurse I want to say it’s always cool that you acknowledge that we exist when you have these conversations. Thank you. I also find that lower carbs and higher protein allow me to perform my best and feel my best with my training. Nothing too crazy, around 100g of carbs makes a big difference for me.
beingL .. You are a nurse.. So why would you not talk about your fat intake? This is where the problem lies. Keto or Fat burning is Fat and Cholesterol as your energy source...and why the most Keto experts have it all wrong, If you think protein is how you do this... Protein burning is Acidosis!! Do your research!
As a ketogenic dietitian and the daughter of engineers, I loved this podcast so much! It’s time to clarify the vital role cholesterol and lipoproteins play in optimal health 🙌👏
Very enlightening. Wow, I keep asking my doc why my cholesterol LDL is going up higher than it’s ever been, despite low carb, lower fat, exercise, losing 30 lbs. she told me it’s probably “familiar” (hereditary) and I should take statins. I’ve been resisting, when I took epidemiology I happen to choose the Framingham study to analyze for my term paper (in 1993) and my take away from that was that it’s conclusions were not based or proved on causation. I understand so much more now. Thanks for this content!
My total cholesterol and HDL have consistently been high for the past 30 years. Doctors have said it’s fine (no statins recommended) because the HDL is so high, highest they’ve seen. I continue to have a pretty high fat intake. Love this podcast 👍
unfortunately the host and his crew are a bunch of jackholes, at least their behavior, language, and ghetto actions in this podcast. Otherwise yes, the guest has some really valuable information to pass along.
@@peternct811 do you realize you're listening to people with no education in dietetics? The only reason these two have any views is because they're telling people good things about their bad habits, which in the end is false information.
Ive seen Dave before and love his work. Never have I enjoyed the presentation of Dave, his research and his idea's as I did on your show. FUN, EXCITING & ENTERTAINING! Thanks for making the upload so easy.
I had "dangerously high" cholesterol, blood pressure and triglycerides, despite a lifetime of athletics (Ironman Triathlete) and eating an extremely low-fat, clean "athlete's diet (LFHC). I became a vegetarian for an entire year and it had zero effect. After 6 months of a Paleo/Primal way of eating, all numbers were in the "normal" range. My Doctors were stunned.
becoming vegetarian for an entire year is meaningless because you are eating cheese , milk and dairies . That is animal food.Stupid is as stupid does. You would pay eventually with a cancer down the road.
This research so makes sense!! I have familiar hyperlipidemia. So does my dad and his siblings and most of my cousins. But no one is dropping dead from heart disease young! In fact my dad turns 85 in 2 months. He is the 3rd oldest of 8 and all are living!!! My doctors always freak out with my cholesterol levels. I did the low fat diet for decades. I was miserable, low energy and had a fatty liver with my cholesterol going up and gaining weight! I've gone back to adding healthy fats into my diet. I've lost 22 lbs so far and keeping it off. I do not eat any processed foods. I am celiac so no wheat, eye or barley. But I now have flax, almond, coconut and other flours in my diet. I feel so much better!! Yes more energy! I expect my cholesterol levels to be higher do to genetics and having CRPS. I have had several stress test and no heart disease! Go figure. Bad reaction to statins. I volunteer to give blood for any study for cholesterol!!! Love this show!
Since starting the blog, I've had a surprising number of people write to me with stories like yours. Two of them were from immigrant families where they had poor access to healthcare where they came from, yet each generation lived into its 80s and 90s. But once here, it was found half the family had very high cholesterol. Given their original family history, they all refused statins and it didn't change their (already impressive) lifespans.
But it is clearly more complex than this. 50% of people with FH will develop early coronary artery disease, with significant early mortality (~25x early cardiovascular mortality risk). FH is (mostly) a mutation in the LDL receptor, so it should still play a negative role in this model of cholesterol. It is likely that there are lifestyle and other genetic factors at play determining which people with FH have the bad phenotype. I would agree that the evidence of significant benefit from statins is poor (jaha.ahajournals.org/content/3/6/e001236)
Hi Sherry, I'm glad you are feeling better and I think that is wonderful. I have been into LCHF for several years. I recently ran into the problem of high oxalate in foods that people often start eating when they are trying to be more healthy. I seem a number of these on your list of foods you are eating and thought you might appreciate a heads up about the oxalate. If you want to look into it, here is the webpage I would refer you to. sallyknorton.com Best wishes and good luck.
I love the humorous interruptions. References, very important. I am a medical lab technician in Guatemala. I would love to try this and upload my data. Regards.
I stopped taking my statins about eight months ago, have lost 60 Lbs. and fee better than I have in years. During the years I took statins I went up to 241 lbs and I am only 5'8". Yes I became obese. Just two days ago I reached my initial goal of 180 lbs. I am taking a short break and then will try to take off another 10 lbs. I took statins for 8 years and it was killing me, so I made the decision that if I was going to die, I wanted it to be on my own terms. After about six months on a strict Ketogenic diet my overall Cholesterol shot up to 244 from about 150 while I was on Statins. I am 73 and now ride my bicycle 20 miles twice a week and walk at our local park and do some exercise with weights. also while on statins, I was diagnosed with "non-diabetic" Peripheral Neuropathy in my feet, (it felt as if my nerves were being destroyed) as well as Stucco Keratosis on my arms and legs. Now that I have stopped taking statins for the last 8 months both have just about disappeared. After watching two of your videos I know that I made the correct decision to save my own life regardless of what my Cardiologist wishes or believes !!! Keep up the good work my friend, you are doing a great service to those of us who want to know the truth.
Fear is used by doctors to pharma to sell their pills. It's like where ever fire was there you find Fire Brigade personnel & researches conclude they are responsible for every fire for they were at the scene. Instead of taking care of the causes they want to treat symptoms, the same way instead of treating whole body, mind & soul together they treat humans as metal machines which are fixed with part change or repair. I've personally seen people who took Omega 3 fat had every lipid test with results as normal, BP & Diabetes too will come down with diet & exercise, but money pharma can't make if all people follow this regimen.
BRING DAVE BACK!!! Also, would love to get involved as a test subject or in any other capacity (former MT, current oncology researcher here). Maybe get going on a sample bank?
31:32 - "Cholesterol is not the driver, cholesterol is the passenger..." 40:21 - Without the damage to the vessel wall in terms of inflammation, you can have cholesterol that doesn't offload"... LDL particles are not just the "passenger." The actual atheroma is made up of mostly cholesterol. Serum cholesterol is not just a biomarker but actually causes inflammation. To reduce plaque and heart attacks, reduce LDL itself. "serum cholesterol rose in proportion to the total fat intake (r = 0.67) and even more strikingly in proportion to the intake of saturated fatty acids (r = 0.87). Fatal coronary events rose in proportion to the serum cholesterol level (r = 0.80). At the two extremes, serum cholesterol varied from a mean of 165 mg/dl in the Japanese fishermen to 270 mg/dl in the East Finnish foresters. This difference was accompanied by a 13-fold higher incidence of coronary events in the East Finnish. The other 14 cohorts lay more or less on a line relating dietary saturated fat intake and serum cholesterol. Although certain deviations from this line have been proposed to contradict Keys’ conclusion, it is likely that the deviations reflect local environmental or genetic factors that modify the relation between fat intake, serum cholesterol, and heart attacks in specific populations. However, they do not negate Keys’ general conclusion that high fat intake leads to high cholesterol and to heart attacks." (Goldstein & Brown, 2015, para. 11). References Goldstein, J. L., & Brown, M. S. (2015). A century of cholesterol and coronaries: from plaques to genes to statins. Cell, 161(1), 161-172. www.sciencedirect.com/science/article/pii/S0092867415000793
"Confounding variables?" No. "Association is not causation." Nobody said otherwise. Off topic strawman argument attempt noted. Nobody is challenging the fact that high fat intake increases serum cholesterol. Please address the specific point in the last sentence, supported by the entirety of the preceding sentences I quoted from Goldstein and Brown (the Nobel winners and discoverers of LDL receptors). Can you guess what intervention is routinely used to raise serum cholesterol in all animal studies on diet and detrimental effects of elevated serum cholesterol? If you guessed dietary saturated fat, you are correct. It isn't sugar. It isn't refined wheat, it is saturated fat and when it is combined with dietary cholesterol (within animal products), this amplifies the critical strain on LDL receptors in the field. If dietary cholesterol was not helpful to omit in a healthy diet, cardiologists would be urging their patients to avoid blueberries, blackberries, and soluble fiber in general. Get with the program. "Especially true for complex systems." Especially true for complex systems - such as health risks of diseases of affluence is the fact that there are multiple causes, contributing or composite causes, precipitating causes, underlying causes, not a single causal factor. In fact, no other variable besides cholesterol has been implicated more or has had more evidence to support the roles in acquiring atherosclerosis. Moreover, cholesterol is being studied increasingly for it's role in elevated cancer risk.
At lot of specious rambling for a person who has no idea if the Finnish study, for example, was thorough in designing a multivariate analysis. Even when the attempt is made to control for confounding variables, the fact that our collective understanding of the metabolism (including epigenetics, genetic polymorphisms, and the microbiome) is still at a very crude level inherently sets up superficial analyses. That's complexity and if you had formally studied medical science paradigms such as oncology, immunology, or neurology for years then you might have an inkling of what complex systems look like.
"At lot of specious rambling for a person who has no idea if the Finnish study, for example, was thorough in designing a multivariate analysis" A lot of bland denial of the lipid hypothesis and 50 years of available evidence, off-topic strawman attempts, mind-wandering speculation, and unanswered questions on your part, considering the fact that there is more evidence linking dietary saturated fat to atherosclerosis and you present no evidence of any type to contest this fact. "Even when the attempt is made to control for confounding variables, the fact that our collective understanding of the metabolism (including epigenetics, genetic polymorphisms, and the microbiome)" Now that you've given up on the subject, you bring up another problem with the aberrant diet of animal fat" The argument you are now faced with is that meat causes heart disease by multiple mechanisms of action and cholesterol is implicated not just in HD but cancer, as well. A meta-analysis summarizes nothing new. "Our results suggest that vegetarians have a significantly lower ischemic heart disease mortality (29%) and overall cancer incidence (18%) than nonvegetarians" Ann Nutr Metab. 2012;60(4):233-40. Microbes in gastrointestinal health and disease. Gastroenterology 2009;136:65-80. Backhed F: Host responses to the human microbiome. Nutr Rev 2012;70 Suppl 1:S14-17. Koeth RA, Wang Z, Levison BS, et al: Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med 2013. There's numerous mechanisms of action by which meat causes HD, Ca, AD, etc... Notice vegans also metabolize chol more effectively. "Remnant removal from circulation, estimated by cholesteryl oleate FCR was faster in vegans, but the lipolysis process, estimated by triglyceride FCR was equal. Increased removal of atherogenic remnants and diminution of cholesteryl ester transfer may favor atherosclerosis prevention by vegan diet" PMID: 21937206 Together, these data indicate that hypercholesterolemia may be responsible for a premature increase of oxidative stress and in turn CD40L up-regulation, thereby contributing to early atherosclerosis. Journal of the American College of Cardiology Volume 49, Issue 19, 15 May 2007, Pages 1974-1981 Early Increase of Oxidative Stress and Soluble CD40L in Children With Hypercholesterolemia www.sciencedirect.com/science/article/pii/S073 "you might have an inkling of what complex systems look like." Off topic. You repeated yourself, again. Nobody said that the difficulty humans have metabolizing dietary saturated fat, cholesterol, and atherosclerosis were not complex systems for humans. My point is precisely that it is more difficult for herbivores and frugivores to digest dietary saturated fat and cholesterol. This is precisely why true carnivores do not get atheroslcerosis but humans do.
Given up? LOL. Not on reasoned analysis. You're all over the map with off the charts mania. We're not going to find common ground. Best of luck with your dietary and lifestyle strategies.
@@stevenw4549 doctors tend to be childish because if we are too serious we explode from stress, i completely understand zdogg. i think he´s just trying to help people and got excited and, as far as i can tell dave wasn't bothered with the interruptions, either way take a chill pill y'all
Changes everything, validates huge rabbit hole of truth.... love the scientific retroduction. There’s a ton of information here to change and heal many bodies. Good work.
Haven't finish watching but this makes sense because my 30 year old son who eats lots of fatty foods had his cholesterol checked & everything was normal . Whereas I try to eat lean healthy meats in small portions & my LOL is bad.
My experience within the Clinical or Medical Laborstory is: everyone measures lipids, fee measure critical inflammation markers. Therefore there is a bias in correlating clinical evidence with above or below normal values of lipids. It is important but it is very interesting to see this clinical approach viewing all as a system.
This,along with several other things i have rEAD THIS WEEKEND,HAS MADE ME FEEL SO MUCH BETTER! Sorry for the poor and uncorrected typing.I am a nurse and also an Idiopathic vfib arrest,cardiogenic shock requiring ECMO/Impella and 25 day hospital stay survivor.I was morbidly obese at the time,but had a totally clean heart cath. I have had an extensive still negative workup of this arrest.I still knew I needed to make a change or i was going to become diabetic and hypertensive etc... I have had one gyne tell me I had PCOS. My husband is also type 2 d.m. His A1C was 11.2 and hadnt been under 9 in 12 years at that point. Al things totalled, it was time to flip the script before one of us ended up back in the ICU.. So in February of this year ,I started keto and the hubby went low carb(free feeding low carb,not tracking.) I have lost 56 lbs since starting keto,and about 3 mos ago I started doing HIIT classes 3x/week. I love them! I am going to keep pushing forward with this healthy lifestyle.Thursday I had my first lipid profile done since June of 2017. My total cholesterol went from 175-219,My hdl went from 38-47,my triglycerides went from 179-92,my hdl went from 102-153.6. My doc is nervous about this. He asked me to consult with my cardiologist when I see her next month,about whether I need to add a lipid med. I will talk to the cardiologist about my LDL, but I cannot even entertain the idea of starting a statin. I hope she will be amenable to working with me ,but I know I don't need one. This video is very helpful information and along with several other sources I have read thru this weekend, I think i now also will not fast for my next blood draw and see what that looks like. I have shed 3 more lbs this last couple of weeks so I suspect this is all playing into it all. The big thing too,for me, is clearing up in my own head,the resurgence of the fat phobia.It was trying to crop back up . I am going to stay the course ,and try to convince my docs to work with me on this, THank you all for sharing this,it makes so much more sense.
Hi - I am fighting the same battle with my "Functional M.D." So sad that many physicians are not tuned in to Keto diets. I almost gave it up, until I heard Dave Feldman's explanation. Bless you Dave, keep sharing and perhaps more doctors will become educated. Meanwhile, we must not give up on Keto but share Dave's website cholesterolcode.com to help educate our health professionals.
So to bring my ldl cholesterol down and hdl up, I just need to do keto diet? Is that what they’re saying? I’ve watched for about an hour and am still confused about what to do or what anything might indicate
@@charlenequiram1145 It's absolutely horrible that doctors want to immediately put you on statins based on your LDL-C, without even ordering a particle test.
I was stuck with my vegan friends, snowed in, found a cabin in the woods for a week. Food available were 2 ten lbs bags each of organic long grain rice and organic black beans ( about $46 total from Cosco) We had back packs of fresh and dried org fruits for energy, we always do. Weather turned and we found the cabin which obviously belonged to a vegan snow athlete. ( We also found several glass jars of dried mushrooms and spouted pumkin seeds with a note : "If you needed refuge from the weather, help yourself". We ate rice and beans and mushrooms for a week with our fruit. We all lost weight in our midsection, felt fitter and more firm, muscles rock hard and defines Even those without abs showed abs, slept like babies, non of us got sick from the freezing cold also inside ( no heat) non of us lost muscle or got depressed. Actually we all felt happier and healthier then ever. VEGAN FOR LIFE. Everyone stayed vegan. This was 2012. We're all still Daredevil, extreme althletes, even older we experience no more pain or recovery periods. #Vegan #Plamtbased
This helps SO much! Just stated Low Carb/High Fat eating plan. Cholesterol almost doubled to 256 and LDL at 176.....but my Triglycerides LOWEST in my life!! at 66. A1C to 5.6 from 5.6, This gives me great data to show my MD who will spaz over my lipid profile. BTW, I DID fast the day or two before my blood draw!!!
Dave, do you have any thoughts on a keto diet focused on poly and monounsaturated fats while minimizing saturated fats? I've been on keto for a few months now with grapeseed, avocado, and olive oils making up the majority of my caloric intake.
I'm a hyper-responder (33 tryglycerides, 133 HDL, 160 LDL) so it's nice to hear this and relax because I said HELL no to the statin she recommended. Also I had my test 2 days after running a 1/2 marathon, which would naturally elevate the levels due to the muscle repairs going on!
So... When we fast for lab work at our yearly physicals, we are unintentionally increasing our ldl markers and therefore we should start doing labs not fasting and fasting to contrast and compare. Am I correct?
No. What you want to know is what your fasting triglycerides measure. Look up what the problem with fasting triglycerides is. These indicate absolute metabolic issues. Don’t know if they get to this in the clip.
Common Zdogg, you’re the man, but please get a registered dietitian on the show to discuss nutrition-related topics in the future. We literally spend 6 years focusing on metabolism, medical nutrition therapy and pathophysiology, and RDs are typically overlooked and not consulted for nutrition-related diseases. I have seen countless patients with DM and CKD that have NEVER been referred to a dietitian for meal planning and counseling. USE YOUR RESOURCES!! Honestly, you asking a software engineer to discuss this is a bit of a slap in the face, even though I found his information quite interesting haha :)
They mentioned the study about very young soldiers dying in the Korean war who were found to have atherosclerosis on autopsy. If I'm not mistaken, in that study the American soldiers were found to have atherosclerosis while the Korean soldiers did not. Is that right? Anybody?
So are they saying that you can have a high LDL in your blood but not necessarily deposits of cholesterol in your arteries? I have been eating a low-carb moderate healthy fats and protein coupled with stress reduction weight bearing exercise and some aerobic type activity including yoga at least two to three times per week. My recent lab work showed a high HDL and the highest LDL I've ever had however my triglycerides were super low. I was initially concerned but still trying to figure it out.
I thought it was very interesting and informative. I enjoyed the kidding around and light humor, it was that much. This was a tough subject to understand, he made it very easy to understand. Great job guys.
My cholesterol numbers: HDL- 78 LDL- 252 Triglycerides- 78 I'm 16 and I discussed this with several doctor. One doctor said that keto diet works for adults, but for teens no. She specifically said since the research done on hyper-responders is of adult population, then it doesn't apply to teens. It doesn't make much sense what she is saying because LDL has the same function with me as with an adult. I would like to understand whether LDL cholesterol levels and young age have any risk for early CVD.
You must make it a point to go see a functional medicine doctor your standard practitioner will not lead you down the right path they do not have the background or information and often are resistant to models which challenge their traditional medical school training.
My total cholesterol is often cray low such as 120s. My HDL is regularly 65-72. We have a lot of depression and suicide in my family, and I look forward to future studies into the links between erratic behavior (completed suicides) and very low cholesterol.
i did the same - keto diet for 4 months, felt amazingly good, mentally and physically. total cholesterol 300 and ldl very high. im gonna wait 3 months and get it checked again.
This is great info. I always wondered how useful the 1 x per year lipid panel was. Also heard a show years ago on WBAI Pacifica with Dr. Majid Ali who was explaining what the different lipoproteins were and that they were actually the same but I wasn't sure I understood him. Dave really cleared this up.
I think Dave had fun with them,I certainly enjoyed it. I actually got a lot of information in this interview where I usually end up spacing out,they had my total attention.
46 year old male 5 ft 9 last febuary weighed 230 now 180 or a little less,exercise and lift weights 3 to 5 days a week.I have no idea what my cholesterol was before but now it's high total-388,hdl-54,triglycerides-115,ldl-308.ldl pattern A.Am i ok or fixing to kick the bucket?
Guy Clark I agree with you ! I’m watching my mother in law fade away mentally due to being on Lipitor for the last 20 years while eating the standard American diet disguised as an effective diet for diabetic health. Not one doctor told her to change her diet and rid herself of diabetes, they just added pill after pill and now she’s a shell of her former self.
My diet is whole food and my macros are P=40% F=40% C=20%. Last year my Cholesterol was 339 and my GP wanted me on Statins, I passed on that. But last week, my blood test showed 384 on my Cholesterol. Getting confused because my HDL went way up and my Trigs have gone way down...big time really. My BMI is 24.....any thoughts on this ? Also down another 15 lbs this year and I feel like Superman at 56. I could be a Hiperresponder.....any thoughts on this ? Great video again, Thank you
My Cholesterol is now down to 135 after a week in the Hospital for a stroke and another stent. High Fat does not work for me. Plus a have a bypass surgery in 3 months. High fat almost killed me.
Interesting theories. I definitely agree that the story is deeper that what we've learned so far, Lp(a), TMAO etc. but everything here is still pretty theoretical. There's a lot more than just Framingham to back up the risk of high LDL. I just want to know ZDogg; what do you tell your patients with an LDL of 190?
Indeed -- one of the first pieces I found early on was on high cholesterol with anorexia. Which, again, makes mechanistic sense. This is likewise seen in what I mention in the video as Lean Mass Hyper-responders. Less adipose (stored fat on the body) necessitates more low density lipoprotein trafficking for needed energy (triglycerides). cholesterolcode.com/are-you-a-lean-mass-hyper-responder/
I'm a plastics/processing engineer myself and completely agree with the control group study and the OCD that would go along with the group I'm studying just because in a statistics stand form variables play the biggest role and knocking out anyone who might be lying or cheating slightly and using cognitive dissonance to play along would be my biggest worry
Yep -- it's strange to me how often medical professionals don't see this as a likely issue in a study. And thus, this is why I have a problem nutrition studies in general. Too many broad, categorical conclusions made about a single variable when often dozens to even hundreds of variables are not being controlled for.
Because all the people using your protocol never did a single cheat day or done things abit differently, despite the diet itself being unusual and unsustainable?
I am trained as a massage therapist and my husband has worked in IT networks and software engineering. We find lots of connections to how many things our respective subjects have in common.
I am looking at everything David has to say. Very informative. ZDoggMD, Maybe you could invite Hannah Yoseph to the show. She is the author of the book: How Statin Drugs really work ~ and kill you one cell at a time.
I got "deadly" levels of total cholesterol (359). I should have been dead a year ago. Instead, I feel way better than 10 years ago when I considered it to be my apex years.
My triglycerides are over 5 hundred,run 2 miles don't feel any pain,when done with 2 miles i feel that not enough and go for 1 more mile.i am over 50 and feel like never before
If you have had this for 10 years then why don't you get an angiogram done and make it a medical record for Plant Based Diet doctors like Esselstyn, Neal Bernard, McDougall, etc eat dirt
triglycerides are other thing and they are dangerous do not get confuse with cholesterol and do not have symptoms or you will feel bad when you run or exercise
Cool stuff. If these ideas were extended to patients with Anorexia Nervosa it might explain some of the hypercholesterolemia we see. Interestingly enough, many patients with AN are also on very low-fat diets. Obviously, there is a lot more going on physiologically by that point, but it could very well be a contributor. I honestly hope more research is done on cholesterol.
This is super interesting! Two questions are lingering for me: 1) How does the fact that atheromas tend to form in certain locations (certainly coronary arteries, carotid artery, etc), fit into this discussion? 2) Mechanistm-wise, so this means people with familial hyper cholesterolemia basically have an exaggerated vascular damage response?
Atheroma's form throughout the body not just certain locations. That's the reason people with heart disease have cold hands and feet, high blood pressure, don't hear as well, don't smell as well and have erectile dysfunction. In fact most if not all chronic disease is a result of poor oxygenated blood flow to various organs of the body.
@@cutabove9046 But it seems like they have tendencies to form in certain locations. With heart attacks, the LAD artery is most commonly affected, why is that? Also atheromas in the carotid arteries, renal arteries, etc. I never hear about atheromas in the hepatic or splenic arteries for example. But it could be that maybe these just don't cause morbidity (esp compared to MIs or strokes). Either way, I'm just curious to know the dynamics of these lesions throughout a person's life.
@@chocoman3233 The pressures that cause the damage are highest near the heart and major organs. However, long before you'll see the consequences to the major organs the smaller arteries feeding the hands and feet show up long before. People simply don't realize that cold hands and feet aren't a symptom of a warm heart. It's a symptom of heart or more accurately arterial disease. Oh, the damage starts first at junctions where blood flow splits off because the pressures and swirling are highest at those points.
@@cutabove9046 Ahhhh I see I see. Thank you. Maybe also some eddie currents make things more likely to deposit and damage the vessels? You sound like you are familiar with the atherosclerosis literature. Anything about how to clear atheromas (over time), if possible?
I read some where that people who die and could not eat before they died have very high levels of cholesterol in their bodies. Is that rue? If it is then eating high fat does not cause the body to have high cholesterol, right?
So wait a minute.... Does this lead to: 1. Fasting before a LDL test will spike your LDL level 2. Your LDL will be high and your GP will prescribe you statins.. Oh my...
this is dangerous to claim factually... the body has a fasting and a fed state and people on keto are on fasting state, you could claim that this behavior is true for keto, but in fed-state people the video doesn't provide info because the study was focused on keto only patients, which is a selection bias. the difference is huge because the fed state has completely different hormonal levels. TL;DR you are right, but only in ketogenic diet patients, we dont know if everyone else will be too.
I have had "high" readings of LGL and HDL cholesterol at my last physical and I intermittent fast. I have only started having these readings since since I started following a IF and Ketogenic lifestyle 4 years ago.
I would consider coronary calcium scores or intima thickness as part of a good test. Con these tests be added to his research? Some feel that high blood sugars glyvosolate or denature endothelial tissue leading to vessel damage. We have all seen diabetics with excellent distal pulses and horrible foot ulcers.
I think we obviously have to look at multiple factors, and it also needs to be studied over time. Clearly, I consider it a good sign my CIMT, CAC, heart CT, etc appear to be excellent after 2.5 years on this diet, but I don't claim this is Bro Science Proof -- it's just as much a baseline and I need to report it if it changes for better or for worse. I don't take too much comfort in any single metric or with any snapshot in time.
Gee wow it’s like maybe we shouldn’t force health choices on our fellow citizens because we are constantly learning no matter how long a topic is studied
not once did they mention BHB from being keto which I feel is one of the number one reasons to go keto! Energy is everything in life and the type of energy you get from BHB is over the top compared to spiking insulin getting energy from glucose
Excellent point, Jean. To be sure, we covered so much we just didn't quite get around to that. But FWIW, on an ATP-to-ATP basis, your cells are arguably powered more by fatty acids directly (brought by LDL as TG, or NEFAs) when on a keto diet than BHB (which are disproportionately taken up by the brain since they can cross the blood-brain barrier). Certainly, I spend more time on the lipid side of the fence, but the benefits of ketones, especially for the brain, are well documented in the keto community.
the only problem with the video was that there is an overwhelming majority of the audience out there that doesn't know what you guys are talking about with all the fancy words , even glucose ,glycogen ,carbs,sugar ext... there is a quote" if you can't teach it to a second grader you don't know it yourself " I say skip all the fancy talk, get out to the general public, that high healthy fat diets with 40 carbs/ sugar or less per day mainly coming from green veggies with lots of high fat,like avacodo, olive oil,mct oil,coconut oil,Kerry gold butter,grass-fed beef, and pasteurized eggs ext is healthy!
Fair point, Jean -- but it was hard to avoid when getting into the specifics on the topic. As far as a LCHF/Keto diet in general, there are plenty of better people than myself who make great videos on the topic. And I may actually return to ZDogg's show at some point in the future to give my own intro to the diet, in which case we likely will be avoiding the much larger words. :)
Dave, this interview with Dr. Damania changed my life. Sure some items discussed went a bit more technical than I could comprehend on first listen, but that pushed me to... :::gasp::: do some research and learn the details for myself. And I'm not sure how a 2nd grader could understand everything you covered if PhDs are still having a hard time grasping it (though your recent breakdown at Low Car Breck (ruclips.net/video/0LuKwsz9Woc/видео.html) was great at helping simplify the concepts). Keep up the good work, Dave!
jean paul fox Biologist here, the information is there to influence research: go read scientific papers and be careful of who funded what, understand placebo effects, etc.
So, did Dr. Z participate in the exercise and track his eating and then doubling it, with blood testing? What were his results, if so? Greetings from NYC!
My cholesterol over the past 15 years has always been about 200-210 with LDL being 140 and HDL @ 30, then I decided to go on the ketogenic diet and being very strict for 6 months, my cholesterol shot right up Total @ 285 and LDL 210 and HDL @ 32. I guess it doesn't suite me.
That explains my high LDL count on my annual lipid panel. . My score for years was 212-230 total cholesterol. I would reduce my fat intake a couple of weeks before the test in order to try and lower it for test day. Fortunately my HDL was on higher end and my Trigs were in normal range. Because I have a family history of Alzheimer’s, I read Wheat Brain and immediately went low carb (less than 50 grms). Then I sought out info on RUclips and that is where I discovered Keto. This started in September, I quickly lost 25lbs. Can’t wait for my lipid panel this April.
@ZDoggMD, at 49min. you talk about a weird reaction in the chest . I had something similar when starting keto, and used the have it sometimes when just not having had a meal for some time (before I tried keto). Any idea what causes that? I assumed it was was organs screaming 'give me sugar!' :). It usually was ok again after eating something. But it feels very different from just being hungry. Anyway, it went away after some weeks and now can skip a meal without any negative effect.
I strongly advise those of you , who got fed up with the too many interruptions and other frustrations in this video , to follow the link to Dave Feldman's website , and also here on RUclips , he does have his own channel. I have not checked yet, but bet there's a Facebook group that helps those with the same mindset that Dave Feldman, has , want to learn more , receive support, and more. At least for me, I got a first time introduction to Dave Feldman, and if for nothing else that was the most important and valuable piece.
Pathogenic pathway for CVD is well known at this point, but I'm not convinced highly elevated LDLc is not a risk factor. It's clearly not the primary risk factor compared to other, such as chronic inflammation, oxidative stress, elevated glucose, etc.
The information about how our amazing bodies function is tremendous. I have been living a low carb life for nearly a year. I have lost 40 lbs and feel better than I have for years. I do have one issue guys, there is no way I can believe that the marvelous design that is our body did not have a Designer.
Thank the creator, the best engineer ever. He did all the initial build in 6 days and a reproduction system to boot. Of course we have no knowledge of how long his day was. Perhaps a minute or 2 or... 6 earth revolutions, then he rested after engineering everything, including earth and the heavens..
In everything I’ve learned over the last two years, sugar (and the ensuing insulin spike) causes inflammation on the inside of the vessels so the small density LDLs can stick, kind of like velcro. That’s why I don’t use real sugar anymore. Monk fruit and stevia only. Carbs per say aren’t the enemy (non starchy veggies) I’m so glad that this information is being broadcast! I’m trying to get my husband to get his doctor to understand this!! I’ve heard someone refer to the liver as “the soccer mom” of all the organs!!
Could it be that when people are septic, that the LDL is being used as filler to fill holes in the epithelial walls? So there is a drop in the LDL because it’s being used for fixing ?
Like to see this one redone with a more chill tone so I could share with my professional friends and more in the "weeds" details and less repetition of details that pros should know anyway. Great stuff.
Thanks Dave, have you come across Nathan Pritikin, I wonder if the results on his dietary program would be opposite of Keto. I still believe MI's are common with too much high fat cholesterol and lack of exercise as both of my grandfathers passed at 59/69 from this, they weren't smokers either. However when their brothers live to 90 I don't think it's genetic..
I seem to feel terrible the higher my LDL cholesterol is, it's like a general sense of tiredness combined with something I'm not sure of... shaking, trembling am I working up to a seizure? I do have anxiety but it seems to go up with my LDL. What I do know is anxiety meds combined with statin basically makes me a zombie. On a keto diet, getting tired of salmon it's starting to feel dry. Gonna get some macadamia nuts for the omega 7. Might switch to almonds and peanuts if I decide to take a break from salmon (still need proteins and macadamia nuts are pretty low in protein per calorie). One thing is for sure I don't want to be on statin or sedatives for the rest of my life, and carbs is difficult because it leaves me light headed shortly afterwards.
I used to "study" for a cholesterol test. I would eat oatmeal for breakfast, vegetables for lunch, and a regular dinner. I did this 2 weeks before my cholesterol test and all my numbers were good. If I didn't do this, my cholesterol numbers were bad.
Here is what doctors believe in -- not getting sued; prescribing exactly what all the other doctors are prescribing which is relayed to them by drug reps (and it's always the latest drug on the market);prescribing only what that patient's insurance will cover so they are not called upon to argue with the insurance company for waivers. And by the way they can't be sued for damaging your health as long as they followed standard practices (again, dictated by the drug companies and insurance companies including medicare). And, finally, doctors know virtually nothing about what these guys are talking about. They are clinicians -- listen for an actionable "complaint" and prescribe for that specific complaint. Period. No longer are doctors diagnosticians. Again labelling someone with any specific condition other than what is obvious from a test result can change a person's life -- career, ability to get insurance, etc. which someone may sue a doctor for but if the doctor fails to diagnose except for what tests say they are protected. Clinical practice lags behind absolute, irrefutable knowledge from medical researchers they say an average of TWENTY years! That estimate comes from the medical industrial complex self evaluation. Look at stents for a great example. Debunked well over a decade ago by medical research, mainstream,, done more every year because doctors like doing them. Robots and AI will replace doctors because their jobs have been reduced to nothing more than what a machine will do better. That said, your idea is a good one but medical researchers, insurance companies and drug companies should make up the panel since they are driving the bus. Pease and good health.
What would we do without guys like this, you often wonder if eating, LCHF is the right thing, most of us try to read up on stuff, but mainly we go on blind faith. for me on the starch diet, my cholesterol went up. on LCHF it is still up but my LDL has plumeted, exactly what he is saying here.
Great video for me. Dave I am just wondering a lot about this. I have been LCHF for 8 months and my A1C has drop from 13 to 6.2 BUT... my cholesterol has skyrocketed (TC 388 LDL 287 and by HDL has gone up to 81 with Triglycerides at 99. Doctor is freaking and wants 80mg Lipitor stat. I also did a CAC and the score knocked me over 880! I am 68, feel great - but the numbers are scaring me. Next week I will do a Cardio Stress test to see how that goes. Not over weight - in fact I am now at my college weight having lost 27 lbs on LCHF. MD suggested get off the LCHF but I only eat once or twice a day now and am very satiated - no need to change what feels good. On Vegan I always felt hungry. I'm sure ZDog will fall over with my numbers but is there anything else I can do and avoid statins (I know you don't give medical advice - but just an opinion would help. Thanks for your great work.
beanwinker Yes -- this does not constitute medical advice, I'm just reporting my research to date. Your numbers are actually very similar to mine, which is typical of a Lean Mass Hyper-responder ( cholesterolcode.com/are-you-a-lean-mass-hyper-responder/ ). The irony is -- as my research is bringing light to -- the leaner and/or athletic you are, the higher your LDL-C/-P will likely be on LCHF/Keto. But this makes mechanistic sense ( please also see my Simple Guide series here: cholesterolcode.com/a-simple-guide-to-cholesterol-on-low-carb/ ). You're trafficking more energy from fat (fatty acids bundled as triglycerides) relative to someone on a carb-centric diet. As I mention in the video, I don't claim to have certainty LDL-C/-P is not an independently causative agent for atherosclerosis -- I just find the case impressively weak. There are several articles on my site that dig into this, particularly with the data my experiments are bringing to light. Moreover, I have several LCHF hyper-responders like myself who I monitor the labs of and they have extremely low markers for inflammation, post-cardiac enzymes, and CIMT progression to name just a few. I'm sorry to hear about your CAC score. Although to be sure, it is unlikely that was developed in 8 months of a keto diet as you'll see while researching this topic -- which I highly recommend. Progression of this score is arguably far more relevant than the score itself. If you've been on a standard American diet most of your life, your score isn't that unlikely given your age, but is certainly something to take seriously. Whether you stayed low carb or not, I'd definitely recommend being more proactive about reducing inflammation and oxidative stress.
Thanks so much Dave. I agree that it was the SAD diet and being convinced that low fat high carb was correct. Thanks also for the advice on reducing inflammation - full focus now. Will be spending the evening reading your material with gratitude for what you are doing!
Hi Richard-- I could certainly understand your concern for bad medical advice on the internet, I'm sure we both see quite a lot. But to be sure, I think I've answered each of your issues in the original comment above: - Your concern I'm insisting LCHF is appropriate and blood/imaging is fine is actually the opposite of what I said. ^^^ *"As I mention in the video, I don't claim to have certainty LDL-C/-P is not an independently causative agent for atherosclerosis -- I just find the case impressively weak."* ^^^ and *"Whether you stayed low carb or not, I'd definitely recommend being more proactive about reducing inflammation and oxidative stress."* - Now conversely, you do realize why this new data is extremely relevant. If a short window of a few days can have such a strong inverse relationship to resulting LDL-C, then all studies that didn't tightly control for the participants' dietary intake before the blood draw are missing the biggest confounder. Not just the composition of the diet in terms of macros, but the total quantity (particularly dietary fat).
Hi Richard -- I think you're more interested in a reddit-style dialog than I am. I'm not as much of a fan insisting certain statements and phrases be made a certain way or the other side can fill in a different definition for them. Of course when I speak of "inflammation" I'm speaking of chronic inflammation in the context of cardiac concerns. You, myself, and beanwinker know I wasn't talking about acute inflammation from something like twisted ankles. And if he or you were uncertain, they could have asked for clarification. I tried in the previous comment to further emphasize what I was saying instead of your interpretation of it, in case it was a genuine misreading. But we both know I'm not telling anyone to drink green tea. And if you thought I was, you could simply ask, "Dave, are you making dietary recommendations instead of having someone consult a doctor?" To which I'd insist that no, I wasn't doing either one. (See original statements) If you want to make more comments insisting I'm saying something I haven't said, or imply something outlandish we can be intellectually honest about instead, I'd prefer to pass on this dialog. But if you'd like to know my opinions or prefer further clarification in a respectful manner, I'm interested.
@Dave Feldman - I most certainly understood what you were sayin with no expectation of medical or dietary advice. I respect your work and am gathering as much information as I can to formulate a lifestyle plan that keeps me alive. Of course I am going to see a cardiologist as well as have testing done and follow up. I asked you for information and not Richard Tang. Any presumption on his part that you are misleading me is false.
The triglyceride to HDL ratio is the stronger predictor of heart disease, much more so than “just” high cholesterol and LDL/HDL ratios. It is important to understand there are other predictors and not just “high” cholesterol that indicate a potential problem.
yes I want him to come back! So glad to see you address this! I’m a nurse been doing Keto- lost 120 pounds off 7 meds and have never felt better. It’s absolutely saved my life-and I was a non-believer and thought why not try it for a month. Have never quit !
Z dogg makes it very pretty clear on the front end that he is an entertainer, the first clue being that he goes by Z Dogg. If you'd prefer a more dead panned exploration of the material, both Peter Atila and Chris Kesser have hours and hours of material on cholesterol/ lipidology.
As a nurse I want to say it’s always cool that you acknowledge that we exist when you have these conversations. Thank you. I also find that lower carbs and higher protein allow me to perform my best and feel my best with my training. Nothing too crazy, around 100g of carbs makes a big difference for me.
beingL .. You are a nurse.. So why would you not talk about your fat intake? This is where the problem lies. Keto or Fat burning is Fat and Cholesterol as your energy source...and why the most Keto experts have it all wrong, If you think protein is how you do this... Protein burning is Acidosis!! Do your research!
As a ketogenic dietitian and the daughter of engineers, I loved this podcast so much! It’s time to clarify the vital role cholesterol and lipoproteins play in optimal health 🙌👏
Very enlightening. Wow, I keep asking my doc why my cholesterol LDL is going up higher than it’s ever been, despite low carb, lower fat, exercise, losing 30 lbs. she told me it’s probably “familiar” (hereditary) and I should take statins. I’ve been resisting, when I took epidemiology I happen to choose the Framingham study to analyze for my term paper (in 1993) and my take away from that was that it’s conclusions were not based or proved on causation. I understand so much more now. Thanks for this content!
My total cholesterol and HDL have consistently been high for the past 30 years. Doctors have said it’s fine (no statins recommended) because the HDL is so high, highest they’ve seen. I continue to have a pretty high fat intake. Love this podcast 👍
ZDogg would you consider inviting Dr. Jason Fung onto one of these discussions and talk about fasting and its effect on insulin levels?
Fung would be too annoyed with this clown always yelling.
and Dr. Fung believes in a high fat diet, not a vegan diet.
@@spaceghost8995 Who is the clown? The host?
It is SAD that this podcast a year later has only 40k views, when I feel like this is literally life-changing information!
unfortunately the host and his crew are a bunch of jackholes, at least their behavior, language, and ghetto actions in this podcast. Otherwise yes, the guest has some really valuable information to pass along.
I think its because the host is so annoying. Working too hard to be funny?
It's false information, not special undercover truths.
@@allencrider How do you know that? Do you work for Pfizer or Merck?
@@peternct811 do you realize you're listening to people with no education in dietetics? The only reason these two have any views is because they're telling people good things about their bad habits, which in the end is false information.
Ive seen Dave before and love his work. Never have I enjoyed the presentation of Dave, his research and his idea's as I did on your show. FUN, EXCITING & ENTERTAINING! Thanks for making the upload so easy.
I had "dangerously high" cholesterol, blood pressure and triglycerides, despite a lifetime of athletics (Ironman Triathlete) and eating an extremely low-fat, clean "athlete's diet (LFHC). I became a vegetarian for an entire year and it had zero effect. After 6 months of a Paleo/Primal way of eating, all numbers were in the "normal" range. My Doctors were stunned.
opposite happened for me.
Steve F I
Low fat is bad. Low carb is good
Good saturated fat rocks!
becoming vegetarian for an entire year is meaningless because you are eating cheese , milk and dairies . That is animal food.Stupid is as stupid does. You would pay eventually with a cancer down the road.
This research so makes sense!! I have familiar hyperlipidemia. So does my dad and his siblings and most of my cousins. But no one is dropping dead from heart disease young! In fact my dad turns 85 in 2 months. He is the 3rd oldest of 8 and all are living!!!
My doctors always freak out with my cholesterol levels. I did the low fat diet for decades. I was miserable, low energy and had a fatty liver with my cholesterol going up and gaining weight!
I've gone back to adding healthy fats into my diet. I've lost 22 lbs so far and keeping it off. I do not eat any processed foods. I am celiac so no wheat, eye or barley. But I now have flax, almond, coconut and other flours in my diet. I feel so much better!! Yes more energy!
I expect my cholesterol levels to be higher do to genetics and having CRPS. I have had several stress test and no heart disease! Go figure. Bad reaction to statins.
I volunteer to give blood for any study for cholesterol!!!
Love this show!
Since starting the blog, I've had a surprising number of people write to me with stories like yours. Two of them were from immigrant families where they had poor access to healthcare where they came from, yet each generation lived into its 80s and 90s. But once here, it was found half the family had very high cholesterol. Given their original family history, they all refused statins and it didn't change their (already impressive) lifespans.
But it is clearly more complex than this. 50% of people with FH will develop early coronary artery disease, with significant early mortality (~25x early cardiovascular mortality risk). FH is (mostly) a mutation in the LDL receptor, so it should still play a negative role in this model of cholesterol. It is likely that there are lifestyle and other genetic factors at play determining which people with FH have the bad phenotype.
I would agree that the evidence of significant benefit from statins is poor (jaha.ahajournals.org/content/3/6/e001236)
Hi Sherry, I'm glad you are feeling better and I think that is wonderful. I have been into LCHF for several years. I recently ran into the problem of high oxalate in foods that people often start eating when they are trying to be more healthy. I seem a number of these on your list of foods you are eating and thought you might appreciate a heads up about the oxalate. If you want to look into it, here is the webpage I would refer you to. sallyknorton.com Best wishes and good luck.
Christopher McMaster do you have a working link about the statins? I have FH and am on a statin with a fatty liver and am trying to learn more!
Sherry M ㅃ
thanks for this. i am a plant based ketoer. my cholesterol went up after 8 months and MD wanted to put me on Lipitor but i said NO WAY!!
I love the humorous interruptions.
References, very important.
I am a medical lab technician in Guatemala. I would love to try this and upload my data. Regards.
They need to publish this data and change how people evaluate detrimental effects of cholesterol.
This may explain why my LDL and total cholesterol significantly dropped after eating 20 to 40 raw almonds (which are rich in fat) daily. Makes sense.
I stopped taking my statins about eight months ago, have lost 60 Lbs. and fee better than I have in years. During the years I took statins I went up to 241 lbs and I am only 5'8". Yes I became obese. Just two days ago I reached my initial goal of 180 lbs. I am taking a short break and then will try to take off another 10 lbs.
I took statins for 8 years and it was killing me, so I made the decision that if I was going to die, I wanted it to be on my own terms. After about six months on a strict Ketogenic diet my overall Cholesterol shot up to 244 from about 150 while I was on Statins. I am 73 and now ride my bicycle 20 miles twice a week and walk at our local park and do some exercise with weights.
also while on statins, I was diagnosed with "non-diabetic" Peripheral Neuropathy in my feet, (it felt as if my nerves were being destroyed) as well as Stucco Keratosis on my arms and legs. Now that I have stopped taking statins for the last 8 months both have just about disappeared. After watching two of your videos I know that I made the correct decision to save my own life regardless of what my Cardiologist wishes or believes !!! Keep up the good work my friend, you are doing a great service to those of us who want to know the truth.
Fear is used by doctors to pharma to sell their pills. It's like where ever fire was there you find Fire Brigade personnel & researches conclude they are responsible for every fire for they were at the scene.
Instead of taking care of the causes they want to treat symptoms, the same way instead of treating whole body, mind & soul together they treat humans as metal machines which are fixed with part change or repair.
I've personally seen people who took Omega 3 fat had every lipid test with results as normal, BP & Diabetes too will come down with diet & exercise, but money pharma can't make if all people follow this regimen.
@@devdathmdsouza Hi. Ahh, excellent, we seem to forget how heavy hitters Omega-3s can be, especially for inflammation.
Well done!
This is a very convincing story. Best interview I have seen of Dave Feldman. Thanks!
BRING DAVE BACK!!! Also, would love to get involved as a test subject or in any other capacity (former MT, current oncology researcher here). Maybe get going on a sample bank?
31:32 - "Cholesterol is not the driver, cholesterol is the passenger..."
40:21 - Without the damage to the vessel wall in terms of inflammation, you can have cholesterol that doesn't offload"...
LDL particles are not just the "passenger." The actual atheroma is made up of mostly cholesterol. Serum cholesterol is not just a biomarker but actually causes inflammation. To reduce plaque and heart attacks, reduce LDL itself.
"serum cholesterol rose in proportion to the total fat intake (r = 0.67) and even more strikingly in proportion to the intake of saturated fatty acids (r = 0.87). Fatal coronary events rose in proportion to the serum cholesterol level (r = 0.80). At the two extremes, serum cholesterol varied from a mean of 165 mg/dl in the Japanese fishermen to 270 mg/dl in the East Finnish foresters. This difference was accompanied by a 13-fold higher incidence of coronary events in the East Finnish. The other 14 cohorts lay more or less on a line relating dietary saturated fat intake and serum cholesterol. Although certain deviations from this line have been proposed to contradict Keys’ conclusion, it is likely that the deviations reflect local environmental or genetic factors that modify the relation between fat intake, serum cholesterol, and heart attacks in specific populations. However, they do not negate Keys’ general conclusion that high fat intake leads to high cholesterol and to heart attacks." (Goldstein & Brown, 2015, para. 11).
References
Goldstein, J. L., & Brown, M. S. (2015). A century of cholesterol and coronaries: from plaques to genes to statins. Cell, 161(1), 161-172. www.sciencedirect.com/science/article/pii/S0092867415000793
Confounding variables? Association is not causation. Especially true for complex systems.
"Confounding variables?"
No.
"Association is not causation."
Nobody said otherwise. Off topic strawman argument attempt noted. Nobody is challenging the fact that high fat intake increases serum cholesterol. Please address the specific point in the last sentence, supported by the entirety of the preceding sentences I quoted from Goldstein and Brown (the Nobel winners and discoverers of LDL receptors). Can you guess what intervention is routinely used to raise serum cholesterol in all animal studies on diet and detrimental effects of elevated serum cholesterol? If you guessed dietary saturated fat, you are correct. It isn't sugar. It isn't refined wheat, it is saturated fat and when it is combined with dietary cholesterol (within animal products), this amplifies the critical strain on LDL receptors in the field. If dietary cholesterol was not helpful to omit in a healthy diet, cardiologists would be urging their patients to avoid blueberries, blackberries, and soluble fiber in general. Get with the program.
"Especially true for complex systems."
Especially true for complex systems - such as health risks of diseases of affluence is the fact that there are multiple causes, contributing or composite causes, precipitating causes, underlying causes, not a single causal factor. In fact, no other variable besides cholesterol has been implicated more or has had more evidence to support the roles in acquiring atherosclerosis. Moreover, cholesterol is being studied increasingly for it's role in elevated cancer risk.
At lot of specious rambling for a person who has no idea if the Finnish study, for example, was thorough in designing a multivariate analysis. Even when the attempt is made to control for confounding variables, the fact that our collective understanding of the metabolism (including epigenetics, genetic polymorphisms, and the microbiome) is still at a very crude level inherently sets up superficial analyses. That's complexity and if you had formally studied medical science paradigms such as oncology, immunology, or neurology for years then you might have an inkling of what complex systems look like.
"At lot of specious rambling for a person who has no idea if the Finnish study, for example, was thorough in designing a multivariate analysis"
A lot of bland denial of the lipid hypothesis and 50 years of available evidence, off-topic strawman attempts, mind-wandering speculation, and unanswered questions on your part, considering the fact that there is more evidence linking dietary saturated fat to atherosclerosis and you present no evidence of any type to contest this fact.
"Even when the attempt is made to control for confounding variables, the fact that our collective understanding of the metabolism (including epigenetics, genetic polymorphisms, and the microbiome)"
Now that you've given up on the subject, you bring up another problem with the aberrant diet of animal fat"
The argument you are now faced with is that meat causes heart disease by multiple mechanisms of action and cholesterol is implicated not just in HD but cancer, as well. A meta-analysis summarizes nothing new. "Our results suggest that vegetarians have a significantly lower ischemic heart disease mortality (29%) and overall cancer incidence (18%) than nonvegetarians" Ann Nutr Metab. 2012;60(4):233-40.
Microbes in gastrointestinal health and disease. Gastroenterology 2009;136:65-80.
Backhed F: Host responses to the human microbiome. Nutr Rev 2012;70 Suppl 1:S14-17.
Koeth RA, Wang Z, Levison BS, et al: Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med 2013.
There's numerous mechanisms of action by which meat causes HD, Ca, AD, etc... Notice vegans also metabolize chol more effectively. "Remnant removal from circulation, estimated by cholesteryl oleate FCR was faster in vegans, but the lipolysis process, estimated by triglyceride FCR was equal. Increased removal of atherogenic remnants and diminution of cholesteryl ester transfer may favor atherosclerosis prevention by vegan diet" PMID: 21937206
Together, these data indicate that hypercholesterolemia may be responsible for a premature increase of oxidative stress and in turn CD40L up-regulation, thereby contributing to early atherosclerosis. Journal of the American College of Cardiology Volume 49, Issue 19, 15 May 2007, Pages 1974-1981 Early Increase of Oxidative Stress and Soluble CD40L in Children With Hypercholesterolemia www.sciencedirect.com/science/article/pii/S073
"you might have an inkling of what complex systems look like."
Off topic. You repeated yourself, again. Nobody said that the difficulty humans have metabolizing dietary saturated fat, cholesterol, and atherosclerosis were not complex systems for humans. My point is precisely that it is more difficult for herbivores and frugivores to digest dietary saturated fat and cholesterol. This is precisely why true carnivores do not get atheroslcerosis but humans do.
Given up? LOL. Not on reasoned analysis. You're all over the map with off the charts mania. We're not going to find common ground. Best of luck with your dietary and lifestyle strategies.
In spite of interesting and valuable information, the overdramatized reactions and interruptions, are distracting and frustrating. Let the man speak!
Can you give me a example what kind of fat I should eat more higher fat
Howard Sterne....
@@stevenw4549 doctors tend to be childish because if we are too serious we explode from stress, i completely understand zdogg. i think he´s just trying to help people and got excited and, as far as i can tell dave wasn't bothered with the interruptions, either way take a chill pill y'all
@@forerofore Perhaps but just looked stupid to me anyway. Also annoying. Sorry.
Distracting and loses the thread
Changes everything, validates huge rabbit hole of truth.... love the scientific retroduction. There’s a ton of information here to change and heal many bodies. Good work.
Thank You for this. It's the same battle I'm having with my Health Care Provider over high Cholesterol labs. I do not want meds for it.
Thank god for guys like you, we need you nerds.. to promote the correct way!
Haven't finish watching but this makes sense because my 30 year old son who eats lots of fatty foods had his cholesterol checked & everything was normal . Whereas I try to eat lean healthy meats in small portions & my LOL is bad.
LDL
Metabolism reduces with age
My experience within the Clinical or Medical Laborstory is: everyone measures lipids, fee measure critical inflammation markers. Therefore there is a bias in correlating clinical evidence with above or below normal values of lipids. It is important but it is very interesting to see this clinical approach viewing all as a system.
Yellow Paper lol sounds better 😀
This,along with several other things i have rEAD THIS WEEKEND,HAS MADE ME FEEL SO MUCH BETTER! Sorry for the poor and uncorrected typing.I am a nurse and also an Idiopathic vfib arrest,cardiogenic shock requiring ECMO/Impella and 25 day hospital stay survivor.I was morbidly obese at the time,but had a totally clean heart cath. I have had an extensive still negative workup of this arrest.I still knew I needed to make a change or i was going to become diabetic and hypertensive etc... I have had one gyne tell me I had PCOS. My husband is also type 2 d.m. His A1C was 11.2 and hadnt been under 9 in 12 years at that point. Al things totalled, it was time to flip the script before one of us ended up back in the ICU.. So in February of this year ,I started keto and the hubby went low carb(free feeding low carb,not tracking.) I have lost 56 lbs since starting keto,and about 3 mos ago I started doing HIIT classes 3x/week. I love them! I am going to keep pushing forward with this healthy lifestyle.Thursday I had my first lipid profile done since June of 2017. My total cholesterol went from 175-219,My hdl went from 38-47,my triglycerides went from 179-92,my hdl went from 102-153.6. My doc is nervous about this. He asked me to consult with my cardiologist when I see her next month,about whether I need to add a lipid med. I will talk to the cardiologist about my LDL, but I cannot even entertain the idea of starting a statin. I hope she will be amenable to working with me ,but I know I don't need one. This video is very helpful information and along with several other sources I have read thru this weekend, I think i now also will not fast for my next blood draw and see what that looks like. I have shed 3 more lbs this last couple of weeks so I suspect this is all playing into it all. The big thing too,for me, is clearing up in my own head,the resurgence of the fat phobia.It was trying to crop back up . I am going to stay the course ,and try to convince my docs to work with me on this, THank you all for sharing this,it makes so much more sense.
Hi - I am fighting the same battle with my "Functional M.D." So sad that many physicians are not tuned in to Keto diets. I almost gave it up, until I heard Dave Feldman's explanation. Bless you Dave, keep sharing and perhaps more doctors will become educated. Meanwhile, we must not give up on Keto but share Dave's website
cholesterolcode.com to help educate our health professionals.
So to bring my ldl cholesterol down and hdl up, I just need to do keto diet? Is that what they’re saying? I’ve watched for about an hour and am still confused about what to do or what anything might indicate
Dave is the man, also check out Dr Paul Mason if you like to understand the mechanisms causing LDL to become damaged
FreeMocean I love Paul Mason, MD. Used his videos to figure out I’m Pattern A and don’t need Statins.
@@charlenequiram1145 It's absolutely horrible that doctors want to immediately put you on statins based on your LDL-C, without even ordering a particle test.
Love Dr Paul Mason
Does anyone know if the host ever tried the cholesterol test protocol?
Great show, thanks for the info. This explains so much of what I am seeing in my own numbers.
I was stuck with my vegan friends, snowed in, found a cabin in the woods for a week.
Food available were 2 ten lbs bags each of organic long grain rice and organic black beans ( about $46 total from Cosco)
We had back packs of fresh and dried org fruits for energy, we always do. Weather turned and we found the cabin which obviously belonged to a vegan snow athlete. ( We also found several glass jars of dried mushrooms and spouted pumkin seeds with a note : "If you needed refuge from the weather, help yourself".
We ate rice and beans and mushrooms for a week with our fruit.
We all lost weight in our midsection, felt fitter and more firm, muscles rock hard and defines Even those without abs showed abs, slept like babies, non of us got sick from the freezing cold also inside ( no heat) non of us lost muscle or got depressed. Actually we all felt happier and healthier then ever. VEGAN FOR LIFE. Everyone stayed vegan. This was 2012. We're all still Daredevil, extreme althletes, even older we experience no more pain or recovery periods. #Vegan #Plamtbased
Hope this helps someone. Sure helped 9 of us.
This helps SO much! Just stated Low Carb/High Fat eating plan. Cholesterol almost doubled to 256 and LDL at 176.....but my Triglycerides LOWEST in my life!! at 66. A1C to 5.6 from 5.6, This gives me great data to show my MD who will spaz over my lipid profile. BTW, I DID fast the day or two before my blood draw!!!
This was A-MA-ZING! I've been so enlightened and inspired by listening to Dave Feldman's lectures and interviews.
Dave, do you have any thoughts on a keto diet focused on poly and monounsaturated fats while minimizing saturated fats? I've been on keto for a few months now with grapeseed, avocado, and olive oils making up the majority of my caloric intake.
Good Keto IF> way to go.. Omega3 Fish oil. and vit K2 helps reduce plaque. also Measure TG/HDL Ratio is important below 2 lower being good.
I'm a hyper-responder (33 tryglycerides, 133 HDL, 160 LDL) so it's nice to hear this and relax because I said HELL no to the statin she recommended. Also I had my test 2 days after running a 1/2 marathon, which would naturally elevate the levels due to the muscle repairs going on!
Wow, 133 HDLs. Amazing. What protection, Crazy. (you sure?)
So... When we fast for lab work at our yearly physicals, we are unintentionally increasing our ldl markers and therefore we should start doing labs not fasting and fasting to contrast and compare. Am I correct?
No. What you want to know is what your fasting triglycerides measure. Look up what the problem with fasting triglycerides is. These indicate absolute metabolic issues. Don’t know if they get to this in the clip.
Common Zdogg, you’re the man, but please get a registered dietitian on the show to discuss nutrition-related topics in the future. We literally spend 6 years focusing on metabolism, medical nutrition therapy and pathophysiology, and RDs are typically overlooked and not consulted for nutrition-related diseases. I have seen countless patients with DM and CKD that have NEVER been referred to a dietitian for meal planning and counseling. USE YOUR RESOURCES!! Honestly, you asking a software engineer to discuss this is a bit of a slap in the face, even though I found his information quite interesting haha :)
There is different size LDLs right?
Smaller being the worst?
Shasta Fog And the oxidized ones which are generally small cause they been around awhile.
They mentioned the study about very young soldiers dying in the Korean war who were found to have atherosclerosis on autopsy. If I'm not mistaken, in that study the American soldiers were found to have atherosclerosis while the Korean soldiers did not. Is that right? Anybody?
So are they saying that you can have a high LDL in your blood but not necessarily deposits of cholesterol in your arteries? I have been eating a low-carb moderate healthy fats and protein coupled with stress reduction weight bearing exercise and some aerobic type activity including yoga at least two to three times per week. My recent lab work showed a high HDL and the highest LDL I've ever had however my triglycerides were super low. I was initially concerned but still trying to figure it out.
I thought it was very interesting and informative. I enjoyed the kidding around and light humor, it was that much. This was a tough subject to understand, he made it very easy to understand. Great job guys.
I just wish the host could shut up for a minute and let the guest finish a thought
He has gotten a lot better at these recently. Constantly shouting jokes at the background guys is what was irritating me the most
My cholesterol numbers:
HDL- 78
LDL- 252
Triglycerides- 78
I'm 16 and I discussed this with several doctor. One doctor said that keto diet works for adults, but for teens no. She specifically said since the research done on hyper-responders is of adult population, then it doesn't apply to teens. It doesn't make much sense what she is saying because LDL has the same function with me as with an adult.
I would like to understand whether LDL cholesterol levels and young age have any risk for early CVD.
You must make it a point to go see a functional medicine doctor your standard practitioner will not lead you down the right path they do not have the background or information and often are resistant to models which challenge their traditional medical school training.
My total cholesterol is often cray low such as 120s. My HDL is regularly 65-72. We have a lot of depression and suicide in my family, and I look forward to future studies into the links between erratic behavior (completed suicides) and very low cholesterol.
Rebecca Evans check your thyroid
i did the same - keto diet for 4 months, felt amazingly good, mentally and physically. total cholesterol 300 and ldl very high. im gonna wait 3 months and get it checked again.
This is great info. I always wondered how useful the 1 x per year lipid panel was. Also heard a show years ago on WBAI Pacifica with Dr. Majid Ali who was explaining what the different lipoproteins were and that they were actually the same but I wasn't sure I understood him. Dave really cleared this up.
I think Dave had fun with them,I certainly enjoyed it. I actually got a lot of information in this interview where I usually end up spacing out,they had my total attention.
46 year old male 5 ft 9 last febuary weighed 230 now 180 or a little less,exercise and lift weights 3 to 5 days a week.I have no idea what my cholesterol was before but now it's high
total-388,hdl-54,triglycerides-115,ldl-308.ldl pattern A.Am i ok or fixing to kick the bucket?
Doc I feel the increase in Liptitor and decrease in fat diets is leading to increases of Alzheimers....Thoughts?
Guy Clark I agree with you ! I’m watching my mother in law fade away mentally due to being on Lipitor for the last 20 years while eating the standard American diet disguised as an effective diet for diabetic health. Not one doctor told her to change her diet and rid herself of diabetes, they just added pill after pill and now she’s a shell of her former self.
@@umayaswellcallmejesus1489 Because that's what (most) doctors do, push pills.
My diet is whole food and my macros are P=40% F=40% C=20%. Last year my Cholesterol was 339 and my GP wanted me on Statins, I passed on that. But last week, my blood test showed 384 on my Cholesterol. Getting confused because my HDL went way up and my Trigs have gone way down...big time really. My BMI is 24.....any thoughts on this ? Also down another 15 lbs this year and I feel like Superman at 56. I could be a Hiperresponder.....any thoughts on this ? Great video again, Thank you
So when you get labs while loosing weight cholesterol will be more present in your blood. Thus labs will be high.
My Cholesterol is now down to 135 after a week in the Hospital for a stroke and another stent. High Fat does not work for me. Plus a have a bypass surgery in 3 months. High fat almost killed me.
Interesting theories. I definitely agree that the story is deeper that what we've learned so far, Lp(a), TMAO etc. but everything here is still pretty theoretical. There's a lot more than just Framingham to back up the risk of high LDL.
I just want to know ZDogg; what do you tell your patients with an LDL of 190?
Good point
But then why has ldl been discarded by the risk calculators?
His theory could explain high cholesterol levels in patients with eating disorders.
Indeed -- one of the first pieces I found early on was on high cholesterol with anorexia. Which, again, makes mechanistic sense. This is likewise seen in what I mention in the video as Lean Mass Hyper-responders. Less adipose (stored fat on the body) necessitates more low density lipoprotein trafficking for needed energy (triglycerides).
cholesterolcode.com/are-you-a-lean-mass-hyper-responder/
I'm a plastics/processing engineer myself and completely agree with the control group study and the OCD that would go along with the group I'm studying just because in a statistics stand form variables play the biggest role and knocking out anyone who might be lying or cheating slightly and using cognitive dissonance to play along would be my biggest worry
Yep -- it's strange to me how often medical professionals don't see this as a likely issue in a study. And thus, this is why I have a problem nutrition studies in general. Too many broad, categorical conclusions made about a single variable when often dozens to even hundreds of variables are not being controlled for.
Because all the people using your protocol never did a single cheat day or done things abit differently, despite the diet itself being unusual and unsustainable?
I am trained as a massage therapist and my husband has worked in IT networks and software engineering. We find lots of connections to how many things our respective subjects have in common.
I am looking at everything David has to say. Very informative. ZDoggMD, Maybe you could invite Hannah Yoseph to the show. She is the author of the book: How Statin Drugs really work ~ and kill you one cell at a time.
I got "deadly" levels of total cholesterol (359). I should have been dead a year ago. Instead, I feel way better than 10 years ago when I considered it to be my apex years.
My triglycerides are over 5 hundred,run 2 miles don't feel any pain,when done with 2 miles i feel that not enough and go for 1 more mile.i am over 50 and feel like never before
@@dizi2765 Jimmy Fix felt the same too. Do you know who Jimmy Fix was? That could be your destiny .
If you have had this for 10 years then why don't you get an angiogram done and make it a medical record for Plant Based Diet doctors like Esselstyn, Neal Bernard, McDougall, etc eat dirt
triglycerides are other thing and they are dangerous do not get confuse with cholesterol and do not have symptoms or you will feel bad when you run or exercise
ruclips.net/video/vp1TjW28Kto/видео.html
Great show and explaining, I subscribed!
ZDoggMD- 4 years later and you look healthier now! Way to go!
Cool stuff. If these ideas were extended to patients with Anorexia Nervosa it might explain some of the hypercholesterolemia we see. Interestingly enough, many patients with AN are also on very low-fat diets. Obviously, there is a lot more going on physiologically by that point, but it could very well be a contributor. I honestly hope more research is done on cholesterol.
I know it's all lies but the public needs to be set free from this health damaging lie!!🙏💜✌
Do a show on metformin, diabetes, stroke.
Thank you, thank you. This was so informative along with a great deal peace of mind.
This is super interesting! Two questions are lingering for me: 1) How does the fact that atheromas tend to form in certain locations (certainly coronary arteries, carotid artery, etc), fit into this discussion? 2) Mechanistm-wise, so this means people with familial hyper cholesterolemia basically have an exaggerated vascular damage response?
Yes , this needs to be elaborated on.
Well spotted.
Atheroma's form throughout the body not just certain locations. That's the reason people with heart disease have cold hands and feet, high blood pressure, don't hear as well, don't smell as well and have erectile dysfunction. In fact most if not all chronic disease is a result of poor oxygenated blood flow to various organs of the body.
@@cutabove9046 But it seems like they have tendencies to form in certain locations. With heart attacks, the LAD artery is most commonly affected, why is that? Also atheromas in the carotid arteries, renal arteries, etc. I never hear about atheromas in the hepatic or splenic arteries for example. But it could be that maybe these just don't cause morbidity (esp compared to MIs or strokes). Either way, I'm just curious to know the dynamics of these lesions throughout a person's life.
@@chocoman3233 The pressures that cause the damage are highest near the heart and major organs. However, long before you'll see the consequences to the major organs the smaller arteries feeding the hands and feet show up long before. People simply don't realize that cold hands and feet aren't a symptom of a warm heart. It's a symptom of heart or more accurately arterial disease. Oh, the damage starts first at junctions where blood flow splits off because the pressures and swirling are highest at those points.
@@cutabove9046 Ahhhh I see I see. Thank you. Maybe also some eddie currents make things more likely to deposit and damage the vessels?
You sound like you are familiar with the atherosclerosis literature. Anything about how to clear atheromas (over time), if possible?
Does low carb, intermittent fasting cause elevated fbs?
I don't understand the inversion. This, saturated fat, or works for pufa? Long-term will it raise?
I read some where that people who die and could not eat before they died have very high levels of cholesterol in their bodies. Is that rue? If it is then eating high fat does not cause the body to have high cholesterol, right?
So wait a minute.... Does this lead to:
1. Fasting before a LDL test will spike your LDL level
2. Your LDL will be high and your GP will prescribe you statins..
Oh my...
this is dangerous to claim factually... the body has a fasting and a fed state and people on keto are on fasting state, you could claim that this behavior is true for keto, but in fed-state people the video doesn't provide info because the study was focused on keto only patients, which is a selection bias.
the difference is huge because the fed state has completely different hormonal levels.
TL;DR you are right, but only in ketogenic diet patients, we dont know if everyone else will be too.
A'bad Pris'ner Exactly. This is the conclusion of my mother' GP. The reaction is to order statins.
I have had "high" readings of LGL and HDL cholesterol at my last physical and I intermittent fast. I have only started having these readings since since I started following a IF and Ketogenic lifestyle 4 years ago.
The topic is important, the guest is very informative, but the "host" carries on like an idiot, distracting his audience and keeping his ratings low.
Yes!
Great job. I, as a librarian, was able to follow the interview.❤ thank you.
Fascinating work. I wish more medical science was done as well. What, if any have been the developments from this?
I would consider coronary calcium scores or intima thickness as part of a good test. Con these tests be added to his research? Some feel that high blood sugars glyvosolate or denature endothelial tissue leading to vessel damage. We have all seen diabetics with excellent distal pulses and horrible foot ulcers.
I think we obviously have to look at multiple factors, and it also needs to be studied over time. Clearly, I consider it a good sign my CIMT, CAC, heart CT, etc appear to be excellent after 2.5 years on this diet, but I don't claim this is Bro Science Proof -- it's just as much a baseline and I need to report it if it changes for better or for worse. I don't take too much comfort in any single metric or with any snapshot in time.
Gee wow it’s like maybe we shouldn’t force health choices on our fellow citizens because we are constantly learning no matter how long a topic is studied
not once did they mention BHB from being keto which I feel is one of the number one reasons to go keto! Energy is everything in life and the type of energy you get from BHB is over the top compared to spiking insulin getting energy from glucose
Excellent point, Jean. To be sure, we covered so much we just didn't quite get around to that. But FWIW, on an ATP-to-ATP basis, your cells are arguably powered more by fatty acids directly (brought by LDL as TG, or NEFAs) when on a keto diet than BHB (which are disproportionately taken up by the brain since they can cross the blood-brain barrier). Certainly, I spend more time on the lipid side of the fence, but the benefits of ketones, especially for the brain, are well documented in the keto community.
the only problem with the video was that there is an overwhelming majority of the audience out there that doesn't know what you guys are talking about with all the fancy words , even glucose ,glycogen ,carbs,sugar ext... there is a quote" if you can't teach it to a second grader you don't know it yourself " I say skip all the fancy talk, get out to the general public, that high healthy fat diets with 40 carbs/ sugar or less per day mainly coming from green veggies with lots of high fat,like avacodo, olive oil,mct oil,coconut oil,Kerry gold butter,grass-fed beef, and pasteurized eggs ext is healthy!
Fair point, Jean -- but it was hard to avoid when getting into the specifics on the topic. As far as a LCHF/Keto diet in general, there are plenty of better people than myself who make great videos on the topic. And I may actually return to ZDogg's show at some point in the future to give my own intro to the diet, in which case we likely will be avoiding the much larger words. :)
Dave, this interview with Dr. Damania changed my life. Sure some items discussed went a bit more technical than I could comprehend on first listen, but that pushed me to... :::gasp::: do some research and learn the details for myself. And I'm not sure how a 2nd grader could understand everything you covered if PhDs are still having a hard time grasping it (though your recent breakdown at Low Car Breck (ruclips.net/video/0LuKwsz9Woc/видео.html) was great at helping simplify the concepts). Keep up the good work, Dave!
jean paul fox Biologist here, the information is there to influence research: go read scientific papers and be careful of who funded what, understand placebo effects, etc.
So, did Dr. Z participate in the exercise and track his eating and then doubling it, with blood testing? What were his results, if so? Greetings from NYC!
My cholesterol over the past 15 years has always been about 200-210 with LDL being 140 and HDL @ 30, then I decided to go on the ketogenic diet and being very strict for 6 months, my cholesterol shot right up Total @ 285 and LDL 210 and HDL @ 32. I guess it doesn't suite me.
You know -- for a half a sec, I didn't realize it was you and I thought, "two low HDLers in one thread, what are the odds?" :D
Dave Keto that bad hey 😆
That explains my high LDL count on my annual lipid panel. . My score for years was 212-230 total cholesterol. I would reduce my fat intake a couple of weeks before the test in order to try and lower it for test day. Fortunately my HDL was on higher end and my Trigs were in normal range. Because I have a family history of Alzheimer’s, I read Wheat Brain and immediately went low carb (less than 50 grms). Then I sought out info on RUclips and that is where I discovered Keto. This started in September, I quickly lost 25lbs. Can’t wait for my lipid panel this April.
@ZDoggMD, at 49min. you talk about a weird reaction in the chest . I had something similar when starting keto, and used the have it sometimes when just not having had a meal for some time (before I tried keto). Any idea what causes that? I assumed it was was organs screaming 'give me sugar!' :). It usually was ok again after eating something. But it feels very different from just being hungry. Anyway, it went away after some weeks and now can skip a meal without any negative effect.
I strongly advise those of you , who got fed up with the too many interruptions and other frustrations in this video , to follow the link to Dave Feldman's website , and also here on RUclips , he does have his own channel. I have not checked yet, but bet there's a Facebook group that helps those with the same mindset that Dave Feldman, has , want to learn more , receive support, and more. At least for me, I got a first time introduction to Dave Feldman, and if for nothing else that was the most important and valuable piece.
This is fun stuff guys. This is how we should reach medicine. Make it fun. Bring on the analogies. Cruise ship==LDL-P was especially a good one.
Pathogenic pathway for CVD is well known at this point, but I'm not convinced highly elevated LDLc is not a risk factor. It's clearly not the primary risk factor compared to other, such as chronic inflammation, oxidative stress, elevated glucose, etc.
The information about how our amazing bodies function is tremendous. I have been living a low carb life for nearly a year. I have lost 40 lbs and feel better than I have for years. I do have one issue guys, there is no way I can believe that the marvelous design that is our body did not have a Designer.
Amen. I've often thought to myself, all one needs is to study the human body and nothing else to determine there is a creator.
Ellen Kno yes, the breath of life is well beyond me too.
Thank the creator, the best engineer ever. He did all the initial build in 6 days and a reproduction system to boot. Of course we have no knowledge of how long his day was. Perhaps a minute or 2 or... 6 earth revolutions, then he rested after engineering everything, including earth and the heavens..
Jimmy, an amazing story! I am proud of you, going thru this experience. Your friend, Ed Sandoval
In everything I’ve learned over the last two years, sugar (and the ensuing insulin spike) causes inflammation on the inside of the vessels so the small density LDLs can stick, kind of like velcro. That’s why I don’t use real sugar anymore. Monk fruit and stevia only. Carbs per say aren’t the enemy (non starchy veggies) I’m so glad that this information is being broadcast! I’m trying to get my husband to get his doctor to understand this!!
I’ve heard someone refer to the liver as “the soccer mom” of all the organs!!
Dear Dave and Zuban... PLEASE TEACH MED SCHOOL. YOU GUYS ARE BY FAR THE BEST AT TEACHING THIS IN A WAY THAT MAKES SENSE.
Could it be that when people are septic, that the LDL is being used as filler to fill holes in the epithelial walls? So there is a drop in the LDL because it’s being used for fixing ?
Like to see this one redone with a more chill tone so I could share with my professional friends and more in the "weeds" details and less repetition of details that pros should know anyway. Great stuff.
Thanks Dave, have you come across Nathan Pritikin, I wonder if the results on his dietary program would be opposite of Keto.
I still believe MI's are common with too much high fat cholesterol and lack of exercise as both of my grandfathers passed at 59/69 from this, they weren't smokers either. However when their brothers live to 90 I don't think it's genetic..
I seem to feel terrible the higher my LDL cholesterol is, it's like a general sense of tiredness combined with something I'm not sure of... shaking, trembling am I working up to a seizure? I do have anxiety but it seems to go up with my LDL. What I do know is anxiety meds combined with statin basically makes me a zombie. On a keto diet, getting tired of salmon it's starting to feel dry. Gonna get some macadamia nuts for the omega 7. Might switch to almonds and peanuts if I decide to take a break from salmon (still need proteins and macadamia nuts are pretty low in protein per calorie). One thing is for sure I don't want to be on statin or sedatives for the rest of my life, and carbs is difficult because it leaves me light headed shortly afterwards.
So the key is to reduce oxidative stress to the endothelium if the desire is to reduce the risk of cardiovascular disease?
I'm game for Dave's study. What could be better?
PLEASE stop interrupting your guest. Better to look for Dave's fantastic presentations on their own, sans the non-funny remarks. Thanks.
Gregory Dworak Im clicking off & will find another presentation of Dave elsewhere. Thx 🙄
Can one self test insulin levels as we can measure Glucose levels.
I used to "study" for a cholesterol test. I would eat oatmeal for breakfast, vegetables for lunch, and a regular dinner. I did this 2 weeks before my cholesterol test and all my numbers were good. If I didn't do this, my cholesterol numbers were bad.
Mike Ramsay what was your cholesterol numbers to begin with? What did you eat for dinner?
@@JR-kg1dp My numbers were high 200s.
Mike Ramsay How is that bad? Have you or your doctor applied your data to any of the well known cardiac risk calculators?
You're ldl-c drops with higher fat intake? What's the difference between ldl-c and regular LDL
There is no "regular" LRL. It's LDL - C, P & V
I’m definitely going to test this when my next lipid profile is due.
What is the relation between blood pressure and cholesterol?
How about having a live debate with a panel of MD's who believe in medicine to lower cholesterol
Here is what doctors believe in -- not getting sued; prescribing exactly what all the other doctors are prescribing which is relayed to them by drug reps (and it's always the latest drug on the market);prescribing only what that patient's insurance will cover so they are not called upon to argue with the insurance company for waivers. And by the way they can't be sued for damaging your health as long as they followed standard practices (again, dictated by the drug companies and insurance companies including medicare). And, finally, doctors know virtually nothing about what these guys are talking about. They are clinicians -- listen for an actionable "complaint" and prescribe for that specific complaint. Period. No longer are doctors diagnosticians. Again labelling someone with any specific condition other than what is obvious from a test result can change a person's life -- career, ability to get insurance, etc. which someone may sue a doctor for but if the doctor fails to diagnose except for what tests say they are protected. Clinical practice lags behind absolute, irrefutable knowledge from medical researchers they say an average of TWENTY years! That estimate comes from the medical industrial complex self evaluation. Look at stents for a great example. Debunked well over a decade ago by medical research, mainstream,, done more every year because doctors like doing them.
Robots and AI will replace doctors because their jobs have been reduced to nothing more than what a machine will do better.
That said, your idea is a good one but medical researchers, insurance companies and drug companies should make up the panel since they are driving the bus.
Pease and good health.
Usually I sleep through this nerdy staff. First time I felt a host has a keen formula for keeping things clear for us the average students.
What would we do without guys like this, you often wonder if eating, LCHF is the right thing, most of us try to read up on stuff, but mainly we go on blind faith. for me on the starch diet, my cholesterol went up. on LCHF it is still up but my LDL has plumeted, exactly what he is saying here.
Great video for me. Dave I am just wondering a lot about this. I have been LCHF for 8 months and my A1C has drop from 13 to 6.2 BUT... my cholesterol has skyrocketed (TC 388 LDL 287 and by HDL has gone up to 81 with Triglycerides at 99. Doctor is freaking and wants 80mg Lipitor stat. I also did a CAC and the score knocked me over 880! I am 68, feel great - but the numbers are scaring me. Next week I will do a Cardio Stress test to see how that goes. Not over weight - in fact I am now at my college weight having lost 27 lbs on LCHF. MD suggested get off the LCHF but I only eat once or twice a day now and am very satiated - no need to change what feels good. On Vegan I always felt hungry. I'm sure ZDog will fall over with my numbers but is there anything else I can do and avoid statins (I know you don't give medical advice - but just an opinion would help. Thanks for your great work.
beanwinker Yes -- this does not constitute medical advice, I'm just reporting my research to date. Your numbers are actually very similar to mine, which is typical of a Lean Mass Hyper-responder ( cholesterolcode.com/are-you-a-lean-mass-hyper-responder/ ). The irony is -- as my research is bringing light to -- the leaner and/or athletic you are, the higher your LDL-C/-P will likely be on LCHF/Keto. But this makes mechanistic sense ( please also see my Simple Guide series here: cholesterolcode.com/a-simple-guide-to-cholesterol-on-low-carb/ ). You're trafficking more energy from fat (fatty acids bundled as triglycerides) relative to someone on a carb-centric diet.
As I mention in the video, I don't claim to have certainty LDL-C/-P is not an independently causative agent for atherosclerosis -- I just find the case impressively weak. There are several articles on my site that dig into this, particularly with the data my experiments are bringing to light. Moreover, I have several LCHF hyper-responders like myself who I monitor the labs of and they have extremely low markers for inflammation, post-cardiac enzymes, and CIMT progression to name just a few.
I'm sorry to hear about your CAC score. Although to be sure, it is unlikely that was developed in 8 months of a keto diet as you'll see while researching this topic -- which I highly recommend. Progression of this score is arguably far more relevant than the score itself. If you've been on a standard American diet most of your life, your score isn't that unlikely given your age, but is certainly something to take seriously. Whether you stayed low carb or not, I'd definitely recommend being more proactive about reducing inflammation and oxidative stress.
Thanks so much Dave. I agree that it was the SAD diet and being convinced that low fat high carb was correct. Thanks also for the advice on reducing inflammation - full focus now. Will be spending the evening reading your material with gratitude for what you are doing!
Hi Richard--
I could certainly understand your concern for bad medical advice on the internet, I'm sure we both see quite a lot. But to be sure, I think I've answered each of your issues in the original comment above:
- Your concern I'm insisting LCHF is appropriate and blood/imaging is fine is actually the opposite of what I said.
^^^ *"As I mention in the video, I don't claim to have certainty LDL-C/-P is not an independently causative agent for atherosclerosis -- I just find the case impressively weak."*
^^^ and *"Whether you stayed low carb or not, I'd definitely recommend being more proactive about reducing inflammation and oxidative stress."*
- Now conversely, you do realize why this new data is extremely relevant. If a short window of a few days can have such a strong inverse relationship to resulting LDL-C, then all studies that didn't tightly control for the participants' dietary intake before the blood draw are missing the biggest confounder. Not just the composition of the diet in terms of macros, but the total quantity (particularly dietary fat).
Hi Richard -- I think you're more interested in a reddit-style dialog than I am. I'm not as much of a fan insisting certain statements and phrases be made a certain way or the other side can fill in a different definition for them. Of course when I speak of "inflammation" I'm speaking of chronic inflammation in the context of cardiac concerns. You, myself, and beanwinker know I wasn't talking about acute inflammation from something like twisted ankles. And if he or you were uncertain, they could have asked for clarification.
I tried in the previous comment to further emphasize what I was saying instead of your interpretation of it, in case it was a genuine misreading. But we both know I'm not telling anyone to drink green tea. And if you thought I was, you could simply ask, "Dave, are you making dietary recommendations instead of having someone consult a doctor?" To which I'd insist that no, I wasn't doing either one. (See original statements)
If you want to make more comments insisting I'm saying something I haven't said, or imply something outlandish we can be intellectually honest about instead, I'd prefer to pass on this dialog. But if you'd like to know my opinions or prefer further clarification in a respectful manner, I'm interested.
@Dave Feldman - I most certainly understood what you were sayin with no expectation of medical or dietary advice. I respect your work and am gathering as much information as I can to formulate a lifestyle plan that keeps me alive. Of course I am going to see a cardiologist as well as have testing done and follow up. I asked you for information and not Richard Tang. Any presumption on his part that you are misleading me is false.
Why is cholesterolcode.com being flagged as not secure?
Most people who have heart attacks have low cholesterol . What's important is LDL and HDL .
The triglyceride to HDL ratio is the stronger predictor of heart disease, much more so than “just” high cholesterol and LDL/HDL ratios. It is important to understand there are other predictors and not just “high” cholesterol that indicate a potential problem.
Right on .