Is High-Dose Olanzapine an Option for Treatment-Resistant Schizophrenia?

The Psychopharmacology Institute is an online platform offering unbiased, practical psychopharmacology updates for healthcare providers, with content updated monthly. It also presents opportunities to earn CME and SA credits.
In this Quick Take, Dr. Oliver Freudenreich discusses the efficacy of high-dose olanzapine for treatment-resistant schizophrenia. He also clarifies the circumstances under which certain patients might favor a higher dose of olanzapine over switching to clozapine, along with potential side effects to consider.
Find the transcript of this section here: psychopharmaco...
Did we mention you can also earn CME credits? This is something that you can take advantage of as a Silver or Gold member. Want to know more about Quick Takes and memberships? Click here: psychopharmaco...
#SchizophreniaTreatment #OlanzapineDosage
#TreatmentResistantSchizophrenia #ClozapineVsOlanzapine

[@plockacherrys5765]

Add metformin

[@walkaboutinside]

Additionally, Olanzapine can be switched to depot if adherence is an issue. Although, there has been a shortage (at least in Australia) of Olanzapine depot.

[@TomSUGNET]

It is rarely used due to risk of post-injection anticholinergic delirium and nurses say that they have more important things to do than to be observing a patient for hours