I remember Apo B48 = Chlymicrons as, "I just ate, so I have B48" (ate = 8) bc Chylomicrons are only present following dietary Triglyceride consumption.
Bro I can't believe you are providing such quality content for free! You are a life saver and all the future physicians are in your debt. God bless you man.
Omg, this was a fantastic way to break it down. And the mnemonics for lipid transports are way too good. I've written all of them down on my First Aid.
B48 = transports into lymphatic system, HDL adds C2 and E, in the blood circulation. C2 activates LPL to release the triglycerides for storage E then then break them into remnants for recycling. The chylomicron goes into the liver where it will be recycled.
hi dirty thank you for all the videos. I wonder if it is possible to integrate this video to lipid lowering drugs? because drugs are also highly tested. could you make a video about lipid lowering drugs as well? thank you so much!
I dont get why insulin cause breakdown of triglycerides to form fatty acids i though this happen by glucagon or something during starvation... activating lipase shouldnt insulin promote triglycerides formation due to excess glucose in blood
doesn't Insulin 'drive' the fatty acids into the cells rather than 'break down' triglycerides into fatty acids? and I think ApoE is the key that allows the remnant Chylo. to "Enter" into the liver.
enterocytes abosrb fatty acids and cholestrol, packaging them into triacylglycerols inside chylomicrons, then they circulate the blood until they go to endothelial cells of capillaries neighbouring other tissues. They are converted back to fatty acids and other substances that can easily pass through the membrane there by LPL and there they are either used for more energy or converted to triacylglycerol by combining it with glycerol. insulin drives LPL, while glucagon drives HSL. Now why doesn't the human body just directly send triacylglycerols through the membrane....i have no clue, guessing it is too big.
Hello, can I get some screenshots of your illustrations for my presentation in my class? The illustrations you made are so easily understandable. You made it very clear thank you. Of course, I'll put the link to your channel for the source
8:25 threw me in for a loop man, wasted like 20 minutes trying to understand your whole explanation cause your're not wrong but you're also not entirely right either lol let me explain: You say that in type 1 DM you are unable to store fats because insulin mediates the breakdown of fatty acids and storage of said fatty acids which technically is like 10% of whats really going on. The true cause of the weight loss is the unnopposed action of glucagon which activates HSL within the adipocytes, and this in turn metabolizes stored fatty acids for energy production since these patients are unable to yield energy from the glucose . Like i said you're not wrong your wording is just confusing. Great video though honestly, I wouldnt have made it through these first 2 years of med school without some dirty little medicine, love your content my guy!
With B48 it enters the Blood stream
With C2 it acts on the Capillary endothelium of muscle &fats
With E it Enters into the liver
I remember Apo B48 = Chlymicrons as, "I just ate, so I have B48" (ate = 8) bc Chylomicrons are only present following dietary Triglyceride consumption.
Bro I can't believe you are providing such quality content for free! You are a life saver and all the future physicians are in your debt. God bless you man.
i dont believe that 3 people disliked this ig they are the teacher who explains everyting in a complex fucking way
I'll forsure make sure to tell all my friends at my med school about your videos great videos man
Dr . D , God bless you 👍. Thanks for the great videos,
Seriously thank you! You’re a godsend
its great dude , love the way you explain
Thank you for this beautiful video! You made it really easy to understand and remember.
Phenomenal as always, thank you dirty
Omg, this was a fantastic way to break it down. And the mnemonics for lipid transports are way too good. I've written all of them down on my First Aid.
Whooaoa
After multiple attempts to learn, I’m beginning to have a grasp of it finally😊thanks a thousand times
What are you man where do you get all these incredible mnemonics this is unreal
He's extraterrestrial.
As he once said, he's a humanized bot sent to Earth to teach us medicine in a 'fun' way :p
@@Umir445566 😂😂
All concepts are clear. Thank you!!
Thank you for the great videos, :)
omg dirty medicine how are you so good at this..
Sir, please make a video on glyco-lipid metabolism. Your videos are so awesome!
Love this explanation
B48 = transports into lymphatic system, HDL adds C2 and E, in the blood circulation. C2 activates LPL to release the triglycerides for storage E then then break them into remnants for recycling. The chylomicron goes into the liver where it will be recycled.
hi dirty thank you for all the videos.
I wonder if it is possible to integrate this video to lipid lowering drugs?
because drugs are also highly tested.
could you make a video about lipid lowering drugs as well?
thank you so much!
thanks man I can’t thank you enough
What an explanation, great work🙀
Thank you.
These are some top videos bro 👍🏻
Very very very helpful !!! 👍👍
this is SO GOOD
GOAT stuff 🙌🙌
This is really helpful, thanks☺
I dont get why insulin cause breakdown of triglycerides to form fatty acids i though this happen by glucagon or something during starvation... activating lipase shouldnt insulin promote triglycerides formation due to excess glucose in blood
You are my friend dirty medicine that for making me understand this difficult subject on lipid transport. I love uuu
Nice video. Tks a lot
those 4 people disliked this because they thought the thumbs-down button is download
DAMN XD
Mate. Did the HDL Arrive on a magic carpet?
Cool .. thanks ..
Hi Doctor
Are there any videos about Malate Aspartate shuttle or glycerol phosphate shuttle and do these pathways come in USMLE or never?
thx
Very nicely described
im starting to believe that the bomber is the exact reason why they named apob48 like that :0
u have simpliefied this so much. am watching this while reading fa and its such a cluster fuck. THANK YOU SIRRRRR.
doesn't Insulin 'drive' the fatty acids into the cells rather than 'break down' triglycerides into fatty acids? and I think ApoE is the key that allows the remnant Chylo. to "Enter" into the liver.
enterocytes abosrb fatty acids and cholestrol, packaging them into triacylglycerols inside chylomicrons, then they circulate the blood until they go to endothelial cells of capillaries neighbouring other tissues. They are converted back to fatty acids and other substances that can easily pass through the membrane there by LPL and there they are either used for more energy or converted to triacylglycerol by combining it with glycerol.
insulin drives LPL, while glucagon drives HSL. Now why doesn't the human body just directly send triacylglycerols through the membrane....i have no clue, guessing it is too big.
Weldone
❤️❤️
Hello, can I get some screenshots of your illustrations for my presentation in my class? The illustrations you made are so easily understandable. You made it very clear thank you. Of course, I'll put the link to your channel for the source
feel free
I love you
Chylomicrons? What is that?
Chylo=juice micro=micro?
Good vids, though a little bit too much of repetitions. (I'd rather like to get the whole picture quick, then potentially re-watch it)
What reference do you use?
usually primary literature journals and databases that contain them
Please make more videos n
Can we please have part 3 lipid transport sir I am in dire need of that exam soon
ruclips.net/video/_wXWL8jidL4/видео.html
8:25 threw me in for a loop man, wasted like 20 minutes trying to understand your whole explanation cause your're not wrong but you're also not entirely right either lol let me explain:
You say that in type 1 DM you are unable to store fats because insulin mediates the breakdown of fatty acids and storage of said fatty acids which technically is like 10% of whats really going on.
The true cause of the weight loss is the unnopposed action of glucagon which activates HSL within the adipocytes, and this in turn metabolizes stored fatty acids for energy production since these patients are unable to yield energy from the glucose . Like i said you're not wrong your wording is just confusing. Great video though honestly, I wouldnt have made it through these first 2 years of med school without some dirty little medicine, love your content my guy!
This shit sucks, thanks