I have a question mark about haptoglobin . the reason why it decreases is actually caused by the binding of free hemoglobin which increased in the serum bc of hemolytic anemia. not because they are attacked by the neutrophils . so actually free haptoglobin number changes there is no harm to its structure
Yes. Haptoglobin only binds free hemoglobin in the plasma (not inside the RBC or macrophage). With extravascular hemolysis, the macrophage degrades the hemoglobin, and no free hemoglobin is released into the blood. So haptoglobin levels remain constant in extravascular hemolysis. But they bind to free hemoglobin released by increased intravascular hemolysis, meaning they're used up, so then in intravascular the haptoglobin value is decreased.
Medicosis perfectionalis, you asked us to explain the difference between macrophage, monocyte, and histiocyte. This was a very good question because these terms are confusing. But there is not a perfect answer, because these terms are confusing. Ideally, the macrophage is the umbrella term for any phagocytic agranulocyte. This can be divided into two major categories: 1) The histotiocyte is the macrophage of solid tissue. 2) The monocyte is the macrophage of blood. However, there is a lot of misuse/confusion/disagreement on how these terms are used. I had to look at dozens of definitions before I figured this out. Did I get it right? Thanks for making me investigate this. I had been lost in the confusion up to now. It's starting to become clear now.
this video is super helping me to solve the learning objectives that i need to be coping with right away tomorrow and easy to understand. big shout out to the owner of this channel tho. BIG LOVE😍
I love how you integrate biochemistry in pathophysiology! Can you please tell me, if you were to start from the very beginning, is reading Goljan the best initial step? haha or biochemistry? I just started studying for step 1 and I'm so lost from where to start. WAY past pre-clinical years in md school, forgot it all
Very helpful and to the point video!Thank you!!May I ask....G6PD deficiency causes both intravascular and extravascular hemolysis?Have I understand right ??
I think hemolysis causes normoblastic macrocytic anemia. As there is increased demand the immature red cells having bigger mcv will be released into the circulation resulting in macrocytic anemia. As there is no B12,folate deficiency there will be no dna maturation lag and normoblastic anemia (not megaloblastic). Am i right ?
These celles are the same cells the difference is in their localisation ,when they are in blood circulation we call them monocytes , in pulmonary tissue we call them macrophages ans in other tissues we call them histiocytes ... i know something is missing in my explenation 😅😅😅
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I have a question mark about haptoglobin . the reason why it decreases is actually caused by the binding of free hemoglobin which increased in the serum bc of hemolytic anemia. not because they are attacked by the neutrophils . so actually free haptoglobin number changes there is no harm to its structure
Yes. Haptoglobin only binds free hemoglobin in the plasma (not inside the RBC or macrophage). With extravascular hemolysis, the macrophage degrades the hemoglobin, and no free hemoglobin is released into the blood. So haptoglobin levels remain constant in extravascular hemolysis. But they bind to free hemoglobin released by increased intravascular hemolysis, meaning they're used up, so then in intravascular the haptoglobin value is decreased.
Medicosis perfectionalis, you asked us to explain the difference between macrophage, monocyte, and histiocyte. This was a very good question because these terms are confusing. But there is not a perfect answer, because these terms are confusing.
Ideally, the macrophage is the umbrella term for any phagocytic agranulocyte. This can be divided into two major categories:
1) The histotiocyte is the macrophage of solid tissue.
2) The monocyte is the macrophage of blood.
However, there is a lot of misuse/confusion/disagreement on how these terms are used. I had to look at dozens of definitions before I figured this out. Did I get it right?
Thanks for making me investigate this. I had been lost in the confusion up to now. It's starting to become clear now.
You’re excellent 👏👏
MISTAKE: there is a mistake in this video...PLEASE read the description below the video! My appologies!
I think even in the caption there is a mistake . You said the complex is in the rbcs not the plasma
So no one gets confused
Thanks, you're helping medical students from all over the world! best wishes from Spain.
You’re very welcome 😊
Monocyte in the blood. when in tissues, monocyte becomes Mo. Histiocyte is a macrophage found in connective tissue.,
You got it!
''the liver can't handle this insanity'' lol I don't know why I find this funny :-)
😂😂
this video is super helping me to solve the learning objectives that i need to be coping with right away tomorrow and easy to understand. big shout out to the owner of this channel tho. BIG LOVE😍
Thanks a million! I wish you the best of luck! Please consider sharing these videos with others, if you can! Thanks again!
I can't describe how much your vedio benefits me thank you so much
And I can't describe how much I am thankful to you...Best wishes!
I love how you integrate biochemistry in pathophysiology! Can you please tell me, if you were to start from the very beginning, is reading Goljan the best initial step? haha or biochemistry?
I just started studying for step 1 and I'm so lost from where to start. WAY past pre-clinical years in md school, forgot it all
Start with pathoma, then do biochemistry followed by Goljan!
You said sickle cell rbc undergoes extravascular hemolysis but in robbins its clearly mentioned that it undergoes intravascular hemolysis
It's both!
I think u should review the pathophysiology of decrease haptoglobin
True. I've corrected my mistake and made a whole video titled “Haptoglobin”.
Thank you 🙏
according the Pathoma and Medscape : decreased serum haptoglobin is more likely in intravascular hemolysis.
Watch this video to understand the whole picture: Intravascular Vs Extravascular Hemolytic Anemia ruclips.net/video/RIA_v4PLimc/видео.html
Very helpful and to the point video!Thank you!!May I ask....G6PD deficiency causes both intravascular and extravascular hemolysis?Have I understand right ??
Put the speed on 1.25x it will be way better🙄
For me 1.75× is better ✌️
Thank u so much sir...i clearly understood d concepts..it was really awesome🤗
You’re very welcome 😊
Thank you. I love every video you post. Keep it up!!!
Thanks a million for your kind words! My pleasure!
I think hemolysis causes normoblastic macrocytic anemia. As there is increased demand the immature red cells having bigger mcv will be released into the circulation resulting in macrocytic anemia. As there is no B12,folate deficiency there will be no dna maturation lag and normoblastic anemia (not megaloblastic). Am i right ?
were you recording this video in the bathroom?
Is that heptoglobin decrease in intravascular hemolysis too?
Yes
Does haptoglobin decrease in both types of hemolysis?
Sickle cell disease, sperocytosis g6pd are intravascular but you said extravascular
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amazing!!! 🔥🔥🔥🔥🔥
Thank you 😊
Very nice video, thanks alot
My pleasure!
Thanks so much
You mentioned G6PD AS Extravascular and you mentioned it as INTRAVASCULAR as well????
Sorry 😐
It's intravascular.
Very helpful. Thanks. Final year B.Pharmacy (South Africa)
Thank you so much 😊
Good luck!
g6pd deficency is intravascular hemolysis not extravascular
Agree
What all are intravascular?
Thx...wonderful
These celles are the same cells the difference is in their localisation ,when they are in blood circulation we call them monocytes , in pulmonary tissue we call them macrophages ans in other tissues we call them histiocytes ... i know something is missing in my explenation 😅😅😅
That’s very good actually 👍👍
I can add : in the liver they r named kupfër cells 😊
Absolutely 👏
What treatment this is extravascular hemolysis??pleas tell me??
It depends on the cause
@@MedicosisPerfectionalis Cause of death if not treatment
I am not sure I understand
G6PD causes intravascular hemolysis instead of extravascular hemolysis
Thank you Dr
My pleasure 😇
false information the heptoglobin is a plasma protein not rbc
Thank you so much for correcting me..You’re absolutely right...I will write a correction in the description of the video...thanks again!
Have you even played a video game called Portal? Am I the only one who think you sound like GLados in the game lol??
Btw very nice video as usual, thank you!
Thanks a lot
I have checked that game...and LOL! That’s true!
😍
You are awesome! You know that.?
Oh, Yeah...Haha...Thanks a ton!
Hemolysis effect in laboratory result at least two example
What do you mean?
@@MedicosisPerfectionalis how does the effect of hemolysis in a laboratory result (two example)
you are so كيوت
Cheer up, man! It looks like you're anemic.
:)