I've always interpreted this as a compensatory mechanism for a dysfunctional energy metabolism. I have often felt horribly hyper-adrenalized when I crashed without the option to rest, having to "push through" until I got home.
@@cenciacencia7551 Did you find anything that helps against the adrenaline? My daughter is constantly in fear for hours, sometimes days, when anything happens (loud door)
@@angelikasusanne2830unfortunaly no. But in past when I had Xarelto symptoms were a bit "lighter" specially during mens.cycle. Thinking to start to take it again
If I was going into a laboratory for research I would be feeling stressed as an ME patient. There’s always that, “How long is the crash going to be this time? How bad are the symptoms going to be?” So imagine being aware you’re soon going to do an exercise test and these are your last functioning hours before becoming seriously sick possibly for months. If we get a cure, we will owe a lot of people a lot of gratitude. My crashes have become less severe when I learned (as much as I am in control of) to not use adrenaline to push through declining function. So I feel not very good at the time but not so bad the next day (or week or month). It’s not merely that I’ll disengage from something taxing sooner. It’s that I don’t expend as much energy on it. My own sense of my body is that adrenaline worsens symptoms. Socially, people have to take me as I am with cognitive dysfunction making my speech halting etc. The findings as presented by Dr Younger fit my expectations based on my own experience.
the stellate ganglion block injections were the turning point for me probably because it helped reduce adrenaline. the interesting thing my doctor told me was that the nerves of the sympathetic nervous system tend to shrink in size after an SGB and revert to their normal size with extended use. the improved sleep it gave helped heal my body over time, restore dopamine levels that are needed so that the body is not forced to compensate with noradrenaline which constricts blood vessels in the brain and causes the stress that causes adrenaline to shoot up. I had low bp however, probably because of long term low grade infection from viral reservoirs, which is why guanfacine which is an beta-adrenergic antagonist helped, it also made me extremely sleepy as even less blood reached my brain. oh and i'm still in full remission
Congrats on your remission! Glad that the SGB worked well for you. Which symptoms did the guanfacine work for? Any side effects besides the drowsiness? Did you feel hungover after waking up from a night's sleep after taking the guanfacine? Thanks.
@@Truerealism747 hi, i'm sorry, I have written in previous videos so forgot to clarify all details. I had ME/CFS for 10 years. I achieved remission in may after a year, with SGB injections, 20 HBOT sessions, and LSD therapy and some other factors. SGB def felt like the true turning point but a lot of other things contributed to my recovery.
@@katnisseverdeen2.016 guanfacine worked well for restlessness, palpitations, brain fog in that it seemed to slightly increase my attention span by reducing stress. but the somnolence was extreme even at 1 mg, so i ultimately stopped taking it. but it helped me realise adrenaline was part of my problem.
I wouldn't be surprised if the ME/CFS group in those studies included a POTS subgroup with adrenergic involvement, given the high comorbidity. They could easily have driven the entire difference from healthy controls. - Jarred Younger
@@youngerlab Doctor Younger , Are the ‘ low adrenaline ‘. conditions you mention , part of the over-all symptomatology . Our experiences are that everything you have mentioned comes and goes , including the ‘ low adrenal function ’ ‘ condition . Thank You , for all your efforts .
Thank you ! Yes , I had elevated cortisol on 24 hour urine. I am a “typical “ M.E./ CFS patient. Importantly, I have been diagnosed ( neurosurgeon ) with a small posterior fossa, short clivus bone, steep angle of the tentorium , high arched palate. A CINE MRI showed reduced CSF flow in lower left cerebellar area, and spinal fluid jets in the cervical canal. Chiari 0. But equally important I have an unstable upper neck ( C-1/C-2) which greatly influences all symptoms and the sympathetic surges which result in blood pressure spikes, flushing, sweating. Importantly, sacral/ pelvic function influence the neck - as described by the great osteopaths - Upledger, Sutherland , more. Spent 25 years on this - after neck/pelvis injury. Keep hoping for more research into the critical interconnections of the musculoskeletal and central nervous systems.
I have ME. Beta blockers bring my nutty heart rate down, though sleep doesn't automatically follow. This damn disease rewires us to lie down during the day and be hyper-alert at night. I'm very interested in Robert Naviaux's dauer theory & how that manifests in homeostatic reversal. That is the nub of things with this disease, IMO.
thanks for the update. As a ME/CFS patient i think the researchers of this paper are doing a mistake : they are focused on the consequences of the illness. ME/CFS disturbs many many things. I think it is not important to work on those consequences. If I were a researcher on ME/CFS I would focus on the cerebrospinal fluid of ME/CFS patients. I think the clue is there. Something is not right in my cerebrospinal fluid, some molécules shouldn't be there or a chemical process is not being done properly or a very small part of my brain is stuck in a wrong chemical state. I can feel physically the part of my brain that is ill, not all my brain is ill. Just a little part in the center right of my brain. When I look at a brain map I would say it is a small piece of Cingulate Gyrus, or maybe amygdala. I guess what the researchers reallys needs is a biopsy of the sick part of the brain, but we don't want to die :) So i would focus on the cerebrospinal fluid, i am sure the sick part leaves some chemicals. I gues it requires the work of very high skilled chemists, I hope AI will help them in a few years.
I would argue that at least for some, elevated adrenaline and noradrenaline, over time, can actually cause ME. I would certainly argue that point in my case. I grew up in a very violent & turbulent household. I was anxious at least by the time I was 3. My body would switch to fight/flight in an instant for decades. I became worse in my late 30s. Couldn’t sit still, couldn’t focus. Felt agitated. I took up working out & mountain hiking. I’d hike til I was exhausted bc that’s the only thing I could do to alleviate those feelings caused by too much adrenaline. By my later 30s, I started exhibiting autoimmune disorders and signs of ME/CFS (although it went undiagnosed). Now my ME is severe. I can’t walk around much or stand too long without having orthostatic intolerance. I can’t even do a quick grocery run. I’ll get very symptomatic very quickly. It feels like I’m having a heart attack. I have to lay down wherever I am immediately, or I’ll throw up, or pass out. I turn pale, sweat profusely, get nauseous. Heat will also cause this. I used to like the heat. Now I can’t handle anything over 72F without increasing the intensity of my symptoms. I def feel better in colder weather. I’m stuck inside now. Can’t do much without causing ME symptoms to flare.. can’t even speak out loud much. .. I still get angry when I think what my family did to me. I thought I’d be free when I turned 18. I’m 56 and lost everything by age 44. I’d worked so hard to get my head on straight, got an education, have a decent life. I thought I’d succeeded despite them, but I was wrong. They messed up my entire autonomic NS. They messed up how my brain is wired, my endocrine system. As a result I developed autoimmune disorders. Eventually I started showing signs of ME in 2008. Sorry got a little wordy, but I def think I’m a case in which elevated adrenaline and noradrenaline caused ME.
"A chemical process is not being done properly" I agree with this. If slow brain waves help flush waste out of the brain during deep sleep, and we have a disease that prevents deep sleep .. no wonder my brain feels like a toxic waste dump.
You are right too . But this research / study is to help validate ME/CFS sufferers . You see other people ( who do not experience what you experience ) need assurance that you are experiencing what you are experiencing . It is very important research , and explains many of the signs and symptoms experienced .
Sometimes I think we should throw away the terms healthy people use to describe symptoms and get together to invent new language to describe our experiences. “Fatigue” is what newly-ill me might have used in an attempt to make sense of symptoms. But now I might say, “My brain feels like it’s in a lot of pain but doesn’t have the pain receptors to communicate pain. This agony but not pain sensation feels to me like the equivalent result.” My anecdotal, subjective descriptions might be of limited help guiding research, but I sure am curious what is actually occurring there (and how not to experience it).
Re: insomnia and noradrenaline: I have POTS as well as ME/CFS. I had severe insomnia for months--waking every 30-60 minutes, tachycardic and sweating. None of the standard sleep meds helped at all. Severity correlated with the amount of time upright/tachycardic that day. The game-changer: slow-release Clonidine (reduces noradrenaline) at bedtime. I can now sleep for several-hour periods of time, an incredible relief.
My daughter has severe ME/CFS, POTS and Mast Cell Activation. When she was in the most severe phase, she also suffered Paroxysmal Sympathetic Hyperactivity ("adrenaline dumps"), which were very worrying. Her available energy would decline, then suddenly she would have higher energy levels for a while, then collapse completely (to the stage that she couldn't even move her head while lying down, much less move her limbs, and could barely communicate). She would have significant pain that moved from place to place, one limb would be cold and waxy while the other was warm, and she was highly sensitive to all sensory input (noise, light, smell etc).... She would slowly recover over an hour or two, but while it lasted it was as though she only had the energy for the next heartbeat and the next breath.. there was nothing left over for anything else... scary... very scary. After a few of these episodes we decided to try giving her oxygen from a portable oxygen concentrator, and this helped a lot, speeding her recovery and reducing the severity of her symptoms. I have seen very little discussion around the use of oxygen in ME/CFS, but we have found it helpful during severe episodes like these PSH events and "crashes". Another very dangerous aspect of the PSH events was that during the time that she had elevated energy levels, she often made bad, sometimes dangerous, decisions: once she grabbed the car keys and went for a drive.. if she had run out of energy and collapsed while driving, someone could have been hurt or killed. Another time she had to be restrained from going swimming in the ocean, where she could easily have drowned. These acute events are different to the chronically elevated adrenaline levels being discussed in this video, but indicate that disturbances of the sympathetic nervous system can be part of this condition.
Its not just the physiology around dystautonomia,orthostatic intolerance +/- POTS,chronic hypovolemia etc etc driving this, its the catastrophically negligent treatment by the system and family and friends that breeds friggen terror ie how do I cope? How do I survive in the future??? What other people this severely ill and their support people are abused like this??
Reasearch is ongoing! I'll hold on as long as I have to! 💪Btw could you make a video where you go over the development/history of me/cfs research? It feels like many advancements are being made in the last 2 years but it's hard to put this into perspective. Thanks and have a great day! :)
High adrenaline in me/cfs is simply a compensatory mechanism. overly relaxed blood vessels leading to subpar blood pressure to the brain signals for adrenaline release to constrict vessels. It’s a fucking never ending loop. That is until chronically your adrenals just can’t keep up🥴
I definitely have the adrenalin spikes, usually as I'm about to nod off. I do not have daytime sleepiness. I haven't had a nap in 15-20 years. I miss that.
I didn't mention in the talk that it is possible to measure the adrenaline spikes with a continuous glucose monitor (the ones used for diabetes). The adrenaline spikes would show up as a sudden increase of blood glucose even though you didn't eat. It isn't covered by insurance for that purpose, though, and they are pretty expensive. - Jarred Younger
Many ME/CFS patients (anecdotally) test as having low morning cortisol and high evening cortisol. Does cortisol relate to adrenaline and noradrenaline? Also, is there a relationship between adrenaline and noradrenaline and elevated cytokines?
If POTS is common in this population, wouldn't you expect this outcome for orthostatic testing for adrenaline? My heartrate goes from 70 at actual rest to over 120 standing. Also, if these patients are anything like me they have experienced serious abuse in heathcare facilities, so your instinct that this methodology is faulty is probably accurate. Thanks for talking about what you find!
I thing this describes me well as a kid. I had really cold hands, very sensitive to the cold, and I relied on sweets to get my going through my business shifts. So much so that one of the other CNAs thought I was type 1 diebetic. However I'm not, my sugar levels have never spiked high. I think my body just knows when it needs the extra umph to get me going. It doesn't really work like thay for me now, I also have depression so getting energy and dragging this emotional bagged around isn't easy. Everything action takes so much work now.
One of my adult daughters had a 24hr urine test a few years ago. The results were she had high norepinephrine, but the endocrinologist just said it was interesting and discharged her. She has fibromyalgia.
Those endocrinologists ( most ) are useless . Even if they find something out of the ordinary , they usually do not know what to do about it , mainly because there is nothing that can be done .
Fibro is just a bunch of nonspecific autoimmune issues they haven't put into another disease name. I got rid of mine when I got my silver fillings out, it was the first thing to heal. Then my thyroid, then my gut. There are so many overlaps in autoimmune issues
Hi there! Thank you so much for your videos and for all you do. Could you please speak about Dr. Howard Schubiner‘s approach to chronic pain and the whole ‘mind-body’ paradigm of research as it applies to CFS and FM?
I appreciate the caveat you mention about the impact of travel and participation in studies (possibly seated upright for an extended time) in a lab environment on ME/CFS patients. I think that could be a salient point, actually: what would be "at rest" for healthy people is stressful, to the point of triggering a sustained "fight or flight" adrenergic response, in ME patients.
Yes this was my first thought too when he mentioned it. I just imagined the physical toll of travelling, maybe having to remain upright in a wheelchair in some lab environment would quite possibly increase adrenaline. I guess it still provides useful information as this spike in adrenaline could be playing a part in triggering PEM.
Primary and secondary hyperaldosteronism have common symptoms, including: High blood pressure Low level of potassium in the blood Feeling tired all the time Headache Muscle weakness Numbness
Lead exposure increases adrenaline and noradrenaline levels, and has independently been correlated to cfs. Here's another snippet, unfortunately there's almost no research on this: "Calcium (no specified dose) was introduced by participants at six months to two years and showed statistically significant improvement in fatigue (p=0.01), yet was based on five participants."
Yes this drives me crazy too. I get it this burning nerve pain all along my spine, rib cage and even in my eyebrows! I also get a different type of burning sensation in my blood which feels like toxic poison like hot battery acid. Its all so frustrating!
This is good clarification for me in trying to understand mechanisms of action for adversely affecting the degree of paralysis necessary to achieve to reach a point of best functionality of deep slow wave sleep during the first couple of hours of sleep. Now, my current understanding is that the quantum biology of light researchers and medical people have emerging information about circadian rhythm and daylight spectrum necessarily being set effectively by exposure every morning to near infrared-rich light of dawn and the first two hours. This enables pathways of light energy to reach deeply into brain tissue mitochondria to set up higher mitochondrial function levels. Now, if they are correct about this, there are a lot of implications that also have significant scientific literature support to afford much better mechanistic functionality of many hormones, especially D3 and its other metabolites and also mitochondrial melatonin, to increase the electron transport chain efficiency. How this applies to sleep quality seems very important to study, and your explanation of adrenalin increases seem to play into these quantum light biology issues. Many of these researchers seem to be pointing to our current indoor living environments as being quite problematic, to say the least. Research is strongly suggesting that LED light (very narrow band sky blue wavelength) BY ITSELF without the near infrared light always present in daylight to beneficially combine with the LED light, leave our indoor lighting very toxic. If they are correct about this, it can be adversely affecting sleep quality for repair and replace mechanisms to be 'switched on' fully for nighttime healing. LED light by itself, screws up the pineal melatonin/cortisol ratio, leaving the cortisol too high when going to sleep, which allows the adrenalin to remain too high to reach deep slow wave sleep. Currently this is my understanding gathered from all of these quantum biology folk. I would love to be wrong about this, because it has far-reaching implication for society IMHO. So, search it all yourself: quantum biology, daylight, indoor LED blue light, mitochondrial dysfunction. This goes deep into scientific papers, astrophysics of light and right down into 'solar battery cells'. This suggests lifestyle changes are critical for chronic disease prevention and treatment.
In the meantime, I now get out into the DAYLIGHT early and often (every several hours) just for 10 or 15 minutes, w/o sunblock, sunglasses etc. And, this can be effectively done in the shade, for free! And the NIR can penetrate through clothing, deep into tissues to benefit mitochondria.... and better sleep. Just do not get so much sun that you burn! Read the research carefully! And, apparently labs need to control for light quality, to add more effective quality.IMHO.
I have noticed that since my condition has become severe that I’m easily rattled or upset and have trouble sleeping. Could be related to brain fog. But I do spend a lot of effort trying to stay calm.
This is very interesting, Dr Younger. It would help to explain why insomnia is a problem for many ME/CFS patients (including myself). I wonder if the extra adrenaline is the body's way of compensating for the poor energy production that's a hallmark of this illness. Are there any treatment implications or possibilities for this subgroup of patients with high adrenaline? Thank you.
Hyperaldosteronism occurs when the adrenal glands release too much aldosterone . Primary hyperaldosteronism is due to a problem of the adrenal glands themselves . Most cases are caused by a noncancerous (benign) tumor of the adrenal gland .
Secondary hyperaldosteronism is due to a problem elsewhere in the body that causes the adrenal glands to release too much aldosterone . These problems can be with: Genes Diet Medical disorders such as with the heart, liver, kidneys, or high blood pressure . The condition mostly affects people 30 to 50 years old and is a common cause of high blood pressure in middle age .
I appreciate this video and it's very interesting to hear your take on this meta analysis, but I disagree that the primary purpose of adrenaline is to prepare us for fight/flight: the primary purpose is to make sure the brain gets fuel. Adrenaline and cortisol are activated by low blood sugar, and their most important job is to avoid that the brain dies from lack of fuel. What we call the stress hormones are actived without a stressful situation if we fast for too long, or if there is low blood glucose for any other reason - and hypoglycemia is not uncommon for ME/CFS patients. I'm always confused this is not talked about more. The most important thing I've done for stabilizing my symptoms is avoid low blood sugar, as it clearly activate adrenaline, which is pro-inflammatory. Could there be a connection between this disregulation of the hormones that regulate the blood sugar, and the Itaconate shunt hypothesis? Something is off with our metabolism, and when you consider there's something off with oxygen in the brain, blood circulation, etc, could this affect activation of adrenalin? Could findings of low levels of cortisol be linked to the high levels of adrenalin? I'm left with a lot of questions. (I don't call them the stress hormones, because research has shown mice without adrenal glands can have a fight/flight-response, and osteocalcine is thought to be the hormone that triggers fight/flight, and precede the activation of adrenalin and cortiosol.)
@oh_lalala ... You said ~ "Adrenaline and cortisol are activated by low blood sugar''- Just wondering ''how'' this can be true ? I have HIGH Blood Sugar [working on lowering this btw : ) ]but I have High Cortisol levels as well as High Adrenaline ! n.b. This is all ''new'' to me ~ Thanks, Cindy
@@cindyglass5827 hi Cindy, I'm sorry I don't know enough about high blood sugar to be able to explain why you have that with high adrenaline and cortisol - but blood sugar regulation is not the only thing these hormones are involved in, even though they are essential for that. Hope you find some good sources to make sense of it! I just think it's important more people know about the connection, and that for some avoiding low blood sugar can be a helpful tool. That you have a different blood sugar issue highlights how we could use more information about the metabolic side of ME/CFS, and more information about what that might mean for patients with differing symptoms.
I can fully relate to all of this, & have felt it in my body for the almost 3 decades I’ve had this vile ME. I get huge adrenaline surges upon awakening quite often, & it’s awful. Loud or unexpected noises do it to me too. The nervous system in my body feels wrecked. How can we stop these surges, & the higher adrenaline? Most of the time I feel physical anxiety in the pit of my stomach (even though I’m not actually anxious at all in my mind). Thank you for all you do.
I have the same thing. I was told it's sympathetic dominance. I'm on beta blockers but even that is not enough I still feel too much adrenaline all the time
Hello Dr. Younger. Your video resonates with me deeply, as it perfectly addresses what I've been experiencing since my diagnosis in 1979. I have adrenal insufficiency with low cortisol levels (confirmed by an ACTH test) dropping often down to 1.1L. In addition, I also have muscle weakness related to spinal muscular atrophy (SMA) involving the SMN1, SMN2, and SMN3 genes. Or are VLCFAs, Adrenoleukodystrophy (X-ALD) involved? Thank you for shedding light on the often neglected hormone issues.
Hyperaldosteronism occurs when the adrenal glands release too much aldosterone . Primary hyperaldosteronism is due to a problem of the adrenal glands themselves . Most cases are caused by a noncancerous (benign) tumor of the adrenal gland .
Secondary hyperaldosteronism is due to a problem elsewhere in the body that causes the adrenal glands to release too much aldosterone . These problems can be with: Genes Diet Medical disorders such as with the heart, liver, kidneys, or high blood pressure . The condition mostly affects people 30 to 50 years old and is a common cause of high blood pressure in middle age .
Adrenaline rushes are well known in ME (as opposed to 'ME/CFS'), but to temporarily overcome exhaustion and not typically in bed at night. That would rather suggest obstructed sleep apnea. People with apnea regularly get misdiagnosed with CFS or 'ME/CFS'.
I think it is estimated 90% of those with obstructive or central apnea are undiagnosed and untreated. I think everyone with any chronic fatigue should have their sleep investigated. It can be hard to get a full sleep study, but the at-home kits are getting better, and would certainly catch oxygen deprivation at night. Just my opinion, but I would go so far as to say a clinician should probably not diagnose someone with CFS or ME until ruling out apnea. - Jarred Younger
I honestly don't understand why I need so much sleep. Everyone around me seems to operate just fine on 4-5 hour's of sleep. I can fall asleep at the same time as them wake up drop the kids off then need a 3-4 hour nap once I'm out of work. Are men just build this way?
High heart rate low bp is a hallmark symptom I have had for the 28 years I have suffered from CFS. Average is 90 over 60 80 bpm. But have often had lower than this 75 over 55. Rarely if ever higher than 110 over 80. And the low readings high heart rate seem to be correlated with my crashes.
@@eddie8489 Had neuropathy in arms and pins and needles on face when I was in a moldy house. Not any more. I have heard of people referring to the face thing as Bells Palsy, I never had any paralysis and symptoms were transatory so I wouldn't refer to it that way but I understand why some people do. Also heard the condition correlated with lymes. I don't trust the lime tests but they came back negative on two separate occasions. Blood circulation has been an issue for me. I stupidly ate a bunch of french fries because I associated them once with lowering of my symptoms and I really like them. Did that for a couple of years so much so my cholesterol got into the unhealthy range. So much so dr's wanted to put me on statins. I am still just over healthy range but I try to eat lots of veggies and beans and things with lots of fiber low fat and calorie restriction. My BMI is 22.5. Reason why I think my circulation is poor is especially my feet used to get cold super easy. I think that has gotten better since I have been anally focused on my diet for the last 6 or 7 years. I still have to be careful not to push myself too hard but am pretty active as far as CFS/ME goes. I still crash and loose a day or two than recover. I can run all day minus the occasional death nap as long as I don't push. IE work in my garage on projects that likely will induce a crash if I say work for 5 or 6 hours straight a couple of days in a row. Sitting in my bed with my computer in my lap I can do 7 or 8 hours a day. So I don't see it that way but lots of people might call me lucky. Still struggle with brain fog. It's easy for me to watch youtube. Doing something my taxes or studying stock charts, organizing things on my computer, learning how to use programs I am interested in all wears me out very quickly. I can only do so much. I am 65. It's getting to the point where lots of people my age without CFS have health issues just as bad albeit in different ways probably worse than CFS without the PEM. So I guess I am lucky to have what I have. Have so much I want to do though and can't do it. Gardening, building things fixing things, creating things, traveling. So frustrating! Digestive issues are not as bad anymore. I attribute that to mold avoidance, gluten avoidance, calorie restriction and because it's virtually impossible to find certain foods that trigger me I eat small amounts of a wide variety of foods every day. When I crash from over exertion a lot of the digestive issues rear their ugly heads.
Luto com fadiga crônica há 10 anos e sempre percebi que me sentia pronta pra correr em fuga ou lutar. Testei cortisol no sangue e é elevadíssimo (mais que o dobro do normal). Penso que esse é o caminho; adrenalina.
I hope you can figure that out. I can't give medical advice, but you may want to get a 24-hour urine test of the cortisol, adrenaline, and noradrenaline. If they are high, there are many things that should be investigated. - Jarred Younger
It does make sense. If adrenal response for pm workers is affected on top of having the CF/ME plus other genetic rheumatological disorders then I could see how other factors of the adrenal glands could really affect one. As you mentioned it would be a sub group. If one has a definite correlation with a parent that has had immune system issues and even cancer like multiple myeloma and endocrinologist with a rheumatologist would be a good idea besides a hematologist. Does insurance pay for it? Not likely but maybe requesting a 24 hr urine if one knows that certain labs have come back and might seem suspicious it is a good way to bring it up.
The 24-hour urine test is pretty cheap and routine for any medical practice. I would think most insurance companies would cover it. The justification for the test would be unexplained symptoms like heart palpitations, sweating, anxiety, etc. - Jarred Younger
I have it, PSA and obvious immune system issues since childhood. Not exactly quality of life but as most, do our best to keep educating and trying to help minimize the bad stuff as much as we all can. Certainly not here looking for a cure all but something that helps us get by as all feel the med squeeze and hope the best of course and appreciating the immense amount of testing involved. I am here likewise as an observer and if I hear or read something applicable it is truly appreciated. 😊
@@youngerlabyes indeed, it should be ok’d. A very close relative is having all the testing I had done. Isn’t that wild? Genetic factors with other complications. Ty.😊
I’m going to watch it, and I’m looking for things that can lower my adrenaline. I have for 4,5 yr long covid and then a tick bite which ended in neuroborreliose in just 2 months. But I have extreme adrenaline since a few weeks and I don’t know what to do. It’s so extreme and continue. Now my LC is going worse sadly. I was recovering.
Is this the same stuff this video talks about? The video is longer for anyone looking for a more in depth video. ruclips.net/video/psALpJG_19Y/видео.htmlfeature=shared
In my unschooled way, I have diagnosed myself with CFS, which I fell ill with in the 1980's. My reasoning was that chronic stress for several years, overactivated and damaged my adrenal production. I've never been completely bed ridden, like I've heard some people experience, but the flare ups come up regularly following overwork. I wonder if the more extreme illness is fibromyalgia, and the milder is CFS.
@@youngerlab just asked chatgpt and from my limited understandig it seems you phrased it perfectly. I had no idea these sort of free floating receptors unbound to any cell membrane existed.
Same feeling here, not a single one did make sense for me, in that case i had catecholamines tested 4 yeras ago and was in the low end of the normal range range
I'm really grateful for Dr Younger sharing updates and developments on what's happening within research, the benefit of which we will eventually see once the basis is proven
He gave me some evidence which I already was counting upon. In my case it is crearly a posture problem. My rib cage is so compress I have very hard time breathing, because my ribs just cannot expand. Correcting my posture through PRI exercises have been absolutely life changing. My brain fog, fatigue, digestion, breathing, etc... Everything got much better and this is what I believe the ultimate way to heal my body completely.
@@AlbaLynxQueen noone said it's just that. but that high adrenaline is part of the picture for some is not far fetched. it doesnt necessarily equate to just an overactive sympathetic nervous system. It was for me, but obviously not the whole story. I needed many different treatments of various modalities to improve. they are not making any claims about the cause.
Here is a link to the discussed meta-analysis paper, but it doesn't seem to be open-access. pubmed.ncbi.nlm.nih.gov/39319943/ - Jarred Younger
I can at least read the abstract and references from germany. Don't know if there's more
I've always interpreted this as a compensatory mechanism for a dysfunctional energy metabolism.
I have often felt horribly hyper-adrenalized when I crashed without the option to rest, having to "push through" until I got home.
I believe the same.
I often feel very very high adrenaline during the crash but gets extreme if I've menstruation and crash
@@cenciacencia7551 Did you find anything that helps against the adrenaline? My daughter is constantly in fear for hours, sometimes days, when anything happens (loud door)
@@angelikasusanne2830unfortunaly no. But in past when I had Xarelto symptoms were a bit "lighter" specially during mens.cycle. Thinking to start to take it again
If I was going into a laboratory for research I would be feeling stressed as an ME patient. There’s always that, “How long is the crash going to be this time? How bad are the symptoms going to be?” So imagine being aware you’re soon going to do an exercise test and these are your last functioning hours before becoming seriously sick possibly for months. If we get a cure, we will owe a lot of people a lot of gratitude.
My crashes have become less severe when I learned (as much as I am in control of) to not use adrenaline to push through declining function. So I feel not very good at the time but not so bad the next day (or week or month). It’s not merely that I’ll disengage from something taxing sooner. It’s that I don’t expend as much energy on it. My own sense of my body is that adrenaline worsens symptoms. Socially, people have to take me as I am with cognitive dysfunction making my speech halting etc. The findings as presented by Dr Younger fit my expectations based on my own experience.
Yep, I’m with you 100%
10:07 it is so very rewarding to hear a researcher like yourself acknowledge these kinds of contextual intricacies!
Good ol' "tired but wired"
"Twired." 😐
It's a special kind of hell, nothing you can do but lie there and endure!
the stellate ganglion block injections were the turning point for me probably because it helped reduce adrenaline. the interesting thing my doctor told me was that the nerves of the sympathetic nervous system tend to shrink in size after an SGB and revert to their normal size with extended use. the improved sleep it gave helped heal my body over time, restore dopamine levels that are needed so that the body is not forced to compensate with noradrenaline which constricts blood vessels in the brain and causes the stress that causes adrenaline to shoot up. I had low bp however, probably because of long term low grade infection from viral reservoirs, which is why guanfacine which is an beta-adrenergic antagonist helped, it also made me extremely sleepy as even less blood reached my brain. oh and i'm still in full remission
Do you have CFS or fybromyalgia are you hypermobile
Congrats on your remission! Glad that the SGB worked well for you. Which symptoms did the guanfacine work for? Any side effects besides the drowsiness? Did you feel hungover after waking up from a night's sleep after taking the guanfacine? Thanks.
@@Truerealism747 hi, i'm sorry, I have written in previous videos so forgot to clarify all details. I had ME/CFS for 10 years. I achieved remission in may after a year, with SGB injections, 20 HBOT sessions, and LSD therapy and some other factors. SGB def felt like the true turning point but a lot of other things contributed to my recovery.
@@katnisseverdeen2.016 guanfacine worked well for restlessness, palpitations, brain fog in that it seemed to slightly increase my attention span by reducing stress. but the somnolence was extreme even at 1 mg, so i ultimately stopped taking it. but it helped me realise adrenaline was part of my problem.
@@Truerealism747 I had ME and hyperadrenergic POTS, not hyper mobile! No fibro either
There’s a subtype of POTS characterized by excess adrenaline and norepinephrine
I wouldn't be surprised if the ME/CFS group in those studies included a POTS subgroup with adrenergic involvement, given the high comorbidity. They could easily have driven the entire difference from healthy controls. - Jarred Younger
yes I had hyperadrenergic POTS before the SGB injections.
@@youngerlab
Doctor Younger ,
Are the ‘ low adrenaline ‘. conditions you mention , part of the over-all symptomatology .
Our experiences are that everything you have mentioned comes and goes , including the ‘ low adrenal function ’
‘ condition .
Thank You , for all your efforts .
Thank you ! Yes , I had elevated cortisol on 24 hour urine. I am a “typical “ M.E./ CFS patient. Importantly, I have been diagnosed ( neurosurgeon ) with a small posterior fossa, short clivus bone, steep angle of the tentorium , high arched palate. A CINE MRI showed reduced CSF flow in lower left cerebellar area, and spinal fluid jets in the cervical canal. Chiari 0. But equally important I have an unstable upper neck ( C-1/C-2) which greatly influences all symptoms and the sympathetic surges which result in blood pressure spikes, flushing, sweating. Importantly, sacral/ pelvic function influence the neck - as described by the great osteopaths - Upledger, Sutherland , more. Spent 25 years on this - after neck/pelvis injury. Keep hoping for more research into the critical interconnections of the musculoskeletal and central nervous systems.
Bro knows more about his skull structure than lookmaxxers do😢. How did you learn all those imbalances?
I have ME. Beta blockers bring my nutty heart rate down, though sleep doesn't automatically follow. This damn disease rewires us to lie down during the day and be hyper-alert at night. I'm very interested in Robert Naviaux's dauer theory & how that manifests in homeostatic reversal. That is the nub of things with this disease, IMO.
thanks for the update.
As a ME/CFS patient i think the researchers of this paper are doing a mistake : they are focused on the consequences of the illness. ME/CFS disturbs many many things. I think it is not important to work on those consequences.
If I were a researcher on ME/CFS I would focus on the cerebrospinal fluid of ME/CFS patients. I think the clue is there. Something is not right in my cerebrospinal fluid, some molécules shouldn't be there or a chemical process is not being done properly or a very small part of my brain is stuck in a wrong chemical state.
I can feel physically the part of my brain that is ill, not all my brain is ill. Just a little part in the center right of my brain. When I look at a brain map I would say it is a small piece of Cingulate Gyrus, or maybe amygdala.
I guess what the researchers reallys needs is a biopsy of the sick part of the brain, but we don't want to die :) So i would focus on the cerebrospinal fluid, i am sure the sick part leaves some chemicals.
I gues it requires the work of very high skilled chemists, I hope AI will help them in a few years.
I would argue that at least for some, elevated adrenaline and noradrenaline, over time, can actually cause ME. I would certainly argue that point in my case.
I grew up in a very violent & turbulent household. I was anxious at least by the time I was 3. My body would switch to fight/flight in an instant for decades. I became worse in my late 30s. Couldn’t sit still, couldn’t focus. Felt agitated. I took up working out & mountain hiking. I’d hike til I was exhausted bc that’s the only thing I could do to alleviate those feelings caused by too much adrenaline.
By my later 30s, I started exhibiting autoimmune disorders and signs of ME/CFS (although it went undiagnosed). Now my ME is severe. I can’t walk around much or stand too long without having orthostatic intolerance. I can’t even do a quick grocery run. I’ll get very symptomatic very quickly. It feels like I’m having a heart attack. I have to lay down wherever I am immediately, or I’ll throw up, or pass out. I turn pale, sweat profusely, get nauseous. Heat will also cause this. I used to like the heat. Now I can’t handle anything over 72F without increasing the intensity of my symptoms. I def feel better in colder weather. I’m stuck inside now. Can’t do much without causing ME symptoms to flare.. can’t even speak out loud much.
.. I still get angry when I think what my family did to me. I thought I’d be free when I turned 18. I’m 56 and lost everything by age 44. I’d worked so hard to get my head on straight, got an education, have a decent life. I thought I’d succeeded despite them, but I was wrong. They messed up my entire autonomic NS. They messed up how my brain is wired, my endocrine system. As a result I developed autoimmune disorders. Eventually I started showing signs of ME in 2008.
Sorry got a little wordy, but I def think I’m a case in which elevated adrenaline and noradrenaline caused ME.
"A chemical process is not being done properly" I agree with this. If slow brain waves help flush waste out of the brain during deep sleep, and we have a disease that prevents deep sleep .. no wonder my brain feels like a toxic waste dump.
You are right too .
But this research / study is to help validate ME/CFS sufferers .
You see other people ( who do not experience what you experience ) need assurance that you are experiencing what you are experiencing .
It is very important research , and explains many of the signs and symptoms experienced .
Also , you are right about the brain . The hypothalamus and the pituitary gland may be greatly affected in these diseases .
Sometimes I think we should throw away the terms healthy people use to describe symptoms and get together to invent new language to describe our experiences. “Fatigue” is what newly-ill me might have used in an attempt to make sense of symptoms. But now I might say, “My brain feels like it’s in a lot of pain but doesn’t have the pain receptors to communicate pain. This agony but not pain sensation feels to me like the equivalent result.” My anecdotal, subjective descriptions might be of limited help guiding research, but I sure am curious what is actually occurring there (and how not to experience it).
Re: insomnia and noradrenaline: I have POTS as well as ME/CFS. I had severe insomnia for months--waking every 30-60 minutes, tachycardic and sweating. None of the standard sleep meds helped at all. Severity correlated with the amount of time upright/tachycardic that day.
The game-changer: slow-release Clonidine (reduces noradrenaline) at bedtime. I can now sleep for several-hour periods of time, an incredible relief.
@@MeganSyverson Does it give you a really dry mouth the next day??
My daughter has severe ME/CFS, POTS and Mast Cell Activation. When she was in the most severe phase, she also suffered Paroxysmal Sympathetic Hyperactivity ("adrenaline dumps"), which were very worrying.
Her available energy would decline, then suddenly she would have higher energy levels for a while, then collapse completely (to the stage that she couldn't even move her head while lying down, much less move her limbs, and could barely communicate). She would have significant pain that moved from place to place, one limb would be cold and waxy while the other was warm, and she was highly sensitive to all sensory input (noise, light, smell etc)....
She would slowly recover over an hour or two, but while it lasted it was as though she only had the energy for the next heartbeat and the next breath.. there was nothing left over for anything else... scary... very scary.
After a few of these episodes we decided to try giving her oxygen from a portable oxygen concentrator, and this helped a lot, speeding her recovery and reducing the severity of her symptoms. I have seen very little discussion around the use of oxygen in ME/CFS, but we have found it helpful during severe episodes like these PSH events and "crashes".
Another very dangerous aspect of the PSH events was that during the time that she had elevated energy levels, she often made bad, sometimes dangerous, decisions: once she grabbed the car keys and went for a drive.. if she had run out of energy and collapsed while driving, someone could have been hurt or killed. Another time she had to be restrained from going swimming in the ocean, where she could easily have drowned.
These acute events are different to the chronically elevated adrenaline levels being discussed in this video, but indicate that disturbances of the sympathetic nervous system can be part of this condition.
Very interesting! Thank you so much for taking the time to do these videos for us Dr Younger 👍
Sure thing - thanks! - Jarred Younger
Its not just the physiology around dystautonomia,orthostatic intolerance +/- POTS,chronic hypovolemia etc etc driving this, its the catastrophically negligent treatment by the system and family and friends that breeds friggen terror ie how do I cope? How do I survive in the future??? What other people this severely ill and their support people are abused like this??
Reasearch is ongoing! I'll hold on as long as I have to! 💪Btw could you make a video where you go over the development/history of me/cfs research? It feels like many advancements are being made in the last 2 years but it's hard to put this into perspective. Thanks and have a great day! :)
High adrenaline in me/cfs is simply a compensatory mechanism. overly relaxed blood vessels leading to subpar blood pressure to the brain signals for adrenaline release to constrict vessels. It’s a fucking never ending loop. That is until chronically your adrenals just can’t keep up🥴
Really appreciate you regularly bringing information directly to us. And grateful for your efforts in general, we're lucky to have you! Thank you.
And it must be said there's elevated adrenaline in autism ADHD what alot if us have albeit undiagnosed in alot.claire weekes found this out to in 1962
yes, audhd here! SGB injections helped my POTS and ME immensely.
@@arasharfaare they dangerous? What kind of doctor prescribes them?
@@arasharfa How many SGB injections did you have? How far apart? Which side of neck? Thanks!
I definitely have the adrenalin spikes, usually as I'm about to nod off. I do not have daytime sleepiness. I haven't had a nap in 15-20 years. I miss that.
I didn't mention in the talk that it is possible to measure the adrenaline spikes with a continuous glucose monitor (the ones used for diabetes). The adrenaline spikes would show up as a sudden increase of blood glucose even though you didn't eat. It isn't covered by insurance for that purpose, though, and they are pretty expensive. - Jarred Younger
@@youngerlab thank you.
Many ME/CFS patients (anecdotally) test as having low morning cortisol and high evening cortisol. Does cortisol relate to adrenaline and noradrenaline? Also, is there a relationship between adrenaline and noradrenaline and elevated cytokines?
This may have to do with insufficient ATP levels in the morning too
Absolutely... Low serum cortisol in testing here too but adequate ACTH response so unlikely to be frank Addison's in my case...
Thanks Dr. for bringing this info to us.
Very interesting. That seems stupid comment but having been involved in pharmaceuticals for decades it's making sense! Hope to hear more
If POTS is common in this population, wouldn't you expect this outcome for orthostatic testing for adrenaline? My heartrate goes from 70 at actual rest to over 120 standing. Also, if these patients are anything like me they have experienced serious abuse in heathcare facilities, so your instinct that this methodology is faulty is probably accurate. Thanks for talking about what you find!
Very interesting, thanks for the summary!
I thing this describes me well as a kid. I had really cold hands, very sensitive to the cold, and I relied on sweets to get my going through my business shifts. So much so that one of the other CNAs thought I was type 1 diebetic. However I'm not, my sugar levels have never spiked high. I think my body just knows when it needs the extra umph to get me going. It doesn't really work like thay for me now, I also have depression so getting energy and dragging this emotional bagged around isn't easy. Everything action takes so much work now.
One of my adult daughters had a 24hr urine test a few years ago. The results were she had high norepinephrine, but the endocrinologist just said it was interesting and discharged her. She has fibromyalgia.
Those endocrinologists ( most ) are useless . Even if they find something out of the ordinary , they usually do not know what to do about it , mainly because there is nothing that can be done .
Fibro is just a bunch of nonspecific autoimmune issues they haven't put into another disease name. I got rid of mine when I got my silver fillings out, it was the first thing to heal. Then my thyroid, then my gut. There are so many overlaps in autoimmune issues
@@sneakypress 100% useless for me, I gave them 40 years and they almost killed me. I healed myself ultimately which is ridiculous but I'm grateful
Hi there! Thank you so much for your videos and for all you do. Could you please speak about Dr. Howard Schubiner‘s approach to chronic pain and the whole ‘mind-body’ paradigm of research as it applies to CFS and FM?
I appreciate the caveat you mention about the impact of travel and participation in studies (possibly seated upright for an extended time) in a lab environment on ME/CFS patients. I think that could be a salient point, actually: what would be "at rest" for healthy people is stressful, to the point of triggering a sustained "fight or flight" adrenergic response, in ME patients.
Yes this was my first thought too when he mentioned it. I just imagined the physical toll of travelling, maybe having to remain upright in a wheelchair in some lab environment would quite possibly increase adrenaline. I guess it still provides useful information as this spike in adrenaline could be playing a part in triggering PEM.
That's been my experience in my personal body lab research.
Dizziness bad anxiety
Headaches pressure sleep not great
Primary and secondary hyperaldosteronism have common symptoms, including:
High blood pressure
Low level of potassium in the blood
Feeling tired all the time
Headache
Muscle weakness
Numbness
The adrenalin can come out at night like hell sometimes for me, if my ANS is very dysregulated.
Thanks Doc.
I do have these issues with adrenal so I am very thankful you are doing this work.
Lead exposure increases adrenaline and noradrenaline levels, and has independently been correlated to cfs.
Here's another snippet, unfortunately there's almost no research on this:
"Calcium (no specified dose) was introduced by participants at six months to two years and showed statistically significant improvement in fatigue (p=0.01), yet was based on five participants."
Love this❤ needs a matching bracelet and earrings 🤩🤩🤩
Please discuss the small fiber neuropathy from long Covid, this burning sensation is making me insane
Yes this drives me crazy too. I get it this burning nerve pain all along my spine, rib cage and even in my eyebrows! I also get a different type of burning sensation in my blood which feels like toxic poison like hot battery acid. Its all so frustrating!
This is good clarification for me in trying to understand mechanisms of action for adversely affecting the degree of paralysis necessary to achieve to reach a point of best functionality of deep slow wave sleep during the first couple of hours of sleep. Now, my current understanding is that the quantum biology of light researchers and medical people have emerging information about circadian rhythm and daylight spectrum necessarily being set effectively by exposure every morning to near infrared-rich light of dawn and the first two hours. This enables pathways of light energy to reach deeply into brain tissue mitochondria to set up higher mitochondrial function levels. Now, if they are correct about this, there are a lot of implications that also have significant scientific literature support to afford much better mechanistic functionality of many hormones, especially D3 and its other metabolites and also mitochondrial melatonin, to increase the electron transport chain efficiency. How this applies to sleep quality seems very important to study, and your explanation of adrenalin increases seem to play into these quantum light biology issues. Many of these researchers seem to be pointing to our current indoor living environments as being quite problematic, to say the least. Research is strongly suggesting that LED light (very narrow band sky blue wavelength) BY ITSELF without the near infrared light always present in daylight to beneficially combine with the LED light, leave our indoor lighting very toxic. If they are correct about this, it can be adversely affecting sleep quality for repair and replace mechanisms to be 'switched on' fully for nighttime healing. LED light by itself, screws up the pineal melatonin/cortisol ratio, leaving the cortisol too high when going to sleep, which allows the adrenalin to remain too high to reach deep slow wave sleep. Currently this is my understanding gathered from all of these quantum biology folk. I would love to be wrong about this, because it has far-reaching implication for society IMHO. So, search it all yourself: quantum biology, daylight, indoor LED blue light, mitochondrial dysfunction. This goes deep into scientific papers, astrophysics of light and right down into 'solar battery cells'. This suggests lifestyle changes are critical for chronic disease prevention and treatment.
In the meantime, I now get out into the DAYLIGHT early and often (every several hours) just for 10 or 15 minutes, w/o sunblock, sunglasses etc. And, this can be effectively done in the shade, for free! And the NIR can penetrate through clothing, deep into tissues to benefit mitochondria.... and better sleep. Just do not get so much sun that you burn! Read the research carefully! And, apparently labs need to control for light quality, to add more effective quality.IMHO.
Love your videos
I have noticed that since my condition has become severe that I’m easily rattled or upset and have trouble sleeping. Could be related to brain fog. But I do spend a lot of effort trying to stay calm.
This is very interesting, Dr Younger. It would help to explain why insomnia is a problem for many ME/CFS patients (including myself). I wonder if the extra adrenaline is the body's way of compensating for the poor energy production that's a hallmark of this illness. Are there any treatment implications or possibilities for this subgroup of patients with high adrenaline? Thank you.
I have high aldosterone from the Adrenal causes high blood pressure
Hyperaldosteronism occurs when the adrenal glands release too much aldosterone .
Primary hyperaldosteronism is due to a problem of the adrenal glands themselves .
Most cases are caused by a noncancerous (benign) tumor of the adrenal gland .
Secondary hyperaldosteronism is due to a problem elsewhere in the body that causes the adrenal glands to release too much aldosterone .
These problems can be with:
Genes
Diet
Medical disorders such as with the heart, liver, kidneys, or high blood pressure .
The condition mostly affects people 30 to 50 years old and is a common cause of high blood pressure in middle age .
'ME/CFS' means something different in about every study, so you can't aggregate the outcomes.
I appreciate this video and it's very interesting to hear your take on this meta analysis, but I disagree that the primary purpose of adrenaline is to prepare us for fight/flight: the primary purpose is to make sure the brain gets fuel. Adrenaline and cortisol are activated by low blood sugar, and their most important job is to avoid that the brain dies from lack of fuel.
What we call the stress hormones are actived without a stressful situation if we fast for too long, or if there is low blood glucose for any other reason - and hypoglycemia is not uncommon for ME/CFS patients. I'm always confused this is not talked about more. The most important thing I've done for stabilizing my symptoms is avoid low blood sugar, as it clearly activate adrenaline, which is pro-inflammatory.
Could there be a connection between this disregulation of the hormones that regulate the blood sugar, and the Itaconate shunt hypothesis? Something is off with our metabolism, and when you consider there's something off with oxygen in the brain, blood circulation, etc, could this affect activation of adrenalin? Could findings of low levels of cortisol be linked to the high levels of adrenalin? I'm left with a lot of questions.
(I don't call them the stress hormones, because research has shown mice without adrenal glands can have a fight/flight-response, and osteocalcine is thought to be the hormone that triggers fight/flight, and precede the activation of adrenalin and cortiosol.)
@oh_lalala ... You said ~ "Adrenaline and cortisol are activated by low blood sugar''-
Just wondering ''how'' this can be true ? I have HIGH Blood Sugar [working on lowering this btw : ) ]but I have High Cortisol levels as well as High Adrenaline ! n.b. This is all ''new'' to me ~ Thanks, Cindy
@@cindyglass5827 hi Cindy, I'm sorry I don't know enough about high blood sugar to be able to explain why you have that with high adrenaline and cortisol - but blood sugar regulation is not the only thing these hormones are involved in, even though they are essential for that. Hope you find some good sources to make sense of it!
I just think it's important more people know about the connection, and that for some avoiding low blood sugar can be a helpful tool. That you have a different blood sugar issue highlights how we could use more information about the metabolic side of ME/CFS, and more information about what that might mean for patients with differing symptoms.
I can fully relate to all of this, & have felt it in my body for the almost 3 decades I’ve had this vile ME. I get huge adrenaline surges upon awakening quite often, & it’s awful. Loud or unexpected noises do it to me too. The nervous system in my body feels wrecked. How can we stop these surges, & the higher adrenaline? Most of the time I feel physical anxiety in the pit of my stomach (even though I’m not actually anxious at all in my mind). Thank you for all you do.
I have the same thing. I was told it's sympathetic dominance. I'm on beta blockers but even that is not enough I still feel too much adrenaline all the time
Very interesting, thanks. I can imagine that adrenaline dysfunction could be influencing other issues (eg anxiety) I have.
Hello Dr. Younger. Your video resonates with me deeply, as it perfectly addresses what I've been experiencing since my diagnosis in 1979. I have adrenal insufficiency with low cortisol levels (confirmed by an ACTH test) dropping often down to 1.1L. In addition, I also have muscle weakness related to spinal muscular atrophy (SMA) involving the SMN1, SMN2, and SMN3 genes.
Or are VLCFAs, Adrenoleukodystrophy (X-ALD) involved? Thank you for shedding light on the often neglected hormone issues.
What about high aldosterone
Hyperaldosteronism occurs when the adrenal glands release too much aldosterone .
Primary hyperaldosteronism is due to a problem of the adrenal glands themselves .
Most cases are caused by a noncancerous (benign) tumor of the adrenal gland .
Secondary hyperaldosteronism is due to a problem elsewhere in the body that causes the adrenal glands to release too much aldosterone .
These problems can be with:
Genes
Diet
Medical disorders such as with the heart, liver, kidneys, or high blood pressure .
The condition mostly affects people 30 to 50 years old and is a common cause of high blood pressure in middle age .
High aches anxiety dizziness high aldosterone hard to sleep all night waiting on specialist
Adrenaline rushes are well known in ME (as opposed to 'ME/CFS'), but to temporarily overcome exhaustion and not typically in bed at night. That would rather suggest obstructed sleep apnea. People with apnea regularly get misdiagnosed with CFS or 'ME/CFS'.
I think it is estimated 90% of those with obstructive or central apnea are undiagnosed and untreated. I think everyone with any chronic fatigue should have their sleep investigated. It can be hard to get a full sleep study, but the at-home kits are getting better, and would certainly catch oxygen deprivation at night. Just my opinion, but I would go so far as to say a clinician should probably not diagnose someone with CFS or ME until ruling out apnea. - Jarred Younger
I honestly don't understand why I need so much sleep. Everyone around me seems to operate just fine on 4-5 hour's of sleep. I can fall asleep at the same time as them wake up drop the kids off then need a 3-4 hour nap once I'm out of work. Are men just build this way?
17 years of LEO ptsd and long C check out sgb or spg I also started Ldn
I hope the SGB or LDN work. Both of those are in my top 10 treatments/interventions to try. - Jarred Younger
@@youngerlabwhere can we find the top 10 things to try by you?
Can you recommend a study on CFS, fibromyalgia and acetylcholine?
Check out my video last week (#035) on the LIFT trial. That is the only CFS or FM study associated with acetylcholine right now. - Jarred Younger
How about Hashimoto's? Sounds familiar.
What treatments are there against this?
High heart rate low bp is a hallmark symptom I have had for the 28 years I have suffered from CFS. Average is 90 over 60 80 bpm. But have often had lower than this 75 over 55. Rarely if ever higher than 110 over 80. And the low readings high heart rate seem to be correlated with my crashes.
Have you had any general anaesthetics ? That is , put to sleep .
If so , when in relation to the 28 years you mentioned .
@@sneakypress Yes once when I was 29. 36 years ago. Had two screws put into my hip socket. Was told it was a long opp with lots of blood loss.
@@sneakypresshas there been a link between general anesthesia and me cfs? Mine started 2 months after surgery
Sounds like your vessels are shot man. Do you also have neuropathy?
@@eddie8489 Had neuropathy in arms and pins and needles on face when I was in a moldy house. Not any more. I have heard of people referring to the face thing as Bells Palsy, I never had any paralysis and symptoms were transatory so I wouldn't refer to it that way but I understand why some people do. Also heard the condition correlated with lymes. I don't trust the lime tests but they came back negative on two separate occasions. Blood circulation has been an issue for me. I stupidly ate a bunch of french fries because I associated them once with lowering of my symptoms and I really like them. Did that for a couple of years so much so my cholesterol got into the unhealthy range. So much so dr's wanted to put me on statins. I am still just over healthy range but I try to eat lots of veggies and beans and things with lots of fiber low fat and calorie restriction. My BMI is 22.5. Reason why I think my circulation is poor is especially my feet used to get cold super easy. I think that has gotten better since I have been anally focused on my diet for the last 6 or 7 years. I still have to be careful not to push myself too hard but am pretty active as far as CFS/ME goes. I still crash and loose a day or two than recover. I can run all day minus the occasional death nap as long as I don't push. IE work in my garage on projects that likely will induce a crash if I say work for 5 or 6 hours straight a couple of days in a row. Sitting in my bed with my computer in my lap I can do 7 or 8 hours a day. So I don't see it that way but lots of people might call me lucky. Still struggle with brain fog. It's easy for me to watch youtube. Doing something my taxes or studying stock charts, organizing things on my computer, learning how to use programs I am interested in all wears me out very quickly. I can only do so much. I am 65. It's getting to the point where lots of people my age without CFS have health issues just as bad albeit in different ways probably worse than CFS without the PEM. So I guess I am lucky to have what I have. Have so much I want to do though and can't do it. Gardening, building things fixing things, creating things, traveling. So frustrating! Digestive issues are not as bad anymore. I attribute that to mold avoidance, gluten avoidance, calorie restriction and because it's virtually impossible to find certain foods that trigger me I eat small amounts of a wide variety of foods every day. When I crash from over exertion a lot of the digestive issues rear their ugly heads.
🙏🏼 Gracias
Luto com fadiga crônica há 10 anos e sempre percebi que me sentia pronta pra correr em fuga ou lutar. Testei cortisol no sangue e é elevadíssimo (mais que o dobro do normal). Penso que esse é o caminho; adrenalina.
I hope you can figure that out. I can't give medical advice, but you may want to get a 24-hour urine test of the cortisol, adrenaline, and noradrenaline. If they are high, there are many things that should be investigated. - Jarred Younger
Obrigada
In Belgium Fibromyalgia and CFS are considered the same thing.
I have anhedonia and feel nothing 24x7, can I still have it?
So folks with fybromyalgia do not what if you have both and like myself confusiin what we have
It does make sense. If adrenal response for pm workers is affected on top of having the CF/ME plus other genetic rheumatological disorders then I could see how other factors of the adrenal glands could really affect one. As you mentioned it would be a sub group. If one has a definite correlation with a parent that has had immune system issues and even cancer like multiple myeloma and endocrinologist with a rheumatologist would be a good idea besides a hematologist. Does insurance pay for it? Not likely but maybe requesting a 24 hr urine if one knows that certain labs have come back and might seem suspicious it is a good way to bring it up.
Have you been checked for tve EDS spectrum?
Inflammation and arthritis is often from EDS.
The 24-hour urine test is pretty cheap and routine for any medical practice. I would think most insurance companies would cover it. The justification for the test would be unexplained symptoms like heart palpitations, sweating, anxiety, etc. - Jarred Younger
I have it, PSA and obvious immune system issues since childhood. Not exactly quality of life but as most, do our best to keep educating and trying to help minimize the bad stuff as much as we all can. Certainly not here looking for a cure all but something that helps us get by as all feel the med squeeze and hope the best of course and appreciating the immense amount of testing involved. I am here likewise as an observer and if I hear or read something applicable it is truly appreciated. 😊
@@youngerlabyes indeed, it should be ok’d. A very close relative is having all the testing I had done. Isn’t that wild? Genetic factors with other complications. Ty.😊
High aldosterone levels
Ty
I’m going to watch it, and I’m looking for things that can lower my adrenaline. I have for 4,5 yr long covid and then a tick bite which ended in neuroborreliose in just 2 months. But I have extreme adrenaline since a few weeks and I don’t know what to do. It’s so extreme and continue. Now my LC is going worse sadly. I was recovering.
Keep an eye on your heart.
Do you have high aldosterone from adrenal causes lots of problems
Is this the same stuff this video talks about? The video is longer for anyone looking for a more in depth video.
ruclips.net/video/psALpJG_19Y/видео.htmlfeature=shared
In my unschooled way, I have diagnosed myself with CFS, which I fell ill with in the 1980's. My reasoning was that chronic stress for several years, overactivated and damaged my adrenal production. I've never been completely bed ridden, like I've heard some people experience, but the flare ups come up regularly following overwork. I wonder if the more extreme illness is fibromyalgia, and the milder is CFS.
CFS is worse
9:23 "circulating receptors"?
That was poorly phrased -- "soluble" beta-1 receptors. - Jarred Younger
@@youngerlab just asked chatgpt and from my limited understandig it seems you phrased it perfectly. I had no idea these sort of free floating receptors unbound to any cell membrane existed.
Has anyone found any of his videos to be helpful in finding a cure for anything?
Begone, troll!!
Same feeling here, not a single one did make sense for me, in that case i had catecholamines tested 4 yeras ago and was in the low end of the normal range range
I'm really grateful for Dr Younger sharing updates and developments on what's happening within research, the benefit of which we will eventually see once the basis is proven
@@andrewgifford7740 can you elaborate on eventually ?
He gave me some evidence which I already was counting upon. In my case it is crearly a posture problem. My rib cage is so compress I have very hard time breathing, because my ribs just cannot expand. Correcting my posture through PRI exercises have been absolutely life changing. My brain fog, fatigue, digestion, breathing, etc... Everything got much better and this is what I believe the ultimate way to heal my body completely.
Just a complete rambling mess
Sounds like brain training people quackery.
what part of it?
@@arasharfa That ME is just an overactive fight- flight response. (High adrenaline and other stress hormones). It's their whole mantra.
@@AlbaLynxQueen noone said it's just that. but that high adrenaline is part of the picture for some is not far fetched. it doesnt necessarily equate to just an overactive sympathetic nervous system. It was for me, but obviously not the whole story. I needed many different treatments of various modalities to improve. they are not making any claims about the cause.
@@arasharfaI think for some..histamine intolerance causes a release of adrenaline to try and tamp down the histamine
@@AlbaLynxQueen Nobody said its the whole answer. Just because you have freedom to type, dont accuse freely.
Love your video and work keep going I'm a cfs suffer ptsd and long c thxs💪🏼💪🏼💪🏼🙏👊💪🏼🫶
Thank you! - Jarred Younger