Granulomatosis with polyangiitis / Wegener's granulomatosis - Usmle step 1 vascular Pathology
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- Опубликовано: 1 окт 2024
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Granulomatosis with polyangiitis (GPA), formerly known as Wegener granulomatosis, is a multisystem disease of unknown etiology characterized by vasculitis and necrotizing granulomatous inflammation of the small arteries and veins. Classic generalized GPA is a triad of necrotizing granulomas of the upper and lower respiratory tract, systemic necrotizing small vessel granulomatous vasculitis, and glomerulonephritis (usually focal segmental). GPA most often occurs in patients in middle age and of Northern European descent (80%-90% of cases), but cases have been reported in children and older adults.
The disease typically presents with upper airway disease and nonspecific complaints such as malaise, arthralgias, fever, and weight loss. Respiratory tract symptoms include sinusitis, otitis media, rhinorrhea, cough, sputum production, chest pain, dyspnea, and hemoptysis.
The disease presents variably on a continuum from limited involvement (which may remain limited for variable periods of time) to a more generalized form with involvement of the upper and lower respiratory tract, kidney, skin, and other organs. Untreated, the generalized form is fatal in less than 2 years; however, long-term remissions are now possible in more than 90% of patients with the advent of cytotoxic therapy.
Complications of GPA include pericarditis, coronary arteritis, myocardial infarction, pancarditis, granulomatous valvulitis, mononeuritis multiplex, and polyneuritis. Laryngotracheal stenosis with stridor can be a complication of GPA and initially may be misdiagnosed as asthma.
usmle
granulomatosis with polyangiitis
wegener's granulomatosis
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sir i actually want very detailed lectures on sperm can you make it , please
Thx
Greetings from Peru
Sir, i am treating for this disease for last 3years
Is it's completely curable??
My Nephew is just 31
@@ashiqaq8428 tell me of your Treatment or cure please & Thank You
I have this disease.
Very uncomfortable so much.
A great respect from Pakistan.Dr Raheela
Soy mexicana y me encanta la forma de explicar, thanks so much for your videos 😍🤗
Thank you for sharing this information with us.
Excellent sir
Which book you are using for pathology ?
Thank you Sir. I have been watching your lectures from my first MBBS.
Great to hear that
a good one, dr
Sir u done great job and thank u sir
Thank u so much and keep watching
two words for you thank you
which country are you from, Sir
my sister needs treatment for this decease, can you help please
👏🏼👏🏼👏🏼👏🏼
Very.very.thanks.for.this.exclusive.approach.
Excellent one
Great doc 😍💛
🤝🤝🤝
Dr. Bhanu Sir, I am searching for the best doctor who treats this disease in Chennai for one of my relatives suffering severely from this GPA. Please advise.
I can suggest you sgpgi lucknow or sgpgi chandigarh for the best doctors and well treatment. My mom is also suffering from this disease. Her treatment is going on in sgpgi lucknow .
@@ateebwarsi12345could you please tell me if your mum got cured by those doctors thank you
Thank you sir!😊
Welcome 😊
Thank you sir!😊
You are welcome!
Awesome sir.
Thank u
Thankuuuuuuu uuuuuuu sir
🤝🤝🤝
I have been diagnosed this disease since 2008
My mom also suffering from 2020..my mom age is 54...under which doctor ur treatment going on...
Your doctor mam...my also suffering....
I have been treated in Kolkata sskm hospital..under nephrology dept
Mam..what is your age now....and what the condition of yours now...??
@@anupamdutta8765 I'm stable now..but in under treatment..
I am suffering from same disease
Hi, Where are you getting this treatment? I meant which hospital and doctor. I am searching for the best doctor who treats this disease in Chennai for one of my relatives suffering severely from this GPA.
@@rajrajan bro, I live in delhi. So I got my treatment from AIIMS .under the team of Dr. Umashanker(Medicine department). For last 7 years i have never been to the hospital because i was feeling better but till now i m taking only 2.5 mg wysolone. Can I know the age of the patient who is suffering from GPA.
Bro my mom is also suffering from this disease i need to discuss about it with u may i have any of your contacts so i can discuss it?
@@ateebwarsi12345 where are you from?
Bro,i live in bihar