COMBI-AD: long-term follow-up of dabrafenib and trametinib in BRAF-mutated melanoma

Georgina Long, PhD, MBBS, FRACP, FAHMS, University of Sydney, North Sydney, Australia, discusses the final results from the Phase III COMBI-AD trial (NCT01682083) of adjuvant dabrafenib with trametinib in patients with BRAF-mutated stage III melanoma. With a median follow-up of 100 months, the study shows that the combination treatment significantly improved relapse-free survival (RFS) and distant-metastasis-free survival (DMFS) compared to placebo. The safety profile remained consistent with previous reports, affirming the long-term efficacy of dabrafenib plus trametinib in reducing relapse and metastasis in high-risk melanoma. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
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