Sir, very helpful video! THANK YOU My formulations are following Makoid-Banakar and Weibull models Please also tell us about the interpretation of these both.
JazakAllah thanks for praise As for your question R2 is maximum correlation of variables with the standard so a better value will be 0.975 to 1. The difference between r2 and adjusted r2 is the reliability factor only. AdjustedR2 adds precision and reliability by considering the impact of additional independent variables that might influence.
understand In my case, in my results I have two models that are more efficient: the Korsemeyer model with R2= 0.9836 and R2_adj =0.9806 and the Makoid-B model with R=0.9839 and R2_adj=0.9791. Which would be better to use?
Many thanks for this useful video. I have dissolution data where the values of R square for zero order, first order and Higuchi models are negative. These are -6.7502, -3.5665 and -1.8404, respectively. For Korsmeyer Peppas R square is 0.6050 (positive). Do you have an idea on how those results can be explained? The experimental data is a bit scattered as I used gravimetric analysis to get the data points and plot the % dissolution vs time graph, I think this is influencing the results. What's your opinion?
You might apply other models also so that you can find the optimum model. The negative values means no correlation or points selected for correlation are not in same trend. The trends which are hyperbolic or drug dissolution completed before the end time then the last points should not have concentrations less than the maximum point values. gravimetric is not an approach for multiple samples use some analytical instruments for analysis.
@@pharmaceuticaltechnologyph1871 Thank you for your response. In this case, I am trying to apply these models for the dissolution of polymers. The dissolution occurs at high temperature hence it's difficult to use instrumental analysis. The polymer precipitates almost instantly when the sample is taken from the reactor, that's the reason why I used a gravimetric approach (weight solute/volume solvent) to analyse this system. I do agree that it's not the best approach but I couldn't find an instrumental technique able to do the analysis at 150 °C or above.
Asalamolekum sir i want to ask can i do modelling of different pH data at a time like you mentioned you did modeling on all the formulations together? Also kindly make video in urdu version as well thanks Alot
sir i have a question when we dissolute drug x in water as a media but the calibration curve done in methanol so for unknown drug x concentration measured against water as blank or adding methanol as well thanks in advance
Calibration cant be made using a evaporable solvent Methanol can only be used in 10 to 20 % ratio remaining will always be water. so the calibration curve will be called as cosolvent based water media. Then it can be used for analysis of drug solution in water.
@@pharmaceuticaltechnologyph1871 so if we used calibration methanol based water, for dissolution in water the reference will be water only or diluted by methanol to mimic calibration set
Methanol or ethanol etc. can be used as co-solvents to increase the solubility of any drug in water. The first solution prepared either by using a organic solvent alone or as co-solvent to dissolve drug will be called stock/standard solution. This will be further diluted to make a solution known as working solution that will be used for specific day analysis. The working solution will be diluted with water alone or buffer of specific pH (at which analysis will be done) for further dilutions that will be used for calibration curve preparation. By this you can compare the calibration curve with sample analysis using water/buffer as reference solution. Hope you get the answer.
You can download a DDsolver from the following link link.springer.com/article/10.1208%2Fs12248-010-9185-1/ Complete Link (Download ESM 2, extract it and run on word by clicking Enable Macros) For more details, this is the original article www.ncbi.nlm.nih.gov/pmc/articles/PMC2895453/ Complete link (Download ESM 2, extract it and run on word by clicking Enable Macros)
It was very helpful for my thesis❤
jazakallah ahsanal jaza for making my PhD work easier
Sir, very helpful video! THANK YOU
My formulations are following Makoid-Banakar and Weibull models Please also tell us about the interpretation of these both.
Thanks a lot for so much informative video..
So nice of you
Hello. excellent video.
I have a question:
what value of R should I take or what is the difference between Rsqr and Radj?
JazakAllah thanks for praise
As for your question
R2 is maximum correlation of variables with the standard so a better value will be 0.975 to 1.
The difference between r2 and adjusted r2 is the reliability factor only.
AdjustedR2 adds precision and reliability by considering the impact of additional independent variables that might influence.
understand In my case, in my results I have two models that are more efficient: the Korsemeyer model with R2= 0.9836 and R2_adj =0.9806 and the Makoid-B model with R=0.9839 and R2_adj=0.9791. Which would be better to use?
Allah bless you. Very informative
So nice of you
Many thanks for this useful video. I have dissolution data where the values of R square for zero order, first order and Higuchi models are negative. These are -6.7502, -3.5665 and -1.8404, respectively. For Korsmeyer Peppas R square is 0.6050 (positive). Do you have an idea on how those results can be explained? The experimental data is a bit scattered as I used gravimetric analysis to get the data points and plot the % dissolution vs time graph, I think this is influencing the results. What's your opinion?
You might apply other models also so that you can find the optimum model. The negative values means no correlation or points selected for correlation are not in same trend. The trends which are hyperbolic or drug dissolution completed before the end time then the last points should not have concentrations less than the maximum point values. gravimetric is not an approach for multiple samples use some analytical instruments for analysis.
@@pharmaceuticaltechnologyph1871 Thank you for your response. In this case, I am trying to apply these models for the dissolution of polymers. The dissolution occurs at high temperature hence it's difficult to use instrumental analysis. The polymer precipitates almost instantly when the sample is taken from the reactor, that's the reason why I used a gravimetric approach (weight solute/volume solvent) to analyse this system. I do agree that it's not the best approach but I couldn't find an instrumental technique able to do the analysis at 150 °C or above.
Asalamolekum sir i want to ask can i do modelling of different pH data at a time like you mentioned you did modeling on all the formulations together? Also kindly make video in urdu version as well thanks Alot
Wa Alaikum Salam
The urdu version videos are also available with similar titles
You can see those if those help
Yes all the data if labelled properly can give the results on same analysis
Thanks 👍
Sir how to draw graph for each model
DDSolver automatically draws graph for each model. But if needed manually then MS office Excel can be used by calculating values for x-axis and y-axis
sir i have a question when we dissolute drug x in water as a media but the calibration curve done in methanol so for unknown drug x concentration measured against water as blank or adding methanol as well thanks in advance
Calibration cant be made using a evaporable solvent
Methanol can only be used in 10 to 20 % ratio remaining will always be water. so the calibration curve will be called as cosolvent based water media. Then it can be used for analysis of drug solution in water.
@@pharmaceuticaltechnologyph1871 but the drug insoluble and if mixed with water may ppt in case of calibration, thanks for responding
@@pharmaceuticaltechnologyph1871 so if we used calibration methanol based water, for dissolution in water the reference will be water only or diluted by methanol to mimic calibration set
Methanol or ethanol etc. can be used as co-solvents to increase the solubility of any drug in water. The first solution prepared either by using a organic solvent alone or as co-solvent to dissolve drug will be called stock/standard solution.
This will be further diluted to make a solution known as working solution that will be used for specific day analysis.
The working solution will be diluted with water alone or buffer of specific pH (at which analysis will be done) for further dilutions that will be used for calibration curve preparation.
By this you can compare the calibration curve with sample analysis using water/buffer as reference solution.
Hope you get the answer.
@@pharmaceuticaltechnologyph1871 sure many thanks
How To Download DD Solver
You can download a DDsolver from the following link
link.springer.com/article/10.1208%2Fs12248-010-9185-1/ Complete Link
(Download ESM 2, extract it and run on word by clicking Enable Macros)
For more details, this is the original article
www.ncbi.nlm.nih.gov/pmc/articles/PMC2895453/ Complete link
(Download ESM 2, extract it and run on word by clicking Enable Macros)
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