Dissolution Data Modeling using DDSolver

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  • Опубликовано: 21 дек 2024

Комментарии • 29

  • @Athena7_7
    @Athena7_7 Год назад +3

    It was very helpful for my thesis❤

  • @nanangqosim6038
    @nanangqosim6038 Год назад

    jazakallah ahsanal jaza for making my PhD work easier

  • @zeeazam5055
    @zeeazam5055 2 года назад +1

    Sir, very helpful video! THANK YOU
    My formulations are following Makoid-Banakar and Weibull models Please also tell us about the interpretation of these both.

  • @bazlasiddiqui2097
    @bazlasiddiqui2097 2 года назад

    Thanks a lot for so much informative video..

  • @JorgeAndrésOrnelasGuillén
    @JorgeAndrésOrnelasGuillén Год назад +1

    Hello. excellent video.
    I have a question:
    what value of R should I take or what is the difference between Rsqr and Radj?

    • @pharmaceuticaltechnologyph1871
      @pharmaceuticaltechnologyph1871  Год назад

      JazakAllah thanks for praise
      As for your question
      R2 is maximum correlation of variables with the standard so a better value will be 0.975 to 1.
      The difference between r2 and adjusted r2 is the reliability factor only.
      AdjustedR2 adds precision and reliability by considering the impact of additional independent variables that might influence.

    • @andrejoan
      @andrejoan Год назад

      understand In my case, in my results I have two models that are more efficient: the Korsemeyer model with R2= 0.9836 and R2_adj =0.9806 and the Makoid-B model with R=0.9839 and R2_adj=0.9791. Which would be better to use?

  • @codigo0281
    @codigo0281 2 года назад

    Many thanks for this useful video. I have dissolution data where the values of R square for zero order, first order and Higuchi models are negative. These are -6.7502, -3.5665 and -1.8404, respectively. For Korsmeyer Peppas R square is 0.6050 (positive). Do you have an idea on how those results can be explained? The experimental data is a bit scattered as I used gravimetric analysis to get the data points and plot the % dissolution vs time graph, I think this is influencing the results. What's your opinion?

    • @pharmaceuticaltechnologyph1871
      @pharmaceuticaltechnologyph1871  2 года назад +1

      You might apply other models also so that you can find the optimum model. The negative values means no correlation or points selected for correlation are not in same trend. The trends which are hyperbolic or drug dissolution completed before the end time then the last points should not have concentrations less than the maximum point values. gravimetric is not an approach for multiple samples use some analytical instruments for analysis.

    • @codigo0281
      @codigo0281 2 года назад

      @@pharmaceuticaltechnologyph1871 Thank you for your response. In this case, I am trying to apply these models for the dissolution of polymers. The dissolution occurs at high temperature hence it's difficult to use instrumental analysis. The polymer precipitates almost instantly when the sample is taken from the reactor, that's the reason why I used a gravimetric approach (weight solute/volume solvent) to analyse this system. I do agree that it's not the best approach but I couldn't find an instrumental technique able to do the analysis at 150 °C or above.

  • @Motivational.bayans
    @Motivational.bayans 8 месяцев назад

    Asalamolekum sir i want to ask can i do modelling of different pH data at a time like you mentioned you did modeling on all the formulations together? Also kindly make video in urdu version as well thanks Alot

  • @phrahman668
    @phrahman668 Год назад

    Sir how to draw graph for each model

    • @pharmaceuticaltechnologyph1871
      @pharmaceuticaltechnologyph1871  Год назад

      DDSolver automatically draws graph for each model. But if needed manually then MS office Excel can be used by calculating values for x-axis and y-axis

  • @hirajaved8876
    @hirajaved8876 2 года назад

    Allah bless you. Very informative

  • @sarmadrkabi5361
    @sarmadrkabi5361 2 года назад

    sir i have a question when we dissolute drug x in water as a media but the calibration curve done in methanol so for unknown drug x concentration measured against water as blank or adding methanol as well thanks in advance

    • @pharmaceuticaltechnologyph1871
      @pharmaceuticaltechnologyph1871  2 года назад

      Calibration cant be made using a evaporable solvent
      Methanol can only be used in 10 to 20 % ratio remaining will always be water. so the calibration curve will be called as cosolvent based water media. Then it can be used for analysis of drug solution in water.

    • @sarmadrkabi5361
      @sarmadrkabi5361 2 года назад

      @@pharmaceuticaltechnologyph1871 but the drug insoluble and if mixed with water may ppt in case of calibration, thanks for responding

    • @sarmadrkabi5361
      @sarmadrkabi5361 2 года назад

      @@pharmaceuticaltechnologyph1871 so if we used calibration methanol based water, for dissolution in water the reference will be water only or diluted by methanol to mimic calibration set

    • @pharmaceuticaltechnologyph1871
      @pharmaceuticaltechnologyph1871  2 года назад +1

      Methanol or ethanol etc. can be used as co-solvents to increase the solubility of any drug in water. The first solution prepared either by using a organic solvent alone or as co-solvent to dissolve drug will be called stock/standard solution.
      This will be further diluted to make a solution known as working solution that will be used for specific day analysis.
      The working solution will be diluted with water alone or buffer of specific pH (at which analysis will be done) for further dilutions that will be used for calibration curve preparation.
      By this you can compare the calibration curve with sample analysis using water/buffer as reference solution.
      Hope you get the answer.

    • @sarmadrkabi5361
      @sarmadrkabi5361 2 года назад

      @@pharmaceuticaltechnologyph1871 sure many thanks

  • @pratu1356
    @pratu1356 2 года назад

    How To Download DD Solver

    • @pharmaceuticaltechnologyph1871
      @pharmaceuticaltechnologyph1871  2 года назад

      You can download a DDsolver from the following link
      link.springer.com/article/10.1208%2Fs12248-010-9185-1/ Complete Link
      (Download ESM 2, extract it and run on word by clicking Enable Macros)
      For more details, this is the original article
      www.ncbi.nlm.nih.gov/pmc/articles/PMC2895453/ Complete link
      (Download ESM 2, extract it and run on word by clicking Enable Macros)

  • @طالبطب-ز9س
    @طالبطب-ز9س 2 года назад

    Please, I need your account in Telegram or any means to communicate with you