Hi there. Any chance I can contact you via email or something?. I have some rather hard questions regarding ERVs insertion loci and struggle to google the answers. Thanks
Amazing example of science communication as usual. Off-topic, but tangential; I find that explaining to people how ERV's work is also a good way of explaining why an mRNA vaccine doesn't insert itself into gDNA. Because unlike a retrovirus, they lack reverse transcriptase and integrase.
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
How we know ERV's really come from retroviruses 1 - 03:25 ERV protein genes match those of retroviruses 2 - 07:40 long terminal repeats just like retroviruses insertions 3 - 8:50 retroviral integrase " fingerprint " are found before and after each ERV 4 - 12:49 some ERV's can still produce full-fledged viruses when celles are stressed 5 - 13:30 population vary in number of ERV's , meaning they are continually get inserted and deleted 6 - 16:06 new ERV insertions have being directly observed in the lab 7 - 18:12 new insertions observed to be quieted Silenced by hosts 8 - 18:58 ERV deletions have been observed in the lab 9 - 20:15 a mouse ERV reverted into full-fledged virus with only 01 mutation 10 - 21:54 virus genome was deduced from human ERV sequences and built in the lab 11 - 23:10 new ERV proteins and new ERV regulators can give immediate benefit to hosts
Jon, you're a very talented and intelligent young man. I'm glad to see you put your talents to good use. Love your channel and watch it with great joy with my 9 year old daughter. True understanding of any subject is only reached when you can explain it in a simple way 👏
If it wasn't one tall tale they believed it would be another one. People have psychological reasons for believing. No amount of cold science will convince most people that they're insignificant nothings on the way to eternal nothingness
How does science teach us that we are insignificant and nothing? Significantance is a matter of perspective and science teaches us that we are something. We exist as complex forms of life. And what does science teach about what happens after death? There is nothing to prove or disprove an afterlife.
This video contains a lot more information about ERV better then the original animation about ERV, I really wish you would do another animation explain the ERV using the same materials in this video.
Great job! Visual, informative. Kudos. I wish, if hasn’t already done so, you could sometimes pair with Forrest Valkai with creating even more engaging content. Your tandem would rock YT.
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
Does anyone know?... What is the oldest ERV in humans and how many mutations does it have? Actually, what ERV has the most mutation in humans and how many does it have, it might not even be the oldest ? I am so curious.
Interesting topic. I don't know the details of the 200 regions of human/ape that resembles virus sequences... Did viruses copy DNA sequences from species like humans/apes? How did viruses originate? Nobody knows. Human DNA builds a human. Design. We are not 8% virus. Viruses are 100% human.
If it was possible to remove the ERV's I wonder what the modern human would be like, because ERV's can cause mutations & changes in us I wonder how physicly or mentaly diffrent we would be?
Working with tissue culture we will newer know this? but if we cannot see tissue culture results how can we know what will be a meaning of viral propagation after stress issues on host organism?
2 Q: Can you make a difference between a man-made virus and a natural virus, is there something which denotes a probabilitiy? An explanation on isolation of viruses, how do we know viruses exist...?
Take with a grain of salt. 1) "Proofreading" isn't 100% reliable. 2) "Proofreading" adjusts for errors in a copy, when copying DNA from original. Virus targets the "original" DNA, thus evading it.
One more question: Do ERV's play a role in the innate immune system? I figure these DNA snippets could form a kind of library of what our ancestors through millions of years had been exposed to. Could immune cells use them for recognizing patterns in current pathogens?
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
James Tour has good review on the probability of abiogenesis We cannot declare with certainty that integrase was not created☺ ERVs have beneficial functions.. Fantastic review! Would be great if targeting fusion / envelope proteins could solve cancer, pulmonary fibrosis , and covid 19. Syncytin is quite interesting for use in gene targeting therapy.
"James Tour has good review" James Tour is famous for directly bearing false witness of publications and quotemining other scientists in this research field. Professor Dave did in his 2 part rebuttal several interviews with the scientists like Cronin and Blackmond etc. Tour was quoting out of context. And they all say Tour is lying about their research work and publications. He even lies how soap works in 1 funny sidenote.
But if god can do anything he could technically make it look like ERVs were inserted at different times. I don’t know why he/she/it would want to fool us but he could in the Christian world view.
You actually see the belief in a deceiver God with a lot of people on the inet. The question is how they justify to trust they put into the God when he claims they'll going to get into heaven and not to be turned into clouds with a "Gotcha!" laugh by a trickster God when he meant "into heaven" by that as further deception. So are people around thinking fossils were faked or were buried by God to test the faith.
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
god 🤣🤣🤣🤣🤣🤣🤣"I don't normally talk about gods because most questions about gods can't be answered scientifically, but this one actually can" Sure buddy, sure.
Reationist rewrite some of the genetic disciplines. e.g. They disagree with mutations causing a benefit to the species or strain and so rewite it saying that mutations can never bring about an advantage. And I ask creationists what is practised genetics based on, creation science or the textbooks? No creationist can answer it and either answer makes them fail and not answering also makes them fail. Not even geneticists who are creationist could answer it.
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
You can totally claim that ERVs were put into humans by the God of your preferred choice. You could also say the same about dinosaur bones and light from distant stars. The problem here is that by saying that you will admit that you’ve been worshiping a trickster god or an evil god who likes to deceive people! If you believe in a benevolent god - ask yourself: “Would a benevolent god trick humans?”
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
Hello I am Algerian medical doctor I am intersted of translating the HRV's Video of stated clearly channel I mean audio translation I will finish it soon this week I send asking permission to use the video with my translation to Arabic And I explained in the letter my motivation And I want to translate this video too I wait a permission from you and the team . I will send you my work if you ask that
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
I'm sorry, but you weren't thinking irrationally enough when you dismissed the idea of god inserting ERVs at the moment of creation. God *could* have inserted ERVs into every animal at the moment of creation, and carefully chosen those insertions to make it look as if all life is descended from a common ancestor with ERV insertions backing that up. But then you have to ask why god would do that... 1) God wants us to *not* believe in him and carefully disguised his hand in creation. God deliberately provided us with evidence that he does not exist. He didn't want our societies contaminated by worshiping him. 2) God loves the gullible and hates critical thinkers. So god provided evidence he doesn't exist in order to have more people to torture in hell for eternity. Only the credulous and gullible get eternal bliss.
Yes indeed. We have the same sort of "excuse" with "dinosaur bones were buried to deceive us in thinking they were belonging to living breathing animals in flesh and blood"-people or the world is just 5 minutes old and all our memories, architecture and written books and tv records were created with the world just 5 minutes ago (while then they are in a denominational battle with the "The world was made 7 minutes and 25 seconds ago"-heretics) - or a favor of mine the biblical flatearthers. ;-) Biblical flatearthers quoting the gospels like Matthew 4: _7 Jesus replied, “It is also written: ‘Do not put the Lord your God to the test.’” 8Again, the devil took Him to a very high mountain and showed Him all the kingdoms of the world and their glory. 9“All this I will give You,” he said, “if You will fall down and worship me."_ That Jesus could not have seen "all the kingdoms of the world" from the top of any high mountain - simply because when the Earth would be round - "THE GLOBE" and not flat you couldn't see all countries - one is at the opposite side of the globe. Like China, Vietnam, the Maya kingdom in America etc. According to the literal word by word faith of the biblical flatearther: The Earth *must therefore be flat* so that the words of Jesus himself and the bible (gospelquote Matthew) can remain literally word for word intact or their "salvation" is in jeopardy. And always you see a photo by NASA of the Earth globe or taken by the russian space agency Roskosmos the photo itself must be faked "CGI" and when you see with your own eyes a ship moving over the horizon it shall be the devil himself sending your eyes a delusion of the Earth's curvature to test your faith and to "let you astray" because nothing in the "fallen world" shall be really real for sure. "Only the credulous and gullible get eternal bliss." I'm not really sure this is the true conclusion for most people. I think more that people with a personality of a combination of a childish "I'm the center of the world" PLUS "There exist at least X+ absurd scenarios they are confronted on a daily bedtime story base to endanger their own narcissistic hubris" is there the main reason. So when they would be pushed out of their bible village surroundings to a muslim qur'an one on a daily base for a while - they would also just adapt that other hell narrative - simply because it appeals after a while as a more repeated threat story to their narcissistic disorder to deal with it. You have that in mental institutions with highly unstable people to adapt to inmate delusions like that the people might be robots or alien shapeshifters to reflect the paranoia of the inmates as own excuses.
@@BarryDesborough There are only two possibilities. The first is that god does not exist. The second is that god is a liar and deceiver. Take your pick.
@@bdf2718, the third possibility is that God does exist, but creationists have got it wrong with their naïve reading of scripture. (I'm an atheist, BTW.)
@@BarryDesborough Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
I find it a little unfortunate that so many people reduce God to a creator. I see god more as an organism and I identify him with the totality of everything rather then with the first cause. When there is a first cause then it is just a part of the totality of everything which is more then the first cause.
@@Justwantahover The totality of everything is the totality of every existing entity and therefore need to include non physical entity’s when they exist.
@@Justwantahover Nothing can came from nothing therefore god didn’t came into being, he always existed. If this means now that time is infinite or that there is an timeless/eternal first cause is another story.
OK, so ERVs were not in the earliest human genomes. You also stated that the genome is not over-filled with ERVs because there is a "mechanism" to "silence" them. Presumably this mechanism would have to have evolved over multiple generations, as it goes. So, how is it that the many generations survived the viral attack before the silencing mechanism had perfected itself?
ERVs were in earliest human genome, that's kinda the point - every organism had to deal with ERVs from the conception of life, and inserted ERVs are found in related organisms at roughly same place in genome, mutated roughly same amount. Therefore silencing mechanism is basically as old as life itself.
Your first argument that ERV's derive from retroviruses is that they match - and so you assure the listeners at ~7:22' that "there's absolutely not doubt" - but where's the evidence that precludes retroviruses having derived from ERV's? I've heard it said that this paper - Holmes E.C., Molecular clocks and the puzzle of RNA virus origins, J. Virology 77:3893-3897, 2003. - indicates retroviruses are probably not older than 50,000 years. Given that human ERV's are so similar to those found in many other organisms - which diverged from human lineage millions of years ago according to Evolutionary Theory - that would mean retroviruses derived from ERV's, not vice versa. In fact, it seems to me, that none of your arguments address this objection but all assume the evolutionary tale. If your premises assume the Evolutionary tale, it is unsurprising, unremarkable and indeterminative that your conclusion affirms Evolution rather than Creation.
The more evidence that's presented,the more theists have facts to refute. It's required for a faith based cult narrative to work. Some are learning we don't live in a geocentric model as they're reading this.
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
@@bili4591 Someone for some reason (boredom?) waved a magic wand and the atoms ordered themselves into supercomplex self-replicating and adaptable structures - sounds much more plausible (no). The gross simplification and ridiculing of a thesis is demagoguery, not argument.
@@username-usernamov this is for me more logic that the universe and life ( that are not infinite and static ) are the will of something beyond us, but this is too early. we need to realize scales of things, size, do more science, more astronomy 🔭 🪐 to understand that we are not the center of anything and we are nothing. and do some quantum physics to understand that what we think that’s « logic » and « normal » are not necessarily « true » a wave particle
@@username-usernamov GOD didn't create us out of boredom, haha. And no, it was not a wave of a magic wand. GOD took 7 days, intelligently designed everything. It is more rational to believe that everything was designed than believing that everything came out of a random explosion to this complexity, by chance.
@@jayyy.333 I know no scientist, thinker or philosopher who believes that "everything came out of a random explosion to this complexity, by chance", and there is no scientific theory that states such nonsense. Though I have long ago discovered that creationists have a fertile imagination, and the practice of thesis substitution is commonplace for them. It is more rational to choose a cognitive attitude that doesn't impede further exploration of the world. Most scientists have chosen one or another form of naturalism, and the results are amazing: astronomers see stars assembling themselves in clouds of interstellar gas (no intelligent designer is involved, lol), geneticists see the evolution of new genes in laboratory experiments, botanists have repeatedly seen the appearance of new species of flowering plants in the wild (at least 6 new species officially recognized by the world systematics have arisen in the last 2 centuries, and exactly 0 new species have been created by some intelligent designer, human or not). A careful look at nature indicates that a principle called self-organization operates at all levels in it. Not the chaos of chance and randomness or intelligent design. The only intelligent designer known to us is man himself, although humans are more likely to imitate nature than to create something fundamentally new. For example, all DNA editing technologies have been borrowed from living creatures that have been editing their genes since time immemorial. P.S. So what do you think some god created us for, and how did you figure it out? And how do you count days if there's no sun yet?
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
You left out how LTRs are also pre-engineered to not leave the nanotechnology factory. And that LINE-1 retrotransposons are specifically designed to detect and autocorrect actual retroviruses and specifically ignore the alleged ERV code which confirms ERVs are more accurately described as polymorphic code packets complete with header/footer instructions very similar to how modern day Internet Ethernet packetized transfer information technology works today. Confirming the ERVs are part of the original source code and not random external virus code. This false claim by the anti-scientific communities is literally claiming something far more sophisticated than a Microsoft Windows operating system environment was randomly built by viruses. Viruses that were carefully engineered to only work in highly specific ways within the operating system or the environment because corrupted. The exact opposite of how viruses actually work.
Not peer reviewed by practising geneticists, though. Only by creation science witch is not peer reviewed or put into practice. Is genetics based on what is in the textbooks or by what is only in creation science books?
@@Justwantahover Appeal to Consensus peer review logical fallacy claims is the exact same process the Vatican used. It's only pure irony Atheists think those logical fallacy arguments can work for their religious beliefs. All science is always creation science. Since all science is only about creation. Textbooks are the same as books in any church organization. Just because an Atheist wrote something down that confirms their religious confirmation biases about God doesn't make it gospel, nor scientific. It's why we scientists talk about how Atheists can't be actual scientists. Atheism is based on a lack of evidence for their religious beliefs about God, on purpose. The exact opposite of the Scientific Method Christians started. ”A little science estranges a man from God. A lot of science brings him back.” - Sir Francis Bacon, established the formal Scientific Method, first used to test the scientific field of study of God called Theology "Religion and science go together. As I've said before, science without religion is lame and religion without science is blind. They are interdependent and have a common goal-the search for truth. Hence it is absurd for religion to proscribe Galileo or Darwin or other scientists. And it is equally absurd when scientists say that there is no God. The real scientist has faith, which does not mean that he must subscribe to a creed. Without religion there is no charity. The soul given to each of us is moved by the same living Spirit that moves the universe." - Albert Einstein, Third conversation (1948): William Hermanns, Einstein and the Poet: In Search of the Cosmic Man (1983), p. 94
Here is a list of questions that a design hypothesis raises. Can you answer any of them? a) What is reverse transcriptase designed to do? Why was it designed? To what purpose? b) What is integrase designed to do? Why was it designed. To what purpose? c) Why were ERVs designed with a viral codon bias? d) What is the design purpose of re-transcribable promoters? e) What were the HERVs that produced the consensus sequence that generated Phoenix designed for? f) What is the design purpose of both exogenous and endogenous KoRV? g) If chimps and humans have commonly located ERVs, what is the design purpose of giving these common ERVs common disabling mutations? h) What is the design purpose of giving some people certain HERVs and not others? i) What is the design purpose of creating different syncytins in different placental lineages?
@@BarryDesborough all of those elementary grade questions are easily answered with yes, they're all designed mechanisms. All code in all life share the same exact codon groups including the same exact 3 start/stop codon command keys for all sequences in all life plant, animal, and microbe. It's proof God designed his code with what we called "Universal Information" design structures. Which explains why viruses share the same exact codon language as all other life. A virus could not infect another organism if it were not pre-designed to have similar command groups to be able to modify existing functions already pre-designed. Chimps and humans share less than 70% code so any common packet points would be meaningless and on the same comparison as you are with a banana that shares 50% of your pre-designed code. LTRs are very similar to how our Ethernet TCP/IP or PPP information transfer protocol technologies are designed with header and footer information to give directions for the packets in the information streams. LTRs have the same kind of promoter/terminator features except that God's information technology transfer designs are still light years ahead compared to our own human primitive technology. We're trying to reverse engineer God's code designs today to further improve our own. Hopefully you and others can catch up to modern science someday and help. "We then examine a particular coding system in DNA and discover that UI [universal information] is conveyed within the genes. Using this DNA evidence and scientific laws governing UI as premises, we are able to develop sound, logical deductions. This leads us to the following conclusion: the God of the Bible exists and He is responsible for originating and embedding Universal Information into biological life.” -Werner Gitt, Director and Professor at the German Federal Institute of Physics and Technology, Germany
OK, so you can't answer any of the questions, @@sfbmod. BTW, many years ago I asked Gitt to provide proofs of his information "theorems". He said he would, given time. Not a sausage since.
What? So where the hell did the ERV come from if it wasn't there at creation? Bwhahahaha! Where did the information come from? RNA DNA? Of course ERVs were there at creation. So wait ERVs came from where exactly? They created themselves!??? Lol
what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
I have a M.Sc. in virology and congratulate you on an excellent review of ERV's accessible to the non-scientist.
Did you spend the COVID period telling everyone how wearing porous masks and standing a few feet from others was stupid? People are such sheep.
Hi there.
Any chance I can contact you via email or something?. I have some rather hard questions regarding ERVs insertion loci and struggle to google the answers. Thanks
Amazing example of science communication as usual. Off-topic, but tangential; I find that explaining to people how ERV's work is also a good way of explaining why an mRNA vaccine doesn't insert itself into gDNA. Because unlike a retrovirus, they lack reverse transcriptase and integrase.
Jon, this is an outstanding effort and the clearest explanation of ERVs that I've seen to date. Thanks. You deserve many more subscribers!
True, but his other channel has more subscribers.
You need to see this, it clearly refutes these arguments:
ruclips.net/video/-2QAdXgcYA0/видео.html
Agree!
I can't believe a video like this needed to be made! XD Creationism is the biggest virus of our time!
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
This is an incredible video… thank you so so much. I have gotten these objections to ERVs so many times and have struggled to articulate the details.
How we know ERV's really come from retroviruses
1 - 03:25 ERV protein genes match those of retroviruses
2 - 07:40 long terminal repeats just like retroviruses insertions
3 - 8:50 retroviral integrase " fingerprint " are found before and after each ERV
4 - 12:49 some ERV's can still produce full-fledged viruses when celles are stressed
5 - 13:30 population vary in number of ERV's , meaning they are continually get inserted and deleted
6 - 16:06 new ERV insertions have being directly observed in the lab
7 - 18:12 new insertions observed to be quieted
Silenced by hosts
8 - 18:58 ERV deletions have been observed in the lab
9 - 20:15 a mouse ERV reverted into full-fledged virus with only 01 mutation
10 - 21:54 virus genome was deduced from human ERV sequences and built in the lab
11 - 23:10 new ERV proteins and new ERV regulators can give immediate benefit to hosts
Jon, you're a very talented and intelligent young man. I'm glad to see you put your talents to good use. Love your channel and watch it with great joy with my 9 year old daughter.
True understanding of any subject is only reached when you can explain it in a simple way 👏
If it wasn't one tall tale they believed it would be another one. People have psychological reasons for believing. No amount of cold science will convince most people that they're insignificant nothings on the way to eternal nothingness
How does science teach us that we are insignificant and nothing? Significantance is a matter of perspective and science teaches us that we are something. We exist as complex forms of life. And what does science teach about what happens after death? There is nothing to prove or disprove an afterlife.
@@slimjim6439 You are the alpha and the Omega. The first and last. Everything and nothing.
@@daithiocinnsealach1982 Everything and nothing? What are you going on about? People aren't "everything and nothing", they're just something.
@@theofriesen9527 He's a troll.
You need to see this, it clearly refutes these arguments:
ruclips.net/video/-2QAdXgcYA0/видео.html
This video contains a lot more information about ERV better then the original animation about ERV, I really wish you would do another animation explain the ERV using the same materials in this video.
This is brilliant & detailed. Thank you 🙌🏻
I just watched your Carl Sagan Baloney Detection Kit video and feel like you could do a whole video on every point he makes. I would love to see that.
I wish I could explain molecular biology as well to others. Once you're deep into it yourself, it becomes harder to communicate the topic to laypeople
Dr. Peel has a tame ape which he calls Matt Powell.
This is a fantastic video. Lots of great information.
Great job!
Visual, informative. Kudos.
I wish, if hasn’t already done so, you could sometimes pair with Forrest Valkai with creating even more engaging content. Your tandem would rock YT.
This is a fabulous video, extremely helpful. Thank you!
Absolutely amazing work ❤❤
Which god?
I get confused.
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
This simply tells us that retrovirus is synthetic virus created in a laboratory,... it's is not a natural zoonotic virus ...😁😁😂😂😂😂
you're great ❤️
Matt Powell has an inflatable banana in his backyard which he calls Dr. Peel
Does anyone know?... What is the oldest ERV in humans and how many mutations does it have? Actually, what ERV has the most mutation in humans and how many does it have, it might not even be the oldest ? I am so curious.
Interesting topic.
I don't know the details of the 200 regions of human/ape that resembles virus sequences...
Did viruses copy DNA sequences from species like humans/apes?
How did viruses originate?
Nobody knows.
Human DNA builds a human. Design.
We are not 8% virus.
Viruses are 100% human.
If it was possible to remove the ERV's I wonder what the modern human would be like, because ERV's can cause mutations & changes in us I wonder how physicly or mentaly diffrent we would be?
Simply , You are a legend
This is a great and well explained video.
Could these viruses have originated in the human genome/animal genome? Only became viruses after shedding from DNA?
Great summary!
This breaks my heart about Koalas. Viruses leave them alone!
Working with tissue culture we will newer know this? but if we cannot see tissue culture results how can we know what will be a meaning of viral propagation after stress issues on host organism?
2 Q:
Can you make a difference between a man-made virus and a natural virus, is there something which denotes a probabilitiy?
An explanation on isolation of viruses, how do we know viruses exist...?
How we can make a clear difference between endogenous retroviruses and retrotransposons ?
Hi , I am teacher and recently one student asked me if human DNA has strong proof reading then how the virus are able to infect human cells
What will be an appropriate answer for this question.
Take with a grain of salt. 1) "Proofreading" isn't 100% reliable. 2) "Proofreading" adjusts for errors in a copy, when copying DNA from original. Virus targets the "original" DNA, thus evading it.
One more question: Do ERV's play a role in the innate immune system? I figure these DNA snippets could form a kind of library of what our ancestors through millions of years had been exposed to. Could immune cells use them for recognizing patterns in current pathogens?
You need to see this, it clearly refutes these arguments:
ruclips.net/video/-2QAdXgcYA0/видео.html
Well,if a mousees endogenous retroviruses get turned back on,is there a 100 percent chance that the mouse would die as a result?
Funny how you can’t have a retrovirus without a host…. Therefore the host came first…..
Every question that begins with "Did god" can be answered with "NO".
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
Aint You tired of the creationists
James Tour has good review on the probability of abiogenesis
We cannot declare with certainty that integrase was not created☺ ERVs have beneficial functions..
Fantastic review! Would be great if targeting fusion / envelope proteins could solve cancer, pulmonary fibrosis , and covid 19. Syncytin is quite interesting for use in gene targeting therapy.
"James Tour has good review" James Tour is famous for directly bearing false witness of publications and quotemining other scientists in this research field. Professor Dave did in his 2 part rebuttal several interviews with the scientists like Cronin and Blackmond etc. Tour was quoting out of context. And they all say Tour is lying about their research work and publications. He even lies how soap works in 1 funny sidenote.
But if god can do anything he could technically make it look like ERVs were inserted at different times. I don’t know why he/she/it would want to fool us but he could in the Christian world view.
You actually see the belief in a deceiver God with a lot of people on the inet. The question is how they justify to trust they put into the God when he claims they'll going to get into heaven and not to be turned into clouds with a "Gotcha!" laugh by a trickster God when he meant "into heaven" by that as further deception.
So are people around thinking fossils were faked or were buried by God to test the faith.
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
god 🤣🤣🤣🤣🤣🤣🤣"I don't normally talk about gods because most questions about gods can't be answered scientifically, but this one actually can" Sure buddy, sure.
Reationist rewrite some of the genetic disciplines. e.g. They disagree with mutations causing a benefit to the species or strain and so rewite it saying that mutations can never bring about an advantage. And I ask creationists what is practised genetics based on, creation science or the textbooks? No creationist can answer it and either answer makes them fail and not answering also makes them fail. Not even geneticists who are creationist could answer it.
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
graphic: polymerizing ??
Religion, Need To
Reject God Invert
His Words Hence
You can totally claim that ERVs were put into humans by the God of your preferred choice. You could also say the same about dinosaur bones and light from distant stars.
The problem here is that by saying that you will admit that you’ve been worshiping a trickster god or an evil god who likes to deceive people! If you believe in a benevolent god - ask yourself: “Would a benevolent god trick humans?”
The great explanatory video, i’m going to pass this on to some anti evolution family members. Cheers 👍👍
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
Religion do everything to preserve their Fairytale Story
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
Hello
I am Algerian medical doctor
I am intersted of translating the HRV's
Video of stated clearly channel
I mean audio translation I will finish it soon this week
I send asking permission to use the video with my translation to Arabic
And I explained in the letter my motivation
And I want to translate this video too
I wait a permission from you and the team .
I will send you my work if you ask that
سيكون من الرائع ترجمته ي دكتور في الانتظار ع احر من الجمر
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
I'm sorry, but you weren't thinking irrationally enough when you dismissed the idea of god inserting ERVs at the moment of creation.
God *could* have inserted ERVs into every animal at the moment of creation, and carefully chosen those insertions to make it look as if all life is descended from a common ancestor with ERV insertions backing that up.
But then you have to ask why god would do that...
1) God wants us to *not* believe in him and carefully disguised his hand in creation. God deliberately provided us with evidence that he does not exist. He didn't want our societies contaminated by worshiping him.
2) God loves the gullible and hates critical thinkers. So god provided evidence he doesn't exist in order to have more people to torture in hell for eternity. Only the credulous and gullible get eternal bliss.
Yes indeed. We have the same sort of "excuse" with "dinosaur bones were buried to deceive us in thinking they were belonging to living breathing animals in flesh and blood"-people or the world is just 5 minutes old and all our memories, architecture and written books and tv records were created with the world just 5 minutes ago (while then they are in a denominational battle with the "The world was made 7 minutes and 25 seconds ago"-heretics) - or a favor of mine the biblical flatearthers. ;-)
Biblical flatearthers quoting the gospels like Matthew 4: _7 Jesus replied, “It is also written: ‘Do not put the Lord your God to the test.’” 8Again, the devil took Him to a very high mountain and showed Him all the kingdoms of the world and their glory. 9“All this I will give You,” he said, “if You will fall down and worship me."_
That Jesus could not have seen "all the kingdoms of the world" from the top of any high mountain - simply because when the Earth would be round - "THE GLOBE" and not flat you couldn't see all countries - one is at the opposite side of the globe. Like China, Vietnam, the Maya kingdom in America etc.
According to the literal word by word faith of the biblical flatearther: The Earth *must therefore be flat* so that the words of Jesus himself and the bible (gospelquote Matthew) can remain literally word for word intact or their "salvation" is in jeopardy.
And always you see a photo by NASA of the Earth globe or taken by the russian space agency Roskosmos the photo itself must be faked "CGI" and when you see with your own eyes a ship moving over the horizon it shall be the devil himself sending your eyes a delusion of the Earth's curvature to test your faith and to "let you astray" because nothing in the "fallen world" shall be really real for sure.
"Only the credulous and gullible get eternal bliss."
I'm not really sure this is the true conclusion for most people. I think more that people with a personality of a combination of a childish "I'm the center of the world" PLUS "There exist at least X+ absurd scenarios they are confronted on a daily bedtime story base to endanger their own narcissistic hubris" is there the main reason.
So when they would be pushed out of their bible village surroundings to a muslim qur'an one on a daily base for a while - they would also just adapt that other hell narrative - simply because it appeals after a while as a more repeated threat story to their narcissistic disorder to deal with it. You have that in mental institutions with highly unstable people to adapt to inmate delusions like that the people might be robots or alien shapeshifters to reflect the paranoia of the inmates as own excuses.
That makes God out to be a liar and a deceiver. Also, what would be the point?
@@BarryDesborough There are only two possibilities. The first is that god does not exist. The second is that god is a liar and deceiver. Take your pick.
@@bdf2718, the third possibility is that God does exist, but creationists have got it wrong with their naïve reading of scripture. (I'm an atheist, BTW.)
@@BarryDesborough Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
Which god are you referring too?
Witch God?
I find it a little unfortunate that so many people reduce God to a creator.
I see god more as an organism and I identify him with the totality of everything rather then with the first cause.
When there is a first cause then it is just
a part of the totality of everything which is more then the first cause.
So God is a "physical" being, is it? How did God come into existence if it is "physical"?
@@Justwantahover
The totality of everything is the totality of every existing entity and therefore need to include non physical entity’s when they exist.
@@Justwantahover
Nothing can came from nothing therefore god didn’t came into being, he always existed.
If this means now that time is infinite or that there is an timeless/eternal first cause is another story.
OK, so ERVs were not in the earliest human genomes. You also stated that the genome is not over-filled with ERVs because there is a "mechanism" to "silence" them. Presumably this mechanism would have to have evolved over multiple generations, as it goes. So, how is it that the many generations survived the viral attack before the silencing mechanism had perfected itself?
ERVs were in earliest human genome, that's kinda the point - every organism had to deal with ERVs from the conception of life, and inserted ERVs are found in related organisms at roughly same place in genome, mutated roughly same amount. Therefore silencing mechanism is basically as old as life itself.
Your first argument that ERV's derive from retroviruses is that they match - and so you assure the listeners at ~7:22' that "there's absolutely not doubt" - but where's the evidence that precludes retroviruses having derived from ERV's? I've heard it said that this paper - Holmes E.C., Molecular clocks and the puzzle of RNA virus origins, J. Virology 77:3893-3897, 2003. - indicates retroviruses are probably not older than 50,000 years. Given that human ERV's are so similar to those found in many other organisms - which diverged from human lineage millions of years ago according to Evolutionary Theory - that would mean retroviruses derived from ERV's, not vice versa. In fact, it seems to me, that none of your arguments address this objection but all assume the evolutionary tale. If your premises assume the Evolutionary tale, it is unsurprising, unremarkable and indeterminative that your conclusion affirms Evolution rather than Creation.
The more evidence that's presented,the more theists have facts to refute. It's required for a faith based cult narrative to work. Some are learning we don't live in a geocentric model as they're reading this.
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
@@bili4591 Someone for some reason (boredom?) waved a magic wand and the atoms ordered themselves into supercomplex self-replicating and adaptable structures - sounds much more plausible (no).
The gross simplification and ridiculing of a thesis is demagoguery, not argument.
@@username-usernamov this is for me more logic that the universe and life ( that are not infinite and static ) are the will of something beyond us, but this is too early.
we need to realize scales of things, size, do more science, more astronomy 🔭 🪐 to understand that we are not the center of anything and we are nothing.
and do some quantum physics to understand that what we think that’s « logic » and « normal » are not necessarily « true »
a wave particle
@@username-usernamov GOD didn't create us out of boredom, haha. And no, it was not a wave of a magic wand. GOD took 7 days, intelligently designed everything. It is more rational to believe that everything was designed than believing that everything came out of a random explosion to this complexity, by chance.
@@jayyy.333 I know no scientist, thinker or philosopher who believes that "everything came out of a random explosion to this complexity, by chance", and there is no scientific theory that states such nonsense. Though I have long ago discovered that creationists have a fertile imagination, and the practice of thesis substitution is commonplace for them.
It is more rational to choose a cognitive attitude that doesn't impede further exploration of the world. Most scientists have chosen one or another form of naturalism, and the results are amazing: astronomers see stars assembling themselves in clouds of interstellar gas (no intelligent designer is involved, lol), geneticists see the evolution of new genes in laboratory experiments, botanists have repeatedly seen the appearance of new species of flowering plants in the wild (at least 6 new species officially recognized by the world systematics have arisen in the last 2 centuries, and exactly 0 new species have been created by some intelligent designer, human or not). A careful look at nature indicates that a principle called self-organization operates at all levels in it. Not the chaos of chance and randomness or intelligent design.
The only intelligent designer known to us is man himself, although humans are more likely to imitate nature than to create something fundamentally new. For example, all DNA editing technologies have been borrowed from living creatures that have been editing their genes since time immemorial.
P.S. So what do you think some god created us for, and how did you figure it out? And how do you count days if there's no sun yet?
Probs where the term dodgy came from. Dodgy retro viruses.
God didn't do anything, because god's FICTION!!
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
according to my religion, that is the only thing god ever did 🙏🙏🙏
You left out how LTRs are also pre-engineered to not leave the nanotechnology factory. And that LINE-1 retrotransposons are specifically designed to detect and autocorrect actual retroviruses and specifically ignore the alleged ERV code which confirms ERVs are more accurately described as polymorphic code packets complete with header/footer instructions very similar to how modern day Internet Ethernet packetized transfer information technology works today. Confirming the ERVs are part of the original source code and not random external virus code.
This false claim by the anti-scientific communities is literally claiming something far more sophisticated than a Microsoft Windows operating system environment was randomly built by viruses. Viruses that were carefully engineered to only work in highly specific ways within the operating system or the environment because corrupted. The exact opposite of how viruses actually work.
Not peer reviewed by practising geneticists, though. Only by creation science witch is not peer reviewed or put into practice. Is genetics based on what is in the textbooks or by what is only in creation science books?
@@Justwantahover Appeal to Consensus peer review logical fallacy claims is the exact same process the Vatican used. It's only pure irony Atheists think those logical fallacy arguments can work for their religious beliefs.
All science is always creation science. Since all science is only about creation. Textbooks are the same as books in any church organization. Just because an Atheist wrote something down that confirms their religious confirmation biases about God doesn't make it gospel, nor scientific. It's why we scientists talk about how Atheists can't be actual scientists. Atheism is based on a lack of evidence for their religious beliefs about God, on purpose. The exact opposite of the Scientific Method Christians started.
”A little science estranges a man from God. A lot of science brings him back.”
- Sir Francis Bacon, established the formal Scientific Method, first used to test the scientific field of study of God called Theology
"Religion and science go together. As I've said before, science without religion is lame and religion without science is blind. They are interdependent and have a common goal-the search for truth. Hence it is absurd for religion to proscribe Galileo or Darwin or other scientists. And it is equally absurd when scientists say that there is no God. The real scientist has faith, which does not mean that he must subscribe to a creed. Without religion there is no charity. The soul given to each of us is moved by the same living Spirit that moves the universe."
- Albert Einstein, Third conversation (1948): William Hermanns, Einstein and the Poet: In Search of the Cosmic Man (1983), p. 94
Here is a list of questions that a design hypothesis raises. Can you answer any of them?
a) What is reverse transcriptase designed to do? Why was it designed? To what purpose?
b) What is integrase designed to do? Why was it designed. To what purpose?
c) Why were ERVs designed with a viral codon bias?
d) What is the design purpose of re-transcribable promoters?
e) What were the HERVs that produced the consensus sequence that generated Phoenix designed for?
f) What is the design purpose of both exogenous and endogenous KoRV?
g) If chimps and humans have commonly located ERVs, what is the design purpose of giving these common ERVs common disabling mutations?
h) What is the design purpose of giving some people certain HERVs and not others?
i) What is the design purpose of creating different syncytins in different placental lineages?
@@BarryDesborough all of those elementary grade questions are easily answered with yes, they're all designed mechanisms. All code in all life share the same exact codon groups including the same exact 3 start/stop codon command keys for all sequences in all life plant, animal, and microbe. It's proof God designed his code with what we called "Universal Information" design structures. Which explains why viruses share the same exact codon language as all other life. A virus could not infect another organism if it were not pre-designed to have similar command groups to be able to modify existing functions already pre-designed.
Chimps and humans share less than 70% code so any common packet points would be meaningless and on the same comparison as you are with a banana that shares 50% of your pre-designed code.
LTRs are very similar to how our Ethernet TCP/IP or PPP information transfer protocol technologies are designed with header and footer information to give directions for the packets in the information streams. LTRs have the same kind of promoter/terminator features except that God's information technology transfer designs are still light years ahead compared to our own human primitive technology. We're trying to reverse engineer God's code designs today to further improve our own. Hopefully you and others can catch up to modern science someday and help.
"We then examine a particular coding system in DNA and discover that UI [universal information] is conveyed within the genes. Using this DNA evidence and scientific laws governing UI as premises, we are able to develop sound, logical deductions. This leads us to the following conclusion: the God of the Bible exists and He is responsible for originating and embedding Universal Information into biological life.”
-Werner Gitt, Director and Professor at the German Federal Institute of Physics and Technology, Germany
OK, so you can't answer any of the questions, @@sfbmod. BTW, many years ago I asked Gitt to provide proofs of his information "theorems". He said he would, given time. Not a sausage since.
What? So where the hell did the ERV come from if it wasn't there at creation? Bwhahahaha! Where did the information come from? RNA DNA? Of course ERVs were there at creation. So wait ERVs came from where exactly? They created themselves!??? Lol
what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.
THIS IS SUCH RUBBISH. CAN'T BELIEVE PEOPLE ARE STILL FALLING FOR THIS MYTH. 🤣😂
Yes you’re true 100%, what a joke lol how a ultra complex organization that give special mecanism needed to answer each survival problem ( adapted in function of the specific environment ) can be the work of a intelligent mind ? no way. put atoms and molecules in a jar, heat it up, wait billion years and yada yada yada all problems are resolved.