Cardiac surgeon says: Cholesterol doesn't matter!!?!
HTML-код
- Опубликовано: 27 сен 2024
- tweet: “I no longer accept paradigm that high LDL cholesterol causes heart disease” - cardiothoracic surgeon
he doesn’t believe high LDL cholesterol causes heart disease
patients have normal or low cholesterol. cholesterol doesn’t matter?
the paradigm that high LDL cholesterol causes heart disease. Is that the paradigm? No
it’s not high cholesterol that causes heart disease. it’s the lipoproteins that carry cholesterol
vehicles determines plaque/artery blockage, whether lipoproteins have more or less cholesterol
usually if cholesterol is high there are more lipoproteins. if they mismatch, risk follows lipoproteins, not cholesterol level
we can count lipoproteins that cause heart disease with apoB
high apoB + low LDL-c = high risk. apoB causes heart disease. High LDL-cholesterol is an indicator, not the cause
"apoB is a better marker of cardiovascular risk than LDL-cholesterol"
"reframe lipid hypothesis as lipoprotein particle hypothesis"
"lipid hypothesis could be re-examined as lipoprotein hypothesis; risk most proportional to particles, not LDL cholesterol"
evidence for vehicles, against cholesterol as cause; experts don’t think there’s a debate
high LDL-c used as indicator of risk
patients have normal or low LDL-cholesterol so high LDL-cholesterol cant be the cause? are patients on cholesterol-lowering drugs?
Statins lower cardiovascular risk, dont eliminate it, still residual risk. Lowering cholesterol slows buildup of plaque, statins stabilize plaque, there is still plaque burden, statins doesn’t eliminate all plaque
common for someone on statins to have low cholesterol but still have risk of heart attack. risk is lower than with higher cholesterol but still residual risk
cholesterol drops after heart attack (Acute phase response)
"Acute coronary syndrome (heart attack) affects lipids/lipoproteins, low density lipoprotein (LDL) and total cholesterol decrease"
heart attack patients' cholesterol is lower. If i'm not aware of APR i might think "they have low cholesterol, cholesterol level has no relation with heart attacks!"
heart disease: Lipid levels during acute phase after heart attack may not reflect lipid levels leading up to heart attack
cholesterol-lowering drugs and change in lipids in acute phase of disease
threshold for high cholesterol is not where risk starts. the higher your cholesterol the more plaque
normal LDL-c = under100mg/dL, but can have plaque. Less than at 150 but not zero
people with ‘normal’ cholesterol can have plaque, yet high cholesterol is a risk factor
intermediate cholesterol more common
hospitalizations for heart disease + LDL-c levels. cholesterol of 200 is protective? no!!!
more people with cholesterol ~100.
authors: guideline revisions with even lower LDL goals
study: lower LDL cholesterol further
Risk is higher at higher ldl-cholesterol
measure cholesterol before disease. or split randomly, lower cholesterol in half, see who gets heart disease. group that gets drug has lower cholesterol and lower risk. people born with low cholesterol have lower risk of cardiovascular disease and death
LDL-cholesterol = indicator. drugs also lower apoB. if LDL-c and apoB don’t match, risk follows apoB
Bottomline, we don’t ignore high LDL-cholesterol, most of the time it indicates high apoB; if in doubt measure apoB
video: diet to lower apoB
Connect with me:
Facebook: / drgilcarvalho
Twitter: / nutritionmades3
Animations: Even Topland @toplandmedia
References:
jamanetwork.co...
www.pnas.org/c...
jamanetwork.co...
www.ahajournal...
www.ncbi.nlm.n...
www.sciencedir...
www.sciencedir...
pubmed.ncbi.nl...
www.sciencedir...
academic.oup.c...
Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.
#NutritionMadeSimple #GilCarvalho
![Cody Johnson - I'm Gonna Love You (with Carrie Underwood) [Official Music Video]](http://i.ytimg.com/vi/yy9PuYMU29g/mqdefault.jpg)
I swear you are the best health scientist/doctor on the Internet. I listen to many great podcasts, watch several great RUclips scientists, and read many books - but yours are the most compelling. I wish your videos got millions of views instead of many pop ones that do. 👏
thank you!!!
amen
@@tiagovsantunes I agree.
@@tiagovsantunes Thanks! Before I publish an episode, I check to see if Gil has something to say about the subject because he is so thorough. I'm doing that right now about a study on vegan kids and his insight has been gold.
I wasn't gonna watch this video, but then a saw Plant Chomper's comment. That's enough for me... to subscribe.
Incredibly good decision to blur out names. It's the argument that matters, not the individual.
If I could only like your comment more times.
@@StillTrustNo1 Thanks so much for your kind words!
thanks!! we talked it over and decided to try this out. unfortunately doesn't work in the few occasions where we feature video... :(
@@NutritionMadeSimple Still, it will encourage more productive and civil dialog among people compared to just ad-hominems.
You lost credibility right out of the gate by censoring your sources of opinions you disagree with. Yes, we can google the phrase and probably in short time find out who it is, but you went out of your way to make it extra work for the viewer. You will be more credible if you exercise transparency.
Gil, I don't know what I would do without you. Thank you for your excellent explanations.
Man, I just love your personality, you're so likeable. You understand people's mistakes, you dont call them idiots(which I dont mind that much from regular people, but doctors should really not have that word in their vocabulary when talking science, but many call uninformed people idiots on all platforms), you clear musunderstandings perfectly with very good logic and I dont know, its just a joy to hear you talk
Also, if you are interested, I'd love to hear your opinion on dangers of too low cholesterol, of course, not cardiovascular dangers, but those associated with mood and depression and sex hormones. What is the ideal range? Cause just crashing cholesterol seems also dangerous to me
Also, a video about how inflamation interacts with heart disease would also be pretty interesting.
I dont want to force ideas onto you. You should do videos only about what you find interesting and like. I was just rambling.
thank you sir!! we covered the inflammation link in a previous video (the 2 part video with the carnivore doc on joe rogan) but will touch on it again in the future no doubt :)
Yeah, there are some other doctors who I respect for their intelligence, but if they disagree with someone, they will call them all manner of horrible things. It's like how is that productive in any way? They get sensative about being called out and call it "tone policing" but I just think it's common courtesy to show people respect regardless of how much you disagree with them. Doing otherwise only leads to the eventual collapse of society.
Actually, Nutrition Made Simple did a video in low cholesterol. I actually had asked about it too awhile back because I kept hearing about it being a indicator of disease and early death.
There is no such thing as too low cholesterol and there is no correlation between mood disorders like depression and lower sex hormones with low cholesterol, if that were true then we would see higher rates of these things in people with a PCSK9 gene mutation which causes them to have abnormally low cholesterol levels yet we don't and these people also have the lowest rates of heart disease and atherosclerosis due to this. The claims made about the supposed "dangers" of having cholesterol levels that are "too low" are not based on any actual evidence and are just blatantly made up claims, blood cholesterol can never be too low.
There is no evidence that low cholesterol has any detrimental effects. People can have an LDL of 4mg and still function as they did with high cholesterol
Then why aren't doctors ordering apoB tests ? They are still using lipid profile tests
Progress is always slow when massive profits are at stake.
Lipid profile tests still correlate highly with apoB. They’re a good heuristic.
Also, the graph of cholesterol range does imply that LDL cholesterol is not the important causitive factor. The graph can be fixed, not by doing a different study about risk at higher levels, but by dividing the results by the fractions of the population with that reading. If you got a flat line, it would show that there isn't a dose response. Higher cholesterol is correlated to less all-cause mortality in at least two recent studies. The simplistic idea that lowering ldl cholesterol lowers heart disease by the introduction of a statin is like turning off a check engine light in order to fix the engine (at best). Most of the low carb doctors focus on triglycerides and Hdl ratio, not ldl.
My total cholesterol has been high for 7 years now. Last month, it was 300. But my blood presure was 110/75, and my triglyceride was 61. Leading cardiologists here on youtube say that insuline resistence is the cause of heart disease. So you need to pay attention on triglyceride, not cholesterol.
sadly, that's in all likelihood incorrect. both TGs and LDL-c are markers of essentially the same thing, the lipoproteins that carry them. either metric being very high is a red flag. we have videos explaining this in detail and linking the evidence (which is really all that matters, ignore the claims...)
@@NutritionMadeSimple according to those cardiologists' experience for years with their patients, many with low LDL die from heart disease.
@@lowcarbsgood7847 that's precisely the topic of this video
@@NutritionMadeSimple l just don't understand why doctors everywhere always say high LDL cholesterol causes heart disease. So you should take statin and avoid saturated fat. Eat less eggs and less fat from any kinds of meat. But, statin can cause diabetes and heart disease can be triggered by diabetes. So, it's so suck to me. I drink virgin coconut oil that l make myself 2 tsb twice a day, and use it as cooking oil as well. l eat 2 or 3 eggs every single day. I haven't had any problem at all for years and l am 65 years old now. I just always avoid refined carbs like sugar and flour products like bread, pasta and others. My doctor say l am very healthy.
@@lowcarbsgood7847, ApoB is the key metric. There are various ways of lowering it. If you're taking statins, I'd look for one with a low association with diabetes.
What a breath of fresh air. Research is not for everybody, that's why I appreciate trusting a professional. Keep the vids coming!
Thanks for your excellent explanation. This is my cholesterol experience. I used to eat the Standard American Diet. I don’t smoke, and don’t drink alcohol. My total cholesterol was often at 235. I had at times irregular heartbeat, intestinal disorders, faint spells, and loss of vision. I went through numerous test, including observation for heart attack risk. In 1987, I was diagnosed through a biopsy from ulcers in my throat with Leukocytoclastic vasculitis (LCV). My doctors advised drugs for treatment only. I could not tolerate these drugs, and against my doctors advice I changed to a selective starch and plant-based diet. This diet has maintained my health for over 35 years. I recently ate extra amounts of olive oil, and my total cholesterol increased to 275. A physical checkup indicated no health issues. Cholesterol from a strictly plant-based diet has apparently not the negative health effects caused by the Standard American Diet. I maintain now a total cholesterol of about 180.
THANK YOU! Your explanation and analogies made it very easy to understand not only this topic in particular but also how one can be fooled by charts and narratives in general. Hope your mom is doing well.
Confucius said, ... discipline not well, fault of fathers; learning not good, laziness of teachers ...
He works hard to get your attention, his wonderful analogies hook you in.
This is the most underrated channel on RUclips about nutrition. Well done sir, so clear, concise and objective!
Very interesting and well done vid! Follow up Q on cholesterol / LDL levels, what's your take on the Minnesota Coronary Study? My understanding is that the people with significantly lower cholesterol and overall LDL levels were the ones passing away sooner, based on the foods (animal fats vs. processed oils) being supplied in the study. Would love to hear your thoughts
What about the claims that high HDL and low triglycerides and inflammation is more important than low LDL? The claim is that LDL doesn't matter as long as HDL is high and triglycerides and inflammation low.
Thanks,
Alex
Im guessing he would say blood pressure, waist to hieght ratio, and fasting glucose are huge to the equation as well. IF you got diabetes, high blood pressure, and a big belly, high HDL and low triglycerides probably aint gonna save you.
Then again, if you have high blood pressure, a big gut, and diabetes, ya probably gonna have high triglycerides, low HDLs, and tons of inflammation to go with it.
@@alg7096 well, you cant have low trig and high HDL if you have diabetes. Diabetes is the last stage of insulin resistance and high trig is one of the symptom of insulin resistance
It is not a claim. There are multiple studies that confirm this. A Longitudinal Study of 25 years out of China showed that a high Triglyceride to HDL ratio was a better predictor of CVD and CHD (and even Type 2 Diabetes) than high LDL cholesterol levels. It was just one of several.
@@johnow7 "There are multiple studies that confirm this. A Longitudinal Study of 25 years out of China showed that a high Triglyceride to HDL ratio was a better predictor of CVD and CHD (and even Type 2 Diabetes) than high LDL cholesterol levels"
There's lots of confusion about this issue because we are doing studies on unhealthy populations with unhealthy diets, and in which the vast majority of people have steadily worsening atherosclerosis. Basically, if everyone plays in traffic, then variables such as foot speed and reflexes become huge predictors of whether or not people get hit by a car. However, the decision to play in traffic or not play in traffic is still the more important causal variable. Similarly, in industrialized nations in which almost everyone has an unnaturally high levels of LDL (and thus apoB too), these other variables wind up being good predictors of risk of CVD events among people who almost all have elevated levels that cause plaque to form. But if you keep LDL levels in the normal range for a lifetime, apoB winds up being normalized too, and plaque doesn't form. No plaque= no CVD events
Watch this doc's videos on apoB, triglycerides, LDL-cholesterol, HDL. High HDL alone has no positive effect on cardiac health. apoB is the best measure of that health.
Why do doctors test for cholesterol at all? Why not test for Apo B and forget Cholesterol?
I love this guy. Actual science, conducted correctly, and interpreted correctly. If I see a claim in the news, I head to Nutrition Made Simple to get the best scientific interpretation of the data. My Ph.D. is in another field, but I can spot good science vs clickbait.
As usual, you are a great teacher using good analysis and an understanding of evaluating claims & studies. Thank you!
Thanks for this video. I have two future video suggestions....things that seem to keep popping up in discussions of nutrition; the danger of oxalates and the dangers of seed oils. I hope you'll address these in the near future. We appreciate you!
I have been looking at various sources on the internet, trying to make sense of conflicting ideas. It has been very stressful and anxiety ridden, because I only want to figure out what the actual truth is, so I can know the best way to manage my health, and I don't have any expertise in the fields of medicine or nutrition to be able to sort through the conflicting messages put forth by people who, on all sides, have expertise. It makes me, as I said, stressed and anxious.
But then I listen to you, and the stress and anxiety melt away as you explain why these conflicting interpretations of data exist, and how easy it is to come to the wrong conclusion. Fewer 7ft tall people bump their heads than do 6ft tall people, because 7ft people are rare in the population, not because their height protects them from bumping their heads. I will never forget that analogy, and it makes so much sense! That and so many other examples of the way of thinking I am learning from you are helping me to stop stressing out as I gain clarity of thought. Thank you!!
The information that you provide is invaluable to individuals, such as myself, who are high risk for CAD and are trying to manage this. Thank you so much for what you do!
Great explanation! Thank you for sharing your knowledge!
Good to have you back Doctor. You inspire me on WFPB eating.
Thank you for being a "real" internet Doctor to help clear out all the false correlations, snake oils and sensationalization in the WWW.
I love your analogies .. people often have the perception that doctors know everything.. no..they don't.. they're humans too..they can be biased too . And i totally appreciate your accuracy and how updated you are..
We have to learn quite a lot of things in order to become a doc..a ton of mechanisms , processes , weird hard-to-pronounce names , countless number of books.. ... And it can be totally different from the real world ..atleast that's what what our brain makes it seem ... It's impossible to learn everything..so i learn from you ... Everyday.. I'll be preparing for med school this year... And everything seems so different... We don't get to analyse it ...as we remember and try to swallow it down our throats..
Brilliant video explaining the bias behind the misunderstood of this topic. Is there a reason why docs don't measure directly apoB in blood? Why they only measure ldl?
I think that ApoB level determination is more expensive than LDL level. Maybe doctors think that the LDL level is good enough.
(... Or they maybe don't know about ApoB. The cardiologist featured at the beginning of this video is may be an example. ;) )
I don’t think most doctors are up to date on the latest studies and expert hypotheses. The 80’s-paper seemed only like a recent (back then) hypothesis, so that’s probably the reason it’s not part of most current doctor’s education, but now where “the debate is over”, I think it should be and hope so too.
Exactly what I was thinking!
Mostly cuz of cost and only subset of people require apo B measurement
@@osirzz I've been reading comments of videos about ApoB and was amazed that it seems like an exotic, expensive test. I just had my blood work in a walk in clinic in Indonesia and got ApoB test just like that. For about 200$ I had all the works included.
I'm someone who changed my life around through the online advice around keto and fasting. I've lost 100 lbs, look and feel 8 years younger than I am. I was one of the people saying obviously saturated fat isn't the enemy, cholesterol is not the problem, while showing really promising results. HOWEVER, I found your channel about 6 months ago and now a big follower of your channel in addition to my other channels I follow, and you feel like a teacher to me who continues to also give me doses of reality, and to help PUSH me to continue being a lifelong *learner*, and to continue challenging everything I think I "know". Thank you so much for all your work and giving me new perspectives to consider!!
Found your channel yesterday over the Plant Chompers channel and already hooked on your nuanced content. Keep it up man!
oh thanks! I recorded a convo with Chris, is it out yet?
@@NutritionMadeSimple hmm, I don't think so... will keep an eye out
Happy to see you back on RUclips, hope all's better at home for you. Happy New Year.
So why do doctors care so much about LDL and if it’s high to prescribe a statin without knowing what your ApoB is? Sounds like doctors should be checking our ApoB and even if it’s elevated do statins help lower that number?
Another great video which explains things in a way anyone can comprehend. Thanks Gil! It is great to have you back making videos. Best wishes to your mother.
Thank you so much. The content you offer is amazing.
love your content, so much to learn from you even as an MD
I like the idea of blurring the name Gil; it's much better to focus on the idea rather than the person. I find all this 'owning' and 'destroying' on RUclips so childish.
man i love your channel. so glad you're making content again. wish you and your family and specifically your mom the best.
great explanation! thanks for that
Thank you. You have explained this so well.
Welcome back, Dr. Gil
Thanks for the very clear explanation! Keep the videos coming!
I am so glad you’re back and thank you so much happy new year to you and hope the family is doing very well
You are awesome. This is important information. I am so happy you are all about presenting good evidence and arguments with none of the personal attack and appeal to authority bullshit that is so prevalent elsewhere.
A controversial topic! See below & challenge:
“LDL levels can increase for two reasons. First, if you’re eating a ketogenic or low-carb diet and burning fat as fuel, your liver may send out more LDL “boats” to supply fat fuel to your muscles. The empty LDL boats return to the liver to dock, restock, and go back to work. The second reason is more sinister: When you overeat carbs, it’s as if you’re filling your bloodstream with sugar glaciers. The LDL boats bump into these sugar glaciers and get damaged in a process called “glycation.” Glycation, in turn, makes those LDL boats further vulnerable to oxidative stress. Once they’ve been damaged by the sugar glaciers, the LDL boats can’t return to the liver and end up accumulating in your bloodstream. Eventually, they sink down to your artery walls and develop into atherosclerotic plaques, a titanic health catastrophe.”
- The New Mediterranean Diet Cookbook: The Optimal Keto-Friendly Diet that Burns Fat, Promotes Longevity, and Prevents Chronic Disease (Keto for Your Life) by Martina Slajerova, Thomas DeLauer, et al.
you are mistaken: most mds believe it's the cholesterol. non I know have spoken of the ApoB
I didnt know ray romano was an accomplished nutritionist. Awesome bro!
No one ever thought LDL “caused” high cholesterol, it was (is) just an indicator. ApoB is ALSO a marker, a better marker. Cardiologists are (more or less) required (by their med mal insurer) to recommend statins if your cholesterol is over an arbitrarily chosen number. It’s all about the money honey and statins require serious $$$$ monitoring. Your cardiologist only cares about your heart. They can lower risk by lowering cholesterol. Unfortunately, with low cholesterol people die of other diseases like cancer. You can’t live forever. To me the point is to have an old age to enjoy and to enjoy your old age without debilitating disease.
It's really surprising that the importance of ApoB was know in 1980 already. Well done!
The multiple analogies in this video are brilliant!
The cholesterol distribution curve should be normalised based on cholesterol distribution in general population. If both the distribution look the same then it would be a flat curve.
Amazing explanation as always Gil with some great examples to make it easier for us to understand thank you.
Beg to differ with you , doc.
Cholesterol level is problematic only if it is accompanied by high inflammation.
Inflammation can be caused by stress, infection or sugar.
Without inflammation cholesterol level of even 300 is ok, provided Triglycerides /HDL is less than 2 and VLDL is low.
addressed here: ruclips.net/video/Bjh9n2Cw0TY/видео.html
skip to the part on inflammation and CVD
I am seeing you on the Internet after a long time! I have always enjoyed your videos. Welcome back!
It's fantastic that YOU focus on the substance so well and not rely on people's claims, but I think others (like me: not a doctor, but educated and interested) will still have to rely on people like you. It can become really hard and confusing to make sense of all the claims and research. You really have to dig into the research, and have an excellent understanding of the science, to make clear sense of it all. Of course, the benefit of the way you explain things, is that a person like me could perhaps (almost) understand the research by now, if I'd have the time for reading all those papers. Anyway, that's a big accomplishment, so a big thank you, again.
Great information doc, invaluable....
Having worked in the supplement retail business I had a customer who had very high LDL cholesterol. All her existing family members died young from heart attacks. The too had very high LDL. She was doing everything to bring it down to somewhat normal levels. That one case opened my eyes to high cholesterol.
I think doctors are not necessarily researchers or scientists. They've been trained in medicine, but they don't necessarily have the scientific rigor to make new health claims outside their training.
so true
@@NutritionMadeSimple On that very issue I'm surprised you don't have a mini bio in your About section. For example does your PhD or work involve studying nutrition? And if not what do you do professionally?
yeah i should add something at some point! :)
@@NutritionMadeSimple
Not exaggerating it's literally the first thing I look for each time I visit a RUclips channel for my own health.
So... do you have a medical /scientific career based around nutrition or do you do something else and nutrition is more of a hobby?
the effect of different nutrients on physiology and aging in model organisms was one of the topics I researched and published on (all pubs here: scholar.google.com/citations?user=O-_jWUkAAAAJ&hl=en). my PhD was based largely on that research. how 'qualifying' that is is arguable. for example people often ask for consultations and personalized meal plans and 100% of the time I direct them to professional RDs
the true goal of the videos is to empower a lay audience with some scientific reasoning tools to make sense of seemingly confusing evidence. I feel comfortable designing this content based on my professional experience but others are free to disagree!! :)
Very good explanation👍
I’m not native English speaker so these simple explanations are great! Good video!!
Analogies and cat videos are both awesome!
Well then we with iffy LDL should be able to get a apob test... would that let us know how good/bad our veins are at this time... over all the years.....????
Amazing information thanks very much for sharing
Please do a video on creatine. I find such conflicting info on if it is good to take or not. I noticed my BP increased some while taking it so I stopped and now my BP is back where it was before, but according to a lot of info out there it shouldn't have this effect...and then some ppl say it's really bad for your kidneys. I would love some clean cut facts please :)
Thanks so much for important topics you cover, so understandable to public, glad I found your channel.
Excellent video, thank you so much for sharing!
Every time a building is on fire the fire brigade are there. They must have started the fires !!
It's a fun analogy to trot out, but the wrong one: We know that too many fire trucks in the street is what is clogging up the traffic flow.
The surgeon is simply being as sloppy in his statement as most doctors and laypeople. That might not evince a misconception. As for Dr. Carvalho, always brilliant, fundamental analysis. He should be a public policy communicator. What a blessing for us all. He's flipping me on my head- not painless, but appreciated, nonetheless. There are worse things than humility. This is the way to save more lives. I'm changing my ways. Ugh, this thing called life is painfully humbling.
There are a number of reasons for heart disease cholesterol is one of them but not the only. Insulin resistance is also very important.
Thanks Gil! So much conflicting information out there. Maybe you could take a look at the healthcare triage video saying how cholesterol isn't in an issue. It would be great if we could resolve some of the conflicting messages.
it's all about inflammation, not LDL-C. Stop eating shit tons of carbohydrates, rancid PUFAs, and alcohol. Exercise daily. Get good sleep. Lower stress.
"it's all about inflammation, not LDL-C." Actually, even if you eat an inflammatory diet, having a genetic variation that keeps your LDL "low" (normal range) for a lifetime wipes out your risk of a heart attack.
My cholesterol is high and my doctor never orders an ApoB test. I also have high blood pressure that is being treated with medication. I'll be asking her to order that test.
It would be great for advancing the conversation if you had a dialogue with doctors who are experts in & recommend clean keto.
Just love your work. It is so very helpful. These charlatans do so much damage and really hurt the credibility of folks who are doing evidence based work like you. I have referenced your apoB video so many times to the ill informed. Thank you
Just found your channel, great work on this! Subscribed!
Great video doc! Thanks for clearing up confusions and fighting for the truth!!
Awesome video, concise and thorough. Many thanks for uploading, very important topic that has many people confused. My brother who is obese has heard from his nutritionist that LDL is actually good for you and to demonize carbs.
Brilliant! It's a bless that I came across of your video.
Don't look up!
Great show. Clear and simple Perfect way to teach and debunk based on data
Your videos are excellent and really focus of the science behind nutrion and health. Great i stumbled on your content. Keep up the great work.
The question is? Why are so many vehicles?
You're explanations are enlightening. Keep suppling those analogies.
My question is, how many confounders have we identified outside of ApoB? I read and interesting book called The Plot Thickens that discusses an alternative hypothesis. Would be great for you to discuss his arguments.
I still want to know who that doctor is
Me too
I wonder what doctor thinks about so called LMHR phenom?(lean mass high responders) they have very high LDL, but seems to have all other risk factors low.
I would love a long term study on heart attack numbers in correlation with nattokinase/serrapeptase supplementation.
You're an incredible communicator 👌👍
I loved the analogies! Keep them coming!
It's disheartening how social media can create cults! So glad you are here to put content in correct place and explaining the truth!
Cults created on utube😂😂surly not
Seen that graph that we have to have an LDL lower of 50 to have a significant reduction effect, I got to say that that is imposible for the 99% of the population, then this is not the way.
A healthy enough diet lowers LDL like a rock--and as effectively as statins.
Great info and love the analogies, makes it easy to make the point.
Excellent video. Absolutely first class.
Very valuable information on this channel. It is disturbing that a cardiac surgeon would misinterpret studies and scientific conclusions that are so basic to his field of expertise. But, in all fairness, he did not say that the patients he operated on had low cholesterol levels AFTER a heart attack, he just said they had low levels .. he may have been talking about patients he knew or those who did not have a history of high cholesterol. If I am understanding you correctly, even you are saying that apoB levels are probably more indicative of impending cardiac events than overall cholesterol levels? I think it would be beneficial to get clarity from the doctor who posted those remarks.
he came on, look for the convo with dr. ovadia
Had heart attack June 5 2023..72, male 6 ft 2 166 lbs..3 stents… cholesterol 140, ldl 90..hdl 30, triglycerides 300
That's it. I'm going back to cat videos (hahaha).
Can you answer this.. actual percentages of people dying from a heart attack.. (state of NY) 93% of people dying of heart attack had low cholesterol, so only 7% are dying with high cholesterol, if the numbers were the opposite you could call it a serious heart condition, but they aren't.. the data doesn't lie..
it's explained in this very video why cholesterol levels at the time of the event or time of death don't reflect the previous conditions. I know this is very counter-intuitive. prospective evidence is the most powerful, post facto cross-sectional data can be very misleading
What a WONDERFUL video.. And the analogies were superb and on point !
To summarise 4 reasons for the wrong conclusion.
1. In 20% of the people LDL-C and ApoB values don't co-relate.. so these people have low cholesterol but HIGH ApoB and therefore do end up getting heart attacks.
2. The risk factor is CONTINUOUS & not discrete ! And the safe value of 200 which they selected is not accurate .. For zero risk, it shud be 150
3. Some of the patients would have been on Statins - cholesterol lowering drugs, and they wud have got the heart attack from previous Plaques formed before the drugs
4. APR - After an heart attack, for a short period of time, body reduces cholesterol as a shock response, this can confuse the person who is testing immediately after an heart attack
👏
Is a high LDL and low apoB very low risk then? Is that impossible or rare?
He said 20 to 30 percent of people are in that category with low risk for heart disease.
If 50% of his patients have normal cholesterol and 50% have abnormal cholesterol
That is irrelevant as the pool of normal cholesterol is much larger than the pool of abnormal cholesterol.
That is why we use x out of 100,000 to keep the relationship correct.
I get what you’re saying, but isn’t this rather surprising that a Cardiac Surgeon didn’t factor this in? I mean, over 12 years of study, plus the experience involved in actively observing and working with Cardiac tissue, Coronary arteries, prescriptive drugs and other therapies should, one would think, give a surgeon a comprehensive knowledge of the effectiveness of statins at various stages of cholesterol and plaque formation. Besides, there are seriously high stakes at play here - billions and billions of dollars! Why wouldn’t pharmaceutical companies actively sponsor research trying to disprove this surgeon’s comments if at all possible? I would love to see the surgeon’s response to your interesting, informative video. I enjoy looking at two sides of an argument and you are the best RUclipsr I’ve come across on this side of the statin controversy. Much appreciated!
hi, check out our recent video where dr. ovadia and I discussed this ruclips.net/video/mACS1IvytKk/видео.html
I will mention that the anti seed (high linoleic) oil and anti fructose proponents claim that Statins remove benign LDL particles that are built on saturated and monounsaturated fatty acids from the blood because they are not easily glyocosylated and oxidized (which is accurate in terms of organic chemistry) and the LDL particles built off of fructose and linoleic being oxidized and glycosylated makes them less compatible with the channels in the liver that re-uptake LDL normally and in the presence of statins, so while statins lower LDL they don't get rid of the glycosylated and oxidized forms that cause damage. THIS is really the argument against high linoleic acid and fructose, and we do know that LDL particles that arise from linoleic acid and fructose are chemically capable of attaching to glucose and oxygen radicals in a way that LDL built on SFAs and MUFAs can't because they have no or one double bond that can be opened up to stick the LDL particle to free radicals and glucose, while those built of PUFAs have a lot of sites (double bonds) that can stick to them. We also know that there is a fish oil paradox where fish oil seems to reduce heart attack risk up to Omega-3 of about 3 grams per day, but that people who got much more than about 3 grams per day started to have more heart attacks. Rat studies also showed more heart lesions beginning when PUFAs exceeded 4% of daily maintenance calories which, if it can be extrapolated to humans would be about 10 grams of PUFAs per day (where the health benefits peak and start to work down the other side of the inverted U).
I personally don't know if it is true that glycosylated and oxidized LDL built on fructose and PUFAs IS harder to requester back into the liver, but it is true that LDL built on PUFAs and probably fructose are structurally prone to attaching to glucose and oxydative free radicals, and that those built on SFAs and MUFAs are virtually impervious to them.
we recently published a video that directly addresses some of these Qs ruclips.net/video/IFGvs1Qe7cA/видео.html
Thanks for explaining flags and showing how and why misinformation can spread. So two things; 1. Why is it that standard lipid tests do not have ApoB included - at least in my area, and 2. So we accumulate cholesterol, but can we reverse this damage without statins? How do we go about it, and generally what can be the general timeframe. For example, is it as long as it took to accumulate, or is it years. Can’t imagine it would be less than that.
1) good Q and this will probably change 2) most people can lower their cholesterol in days with lifestyle. some can't (genetics). reversal of established plaque OTOH is less clear and much harder if possible at all
I wonder if the risk of cat video viewing increased in people after watching this video…
Balanced, intellectually honest, insightful, and competent. I would trust this guy with my kids.