Hobby chemistry in a nutshell: "This synthesis uses A, B, C, D and E. The first four can be easily bought, but E needs to be distilled from F and G. F can be bought but G can be made by reacting H with..." Awesome to see you work through all these prerequisites throughout various videos though.
@@kadergumus2598 Now you need a different A, B, and C. A and B are about 50 cigarettes each, but C can only be purchased with stamps, so you need to synthesize D to sell for stamps. To get D, you can either have a guard smuggle it in, synthesize it with B, E, and F, or recruit some fellow inmates to acquire it from some other inmates. YMMV though; my yields have not been great.
That's what makes it so fun! lol. I started amateur organic chemistry as a hobby, and I'm pretty surprised at how many of the "restricted" chemicals can easily be made from the non-restricted chemicals with the proper safety setup and procedure.
If you consider the 85% expected yield, times two recrystallizations… 100x.85=.85 first pass .85x.85=.72 second pass So a theoretical 72% compared to the 70% actual is negligible.
I love how he's not affraid to say when something doesnt goes as planned, and also the fact that he will keep trying until he get the results he want while also showing previous fails. I dont even love chem that much but he makes it so interesting that i keep on watching more and more of his content
@@NyanyiC yeah, but considering most homemade "sunscreens" have an spf of 0 or worse, can worsen burns due to being comprised primarily of oils, I'd say that's pretty good.
@@blubberdust what would a ginger be? -100? My sister and bro are ging, they both burn in the shade and she got a sun burn through tinted windows on a coach bus.
I'm in esthetics school and this demo for how sunscreen works with the beads is perfect to help students understand how chemical sunscreen works in absorbing the UV light. Thank you for your awesome videos.
Dibenzylidineacetone (DBA) is actually used to stabilize Palladium(0) in the form of Pd2dba3.CHCl3 which is useful for a number Palladium-catalyzed coupling reactions.
does anyone know why pd(oh)2/c might be a better catalyst than pd/c for carbonyl compounds such as esters and acids? i'm assuming it might have something to do with h-bonding
I remember while in the police academy, for 6 months I was staying up all night writing memos and I successfully watched every video you ever posted while I was writing. I love your videos brotha
I did this reaction in my organic chemistry lab class, and I used almost the same method you used in this video, although with some small variations. Our benzaldehyde and ethanol was analytical grade, and we purified our acetone (technical grade) through distillation (to remove water contamination and other impurities). That could explain why you had that initial cloudiness in benzaldehyde, probably your benzaldehyde was not so pure. To recrystallize the product we used the first method you used, hot ethanol (in the right amount to dissolve all the product), then we added room temperature water (while ethanol was still hot) until complete cloudiness occurred and then we cooled down the solution in an ice bath. Eventually we vacuum filtered the precipitate and dried it in the oven. My yield was 78,2% of raw product, 73,9% of target molecule (we analyzed it through GC-MS and UV-VIS). Not the best but I'm still and undergraduate so totally fine for me. My guess is, as you already aknowledged in the video, that you used too much ethanol and much of the product was still in the liquid phase, though your yield was not bad at all.
I don't remember what our yield was exactly, but I do recall our MP analysis showed that we had a higher percentage of trans,cis and cis,cis stereoisomers than the reaction might typically produce, though trans,trans was still the primary stereoisomer :)
My recipe for home made sunscreen - 1 cup of olive oil - 2 cups of sodium hydroxide - 3 cups of milk of magnesia - 4 cups of melted butter - 5 cups of sugar Mix ingredients in a large mixing bowl, throw it in the garbage and go buy a bottle of sunscreen
When I did the synthesis, it actually went nearly like the clock reaction you mentioned. I dont know why does it happen, but it is pretty cool. I add the acetone and then stirr, and suddenly a ton of stuff falls out of solution after like 60 seconds and the content goes from light yellow to brown-orange and looses transparecy. Really interesting.
In my research lab, we usually have a designated hood with aluminum foil completely covering the window, and protective eye wear when using UV light. Make sure you be careful, because it can mess up your eyes really bad even when used for a short amount of time.
Convert PET to terephthatalic acid and ethylene glycol! It's a simple de-esterification but it would be interesting seeing how you would get the PET to react with it being an insoluble solid at room temperature
I love watching your videos when I’m stressed out it helps me put my focus on something else and they are so relaxing to watch idk why😅I’m so happy I found them!
Some of the benzaldehyde tried to precipitate out when it came into contact with the bit of water in the ethanol. The molecules quickly re-arranged themselves and dissolved in the ethanol afterwards.
Man, many years since you uploaded this but I try watching your vids to fall asleep only to find out that they’re so interesting I watch them till the end 🤣 You’re great, @NileRed Watching from Colombia 🇨🇴.
mannys9130 Yup. I prefer him to nurdrage and others. Though cody's lab's chemistry series comes close. I prefer his metal extraction series and random weird reactions cody does.
i like nilered more for actual educational content, but codies chemistry stuff is very entertaining ... i dislike the shift in his "values"(?) towards grant thompson, so maybe you can collab with him to bring him on a more sciency path? :D
Maric I agree completely man. I use NileRed videos to revise for my chemistry practicals for school, since I take it at A-level. I think the equivalent to American education system is the AP tests.
If you put a vial of dibenzyl acetone on a zinc sulfide screen and exposed it to UV, do you think you could see a "shadow" in the phosphorescence? You could compare to a blank vial of solvent, a sample of commercial sunscreen...
The bittering additives are usually in the ppm range. The rest of the 5% is generally water generated from the distillation process (ethanol forms an azeotrope with water at 95%). So, the 5% really isn't a huge concern. I'm sure if, after recrystallisation, the product was put on a high-vacuum line at RT for 24 h and a proton NMR taken the only residual protons that would be seen are from the ethanol and from water. The additives won't even be detectable.
i find it hilarious watching how his content has slowly shifted from educational and tutorials into entertainment, not because he no longer makes educational tutorials, but because the tutorials are so ridiculous nobody watches them with the intention of following along 😭
this is a great channel to watch when you need to fall asleep. i fall asleep instantly because one im not smart enough to understand anything he is saying and two like math? my minds like nah nah
Great as usual. However, I did notice one error: the reaction you give for the synthesis should produce two water molecules, not one. Also, since you said that crystallization needs to be slow in order to be effective, and your failed first attempt apparently took a while, what do you think about your second one producing much better results after just three minutes?
Definitely invest in a 1 or 2 larger fritted funnels with different porosities. I really hated when I had a huge amount of stuff to filter and didn't have a larger frit. I have some larger 1 liter ones now and it was definitely worth it.
i used to be a t shirt printer repair man, and i learned to hate a chemical called titanium oxide which is white pigment in fabric ink. turns out they use it everywhere. it's also used in sunblock and ranch dressing to make it white. the reason i hated it is because in not soluble in water so it separates and clogs the print head, but i guess in sunblock or ranch dressing it's been emulsified.
The reason why I watch these videos when I should make homework is because I use it as an excuse to not make it and I justify it to myself because it makes me smarter. Jk. The REAL reason I watch these videos because the colors and pretty powders makes my brain give me dopamine
In my opinion the crystalization did not work because at the vacuum filtration point you did not wash the product with ethanol-ecatic acid mixture and you got an oily mixture at the crystalization point. I am a student and in our lab it is a typical problem when somebody skips the ethanol-ecatic acid washing step.
I would love to ask something... I went through few laboratories at our university and we never put the watchglass on a beaker during recrystallization... The true is, that it was almost forbidden to use beakers for reactions, heating and so on... We could use it just for our solutions of acids, bases and salts. We were using just flasks for almost everything. I just want to ask, why there should be watchglass during recrystallization... Thank you for answer :)
How about some substances that change their properties when exposed to UV light? E.g. change their colour, or get hard, or becoming more conductive/resistive to electricity, or more/less soluble in water or some other solvent?
Hobby chemistry in a nutshell:
"This synthesis uses A, B, C, D and E. The first four can be easily bought, but E needs to be distilled from F and G. F can be bought but G can be made by reacting H with..."
Awesome to see you work through all these prerequisites throughout various videos though.
then there's J, which can be bought, but doing so will put your name on a list at the DEA and FBI.
@@kadergumus2598 Now you need a different A, B, and C. A and B are about 50 cigarettes each, but C can only be purchased with stamps, so you need to synthesize D to sell for stamps. To get D, you can either have a guard smuggle it in, synthesize it with B, E, and F, or recruit some fellow inmates to acquire it from some other inmates. YMMV though; my yields have not been great.
It all comes back to benzene
h
That's what makes it so fun! lol. I started amateur organic chemistry as a hobby, and I'm pretty surprised at how many of the "restricted" chemicals can easily be made from the non-restricted chemicals with the proper safety setup and procedure.
I’ve found your videos and they’re incredible interesting but also they’re amazing to fall asleep to. I swear that’s a compliment 😂
I'm glad I'm not the only one!!
I do the same thing! Calm voice and still entertaining enough to watch
Went to watch this to fall asleep to lol
Bro I was scared to say it but I literally put one of his vids on just to go to sleep
Exactly!!!!!!!! God I'm so happy to know I'm not the only one lol
Having lower yield than expected due to multiple recrystalizations is kind of a running theme in your videos, I love it
That's actually a pretty common problem with chemistry.
You always get a lower yield when you want very pure products.
@George I. Klapsides I'm no chemistry expert myself but I think it's something to do with removing contaminations
@@bowel_movement nile red has a whole video about recrystallizations. And your correct
If you consider the 85% expected yield, times two recrystallizations…
100x.85=.85 first pass
.85x.85=.72 second pass
So a theoretical 72% compared to the 70% actual is negligible.
I love how he's not affraid to say when something doesnt goes as planned, and also the fact that he will keep trying until he get the results he want while also showing previous fails. I dont even love chem that much but he makes it so interesting that i keep on watching more and more of his content
Dịch
Spf 3 is no small feat. You made sunscreen from scratch in a home lab, all by yourself, and it actually worked.
Even black people like me are recommended to use a much higher spf than that
@@NyanyiC yeah, but considering most homemade "sunscreens" have an spf of 0 or worse, can worsen burns due to being comprised primarily of oils, I'd say that's pretty good.
Could’ve just used raspberry oil with that spf lmao
i mean... to put it into context, the skin of the average caucasian male has an innate SPF of 3 to 5
@@blubberdust what would a ginger be? -100? My sister and bro are ging, they both burn in the shade and she got a sun burn through tinted windows on a coach bus.
I have no idea what's going on in any of these videos, but seeing the little tornados bounce around in the beakers always makes me happy.
i thought that was just me! it reminds me of those little dancing fruits
The little tornados were 2x trans running after a cis apparently...
@@Hippucytees life imitates life 😉
@@s4ify It does...
@@bbrixnnx The little dancing fruits were 2x trans chasing a cis..
That orange juice looks pretty good.
50th 'like' :)
Cursed comment
Yummy
I tasted one once let’s just say…
It was a little weebish
Mmmmm tangy😂
4:22 instantly turning apple juice into orange juice
He’s juice Jesus
Juiceus
gUlPy GuLpY
Yum 😋
NileRed stands for “No, I Love Endlessly Recrystallising Everything Dammit”
you're actually a genius
😂
I'm in esthetics school and this demo for how sunscreen works with the beads is perfect to help students understand how chemical sunscreen works in absorbing the UV light. Thank you for your awesome videos.
Wow, your videos are so much better now that I took an organic chemistry class. I actually understand what's going on! (mostly)
I wish I could take a class like that but since I'm not interested enough to take a class. I just learn from his videos..
Cookie Roxy same
Cookie Roxy well im interested but i dont feel i need it
@@supercool1312 i just cant be bothered to pay for one
@@emmettbattle5728 I just straight up cant... should have shown I could do better in high school
6:00 science diagrams that look like shitposting
trans trans is a lot more stable
It really does 😌😌
Here i go questioning my gender identity again!
hehe trans juice
Dibenzylidineacetone (DBA) is actually used to stabilize Palladium(0) in the form of Pd2dba3.CHCl3 which is useful for a number Palladium-catalyzed coupling reactions.
Georg Wuitschik
Nerd
does anyone know why pd(oh)2/c might be a better catalyst than pd/c for carbonyl compounds such as esters and acids?
i'm assuming it might have something to do with h-bonding
And it forms a beautiful dark blue powder.
You should make aluminium zirconium tetrachlohydrex, the main ingredient in anti-perspirant.
Nilered be like: chemistry hahahah potassium and water boom boom boom I want you in my room
The 4k is so awesome that I can see all the filth on my monitor.
I just realized the same thing is happening for me, but on my phone XD
Did you clean it yet?
Did you clean it yet? It's been 7 years
I remember while in the police academy, for 6 months I was staying up all night writing memos and I successfully watched every video you ever posted while I was writing. I love your videos brotha
What the hell, how do I keep discovering new NileRed videos I haven't seen before? It's like Christmas!
When he was talking about the trans and cis stuff I wasn’t paying attention and thought it was a video about gender and stuff
_what?_
Uneducated
SPF 3 is a common absorption level for stuff like lip balm, so it’s not that bad
dibenzalaceton irritates skin tho - its used in yellow shades instead
I did this reaction in my organic chemistry lab class, and I used almost the same method you used in this video, although with some small variations.
Our benzaldehyde and ethanol was analytical grade, and we purified our acetone (technical grade) through distillation (to remove water contamination and other impurities). That could explain why you had that initial cloudiness in benzaldehyde, probably your benzaldehyde was not so pure. To recrystallize the product we used the first method you used, hot ethanol (in the right amount to dissolve all the product), then we added room temperature water (while ethanol was still hot) until complete cloudiness occurred and then we cooled down the solution in an ice bath.
Eventually we vacuum filtered the precipitate and dried it in the oven. My yield was 78,2% of raw product, 73,9% of target molecule (we analyzed it through GC-MS and UV-VIS). Not the best but I'm still and undergraduate so totally fine for me.
My guess is, as you already aknowledged in the video, that you used too much ethanol and much of the product was still in the liquid phase, though your yield was not bad at all.
I also did this reaction in orgo 2 lab :)
I don't remember what our yield was exactly, but I do recall our MP analysis showed that we had a higher percentage of trans,cis and cis,cis stereoisomers than the reaction might typically produce, though trans,trans was still the primary stereoisomer :)
@@XREXP0 nerds isnt an insult anymore, get on with the program
My recipe for home made sunscreen
- 1 cup of olive oil
- 2 cups of sodium hydroxide
- 3 cups of milk of magnesia
- 4 cups of melted butter
- 5 cups of sugar
Mix ingredients in a large mixing bowl, throw it in the garbage and go buy a bottle of sunscreen
When I did the synthesis, it actually went nearly like the clock reaction you mentioned. I dont know why does it happen, but it is pretty cool. I add the acetone and then stirr, and suddenly a ton of stuff falls out of solution after like 60 seconds and the content goes from light yellow to brown-orange and looses transparecy. Really interesting.
In my research lab, we usually have a designated hood with aluminum foil completely covering the window, and protective eye wear when using UV light. Make sure you be careful, because it can mess up your eyes really bad even when used for a short amount of time.
To avoid canizaro reaction , you can mix the aldehyde and acetone then add the base slowly, so base attacks the acetone which attacks the aldehyde
Convert PET to terephthatalic acid and ethylene glycol! It's a simple de-esterification but it would be interesting seeing how you would get the PET to react with it being an insoluble solid at room temperature
I love watching your videos when I’m stressed out it helps me put my focus on something else and they are so relaxing to watch idk why😅I’m so happy I found them!
what nara smith watches in her free time
Another beautiful and informative video! You are great sir!
Thanks!
There's more plot in the beakers switching out "conspiracy" than in the entirety of the Twilight series
It cannot be a conspiracy if it's just one person.
The mechanism is just too beautiful!!! Thanks for sharing!
I've made this myself in our labs and it is a very fun exercise. It's fun watching this change colour when you keep it in the sun.
Ilililllllilllllilllllllolllolllliil8llllollliilillllllolilllollllolllollillollolllloilllilloliliillllolloolllollllllllolllloolllolillolilillolololliolllioolllillloloolllllloollllolollolllllllolloollllollllolollllilllllollolllllllollllllllllllolllllllllllllllllllllllollllllllollllllllllllolllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllllli
Some of the benzaldehyde tried to precipitate out when it came into contact with the bit of water in the ethanol. The molecules quickly re-arranged themselves and dissolved in the ethanol afterwards.
In this video he sounds so weary, like eternally tired.
your videos are so addicting I’ve been in a constant state of binge for hhhh idk how long
Omg I'm a relatively new fan and this is the oldest video of yours that's been reccomended to me. Your voice over sounds so different :o
I wish there was a creator making videos like this now of this quality.
I listen to this when running
Man, many years since you uploaded this but I try watching your vids to fall asleep only to find out that they’re so interesting I watch them till the end 🤣
You’re great, @NileRed Watching from Colombia 🇨🇴.
Dang, that's really cool! The demo at the end was really neat too.
nara smith need to take notes
Dude, these videos are SOOOO well made! :D
I misread this as “subscribers”. Literally thought the madman was synthesizing more subs to the channel.
Thanks for the enlightening discussion of using water to help precipitate the product from ethanol. Much appreciated.
I watched this whole vid just to see how you tested the final product.
Watching these videos studying in the 12th grade and being able to relate to most of the reactions is really fun
ALMOST AT 100K SUBS :D
Congratulations !!!!!!
Been here since 8k subs :3
Nile deserves a million subs. My favorite chemistry channel on RUclips.
mannys9130 Yup. I prefer him to nurdrage and others. Though cody's lab's chemistry series comes close. I prefer his metal extraction series and random weird reactions cody does.
i like nilered more for actual educational content, but codies chemistry stuff is very entertaining ... i dislike the shift in his "values"(?) towards grant thompson, so maybe you can collab with him to bring him on a more sciency path? :D
Maric I agree completely man. I use NileRed videos to revise for my chemistry practicals for school, since I take it at A-level. I think the equivalent to American education system is the AP tests.
I am german ^^
I watch NileReds videos as reference for pen and paper (dont ask xD) and out of curiosity mostly xD
I love how he makes jokes with a sorta sarcastic voice
These are amazing to fall asleep to, thank you
Dibenzylacetone can also be used as an organic photosensitizer in certain photochemical transformations!
woah Nigel sounds way more nonchalant in older videos. I kinda like it
Seeing this during the Nara smith diy everything
Five years later and these videos are still solid
3:55 so that's how you make Mountain dew
You should make a channel for all the small experiments that you do to make the bigger ones, like prepping the chemicals
Nile blue
what nara and lucky blue smith thought they were doing 😭
So glad someone got this lmao
Was literally looking for this comment lol
If you put a vial of dibenzyl acetone on a zinc sulfide screen and exposed it to UV, do you think you could see a "shadow" in the phosphorescence? You could compare to a blank vial of solvent, a sample of commercial sunscreen...
And compare it to solution of titanium dioxide or something that's opaque but doesn't specifically block UV!
im wondering if the cloudiness was because of the 5% of addatives in your ethanol to denature it perhaps?
The bittering additives are usually in the ppm range. The rest of the 5% is generally water generated from the distillation process (ethanol forms an azeotrope with water at 95%). So, the 5% really isn't a huge concern. I'm sure if, after recrystallisation, the product was put on a high-vacuum line at RT for 24 h and a proton NMR taken the only residual protons that would be seen are from the ethanol and from water. The additives won't even be detectable.
the thought of dissolving something without a stir bar manually by glass rod are the biggest nightmares of chemists
He beat Nara smith to it
please do a video on your lab, and where and for how much you got yourr lab equiptment.
You explain things better than my university teacher
Ahhh I love RUclips. I always know when it's been a month and a new nilered video is incoming, because I get recommended all of his older vids xD
Someone send this video to Nara Smith's husband!
i find it hilarious watching how his content has slowly shifted from educational and tutorials into entertainment, not because he no longer makes educational tutorials, but because the tutorials are so ridiculous nobody watches them with the intention of following along 😭
this is a great channel to watch when you need to fall asleep. i fall asleep instantly because one im not smart enough to understand anything he is saying and two like math? my minds like nah nah
Great as usual. However, I did notice one error: the reaction you give for the synthesis should produce two water molecules, not one.
Also, since you said that crystallization needs to be slow in order to be effective, and your failed first attempt apparently took a while, what do you think about your second one producing much better results after just three minutes?
One use I can think of is as a ligand for palladium catalyzed coupling reactions
Definitely invest in a 1 or 2 larger fritted funnels with different porosities. I really hated when I had a huge amount of stuff to filter and didn't have a larger frit. I have some larger 1 liter ones now and it was definitely worth it.
This channel should be used in chemistry classes.
"now in HD"
*click on quality*
you mean 4K?
XD
XDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
ECKSDEEEEEEEEEE HAHA MEME Xd
Hest of the Ds
X/Xd ( 4X)=?
XD lol xdxdxdxdxdd
i must say nile's voice is asmr
20 K views, zero dislikes. Pretty good stuff.
Ive made this last year in my undergrad organic chem lab
13:51 the forbidden orange juice
Really nice to see this after hearing all the diy sun screen horrors since I started getting into cosmetic chemistry lol
Gonna have me a nice glass of ice cold ethanol.
i used to be a t shirt printer repair man, and i learned to hate a chemical called titanium oxide which is white pigment in fabric ink. turns out they use it everywhere. it's also used in sunblock and ranch dressing to make it white. the reason i hated it is because in not soluble in water so it separates and clogs the print head, but i guess in sunblock or ranch dressing it's been emulsified.
I thought the title said: “making sunscreen from ranch”
The reason why I watch these videos when I should make homework is because I use it as an excuse to not make it and I justify it to myself because it makes me smarter.
Jk. The REAL reason I watch these videos because the colors and pretty powders makes my brain give me dopamine
I like watching these because i havent a damn clue whats actually going on but its cool to see things changing into other things
anyone thinks that Nile is actually pretty cute?
The test with the uv light is so cool!
One of my products in OChem had a MP of about 30 degrees less than what it was supposed to.
Were you able to calculate the molecular weight of the contaminant?
How did you screw it up THAT much?
Cloudyness may have been from water in the 95% alcohol
На сколько я в курсе, в солнцезащитных кремах для отражения УФ излучения используется мелкодисперсный диоксид титана.
Can you make an instruction manual on how to make this sunscreen..
This is literally what he did
I would love to see a video of yours on how those resins harden under UV light
In my opinion the crystalization did not work because at the vacuum filtration point you did not wash the product with ethanol-ecatic acid mixture and you got an oily mixture at the crystalization point. I am a student and in our lab it is a typical problem when somebody skips the ethanol-ecatic acid washing step.
You and vsauce are what I watch before going to sleep I love it because I fall asleep and dream about chemistry or physics 😂
Him Alpha hydrogen
Mean intellectual:Chad hydrogen
I'm watching this while trying to sleep and hear Nile talking about trans and cis chemicals
I would love to ask something... I went through few laboratories at our university and we never put the watchglass on a beaker during recrystallization... The true is, that it was almost forbidden to use beakers for reactions, heating and so on... We could use it just for our solutions of acids, bases and salts. We were using just flasks for almost everything. I just want to ask, why there should be watchglass during recrystallization... Thank you for answer :)
I wasn't paying attention 100% and then I just heard "Trans, Trans Trans, Cis Cis, Cis" and was like wtf XD
nara smith made this look easier
3:59 Reminds me of two things moutain dew and piss
go see a doctor
How about some substances that change their properties when exposed to UV light?
E.g. change their colour, or get hard, or becoming more conductive/resistive to electricity, or more/less soluble in water or some other solvent?
He made uv bears
OMG sir, where have you been all my chemical life !!!
Hide your oxide, hide your wife
Oh i know that if Nara Smith ever finds this it’s gonna make her day
anyone else here after almost a whole year of watching these vids but still have no idea how the stir bar works?
There is a spinning magnetic field in the hotplate, which moves the magnetic stir bar
In these old videos looks like he is speaking in slow motion compared to the recent ones
Since when do you look at speaking?