For mRNA Vaccines, COVID Was Just the Beginning
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- Опубликовано: 16 сен 2024
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mRNA vaccines stopped the COVID-19 pandemic in its tracks. Now, they're poised to help us against the flu, rabies, cancer, and more.
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My elderly cats have been getting an mRNA shot that relieves their arthritis pain. Unfortunately, they have to get it once a month, which means a ride in the car, which they hate. The shot really makes a difference in their comfort and activity level.
Just move to within walking distance of the vet. Or get a license to practice veterinary medicine yourself.
Ezpz.
Interesting.
My cat gets solencia for arthritis, but that's a monoclonal antibody. I can't find anything about a mRNA cat arthritis medicine.
I had a vet that visited my home. He had a well stocked van with refrigerators for meds and a portable roll out scale. Very stress free.
Just be aware of injection site carcinomas.
My brother is currently in the hospital facing possible amputation (one or both legs) because of an auto-immune problem (something called lymphedema). If there were an mRNA treatment for him, I'd just about lop off my OWN leg to pay for it. I don't think it can be overstated how much even a handful of new therapeutic vaccines would mean to the people who might be cured.
Tell him to leave the hospital asap and get some real help.
Auto-immune disorders still have no cure. There is reserach of course, see SciShow video "A Vaccine That Makes Your Immune System ... Forget?"
Someone above posted about how we have some treatment options for animals with autoimmune disorders, but those are 1/month things. Not sure if that would be enough to combat accute swelling.
@@christopherg2347 there is no immune system, so there are no auto-immune disorders. Just because something is declared as a theory does not mean it is legit. Immunology is actually disproved in many ways. For example, the overwhelming majority of people who have ‘antigens’…are perfectly healthy. We learn that when we do actual mass testing. Conversely, commonly people in ICU will have high antibody titers.
Immunology is just another bad idea from europe. Disregard it, and check out daoist philosophy, where all these things are understood far better, and more comprehensively, and the health precepts flow out of a nature based philosophy.
He needs to wrap his legs very tightly and then wear tight compression socks daily
Is this page an ad?
I was doing mRNA vaccine preclinical studies almost ten years ago for encephalitic arboviruses!
Thanks for your service, it will have helped humanity as a whole
o7
oh yeah? I did this almost ELEVEN years ago. B)
thank you.
how did the animal trials go? any adverse effects?
Thank you for your service
You guys barely scratched the surface of the advancements that mRNA vaccines can provide. Beyond the ability to selectively turn off immune responses, the biggest one in my opinion is to be able to instruct the immune system to target prions (i.e. misfolded proteins). Before mRNA tech existed we had zero treatments for prions but with mRNA we can instruct the immune system to notice and attack prions.
Can you expand on what Prions do/what their actions/functions are in the body? This sounds really neat and I'd love to know more!
@@LaviniaDeMortalium Prions are infectious misfolded proteins that have the ability to misfold other proteins. They infect brain tissue and can basically shut down the function of and destroy neurons, causing spongiform encephalopathies, and the diseases they cause are currently impossible to cure. In addition, they're very difficult to destroy using heat or chemicals unlike typical infectious disease vectors like viruses or bacteria, but luckily they're generally only either inherited genetically or they're contracted by eating infected brain tissue. So don't go eating brains!
@@LaviniaDeMortalium prions attack the brain. It's what causes mad cow disease.
@@LaviniaDeMortalium and it's also causing wasting disease in deer in America.
@@amandajones661 Prions! There we go, it just clicked! Thank you for that Amanda. I appreciate the memory jog
I am really not convinced that this research in the hands of private pharm and its investors will result in anything but insane profits for them until the patent runs out!
* I want science done in the public interest, thanks!*
it is. the public benifits from the results.
now, we do need to do something about the insane prices, but that can be done and still allow the private sector to thrive.
we gotta get rid of the idea of getting rich off the sick
@@Austintwo3no one should profit off of things for everyone, and governments subsidizing these companies allows them to influence massive amounts of control with no accountability. When diseases and illness is preventable, profit is literally in the way
@@ArktheLark business have to make money, but being able to Patent n "claim ip rights" n things like that gotta go for things like meds n such
then we wouldn't have half of the good things we already have
@@ArktheLarkwithout profit there will be no innovation.
Private companies funded by public money and University research.
Clinton did that, fortunately when the Uni does the research the company has no editorial control and relationships have to be disclosed.
"In 2019, the pharmaceutical industry spent $83 billion dollars on R&D. Adjusted for inflation, that amount is about 10 times what the industry spent per year in the 1980s" (Congressional Budget Office). Note, the NIH's total budget in the same year was $39.2 billion. There are specific cases where your statement is true, such as novel Cystic Fibrosis treatments costing exorbitant amounts of money while being the initial research was funded by the public/non-profit charities but this is not the case for all new treatments. I.e. certain monoclonal antibody treatments that were created to treat non-life threatening diseases but now it turns out they cure allergies/may be a treatment for COPD.
The reason I bring this up is because (a) SciShow doesn't need to get into the weeds of drug funding by govt vs pharmaceuticals in each video (b) or the fact academic research in public universities is often funded by private companies (Novo Nordisk's relation to Denmark's universities) etc etc its complicated!!
But because it is misinformation to imply pharmaceutical companies make money off vaccines, which are the most unprofitable health treatment for how effective they are and why vaccines aren't usually funded for known viruses unless there's an outbreak! Vaccines usually require govt intervention to be made at all and we'd all be better off if more nations had reserve facilities to manufacture them.
It also doesn't address the very real problem of underfunding for pharmaceuticals by the public -> right now the voters seem to think its alright leaving what research to prioritize in the hands of "Big Pharma". It also doesn't address the extremely predatory thing "Big Pharma" does with extended internationally binding patents on drugs like insulin WHICH IS THE REAL CASH COW!
Snappy social media critiques get likes but I hope SciShow can make a well researched video that covers these topics or leaves them out until they can do so. Unless ppl are informed about what is happening in medicine, they will be vulnerable to conspiracy theories and health misinformation = worsening health outcomes for everyone!
Born too late to explore the oceans. Born too early to explore space. But born in the perfect time to see such mind-blowing medical discoveries!
First cancer... then hair lost. That order please!
Considering we’re nearing the end of the antibiotic golden age as resistant diseases on the rise, have this new method of fighting them is the new magic bullet.
mRNA is exciting and promising for vaccines, but let’s be honest about their effectiveness for COVID-19. The way we did it only generates antibodies to the spike proteins which change drastically, outpacing vaccine development. A traditional attenuated virus vaccine would’ve granted more broad immune response to other viral proteins.
We have NOT explored the oceans very well if that makes you feel any better 😂
@@emmettturner9452the mRNA based vaccines performed better than the traditional from Novavax and Johnson & Johnson.
Private companies developing the covid vacines were financed by government, even with the obvious incentive to develop a covid vacine they still needed the government to put money in other to make them want to do something
You are expounding the myth that private enterprise takes the big risks. The biggest risk (and the largest sums of money spent) is taken by the public with their taxes funding government research that, 9 times out of ten, doesn't pan out. Private enterprise (e.g. pharmaceutical companies) then takes the research that has panned out (for free) and, makes a for-profit product out of it. They then spout the myth that they took all the risk. New laws are being looked at to make sure that the government (the public) reaps back some of that profit that benefited from public funding.
Those interested can look up the Bayh-Dole Act to know a bit more. The government funded research isn't always taken for free, but in comparison to the often immense returns it's definitely peanuts.
Bringing a drug to market is also expensive. But yes, the US government should get a taste of the profits since they put up the research money. but that’s not the way America does things.
9:35 I find the claim that private companies, by virtue of being privately funded enterprises, are able to undertake riskier research endeavours, questionable. If anything, the need to provide their private investors a return on their investment would incentivise such companies to not take risk, but instead pursue safer endeavours which have a higher likelihood to maximise the return on investment. In fact, the host of this episode implicitly brings this up when she mentions that during the pandemic, research into mRNA vaccines for conditions than COVID19 was shown less attention by private companies because there was less interest into, and thus less funding for, those conditions.
Surely, if the effort invested into different research endeavours was determined not by their capacity to generate financial wealth, but by a socially defined process of prioritisation, then the result of these efforts would match the socially recognised needs of our society better. In turn, it surely would mean that riskier endeavours would not be neglected if the payoff was recognised as high enough, assuming that less risky avenues that achieve the same outcome are not already available or known.
Not to mention that BionTech got 375 Million Euro from the German State to further their investigation into what became the COVID-19 vaccine.
That came after BionTech got 50 and 100 Million EUR in several credits from the European Development Bank starting in 2019.
And let's not forget mRNA research was widely shunned by investors for decades, mostly thriving in the world of (state sponsored) academia. The story about "private companies are the ones moving science forward" is not exactly an uncontested position. I'm surprised at the lack of research done by SciShow before casting that assertion.
That's mostly true for large, established companies. Biotech startups aren't like that. As I understand it, 1) VCs/angel investors gamble on startups 2) 90%+ flop, but the survivors make stupid amounts of $$ 3) startup is acquired by established company, and investors/startup guys cash out. As such, there's plenty of room for risk taking.
People with rare diseases are still screwed though.
@@pierrecurie I can concieve that startups that have less to lose and and are less bound by investor interests follow different buisness strategies than larger, long established corporations. However, doesn't the sucess of any burgeoning enterprise still, in the end, rests on their ability to find a sufficiently large market for their product to offset the cost of their operation, and thus become profiitable enough?
Even if a startup that hasn't found a market, and is thus not profitable, manages to find enough investments to keep it afloat, surely it won't change the fact that this startup isn't profitable. Why then would investors keep investing in it? Surely startups like this represent the "90%+" that you mentioned, while the rest of startups that do suceed in being acquired by larger corporations do so precisely because they have found enough demand for their product to become profitable.
By this analysis, the viability of a buisness enterprise, even a burgeoning one like a startup, still depends on its ability to foster enough demand for its product or service. Endeavours that are expensive to undertake without being suceptible to foster a large enough demand (in other words, endeavours that are risky in the eyes of investors) have very little chance at being financially viable without some kind of subsidies. Yet, just because an endeavour is costly but isn't valuable to a proportionate portion of society doesn't mean that it isn't worth pursuing. The case of research into treatments for rare diseases that you brought up is a typical example.
I am by no means well learned on buisness strategies or market economics, but I don't see how, when all is said and done and all things being equal, finantial profitability and return on investment isn't the final arbiter of which buisness enterprises stay in buisness, and which don't.
@@HectaSpyrit Sometimes investors throw money at dumb ideas like moviepass. Uber/Lyft are barely profitable (their revenues are high, but so are their expenditures).
It's also important to separate risk and market size. Your initial argument was about risk, not market size.
9:30 this is a really bizarre claim to make when considering the billions of government dollars spent to develop and purchase mrna vaccines, including funding of basic research and grants awarded by institutions like the NIH, DARPA, BARDA and others. The NIH itself claimed intellectual ownership of certain key components of the vaccine. How can you make the argument that private companies are MORE likely to fund newer and riskier research when the public was also funding the very companies doing that research since the 80s?
I'm surprised at the lack of research done by SciShow before casting that assertion, for sure.
@WromWrom No surprise here, they always lean liberal and tend to follow the biased research studies.
They may as well slap a "brought to you by Pfizer" sponsor and on this, because that's all it is.
@@WromWrom well, they are SciShow not EconShow
How does what you said disprove SciSchow's assertion? Of *course* governments pumped huge amounts of money into the pandemic: it was an active pandemic killing thousands daily They HAD to pump money into risky research, because ANY solution had to come fast to save lives. When there *isn't* an active mass-death event going on, governments ARE much less likely to fund risky research.
haha wow private ownership of medical knowledge should not be a thing
Why not? Are you willing to fund research for diseases you will even hear about? How ouch are you comfortable with your taxes being raised for the additional cost? You can argue about government spending and priorities and whatnot, but as things stand right now making all medical research public would necessarily mean spending more of your money.
I think the video did a good job of explaining that there are benefits to private research. I have no problem with a company taking on the significant risk and expense of developing a new drug and then seeing the return on that investment. That’s how a capitalist economy works, after all.
I do think there need to be rational limits on IP rights. More akin to the patent Les which expire after (I think) 25 years, rather than the insane copyright laws that expire (again, I think) 75 years after the death of the original owner, especially when that owner is a corporation with legal rights as a person. In my opinion, the real problem is not that IP rights exist for any given situation, but that they can be and are grossly abused for profit.
@@kenrickman6697a lot of research is publicly funded, patented by corporations, and then sold back to us at extortionate prices. the private market should not exist for healthcare, it creates perverse incentives
@@kenrickman6697except a lot of the money for research comes from government funds because pharmaceutical companies don’t want to invest in a product unless they know how long it will take/if they will actually get a result (unless of course they get that sweet sweet government money, and then still patent it for themselves and charge exorbitant amounts of money to make up for the research cost that they totally definitely paid for all by themselves)
@@kenrickman6697 now try without capitalist apologia
@@twinblessings2125 Who said anything about apologizing for anything or anyone? I am mature enough to recognize that the real world isn’t some fantasy playground full of unicorns and rainbows, and just because some twerp thinks they should get everything for free just the way LKN my and daddy raises them, it doesn’t mean it’s ever going to happen. If you want to survive and thrive, you have to see the world as it is, not as you want it to be.
Now, try it again as an adult, whenever you choose to grow up and face reality head on.
Public funding was the basis for mRNA vaccines. You should not be praising the fact that often when publicly funded research looks promising we actively encourage people to found private companies based on it. This harms us all in the long run.
EXACTLY!!! This idea that they're more likely to take risks that publicly funded efforts wouldn't is also baseless. They never give concrete examples and just assume that it's the case. Corporations gatekeeping potentially life-saving revolutionary technology should be illegal. Any benefit is outweighed by this alone.
The global body count is currently in the 10's of millions, with no end in sight, and the serious injuries are at least 10 times that many.
I really like this host. Very audible and humorous delivery.
The potential of biotechnology is insane. Today, I would raccomand to those who want to go to college to study either robotics or biotechnology. This technology will drastically change our lives.
Not in itself so much perhaps. But in combination with personalized medicine that will become possible when new super computers that can process astromical amounts of data in just seconds can map out every gene in the body, and with the help of AI quickly discover patterns of healthy bodies and chemical and biological patterns for certain diseases.
And every human bodies own unique needs will be taken into account, and a perfect combination of different medicines with optimal doses for each person will be given. Every persons own unique biology, age, sex, weight, and such will then be taken into account. This will probably become a revolution in medicine. New diseases will be found, and new cures, and existing cures will be optimized.
@@nattygsbord it's not that deep
@@nathanlevesque7812
Sorry if I came across as dismissive. Biotech is useful for many industries related to food, energy, medicine and building materials.
I do not wanna belittle its importance for medicine.
But I think that AI and supercomputers and personalized medicine will become a huge revolution that will make all other modern medical advances pale by comparison.
IT security feels like a safe bet on the future job market. Especially with a new cashless society, self-driving cars, and "smart homes" where lamps, refridgerators, toasters, washing machines, dish washers, air conditioning, jalousie windows are all communicating with each other through the internet and can be steered from a smartphone.
And if a hacker takes control over all this, then the disaster is total and a persons life is ruined after losing everything.
And the military will of course also love IT specialists. Future warfare will have cyber warfare as its own domain in hybride warfare.
And electronic warfare have proven its importance in Ukraine, and if you can knock out the enemies ability to communicate with his own drones then you have won a lot.
Yes, then end up developing patents for the most corrupt evil companies in the world. 🎉
Patiently waiting for the melanoma vaccine to hopefully get rid of my reoccurrent melanoma for good. ❤
❤ Healing prayers and thoughts for you.
Don't hold your breath. They make much more profit from treating you than curing you.
_reoccurent?_ how many times you had it?
@@Leester-70 You could have been kind and just kept your inside opinion to yourself. Just because you CAN type something doesn't mean you SHOULD.
@@veryberry39 Was I wrong?
I just got done participating in a study of an mRNA avian flu vaccine; I am super pumped about it! Also really happy to do my part.
Thank you for all you're doing to help save the lives of all our families. Especially our elderly more vulnerable to flu etc. Much respect and appreciation
Sounds like it might be a good antidepressant too:-) I think the antidepressant I currently take was originally developed to treat TB. Someone noticed that the treated group of patients were practically dancing around the sanitarium. They were still sick with TB but their mild mania led to the drug being tried for depression. I guess you are just feeling good about doing something to help others, but it remanded me of that story.
lmfao!! Do your part? taking experimental concoctions for the sniffles? Gratz!
@@xwarmanglestop being such a negative Nancy. How do you expect these vaccines and their effects to be studied if people don’t volunteer and do their part
This is the most bot comment I have ever seen in my life.
After having to do chemo for a few months now (about to be in remission), I’m really hopeful about the personalized mRNA vaccines against cancer. Like I’ve had to put life on hold because chemo just wrecked my body. I’m especially excited about how these studies show minimal to no side effects to help the body fight cancer. I’d give anything if this were the norm, I’d be able to get back to living life without like 99% of the worry compared to chemo side effects.
Can you name me one of the studies you've read? All the early clinical trials using mRNA were disaster pre-2020. What have they changed? Id be interested to see what's changed.
@@mangaasFor brain cancer, I recommend reading up on Richard Scolyer. He’s an australian who’s made impressive work on mRNA vaccines for melanoma, but he had to use this approach last year when he got diagnosed with a grade 4 glioblastoma. He’s still in remission, still means the cancer could come back, but good progress because hardly anybody with that cancer lasts a year.
For melanoma, the chance of a personalized vaccine approach reaching to market is by far the greatest with this one. Moderna’s now at phase 3 studies with it. With just the vaccine, survival was around 50%. With the vaccine and immunotherapy, that survival rate reached close to 75%. That’s very impressive with late-stage melanoma.
And also in the video, the mention of a pancreatic cancer vaccine is now in phase 2 studies. There are recent news articles about the cancer vaccines mentioned if you want to read more into them, very interesting stuff!
@@mangaas Just looked back and I had a reply but I guess it got deleted? But there’s some more news articles since then showing that mRNA vaccines are successful. Like BBC’s story on Richard Scolyer, Time Magazine’s article on Moderna’s melanoma vaccine, and like what was mentioned in the video the pancreatic cancer vaccine that’s still in studies.
@@mangaas I think they're talking about 8mins into the video?
This would be an amazing breakthrough to have. I mean cancer treatments have already come so far with DRASTICALLY better survival and full remission rates in the past 30years, so this would be the next amazing step. Here's hoping it comes relatively soon coz yeah, side effects completely crash your life with the isolation periods, nausea and then some of the current methods that OP mentioned.
(I've seen friends and family go through it over the years 😢 so you have my sympathy, brave warriors! 💗👏)
Chemo side effect are nothing compared to mrna side effects. You can recover from chemo. You can never recover from mrna.
We're never gonna get a zombie apocalypse now... Gee, thanks, science!
I don't know what "thumb" to give this video....fascinating science, but for - profit companies? They do it for their own gain, they always will. In India they made a cheaper vaccine with national funds, in Texas they made a cheaper one designed just for children with Dr. Hotep at his university. They provided the access.
💯
lol what a dumb take
@@Jack_Redview you're the dumb one if you think even for a second greed isn't the main objective.
I think people should not knock "for profit" entities doing research for healthcare, just the fact that a company is doing research will further the knowledge. If you remember back in the 15th century, explorers discover the new world, what was the impetus for them to do this endeavor, riches. They were looking for gold, and a quick route to China so that they can bring spices from the Far East to Europe.
@@Jack_Redview
It's called corporate greed. Not intellectual property.
The thumbnail title combo definitely made it look like a clickbait piece on how the Covid vaccine increased cancer rates
It did.
It does . . .
Thats prbly more true than what this actress female is claiming...
Right, thought there was going to be a negative reveal.
I can't help but wonder if this might ultimately lead to the rise of artificial mRNA viruses
Here come.all the online doctors with their knowledge
Comments are full of experts
This is why we need a government owned pharmaceutical company. It would function like the post office and still need to cover all its costs.
The Republican party is doing their best to privatize the post office. They don’t want it to be a government entity. There’s a whole lot of profit that could’ve been made if they didn’t exist.
@@neilkurzman4907not just that, the USPS isn't profitable as it stands. It is a large expenditure in the budget. Hell they still use NG mail trucks.
That's pretty cool. I had cancer five years ago, and just found out I get to fight it again. The leaps in technology in that time span are pretty amazing, so hopefully this round will be a bit easier on the parts of me I'd rather not kill.
Weird side-benefit to mRNA vaccines: very, very few people are allergic to them. There are some traditional vaccines that are made with eggs, so people with egg allergies can’t always take them.
Absolutely agree. I know some people can't take the flu vaccine because they are allergic to eggs.
Yes, but ....... the most used one (about 4.5 billion doses worldwide) was Comirnaty. It uses polyethylene glycol (PEG). A reasonable number of people are allergic to it. Quite a few don't know they are.
@0:23 I thought it was going to keep happening again long enough for you to go into the macarena
Did mRNA vaccines really stopped the COVID-19 pandemic in its tracks? The public was told that these vaccines would stop transmission and infection, which was not fully the case, and while it did help prevent severe illness in certain populations, the push to administer to everyone while still under EAU and the lack of transparency from health authorities and pharma regarding adverse effects/deaths will affect future studies and how will the general public accept them.
This is one of the major reasons I started studying biochemistry. Covid was active just when I got into university, which was great because we were able to see what we can do in real life as professionals.
Her voice is top notch! Very pleasing and easy to listen to.
I believe the technology is good and am not anti-vax but I tried one shot of Pfizer and I was dizzy for weeks. I was bedridden with dizziness for 2 weeks and then was never back to fully the same for about 3 months
You're lucky to be alive, as the millions of dead people can attest to.
You must have drunk a LOT of Kool Aid to believe this tech is good after having gotten injured by it, tsk, tsk... It shouldn't at all be used for healthy people, only its use as bespoke cancer treatment does the cost benefit make sense, considering that you can't know the dose your cells produce, only the dose of instructions you give them, you don't know where in your body the instructions will end up due to the microlipid capsule, and your immune system attacks your own cells for producing the alien (to your body, obvs) proteins, which could now be cells in any of your organs since you don't control where the mRNA ends up
I would love to see them used for herpes or HIV as well. Prep isn’t available or affordable for everyone, and herpes sores, even on the lips, are just awful to endure along with the stigma.
Can't wait for the turbo effects to kick in "suddenly".
My cousin was just diagnosed with stage 1 pancreatic cancer, and he is enrolled in the phase 2 successor to the trial described here. He just had his tumor resection surgery last week, and is doing relatively well. His tumor biopsy sample has been sent off to be sequenced and have the personalized mRNA vaccine made. Hopefully. It's a double-blinded, placebo-controlled trial, so there is a chance that he will get the current standard treatment with a placebo instead of the current standard treatment plus the mRNA vaccine. Here's hoping he's been randomized to the vaccine group, and that his cancer responds to the vaccine 🤞
This is amazing!
Great presentation as well, very informative, thank you so much!
Since I'm definitely immune compromised, I've gotten every vaccination allowed! I love that SciShow covers this important kind of science information! Thanks 🙏🙏👍👍
Sounds like your going to need every chemo allowed also . . .
I love science
Niba has a very pleasant and soothing voice. I’d love to hear her read stories.
I agree, I like her voice.
Just a little slower otherwise I will fall asleep never having the opportunity to enjoy her soothing voice.
@@shaheenbhoola put on 0.75 speed
Her voice is nice indeed but reading stories demands certain "acting" and narration skills. I'm not saying she doesn't have, I do not know, but not everyone is capable of narrating stories. Narrating isn't reading.
@@REMY.C. True.
In the context of the Covid vaccines, the m in mRNA actually stands for modRNA. A nucleoside-modified messenger RNA (modRNA) is a synthetic messenger RNA (mRNA) in which some nucleosides are replaced by other naturally modified nucleosides or by synthetic nucleoside analogues.
Thanks, loud and clear!
I love this channel and follow the content avidly because I respect the accuracy of the content. However I was disappointed to hear the assertion that even in the UK the traditional rabies vaccine can cost up to £200 this is not accurate. UK citizens do not pay for vaccinations or health care. The vaccination is free here. However the vaccine is probably just as expensive for the NHS to buy 😢
This particular video is loaded with dangerous misinformation.
One thing you said was true that they dusted their hands off after getting millions to take their product and they want to do it tons more. The most profitable pharmaceutical ever. No wonder they want to do it again.
I've been waiting for mRNA updates. It's such exciting science!
I’m really enjoying videos with this particular presenter. Their voice is so pleasant, and their comic timing on the asides is elite!
First time catching a video only an hour after its release. And on a topic I find fascinating!
I've taken every inoculation. Sore arm was about it. After 4 years finally caught covid this summer and had a headache and bit of congestion, that's it. Gone in a few days. The inoculation made the illness much less than it would've otherwise been and kept me out of the hospital. Can't wait for a shot to help with cancer. Hope it will be available in time for me. Not getting younger lol.
YES! same here, I've had worse colds, that covid vaccine kept me from spiraling into the hospital 🎉❤
I got covid in march this year, knocked me clean off my slate for a whole week.
I am sure i would have been in a Hospital without the 3 shots i got in the years before (i have at least 2 risk factors. Almost obese and beginning Asthma, getting covid without the shots could have been a death scentence)
@@DJRaffa1000 Yea my best friend is healthy as an ox, he is retired military and still works out daily, and EVEN HE spent 2 or 3 days on a ventilator in the hospital... Said he was really sick and went to urgent care, they saw his blood oxygen was only in the 60s! (Should be up near 99%, dropping even 10% is cause for alarm)... It's a GAMBLE that could cost an entire life, better to be safe and vaxxed, than dead
I had covid twice in 2020, twice in 2021 and I think one time in 2022 and twice in 2023 and once now in 2024. Every time it was like a very mild flu. Never took the vaxx, no point fixing what ain't broke.
@@huldu well yea, you can build natural immunity to any virus.
During the pandemic, Covid proliferation was insanely fast.
So new strains were practically being airdropped.
So yeah, you're probably fine not taking it.
Could an mRNA vaccine work against multiple strains of the flu? I know one issue each fall is that we must guess which flu strain will be dominant and prepare a vaccine for that strain only.
Pretty sure the same issue applies for Flu and mRNA vaccines. Flu is a tricky one, it mutates by changing the spike proteins on it's outside and it's fast at mutating. mRNA vaccines only have instructions for one type of spike protein unless you combine different ones. Problem is that the spike proteins can be any shape combination so it might be tough to make a vaccine for all previous and future flu strains.
@@darkelysium2187 Not all past and future flu strains, just all the stains currently in circulation.
@@billberg1264 That probably won't be hard to make a vaccine for all strains in circulation. The issue is future strains where the virus mutates into a new strain to avoid the vaccine.
There is a research project looking into a universal flu vaccine. The flu virus shape is apparently like a piece of brocolli with the different strains sharing the same base 'stem' and differing in the 'leaves' so to speak. They figure that with the cool things that mRNA vaccines can do they will be able to make a vaccine targeting the stem which will work on all strains of the flu.
Yes, they were developing it for use with the flu and other cold viruses when COVID hit. It would have come out by now regardless they just upped the timeline a little bit specifically for COVID. The entire reason it was being developed was so that it went flu goes bonkers next time we could stop it.
Rabies vaccine cost in India is about 3 to 4 $ only. Come and get one.
Man. This comment section is full of EXACTLY the people I thought it would be.
I had hopes that a SciShow audience would be better informed, but, alas, it seems not. (Although, I can't discount any possible brigading going on, too.)
it's very possible youtube is censoring the people that are commenting what I thought I'd be seeing ahahah
People excited about scientific nes? That must be the case because out of the first fifty or so I browsed, one was vaguely critical about some funding questions
@KSCPMark6742 It definitely seems that whoever runs the SciShow channel knew what was likely and has been working quickly. Some of the comments I myself replied to are already gone.
@@scaper8 Glad to see that, youtube comments can be such a cesspool
I hope they get this vaccine for cancer, wouldn't that be wonderful .
My grandfather passed away due to pancreatic cancer. The hope for these vaccines is real for me🎗️❤
Something I'm curious about, is there any drawbacks to mRNA vaccines? Have there been any long-term studies about any long-term side effects? I'm all for a new tool in the Medic's kit, but I want to know if there's any downsides too.
That's why they do trials. Sometimes they do find that there can be long term side effects for different treatments but the risk is generally quite low. If it was high risk it would have got caught in the trial phase. Then don't forget that the longer that you wait to see if there's a chance of long term side effects, the greater the chance there is that you contract the disease that the vaccine helps to prevent.
To start this off, no, I am not antivax... So don't try to label me as that. With that said -- There are a lot of very bad things that can and have gone wrong from reverse transcribing of the mrna sequences into our DNA (peer reviewed studies have proven this can happen), it can cause a cascade of autoimmune responses throughout the whole body and there is so much that we still don't understand. Remember these same companies and institutions lied saying it would stop the spread of COVID but under oath admitted they never even tested for that end point in their studies. They told us it would stay local in the spot it was injected but autopsies/biopsies/testing has shown the spike protein made by the mRNA vaccines spread systemically throughout your whole body -- brain, eyes, liver, testies, ovaries, heart, and any other organ you may have. mRNA tech has been around for a while and there have been a lot of failed attempts to use it due to too many unknowns and side effects. COVID was basically the government and big pharmas way of strong arming the FDA approval of the tech and making the tax payer literally pay for the machines/processes that make it so big pharma didn't have to make those investments but could 'save they day' and make billions out of the 'goodness or their own hearts'. It's ridiculous. Scishow just lost a heck of a lot of legitimacy with this video in my opinion.
Now for the positives -- there are a HUGE amount of uses for mRNA technologies for fighting disease, I'm not saying the technology is bad BUT with all the companies being for profit and literally controlling the studies that are used for their approval the safety oversight isn't there and you're lying to yourself if you say it is.
We have been at an elevated level of deaths since the role out of the mRNA shots. COVID infections stopped accounting for the deaths a long time ago. A lot of people are dying that shouldn't be, across all age groups and in all the large countries that mandated the shots. No one wants to acknowledge or talk about it in the media. The numbers come from government websites so they're not made up. Sure they are estimates based on previous years BUT if you look at historical predictions they would be a little over, a little under throughout the years but not multiple percentage points above the predicted average for almost the majority of the years. Not saying it's the shot, but boy do the numbers line up pretty well with booster roll outs even with accounting for COVID waves and COVID deaths.
Never underestimate the power of greed.
Never approved for human use, even the inventor said so 4 years ago....
No long-term studies about side-effects and no authorization for human injection.
Mrna is very dangerous and should not be taken.
yes since the late 80s already.
www.ncbi.nlm.nih.gov/pmc/articles/PMC10022421/
I wonder if this kind of science tech could be used for other health issues, like mine... I'm missing 2 out of the 4 proteins in my DNA that makes up my autoimmune syatem.
This host's voice is very smooth and velvety. I slowed down to 1x speed to listen 😆. More please!
Knowing my luck I'll probably die before seeing any of this
I like this reporter. I haven’t watched scissor much for a couple years because that second generation of reporters after the initial ones were not very good.
The first mRNA vaccine tested was on horses.
So much medical advancement begins with testing on horses.
Big animal, less risk and also horses have been traditionally used for so long for this type of thing that we have more data on what to expect from them than many other animals. But they could have used rabbits too
That’s why one horse kick can end us 😅 we empowered the species
I love your enthusiasm and excitement about the subject. Good vid, thanks. "Hank, this lady is a keeper. Please!"
For what it's worth, I find this lady annoying and tedious. Can't we have more of the wonderful Rose Bear Don't Walk?
@@施素珊I'd really love to have her back more. I love this presenter too, though. The one I wish they'd get rid of is...I don't actually know their name, the one with curly hair that comes up for ads and feels the need to shout all the time.
Is there a mRNA vaccine for moneky pox that is on the rise in Africa?
Small pox vaccine works for it to.
Rabies: in Germany it's ~50€/shot. Most insurances will pay it gladly when you can show them that you're travelling to a dangerous region
Very worth noting that the focusing down on Covid was fairly unique. For example, if you look at the crowdsourced computational protein system Folding@home, their usership massively spiked during the pandemic and they put as much of that computation power into covid as they could.
From what I gather about how their system works, they need to break a problem up into discrete pieces that can be farmed out to user computers to be processed - they had people processing those pieces faster than they were able to form new pieces, so they wound up getting a lot done on their older projects as well. (Though people did complain about being assigned non-covid work, because of course they did.
Point being, before covid, they weren't 100% focused on Zika or Ebola or whatever the previous big problem illness was, they had a bunch of different projects running. Covid was the world's medical systems in emergency hyperfocus mode, it's not an example of normal conditions. And hopefully remains exceptional for quite some time.
You might want to look into the money actually, private business get so much money from government to research. Even if they are "footing the bill" on paper, we are ultimately the ones funding it as people and yet they charge us an assload for it. Such bs.
Love this host!
I remember studying the very basic idea of mRNA when i was in Uni before COVID, so when the vaccine was announced for COVID i took it as my responsibility to educate the people around me about how mRNA worked. A lot of people i knew had been fooled by conspiracy theories, and being someone who used to be the same, i kinda knew what to touch on to break them out.
Im glad i got a lot of the people i knew to get the vaccine, especially my parents.
If only this video was around back at the start of COVID, would have saved me a lot of headaches and conflicts with family and friends
Yes. @@captainkirk4271
@@captainkirk4271 "higher cancer rates" link them then, show me a paper that links covid vaccines to cancer. It's not even physiologically possible lmao
One of those conspiracy theories is that the vaccine works.
@@wentoneisendon6502 They wouldn't be able to. Studies linking increased cancer rates to vaccines would be too far in its infancy to even draw reasonable conclusions. Any study that claims to do so is just pure conjecture at this point in time
@@petefrolov1842 Good thing we have solid proof it performs its task in reducing the severity of symptoms. Call that theory confirmed
Rabies shots are ₹400 = 5 USD in India tho???
Girly from the Netherlands here, I went to Kenya to work amongst wildlife for 10 weeks just after the worst of the pandemic had passed and it was recommended to take a rabies shot. I had to take 2 and they were a 110 euros each. But now I got lifelong protection baby hahah and I won't stop working with wildlife anytime soon
Criminal Medical Experiment Without Consent!
great video, great explanation. Now you will see a deluge of Dunnings and Krugers that crap all over this stuff
Or just people who can read and observe without someone in a white coat telling me what to think.
my first thought on hearing the explanations of the covid mrna vaccines was... sickle cell. hope this all comes true
Great. Now make that hiss needle like thing Dr. McCoy on Star Trek uses
Yeah sure that vaccine worked but let me go in for that 10th booster😂 🧠 🧼
Please make a vid or short about alexanders horned sphere. Definitely the most upsetting shape ive learned about all week
My bf got long covid in spite of being up to date. It definitely doesn’t work for everyone, but at least he didn’t get the first strain.
"You fool--this isn't even my final form!"
-mRNA vaccines, probably
Heads up re rabies vaccine cost:
Thailand costs for the rabies series is less than 100 bucks, all out.
No insurance needed.
Important over there because if you DO get bit with an infected animal, the cost for the rabies globulin in Thailand is super super EXPENSIVE. Like thousands of US dollars.
So you pick which you are more concerned about: being immune ahead of time - do it in Thailand. Getting cured after the fact -- do it in America.
I didn't even know HRIG existed before reading your comment, but Googling it a bit, it seems it's given in conjunction with the vaccine as part of Post-Exposure Prophylaxis. Apparently, altogether, PEP for rabies in the US runs from $1,200 to $6,500, with an average of $3,800.
How is Niba so freakin good?!
Genuinely bonkers how many commenters are angry about things Niba didn't say.
I noticed that as well. And sadly, if you try to tell them that wasn't what she said, they'll just double down.
Okay.... I already know this may be a stupid question, but why are preventative human rabies vaccines so expensive and animal rabies vaccines so cheap?
That was the first thing to pop into my head, too!
Need. Basically it's cheap because we've developed it to work well on the animals in bulk however they may experience some nasty side effects. We did this intentionally because by vaccinating the carriers we dramatically reduce the incidents in humans. As such there's not a huge demand for them in humans so when you do need to use them in a human it can be expensive and still sucks because there's no reason to make those vaccines less terrible when they don't need to be used often. Rabies vaccine is super old school vaccine and not a good time. Also humans are naturally resistant and don't actually get sick for months to years after being infected where most animals are going to get sick in a matter of weeks so you can't really retroactively protect your dog the way you can a person.
The fact that we have mRNA vaccines is great news on so many levels; my immunocompromised friend can ONLY get mRNA vaccines. If the Covid vaccine had been any other kind, she wouldn’t have been able to get it. Which sucks because her mom was not properly informed about vaccinations when she was a child, so she found out when her illness hit that she’s actually missing a whole bunch of childhood vaccines, that she can no longer get.
Cost in the UK would be £0 or $0 to the patient as we pay via taxes.
So you pay, you just have no way of knowing what you’re paying.
@@codename495 Actually most people know how much they pay in taxes
@@codename495I'd gladly--yes, GLADLY--pay more in taxes if it meant not going into bankruptcy just to get medical care. And that goes for anyone else who needs it, too. Why are your kind willing to do such crazy gymnastics just to justify your selfishness? You're so terrified of some boogeyman "lazy person" that you refuse to see the benefits to yourselves.
So you still pay... and the cost would not be zero... and its American companies... so still need to lick their boots
@@EC-dz4bq But when you are negotiating for a whole country, prices go down.
Do you think they will use this technique to target interleukin 11 in the human body to manage in reverse age related inflammation and extend our lives. Giving us not just longer lives but longer quality lives?
When will we cure blindness caused by retinal vein occlusion?
Poor guys, in my country, we have a free healthcare system with free vaccines
All your doctors and researchers work for free, with donated materials and power, in buildings that were built for free, on land that was donated by the previous owner?
No: You have a healthcare system that was paid for by taxes earned by hardworking citizens, that had no other option allowed by the state.
@lucienve Yes, you are right. But even if I lived under the bridge, I could get the same high level of healthcare as others, which is beautiful. You mentioned taxes. I have a company and am happy to pay taxes so everyone can have free healthcare.
This video and others like it should really be shown in schools. If kids could see how the vaccinations help (and none of the BS spread by the nutjobs is true) then we would get much better results and far fewer future nutjobs. As I was growing up (and sometime before that) movies used to be shown to kids to provide this kind of education.
What's not true specifically? And why is it necessary to censor? If science can not tolerate scrutiny, it is no different than religion.
For sure. It's crazy how uneducated so many people are about basic science that's been around since George Washington inoculated the continental army against SP. If it weren't for vaccines, we wouldn't have a country. This is the kind of thing all Americans graduating high school should know about.
@@tf5pZ9H5vcAdBp if I could make an assumption, it's because most of the people on the Internet are not media literate. Majority of people don't know the difference between a news article and an opinion piece, and most of them have definitely never even seen a real research paper.
People are too easily swayed on the Internet, and are more likely to believe anything that conveniences them.
Misinformation is harmful, and just like how you'd never want school textbooks to spread false information to our youth, you don't want people who are mentally vulnerable to online manipulation falling for misinformation.
The science is not there to support the claims of the vaccine companies or the government. General consensus should not be confused with facts. I am very fortunate to own equipment needed to see a viral sample. I don't trust most claims
Vaccinations help, when we're talking about things like measles and smallpox it does miracles. The c19 "vaccine" is a joke, plain and simple.
Any protein huh? Hope I can get rid of my goddamn allergies. I have like 20 of them. One of the most important is egg, everyone uses chicken eggs and I can't eat half of the sweets on this planet otherwise I die.
The potential for combining vaccines with mRNA would be great for childhood vacations as the less needles that need to be stuck in a baby the happier everyone is. During the first year of life when babies go to the doctor once every 3 months to get up to 4 shots it sucks and that is with combo shots. I am so happy to be past that stage but for future babies and those in pediatrics this would be great.
It's incredible how quickly technology can move during a global health crisis that also affects the wealthy. The answer to that is of course reverting back to a heavily romanticized version of the 1950s, or even 1980s, that never actually existed.
The only way it affected the wealthy was by driving more money into their pockets.
You also had multiple countries working together to solve the problem.
That girl has a beautiful voice.
Cool video! I'm in cGMP manufacturing of CRISPR edited mRNA products.
5:37 it's free in brasil ;) #salveosus
in Philippines too. Very convenient. They have a law here to mandate that. Just got mine. I got a indigent certificate in 5 mins in our town hall (barangay hall in local language) even if I am not even voting there lol and they gave me my shots for free
Thumbnail unclear. Got mRNA vaccine, and it hasn’t given me cancer.
A great example against the statement that private sector is needed is Cuba. Cuba managed against all odds, to develop vaccines against Covid, have much larger and richer countries ask for help, send doctors around the world and greatly protect its population, having much higher survival rates than a large number of capitalist countries.
And all that under the inhumane and unjustified USA embargo.
So now, private sector is most certainly NOT necessary. A good lesson of what happens when you put the need of the people first, and remove the profit out of the equation.
No mention of the risks? tsk tsk
I am curious to see the vector for mrna vaccine delivery used for research of gene expression/muting. Even vanity traints like gene supression of myostatin. Cant down regulate muscle growth without myostatin.
Ive never seen so many bots in a Comments section 🤷♂️
Looks like all the QAnonweirdo bots got deleted.
surprise! you got mrna.
Nice!!!!
Please, myc peptide deactivator for DEL lymphoma.
So we can make our cells manufacture specific proteins with an mRNA vaccine. How do we shut off the production of these proteins after the desired immune response has taken place? If we dont shut it off can this cause long term damage?