Packaging of DNA Helix | Molecular Basis of Inheritance

DNA packing in Eukaryotes
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Length of DNA double helix in a typical mammalian cell is calculated by multiplying the total number of bp with distance between two consecutive bp, it comes out to be approximately 2.2 metres. In Eukaryotic Cell, histones are a family of basic proteins that associate with DNA in the nucleus and help condense it into chromatin. Histones are organised to form a unit of eight molecules called histone octamer. Nucleosomes constitute the repeating unit of a structure in nucleus called chromatin. The beads-on-string structure in chromatin is packaged to form chromatin fibers that are further coiled and condensed to form chromosomes. Packaging of chromatin at higher level requires additional set of proteins called Non-histone Chromosomal (NHC) proteins. Region of chromatin that are loosely packed are euchromatin, regions more densely packed are called as Heterochromatin.
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[@muthukumar-cn7pr]

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[@gunasekaranlakshmanan5015]

Human body is created by god with invisible functions full of secrets doctor spent her life and studied the secrets and gives her knowledge for the brnefit of mankind we cannot thank her in this life time so i am indebted to her throughout my life time i pray my sat guru radha soami to bestow her transcendent insight to her through meditation by getting nam dhan the rarest gift from sat guru radha soami

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[@gunasekaranlakshmanan5015]

Thank you doctor you are patient to explain the packaging of dna and its details I have gained the knowledge of nucleosome histone prestine non histone prestine.your hard works helps the mankind I pray sat guru radha sosmi to bestow nam dhan the rarest gift of merciful sat guru radha sosmi our effort is needed

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