310 - The relationship between testosterone and prostate cancer, TRT, and more

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  • Опубликовано: 29 окт 2024

Комментарии • 37

  • @PeterAttiaMD
    @PeterAttiaMD  3 месяца назад

    In this episode, we discuss:
    0:01:22 - Background on the TRAVERSE trial: insights into exogenous testosterone and prostate cancer risk
    0:09:50 - The androgen receptor saturation theory: how different organs respond to varying levels of testosterone
    0:16:15 - The relationship between testosterone levels and prostate cancer aggressiveness: how aggressive prostate tumors have lower androgen receptor activity and rely on different growth mechanisms
    0:24:44 - Using the Decipher score to assess prostate cancer aggressiveness and guide personalized treatment strategies
    0:33:12 - Considerations for testosterone replacement therapy: how Ted counsels patients, how TRT can be safely administered in patients with low-grade prostate cancer, and more
    0:41:37 - Advancements in prostate cancer therapies and PSA as a biomarker for precise treatment decisions, minimizing the need for broad androgen deprivation therapy

  • @michaelmurphy7983
    @michaelmurphy7983 Месяц назад +1

    I’m age 61 and was on TRT for about 4 years before a Gleason 6 diagnosis. I was immediately taken off TRT and am on active surveillance. I’ve had two PSA tests since the diagnosis about 9 months ago. Both times my PSA dropped (currently 4.5). I’ve asked two different Urologists to place me back on TRT since I’m suffering from brain fog, depression (family doc put me on Wellbutrin which has done nothing for me), losing muscle mass, etc. but they refuse. Since I’m on active surveillance, I agree with this doc that I can resume my TRT to get my quality of life back while watching my prostate cancer. I’m so grateful to find a doc who shares my perspective on this!!! It gives me hope that I can find a doc who will write me a script for TRT before I lose my marriage and business due to me not being the real me.

  • @healthdoc
    @healthdoc 3 месяца назад +25

    I’m a 75 year old white male who had a testicle removed at age 28 (undecended at birth but only discovered and relocated to the scrotum age 8. When I had a vasectomy it was diagnosed as vestigial with cancer risk and removed). My testosterone level was about 400 at age 60. At age 70 I began injecting exogenous testosterone, Sustanon 250 mg/ml every two weeks. This formula combines four esters with different bioavailability so the serum level is made more constant. I now sit at 850 and feel that I have been able to maintain weight, musculature and fitness levels I surly would have lost without supplementation (6’ 165) I had BPH with a PSA of 14 age 50. Biopsy revealed no cancer but was followed with a TURP. Both of my parents lived to age 92. I feel I made the right choice to push back against nature and extend my vitality.

    • @schmingusss
      @schmingusss 3 месяца назад

      How big was your prostate at age 50?

    • @healthdoc
      @healthdoc 3 месяца назад +1

      @@schmingusssLarge enough that alpha blockers didn’t relieve the urinary constriction and often required self catheterization.

  • @TumbleSensei
    @TumbleSensei 3 месяца назад +11

    If the prostate is enlarging it is under the influence of a growth factor which would be estrogen which would be aromatizing from the testosterone. Not testosterone itself causing the enlargement. Keeping Prolactin and estrogen down is the main thing

  • @skinfiddler
    @skinfiddler 3 месяца назад

    I'm a 72 yo who underwent Brachytherapy for prostate cancer. I was previously on testosterone for two years and felt so much better! At my first PSA check in June my PSA was 0.23 . I was told that after another low PSA test, I'll be able to return to TRT.

  • @lindablankenship3856
    @lindablankenship3856 3 месяца назад

    Great info and really appreciate the mini-Drive format. Please do more of these shorter episodes

  • @StayCoolKeto
    @StayCoolKeto 3 месяца назад +3

    *Would you recommand HCG for an elderly male, with low T and enlarged prostate to see what they feel like before considering TRT?*

  • @steinshaw2490
    @steinshaw2490 3 месяца назад

    Thanks! I think one question I wondered after hearing was answered here, that is, that once the T is above 200 or something that the growth of prostate cancer would not further accelerate as my T went up. Very good discussion. Unfortunately my Gleeson was 4+3 and 3+4 so I did not get to watchful wait. Because my cancer had spread I was not a surgery candidate. After a second series of radiation in 2022 and about a year and a half of ADT (triple play Lupron, Zytiga, prednisone) I stopped about 6 months early (sept 2023) and now I seem to have plateaued at 0.33PSA. I thought it would go higher. Now if I could shake this long covid or PVFS or PEM or whatever the heck is sucking my energy I can get on with life. Keep up the good interviews.

  • @professionalsalonsolutions8608
    @professionalsalonsolutions8608 3 месяца назад

    1 of your best ever. Perfect question and answer and details that has ever been done!

  • @JimmyStatic
    @JimmyStatic 3 месяца назад +3

    I’d love to see a discussion of hCG monotherapy.

    • @AdRock
      @AdRock 3 месяца назад

      Then watch their last one

  • @EtienneLeBoeuf
    @EtienneLeBoeuf 3 месяца назад +4

    I went from 334 to 960 in around 3 months all natural no TRT. This book should be essential reading for all men. Written by a 50s guy with natural T levels higher than most 20s guys
    Complete guide to testosterone by james Francis

    • @DrAvrahamRosenzweig
      @DrAvrahamRosenzweig 3 месяца назад

      Dont promote a foookin book, tell us what to do if you already read it

    • @EtienneLeBoeuf
      @EtienneLeBoeuf 3 месяца назад

      @@DrAvrahamRosenzweig It would take a 460 odd page book to explain it all. 🤣 Basically stop looking for miricle supplements and treat your entire body. Optimise body. Optimise T.

    • @Mansell5Senna8
      @Mansell5Senna8 3 месяца назад

      Eating a high fat diet for example raises T, people have reported 400 to 900, however your SHBG also goes up so your free T doesn't really increase and you dont get those benefits.

    • @stevesettlemier5916
      @stevesettlemier5916 3 месяца назад +1

      Holy Crap! I’ve already a HEADACHE trying to understand this!!!

    • @EtienneLeBoeuf
      @EtienneLeBoeuf 3 месяца назад

      @@Mansell5Senna8 I eat a complete diet. Including all macros and micros avoiding deficiencies.

  • @AdRock
    @AdRock 3 месяца назад +1

    What is your ideal administration method of TRT? Natesto?

  • @jaynecaldwell5286
    @jaynecaldwell5286 3 месяца назад

    Thank you for your work. So much help and knowledge and keeping things on point as much as we are able. I work with patients who are pre-diabetic but come with other ailments and, although, we don't go to medical, I keep a lot in mind for any helps possible for them.

  • @parnellmarketing
    @parnellmarketing 12 дней назад

    I took testosterone injections for 4 years. I got prostate cancer. I had a robotic prostatectomy. Dr’s say the cancer was contained. Should I get back on Testosterone now? My energy sucks!

  • @professionalsalonsolutions8608
    @professionalsalonsolutions8608 3 месяца назад

    So what can you take to prevent your testosterone from turning into dht which would prevent the growth of the prostate?

  • @catkins1307
    @catkins1307 2 месяца назад

    Doctors need to emphasize that a small caloric deficit, regular exercise and resistance training can significantly mitigate the side effects of prolonged ADT...I had 24 months ADT with radiation without significant side effects, due to exercise...

  • @-TroyStory-
    @-TroyStory- 3 месяца назад

    Thanks for disseminating research-backed science and separating fact from fiction. This was extremely helpful.

  • @brianwest3850
    @brianwest3850 3 месяца назад +2

    Does finasteride prevent prostate cancer?

    • @MichaelMerritt
      @MichaelMerritt 3 месяца назад

      He’s spoke about this before and I recall the answer is being the studies showed it delays getting prostate cancer on average but the types of cancers are more aggressive / higher grade tumors when you do get them.

  • @thejeffbosley
    @thejeffbosley 3 месяца назад +1

    27:11 me. Low psa forever, on trt for years, sudden spike in psa…biopsy, bam. Gleason 8. 😱

  • @andrewrivera4029
    @andrewrivera4029 3 месяца назад +6

    My PSA was slowly rising through my 40’s topping out at 6.35 at 52 years young, saw 2 different urologists both of them screamed at me there was no way to lower my PSA and that I needed a biopsy! I started low carb, fasting and time restricted eating FF 2 years I halved my PSA to 3.0! I asked my GP why my PSA went down, she ran out of the exam room! These urologists are millionaire butchers! Now at 58 years young my PSA is 3.8 and my testosterone is 711 doing OMAD carnivore to drive down glucose and insulin which drive cancer.

    • @TheGlobalTravelr
      @TheGlobalTravelr Месяц назад +1

      Thanks for posting. I’m going through a similar situation. Thankfully my wellness Dr directed towards Prolone fasting n CellCore blood adjustment. Now on the hunt for a wellness urologist vs the butchers.

  • @StayCoolKeto
    @StayCoolKeto 3 месяца назад +2

    *Wow. Never been this early before! lets go* 💪👍

  • @salbers
    @salbers 3 месяца назад +1

    Richard Ablin the discoverer of prostate specific antigen and the inventor of the PSA test says that: "The PSA test is therefore not an appropriate tool for early diagnosis of prostate cancer."
    Ablin, Richard J.; Piana, Ronald. The Great Prostate Hoax (p. 9). St. Martin's Publishing Group
    So why are you using it? Do you disagree with him? If so, what is your basis for affording any credibility to the PSA test?

    • @WillBurton3000
      @WillBurton3000 3 месяца назад

      good question. I'm 53, and my dr said i don't need to do a psa test because they're not very accurate and to watch for the typical symptoms. A more accurate test would be great to have.

    • @AdRock
      @AdRock 3 месяца назад

      Watch their prior episode

    • @LeonidasR
      @LeonidasR 3 месяца назад

      PSA is a possible indicator that is all.

  • @jonhumphrey5938
    @jonhumphrey5938 3 месяца назад

    Wow, the number of unexplained acronyms had me switching off at five and a half minutes; real shame as this stuff could be important 🤷