Infants are contraindicated in primaquine because they have an immature enzyme system, particularly involving **glucose-6-phosphate dehydrogenase (G6PD)**. Without proper screening for G6PD deficiency, primaquine can cause **severe hemolytic anemia** and **methemoglobinemia**, (conditions where red blood cells are destroyed or fail to carry oxygen efficiently,) leading to serious complications. Infants are especially vulnerable to these risks.
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Infants are contraindicated in primaquine because they have an immature enzyme system, particularly involving **glucose-6-phosphate dehydrogenase (G6PD)**. Without proper screening for G6PD deficiency, primaquine can cause **severe hemolytic anemia** and **methemoglobinemia**, (conditions where red blood cells are destroyed or fail to carry oxygen efficiently,) leading to serious complications. Infants are especially vulnerable to these risks.