Maximizing Yield and Purity in RNA-LNP Downstream Processing
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- Опубликовано: 6 авг 2023
- Downstream processing of RNA-LNPs can often be a bottleneck during scale-up to clinical production. Maximizing yield and purity is a key concern along with controlling critical process parameters. This panel discussion will examine tangential flow filtration (TFF), an essential step in post-formulation purification of RNA-LNPs, including:
- The essential steps for designing and optimizing downstream processing of RNA-LNPs
- Challenges with scaling TFF processes and controlling key parameters such as filtration cartridge, membrane material and transmembrane pressure
- Strategies to achieve high flux and throughput while maintaining critical quality attributes including size, morphology and yield