Sir please i am expecting reply from you . Sir i had my HPLC test. The result was beta thal trait. To confirm the same i am having test for my sibling as well. Sir it is a fact that if the person has megaloblastic anemia the hba2 levels are elevated & incase of G6PD deficiency also the HBA2 levels are reduced. And right now my sibling is on a mandatory medicine which needs to be taken daily that can cause trigger G6PD deficiency. Doctor suggested not to stop medicine at any cost. Now if sibling undergoes HPLC test how can interpret that resulted HBA2 value is true . Does HBA value give any clue if the person is using medicine that can cause G6PD deficiency & has megaloblastic anemia . Kindly shed some light sir its my humble request please..
In context of your question lets say if it is megaloblastic anemia then the blood smear examination under microscopy and staining techniques will pick it up and then based on further testing for causes of megaloblastic anemia one can reach to root cause. In case of beta thalasemia trait you cannot do anything in terms of treatment because they are always on lower side of HB and they dont respond to oral iron treatment so not recommended. If your sibling has tested positive for G6PD def then all they have to is to avoid oxidative stress, certain foods and medications, and in case you think the 2 conditions have influenced your HBA2 levels then correct the coexisting problems first then recheck HBA2 levels again. That should remove any doubts
Is it possible that barters or gitelmans presents in a older age such as 50+? I have seen a case whic I am in great doubt about and am investigating. She presented with hypokalemia and hyponatremia, and her electrolytes were never stabilized despite effort of 12 days while coma induced.
It is possible but would be very rare specially with bartter syndrome, where rarely a phenotypic variation of type II barter syndrome can present in geriatric age group with hypokalemia, alkalosis and renal,stones
Sir please i am expecting reply from you . Sir i had my HPLC test. The result was beta thal trait. To confirm the same i am having test for my sibling as well. Sir it is a fact that if the person has megaloblastic anemia the hba2 levels are elevated & incase of G6PD deficiency also the HBA2 levels are reduced. And right now my sibling is on a mandatory medicine which needs to be taken daily that can cause trigger G6PD deficiency. Doctor suggested not to stop medicine at any cost. Now if sibling undergoes HPLC test how can interpret that resulted HBA2 value is true . Does HBA value give any clue if the person is using medicine that can cause G6PD deficiency & has megaloblastic anemia . Kindly shed some light sir its my humble request please..
In context of your question lets say if it is megaloblastic anemia then the blood smear examination under microscopy and staining techniques will pick it up and then based on further testing for causes of megaloblastic anemia one can reach to root cause. In case of beta thalasemia trait you cannot do anything in terms of treatment because they are always on lower side of HB and they dont respond to oral iron treatment so not recommended. If your sibling has tested positive for G6PD def then all they have to is to avoid oxidative stress, certain foods and medications, and in case you think the 2 conditions have influenced your HBA2 levels then correct the coexisting problems first then recheck HBA2 levels again. That should remove any doubts
Is it possible that barters or gitelmans presents in a older age such as 50+?
I have seen a case whic I am in great doubt about and am investigating. She presented with hypokalemia and hyponatremia, and her electrolytes were never stabilized despite effort of 12 days while coma induced.
It is possible but would be very rare specially with bartter syndrome, where rarely a phenotypic variation of type II barter syndrome can present in geriatric age group with hypokalemia, alkalosis and renal,stones