Thankyou so much for your continued content support, I really hope your videos begin to pick up the recognition they so badly deserve. It is so strange how your video uploads almost fit my lecturers exact model of the course.I'll often have a lecture and come back to find that you have uploaded a video covering that days topics! Thankyou for doing what you do, for doing it so well and for doing it consistently!
Your explanations are so classy that I can't avoid it.. Am from India 🇮🇳 sir.. Thanks for explaining in free of cost and for showing great concern for students like us..
Will the diol favoure the keton the most in generel. Like if you want reduce a ketone in substance but you also have aldehyd you dont want to be reduced. How will procced to this ?
I love how poetic chemistry seems at times. “Leaving Groups”, “Protecting Groups”, even “Waters of Hydration”. Also I’ve never heard the word labile before. What does it mean in this context Davedawg?
i don't understand in the first reaction we have a primary alkyl attached to bromine it wasn't suppose that we typically do sn1 despite of the nucleophile ??? please answer my question professor
@@ProfessorDaveExplains you said that Ch3O- (methoxide) is a SN2 promoter ,,my question was : it wasn't suppose that when we see a primary alkyl as it's the case in our example we would have a competition between Sn1 and E1
I did not say that. Methoxide can do lots of things. But given that methoxide is a strong base, it is unlikely to do either SN1 or E1, it does not require a carbocation intermediate to react. I think you need to go back to my videos on the basic mechanisms and brush up a bit.
isn't carbon on second carbonyl (ester) more electrophilic than the first (Ketone) since second carbonyl Carbon has 2 oxygen (Comparing to only one on the first) withdrawing the electron density from carbon. And why would highly electronegative element like oxygen donate its electron density instead of pulling the electron cloud from carbon? This question is concerning why the protecting group prefers ketone over esters!
Why is the ester carbon less electrophilic? Wouldn't it be more because there are two more electronegative oxygens pulling electron density away from it as opposed to 1?
I have a question: can I use chemoselectivity to protect an aldehyde group in presence of a ketone group in the same structure? (Or the other way around)
@@Chemicalture1 Ah I see, and I'm glad you passed! Btw replying to old comments has led to some awesome conversations since I've started doing it, and I encourage others to do so as well. 😃
I'm so upset... at myself for not finding these videos until now. I'm literally taking my last ochem final next week. This would have been an amazing supplement for the day before classes. Anyways thanks for making these videos professor Dave. I'll certainly be going back here a few times in the future.
![ARGENTINA vs. BOLIVIA [6-0] | RESUMEN | ELIMINATORIAS SUDAMERICANAS | FECHA 10](http://i.ytimg.com/vi/C3wPtKNbAOA/mqdefault.jpg)
I just took my Organic Chemistry final 2 days ago... You're videos are always so helpful!
How'd the final go?
Thankyou so much for your continued content support, I really hope your videos begin to pick up the recognition they so badly deserve. It is so strange how your video uploads almost fit my lecturers exact model of the course.I'll often have a lecture and come back to find that you have uploaded a video covering that days topics! Thankyou for doing what you do, for doing it so well and for doing it consistently!
+RedabowAndBusmalis my pleasure! spread the word!
Protecting the alcohol. Always a noble and worthy endeavour. :P
Exceptional as usual. I'm always sure to send these videos to my professors so that other classmates can see them!
Such an awesome channel dude, you make it all so simple to digest! And i'm so impressed you do it all in one take! Wish I had this in first year!!
Very nice explanation...
Your explanations are so classy that I can't avoid it.. Am from India 🇮🇳 sir.. Thanks for explaining in free of cost and for showing great concern for students like us..
Great video. Absolutely amazing
Finally I got this concept which I once thought i'll never understand...
wow thank you.
Thank you dear professor
Finally I finish my Orgo study I understand more and more now. I feel so happy thank you a lot😁😁😊🙌🙌
I am assuming you took the ochem classes. If so, how did they go?
@@PunmasterSTP very appreciated and highly recommended
@@meriembouziani1 I am glad to hear that!
@@PunmasterSTP good luck for you
@@meriembouziani1 Thank you! I took ochem a while ago, but I tutor people in it sometimes, so I find myself on here to help stay sharp. 😄
You need for subs, I always watch your videos. You're a legend, all the way from Australia
perfect.
Thank you sir
Will the diol favoure the keton the most in generel. Like if you want reduce a ketone in substance but you also have aldehyd you dont want to be reduced. How will procced to this ?
Thanks sir
I am going to advertise this channel in my society AF!!
i can always use a little promo! thanks kindly!
Stupid question but can sodium bisulfite protect ketone?
Sir, can vicinal glycol be used when we want to protect an aldehyde while reducing a C-C double bond?? or should we use another protecting group?
hmm, reducing a C-C double bond where and how?
Can you make a protecting group practice problem video?
susceptible to nucleophilic attack sounds like a pokemon move
I love how poetic chemistry seems at times. “Leaving Groups”, “Protecting Groups”, even “Waters of Hydration”. Also I’ve never heard the word labile before. What does it mean in this context Davedawg?
Unstable
You are amazing,helpful too
You videos clear my concept. I m just in grade 12 but I can understand B.sc level.
Thank you for your videos
Great video! Is HCl a byproduct when TBDMS replaces the acidic proton? If so, why does the methoxide not preferentially react with the HCl?
i don't understand in the first reaction we have a primary alkyl attached to bromine it wasn't suppose that we typically do sn1 despite of the nucleophile ??? please answer my question professor
i don't understand the question
@@ProfessorDaveExplains you said that Ch3O- (methoxide) is a SN2 promoter ,,my question was : it wasn't suppose that when we see a primary alkyl as it's the case in our example we would have a competition between Sn1 and E1
I did not say that. Methoxide can do lots of things. But given that methoxide is a strong base, it is unlikely to do either SN1 or E1, it does not require a carbocation intermediate to react. I think you need to go back to my videos on the basic mechanisms and brush up a bit.
@@ProfessorDaveExplains = thanks professor dave so it's like hydroxyl OH- ,now i remember so always strong bases are Sn2 and E2 promoters
the best channel , congratulate me because i find your video,thank you!!!!
Thanks to your priority
isn't carbon on second carbonyl (ester) more electrophilic than the first (Ketone) since second carbonyl Carbon has 2 oxygen (Comparing to only one on the first) withdrawing the electron density from carbon. And why would highly electronegative element like oxygen donate its electron density instead of pulling the electron cloud from carbon? This question is concerning why the protecting group prefers ketone over esters!
don't forget resonance, the sp3 oxygen on the ester puts a lone pair onto the carbon. that's why esters are less electrophilic than ketones.
Thank you!
is this the same principle for tosylate and mesylate ions?
Why is the ester carbon less electrophilic? Wouldn't it be more because there are two more electronegative oxygens pulling electron density away from it as opposed to 1?
Ah but one oxygen has a lone pair to donate by resonance! That gives the carbon way more electron density.
thank you god bless
Can you do chemoselectivity please?
ooh good one! i'll add it to the list.
I have a question: can I use chemoselectivity to protect an aldehyde group in presence of a ketone group in the same structure? (Or the other way around)
ooh good one! hmm, there could be but if there is i'm not aware of it!
@@ProfessorDaveExplains then I'm doomed x_x
@@Chemicalture1 I'm just curious; why would you be doomed? Are you trying to carry out such a reaction as part of some research?
@@PunmasterSTP it was for an exam I had to do about 3 years ago. To pass it I didn't need that knowledge in the end. 😂
@@Chemicalture1 Ah I see, and I'm glad you passed! Btw replying to old comments has led to some awesome conversations since I've started doing it, and I encourage others to do so as well. 😃
4:35 aldehydes and ketones
Super sir
wonderful
Sir u follow clayden...
Thanks for protecting us...from ignorance!
sir can you explain protection and deprotection of amino and carboxyl group
i'll add that to the list!
where is the acetal video??
ruclips.net/video/G239CdaEMXo/видео.html
Thanks
How does the TBS group form?
oxygen attacks silicon!
Great! Thank you!
hi jon snow
lol
i have no idea what is going on
Did you watch the videos earlier in the playlist?
ruclips.net/p/PLybg94GvOJ9GtvOUYLW601u1Oiaoat2UF
Can explain nmr
i have tutorials on that
I'm so upset...
at myself for not finding these videos until now. I'm literally taking my last ochem final next week. This would have been an amazing supplement for the day before classes. Anyways thanks for making these videos professor Dave. I'll certainly be going back here a few times in the future.
How'd the final go?
awosme