Drug Reduces the Need for Surgery in Nearly 90% of Patients with HCM, Cleveland Clinic Study Shows

To read more about the VALOR-HCM study, please visit cle.clinic/3ti...
Findings from a Cleveland Clinic-led clinical trial, the VALOR-HCM study, showed that the use of mavacamten in severely symptomatic, hypertrophic cardiomyopathy patients significantly reduced the need for invasive procedures.
To learn more about Dr. Milind Desai, please visit cle.clinic/2Xv...
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[@philiptata3607]

What an amazing designer drug. To be able to target, the cardiac sarcomere without significant effects on skeletal muscles. Seems extraordinary to the layperson. I am on the waiting list in the UK for this drug as it recently got NICE approval. While I am trying to temper my expectations, the results from the different trials are pretty remarkable. It is frustrating being in limbo but hopefully things will move forward soon. Thanks again.

[@MrGreen_]

Hi have you heard anymore about drug been licenced in the UK
I live in ireland was told about drug over a year ago still nothing yet here
My daughter and me have suffer with hyper trophic..
Just curious if you started medication yet regards

[@philiptata3607]

@@MrGreen_ hello there. Yes, the drug was officially licensed by NICE and the MHRA last year(2023). However, it is only just being prescribed in the last few weeks and at a remarkably slow pace. This is partly because of the rigourous protocol and criteria that need to be met for patients to receive this medication. At this rate of progress, it will take a long time indeed for patients who need this medication to receive it. There is some additional positive news, however. In particular, a related cardiac myosin inhibitor (Aficamten) has had very good results and is likely to be approved in the USA by the end of the year and hopefully Europe next year. This medication appears to have fewer drug interactions and less risk of inducing heart failure in a small proportion of patients. It is frustrating to be waiting for these drugs if you need them, as the surgical options really require you to have access to a specialist heart surgery centre.

[@timf2279]

I hope this medication is a winner

[@deandrafernandes6536]

Im in India and my mother has HCM . There's no cures here expect open heart surgery and we do not want to go through with that. What can we do so that she doesn't have to go through surgery and still be cured. This drug is not available here and no doctor suggests a good medicine.