Oral Tranexamic acid for pigmentation
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- Опубликовано: 4 авг 2024
- Facial pigmentation can occur due to various skin conditions. It can be distressing for patients and frustrating for the treating medical professionals. Oral tranexamic acid has been used "off label" to treat pigmentary dermatoses that affect the skin. This video looks at the conditions that could benefit, the dosage used and potential side effects.
Oral tranexamic acid in the treatment of hyperpigmentation disorder beyond melasma: A review. DOI: 10.1111/jocd.15561
Combination treatment of low-fluence Q-switched Nd:YAG laser and oral tranexamic acid for post- inflammatory hyperpigmentation due to allergic contact dermatitis to henna hair dye. Young Bok Lee, Sae Mi Park, Jin-Wou Kim & Dong Soo Yu. DOI: 10.3109/14764172.2015.1114634
Lichen Planus Pigmentosus in North Africa: A Series of 17 Cases
Hakima Benchikhi, MD. doi: 10.17140/DRMTOJ-4-135
A pilot study for triple combination therapy with a low-fluence 1064 nm Q-switched Nd:YAG laser, hydroquinone cream and oral tranexamic acid for recalcitrant Riehl’s Melanosis. Hyuck Hoon Kwon, Jungyoon Ohn, Dae Hun Suh, Hae Young Park, Sun Chul Choi, Jae Yoon Jung, In Ho Kwon & Gyeong-Hun Park. DOI: 10.1080/09546634.2016.1187706.
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I’m glad I found your page. I have post inflammatory pigmentation. I had pityrious rosacea. I have now dark spots everywhere on my body. My skin was so beautiful before that my self esteem has declined tremendously. The determalogist apparently was not use to treating African American skin she had me soak in bleach. It made me sick.
It can be difficult to treat post inflammatory pigmentation. Moisturising is important as it gradually helps reduce the pigmentation.
ruclips.net/video/1DWqdA_yFMo/видео.html
The use of tinted sunscreens is important to prevent the disparity in pigmentation. Here is a video on it
ruclips.net/video/u3cPL4T1g3c/видео.html
#Disclaimer# Please note that this video is for education purposes. It is not meant for personal advice as your own doctor/dermatologist will be the best person to answer specific queries.
Amazing explanation doc!
Thank you, glad it was helpful!
Very useful, thank you!
Welcome, glad it was helpful!
A unique therapeutic option, thanks!
Its is indeed! Thanks for your comment.
Hey doctor! I absolutely love the valuable information you provide through your videos. I have been struggling lately with my skin. I'm Indian, brown skinned, no medical issues, insulin is alright and no genetical abnormalities. I got bad tan on my neck, and my torso is relatively few shades darker than rest of ny my body, my armpits are also heck darker. Can i go with tranexemic acid 500 mg? Recently I injured my skin as well from exfoliants. Really need your advice doc
There are numerous treatments for reducing pigmentation of the skin of which tranexamic acid is one. If pigmentation is prominent in the flexures, another possible differential diagnosis is acanthosis nigricans for which met firming may be helpful. It may be useful to see a local dermatologist to get the diagnosis confirmed first. Here is a video on metformin for acanthosis nigricans.
ruclips.net/video/__Sy0RXZTK8/видео.html
Very good explanation on oral tranexamic acid for pigmentary disorders Thanking 🙏 you Sir
Welcome Rajagopal, glad it was helpful! Here is another video looking at how hair dyes cause facial pigmentation
ruclips.net/video/8MxBjmE8zR8/видео.html
Very good Information Sir 👍 Thank you for sharing🙏
You are welcome! Glad it was helpful for you!
Hi Doctor, I thank God that I landed on this video. Very nice Information and Thanks a lot for sharing. I am in India and 55 years old. I was hopeless due to my skin condition. I used Diprovate MF for a long period. As the medicine is no longer available , I have a serious skin problem. I can see similar skin conditions in the video. I tried homeopathy,ayurveda but no use. Should I take Oral Tranexamic acid?
Thank you for your kind words. The first step before any treatment is to get the diagnosis correct. For this, you will need to see a dermatologist. If they feel you have a condition that may benefit from oral tranexamic acid for pigmentation, then it is worthwhile starting. Also to prevent the existing skin from darkening it is worthwhile using a tinted sun screen. Here is a video on it
ruclips.net/video/u3cPL4T1g3c/видео.html
There are other creams that can help lighten dark areas in the facial skin too. Here is a video on it
ruclips.net/video/nCAI4PE073k/видео.html
Hello Doc, I am a 47 years old male with no health issues. I just have a small melasma patch on my left cheek. Can I take Tranexamic Acid 250 mg pills twice a day for 3 months to see if they will work. I have tried tooical alpha arbutin and Tranexamic acid lotions but no luck so far. Thanks in advance. Your channel is rocking!!!
Thank you for your kind words. Firstly, the diagnosis of melasma needs to be confirmed by a dermatologist. There are other causes for pigmentation on the face. These include maturational hyperpigmentation and also secondary top hair dyes. Here are videos on each of these conditions.
ruclips.net/video/eXsHakj2isg/видео.html
ruclips.net/video/8MxBjmE8zR8/видео.html
If melasma has been confirmed, then tranexamic acid is a useful medication. It is also important to use tinted sun screen to prevent worsening of the pigmentation. Here is a video on it.
ruclips.net/video/u3cPL4T1g3c/видео.html
Thanks doc! Greatly appreciate your prompt response.
Doctor, I am female, living in the UK. I saw a dermatologist a few days ago and was prescribed oral minoxidil (half of a 2.5 mg pill a day) for androgenetic alopecia. I asked about Finasteride as well, but was told that they will prescribe it only if Minoxidil doesn't work). Do you think it's right? I am tempted to use an online pharmacy and ask them to prescribe Finasteride as well as I doubt that Minoxidil will work on its own, since it doesn't reduce DHT.
P.S. I am 44 and started to lose my hair about 1.5 year ago. I haven't thought anything about it at first as my hair was very thick, but my hair loss has been progressing...
We generally try and use oral Minoxidil on its own as it is fairly effective. Most dermatologists would feel uncomfortable prescribing finasteride in women, so I can understand why your doctor is hesitant to do so. One option to control the hormonal component may be to use spironolactone. We use it quite a bit for acne I women and it can be used in combination with minoxidil for hair loss too. Here is a video on spironolactone for acne, but the principles, side effects and dosage of the medication is discussed.
ruclips.net/video/04D24LKdp5U/видео.html
@@skylark386
How to use ? Can you please explain
Hii Doctor,
Can Tranexamic Acid 500mg and roaccutane 60mg bd, be used to treat lichen planus pigmentosus?
My dermatologist prescribed that for over 3 months.
Yes, it is a combination that can be helpful for LPP and dermatologists in Asia use it often. The most important step is to use tinted sunscreens that will help prevent worsening of the pigmentation. Here is a video on it
ruclips.net/video/u3cPL4T1g3c/видео.html
@@DiscoverDermatology Thank you so much Doctor. You are very help. I'll follow your advice.
I have stopped using sunscreens as it was worsening the pigmentation. I'll try as you suggested. 🙏🏽🙏🏽
I developed severe hyperpigmentation after a chemicall burn, all over my face, its been 2 years the pigmentation slightly lightened but for the most part it is visible, can i use trenaxemic acid and see changes?
Tranexamic acid has been used mainly for melasma and other conditions mentioned in the video. It’s probably worth trying in other conditions like mentioned in your question. Tinted sunscreens are also very important to prevent further worsening of the pigmentation. Here is a video on it.
m.ruclips.net/video/u3cPL4T1g3c/видео.html
Here is another video on other treatments for facial pigmentation
m.ruclips.net/video/nCAI4PE073k/видео.html
Hello Doc! I was told that it is not safe if we have clotting disorder. How do we know if we have a clotting disorder? Is there a test for that?
Tranexamic acid has been used to treat some clotting disorders but may need to be avoided in others. There is no specific test for it, but an assessment by a haematologist could be considered if there is a pre existing clotting condition.
Hi sir. I'm suffering from Keratosis pilaris and bcoz of it ,I'm suffering from body pigmentation as well. I'm already taking Isotreitoine from past 2 months. Can I take oral tranexamic acid for kp hyper pigmentation??? Please reply
Tranexamic acid has been used mainly for facial pigmentation, so it's hard to know if it will help post KP pigmentation. Tinted sun screens are probably important to prevent further darkening of the skin. Here is a video on it
ruclips.net/video/u3cPL4T1g3c/видео.html
Hello Doc! I am taking Antoxid HC (30 mg beta carotine) daily and it seems to work on giving me eventone and glowing skin. I am a non smoker with no health issues. I was wondering if it is safe for long term use. Please, advise.
I do not prescribe beta carotene often so not sure of its long term side effects. It has been used in photosensitivity disorders for many years, so it is possibly safe as I am unaware of any significant toxicity with it. Lifestyle measures may be the best way to have healthy skin. Here are a couple of video on how diet and other factors help our skin remain younger
ruclips.net/video/cqvmt6bYWFI/видео.html
ruclips.net/video/CB2D3NUTzDI/видео.html
Thank-you so much!
Hello Doctor, Can I have a virtual appointment. I am suffering from pigmentation from 1.5 yr.
Instead of going to other dermatologist and talk about the content in this video ask for solution, I wish to get the treatment from the person who can look in to my problem and give me a permanent solution.
Hi doctor. My question is can a person who had spontaneous miscarriage take oral TXA to treat melasma ?
For anyone trying to conceive, the best option may be to use topical (cream) treatment. This includes both prevention )with tinted sunscreens) and also lightening agents. here are two videos that explain this.
ruclips.net/video/u3cPL4T1g3c/видео.html
ruclips.net/video/nCAI4PE073k/видео.html
Hi,
I have read up reviews stating that tranexamic acid does help with pigmentation however it causes severe hair loss. And also leads to greying of hair as it hinders melanin production. Is that true?
Any drug can cause any side effect, but I am not aware that it is a prominent well recognised side effect of tranexamic acid. It may occur but is possibly rare.
@@DiscoverDermatology Alright thanks! Yes it is quite a common side effect according to my research. But just wanted to get a medical insight regarding the thought that if something hinders melanin production is it likely to cause greying of hair as well? And if thats true the greying could also be caused by oral glutathione?
Also please let me know which one is more effective oral glutathione or tranexamic for melasma?
@@SK-tt9ix Its o a side effect I have seen in my practice. Oral tranexamic acid is superior to oral glutathione.
@@DiscoverDermatology Alright, Thank you!
would this help with idiopathic acanthosis nigricans in a non diabetic?
Its usefulness is more for pigmentation rather than epidermal changes that occur in acanthosis nigricans. Metformin may be a better option in acanthosis nigricans even in non diabetics. Here is a video on it
ruclips.net/video/__Sy0RXZTK8/видео.html
Thank you for your valuable information, dear colleague. Great video. I have sent you a private message to ask for some clarifications regarding you protocole management of melasma. Thank you
Hi, I did not get any private message about the management of melasma? I am happy to answer them here is required.
Hi Doc, I live in Canada and we can only get Tranexamic Acid tablets in 500 mg pills and they are film coated. Can I split the tablets or should I get sustained release 250 mg tablets from India? Please advise.
Yes, it will be fine to split the tablets. Ideally the 250mg tablets form India may be the best long term plan.
Thank-you so much! You’re amazing!!!
You are most welcome! @@sumitralen3329
Hi Doc, if I may,
with reference to a comment here, I would like to ask which of these combinations would be the most effective to treat LPP for an Indian:
1. Tranexamic Acid 500mg + Roaccutane 60mg
2. Tranexamic Acid 500mg + Glutathione L 500mg
3. Tranexamic Acid 500mg + Roaccutane 60mg + Glutathione L 500mg
The 2nd one was suggested by the dermatologist first. Later when I quoted this comment, he said I could add Roaccutane to the other 2 drugs.
Kindly advise doctor. Thank you.
Hi, I do not treat many patients with dark skin as I work in the UK. From all the lectures I have attended and the personal expetricne in having treated a few patients, a combination of drugs may work better. The dose of Isotretinoin (Roaccutane) used is much lower though, about 10 to 30mg. I do not use high dose isotretinoin as it is likely to cause more side effects. Most dermatologists who are considered experts in treating LPP in dark skin suggest tranexaminc acid with isotretinoin. Glutathione is an optional extra
@@DiscoverDermatology Thanks a lot Dr for that clarification. I really appreciate it.
I have lupus nephritis ,can i take it?? For how long do i have to take it and will the tablet fade the pigment for permanently???
If the rail function is normal, most drugs are safe to use. Tranexamic acid has been used for at least 3 months in most studies and may have to be continued for longer in some.
What are the side effects of tranexsmic acid
Hello doctor, i have mild pcos and irregular periods problem can i take tranexamic acid tablet for my skin barrier issue? If yes then how? And Can i take that with vitamin c tablet? Plz reply 🙏🙏
Oral tranexamic acid is usually used for pigmentary problems. For skin barrier issues, a good moisturiser is required. This video looks at how to treat sensitive facial skin. Though it mentions rosacea, the principles are similar for anyone with sensitive facial skin.
ruclips.net/video/4aFSAKprFj0/видео.html
How to time in use
Thank you sir for wonderful explanation.
Sir I had cyst couple of years ago and right now I am thinking of taking oral medication for my hyperpigmentation. The hyperpigmentation is all over my body and severe around folds. Please do suggest what can I take without much side effect, if not tranexamic acid due to the history of cyst.
The most important step is to identify the cause of the increased pigmentation. You will need to see a dermatologist for that. A common cause of hyperpigmentation in the flexures is acanthosis nigricans and that requires another medication called metformin. Here is a video on it.
ruclips.net/video/__Sy0RXZTK8/видео.html
Once your doctor has made a diagnosis the treatment can be more streamlined
Hello doctor my face is clear but my forehead is darker since 2 year ! sometimes my forehead look some clear but they look darker again can you suggest me tha. Best solution for this
Using tinted sun screens may be the nest way to prevent the skin darkening in the first instance. Here is a video on it
ruclips.net/video/u3cPL4T1g3c/видео.html
Can we stop hydroquinone after 6 months ?? If we stop it then can melasma or pigmentation reverse ??
it depends on the underlying condition. If it is post inflammatory pigmentation, the condition may not recur. Other inflammatory conditions like lichen planus and melasma may come back . One treatment that may prevent pigmentation or at leats prevent it getting worse is the use of tinted sun screens. Here is a video on it
ruclips.net/video/u3cPL4T1g3c/видео.html
Hello Dr. Any specific name of tranexamic acid tablet for best results
We tend to use generic names in the Uk so I. am not aware of any spefici brands Im afraid.
Hello doctor
I'm 26 years old and i have pigmentation due to hormonal imbalance can i take tranexmic acid tablet plz plz reply
Tranexamic acid seems to be beneficial for pigmentation of various causes. It may be worthwhile consulting your own doctor before commencing it. Certainly a worthwhile treatment to consider.
Hello Doctor! I'm a 19 years old female who has been diagnosed with post inflammatory hyperpigmentation all around my lips in big patches. I've taken Zimax antibiotics for 3 months and used azelaic acid 20% for 2 months but still no improvement. Can I take oral tranexamic acid for this?
Tranexamic acid has been reported to be helpful in post inflammatory pigmentation, so may be beneficial in that setting. There are other topical agents that could be helpful too. Here is a video on the evidence based treatments that are effective for melasma and other causes of facial pigmentation.
ruclips.net/video/nCAI4PE073k/видео.html
Sir iam suffering from H S for past 25 years could you kindly refer a Doctor in Chennai,Hyderabad,Bangalore or any place in India sir
In Chennai, Dr V R Janaki, Dr Sarveshawari, and Dr Ananad Nott are very good. I do not know anyone in Bangalore or Hyderabad Im afraid
Doc, can we use 250 mg tranexamic acis twice a day for one month for overall eventoned face and glow?
There have been no studies on oral tranexamic acid to improve the evenness of skin tone. The pigmentary problems usually tend to settle only when oral tranexamic acid is used for many months. There are a couple of other options for skin pigmentation. First is glutathione and here is a video on it
ruclips.net/video/vkjtJW96P6w/видео.html
The other is to use tinted sunscreens to ensure that the existing colour on our face does not get darker. here is a video on it
ruclips.net/video/u3cPL4T1g3c/видео.html
Thanks so much Doc! You are the best!!!
@@DiscoverDermatology Dr can glutathione tablets and oral traxemic tablets taken together or not.
There is no interaction between the two, so they can be used together @@wajeehamalik4611
My malasma is 70% gone after taking TA 250 mg twice a day for 3 months. Should I continue for another 3 months or stop?
The treatment is usually continued for longer periods if it is not settled waiting the first three months. There are studies where it has been used longer than 6 months.
Did you take it for whole month? Or just during periods?
@@DiscoverDermatology1:02
Where did you buy it/what brand?
@@pineapple365 Its avaiilble in the UK. Not sure of the brand name.
Hi again Doc! I started taking 250 mg tranexamic acid tablets twice a day and it’s giving me stomach issues. Is it temporary?
Sometimes the tummy upset settles with time but if it does not, we may need to reduce the dose to one a day or one every other day.
Bonjour Docteur. J'ai 21 ans et je suis atteinte de melasma dermique sur les joues et sur la moustache. Depuis j'ai tenté de voir avec des dermatologues mais rien n'y fait, ils n'ont même pas pu me diagnostiquer ce problème qui me hante clairement la vie. Peut être parce qu'il manque ici énormément de dermatologues pour peaux noires...
Ma question est la suivante: pensez-vous que dans mon cas l'acide tranexamique oral puisse marcher? Si oui, pendant combien de temps cela pourra prendre le traitement?
Et dernière question, est-ce qu'il est possible qu'il ait des conséquences sur la fertilité et autre problème sur la santé?
Merci pour le savoir que vous nous partagez!✨️
Hello, good to hear from you! Tranexamic acid is an option for anyone with melasma irrespective of the colour of their skin. It needs to be used foe about 3 to 6 months. It should not be used during pregnancy. However, it has no effect on fertility long term. Would also suggest the use of tinted sun screens too prevent the pigmentation from worsening. Here is a video on it
ruclips.net/video/u3cPL4T1g3c/видео.html
@@DiscoverDermatology Merci infiniment Docteur!
@@aureekmb1130
Je vous en prie
What laser do you recommend for melasma?
I am not too sure about which laser is best as it varies according to the skin type. It may be best to see a local dermatologist about it.
Sir this medicine can i use for contact dermatitis. My doctor is doing continuously q switch laser weekly twice .is it safe to use q switch laser every week.thank you
If it is the post inflammatory stage of contact eczema it may be helpful. Certain lasers are beneficial, however the lasers could also cause pigmentation in those with dark skin, so it is a bit tricky. A test patch is usually done before treatment is used. I am not sure how frequently lasers need to be sued as I do not do laser treatment myself. @@winifredfernandes9611
@@DiscoverDermatology thank you so much Sir
My friend taking TA for heavy mense, her melasma faded and her skin lightened up!
Very interesting observation and helpful for others to reflect on!
does it comes back after finishing the treatment?
Hello Doc how about Tranexamic acid via iv injection
Im afraid I have not heard of it being use IV.
@@DiscoverDermatology thank you
@@DiscoverDermatology The brand is Traminex
Sir Can i take dis medicine when I'm trying for Baby ??
Ideally, no oral tablet is taken during pregnancy due to its potential actions on the baby. Using tinted sunscreens is a cream and is safe to use during pregnancy. This will prevent further darkening of the skin
ruclips.net/video/u3cPL4T1g3c/видео.html
@@DiscoverDermatology Thank you So much Sir
i am also suffering melasma. 2 days ago my doctor prescribe me tranexamic acid 250mg twise a day. any side effect for male?
The side effects are similar to females except, of course, the menstrual changes. Tummy upsets seem to be the most side effect.
#Disclaimer# Please note that this video is for education purposes. It is not meant for personal advice as your own doctor/dermatologist will be the best person to answer specific queries.
hows your condition now.?
Dr completing 3 months course for melasma if we stop medicine will melasma hit back .or how we will maintain this.
It is difficult to predict melasma. To prevent it recurring, it may be worthwhile using tinted sun screens so that the facial skin does not darken. Here is a video on it
ruclips.net/video/u3cPL4T1g3c/видео.html
There are other over the counter creams that can maintain the colour of the facial skin. The cream mentioned in the middle to end of this video may be helpful.
ruclips.net/video/nCAI4PE073k/видео.html
@DiscoverDermatology thxs a lot Dr..prayers for you from pakistan 🇵🇰
@DiscoverDermatology Dr during monthly cycle these oral trax tablet must be stopped for 3 or 4 days or should be continued pls guide ?
Thanks for your kind words!@@wajeehamalik4611
It can be continued throughout and does not need to be changed for the periods. The dose is different when it is used for continuous periods. For melasma it is used all the time. @@wajeehamalik4611