Risks Of ADT in Recurrent Prostate Cancer
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- Опубликовано: 12 дек 2021
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What are the risks of early ADT in men with biochemically recurrent prostate cancer? Dr. VanderWeele specializes in the treatment of genitourinary (GU) cancer from a medical oncology perspective. His research efforts have focused especially on altering the course of potentially lethal GU cancers using targeted therapies. Interviewed by Darryl Mitteldorf, LCSW from Malecare
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i AM 70, to negate the ADT : I go to HIIT, 6 times a week and personal training 2 ti,es a week. Prostate Cancer has made me a more physical fit person. What a paradox.
So it seems the initial biopsy knocks loose micro clusters of prostate cancer cells that are then missed by initial radiation or prostatectomy. These liberated cancer cells appear years later (known as bio-chemical recurrence) and doctors then play "wack-a-mole" with hormone therapy, more radiation and/or chemo trying to chase them down. Meanwhile the patient suffers with all the side effects that in some cases are worse than the disease. I wonder if shaking rattles, chanting incantations and sprinkling the patient with fairy dust would become the standard of care if the medical industrial complex could figure out how to monetize it.
I'm very against the idea of the initial biopsy as the requirement to initiate treatment!
There are some countries in the world that have already bipassed that initial biopsy.
How can we get this going here?
No if you would talk some sense people might pay attention to you. You offer nothing to this discussion.
ADT just attempts to weaken cancers, but does not remove it. Additionally, ADT often gives way to CRPC in a median of 14-20 months. Far better to strike cancer "at the throat"- A ketogenic diet with intermittent fasting can also weaken cancers, without toxifying the patient.
@@andreadamascceno2139because its all about money and making people sicker and sicker to become repeat cancer patients!! Pure evil!!
@@F8Tributo Im sorry but I am studying all of these abbreviations. What is CRPC. Is is cancer resistent prostate cancer?
Thanks for the interview.
It's good to understand all the possible treatments and how to understand your doctor's words!
Thank you for always providing good information and dialogue with practitioners
Great video... Thank you very much!!! Just wanted to say I found your video very helpful.
Thanks for sharing your appreciation
You ask very good questions, thank you. Is there an index of these presentations from your interviews?
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Very interesting intelligent discussion ! Thnx very much !
Thanks for sharing your appreciation
I am 66 years old and had an MRI of the prostate a couple days ago and a PSA of 5.5 and have had pain in the right testicle for 4 or 5 months. Won't hear the results of the MRI until this coming Friday. Hope I don't have cancer.
My PSA was 5.6 I was diagnosed with prostate cancer I had my prostate removed 8 weeks ago ... I'm sorry to say you most likely have prostate cancer good luck with whatever you do... by the way I'm 65
I was diagnosed Sept'23 with G7 and decided no INVASIVE Surgery so I was a RO who with my feeling about ADT he sent my slides to Artera-AI with his comments to determine if I would or would not benefit with ADT. Result is I will not be receiving ADT and proceeding with IMRT high dose treatment in May.
What was your PSA when you were diagnosed?
So when the prostate is removed why not use radiation in the bed of the immediately
2 years ago i was benge drinking. Had a biopsy. Gleason 6. Stopped drinking. Saw palmetto. Pumpkin seeds. Exercise. 2 years later PSA is 13. At the first biopsy it was 8. Another biopsy is scheduled.
Did you use wheat grass fasting? With reduced calorie KETO?
Can you do the radiation treatment without hormone treatment? What is the success rate without hormone treatment, just radiation alone?
Excellent questions. I also wonder if there's a positive benefit to a titrated dose of ADT in terms of fighting cancer but not totally blocking the hormones. Thus reducing the deadly and/or quality of life side effects.
@@robertmonroe3678I was diagnosed as Gleason 4 + 3 Unfavorable two years ago. I did radiation but refused the hormone treatment. My PSA has been steady at .016. No guarantee about the future, but I think I made the right decision.
Yes I am taking radiation therapy right now without hormone therapy
Wonderful questions actually stumping this doctor several times. There is reason and value to do ADT (and or antagonist drugs) FIRST, especially if you are high risk and non-metastatic and then recheck with PSA blood test, MRI or PMSA PET scans to see if there is ANY cancer still there at all. Wouldn't this effectively put off surgery or radiation?
Seems like the doc downplays many of the side effects while the host probes appropriately.
Typical of someone not going through it themself. Find a doctor that has pc and is going through ADT, and their response is 100% more intense. Be specific, your dick and you balls shrink to the size of a pre-pubescent boy, you are up all night with hot flashes, extreme fatigue, significant loss of body muscle mass resulting in loss off ability to enjoy life, loss of body hair, impairment of cognitive abilities, etc. As a 60 year old man, in two years you will feel like you are 75 - 80 years old.
@@jimha8139 This isn't typical
@@jimha8139 Your comments ACCURATELY describe my 2yrs on ADT.
Read the book invasion of the prostate
I could very easily say, the doctor, just like the majority of oncologists prefer to start treatment radically not caring on the patients suffering from the side effects. There's probably no significant money to be made from ADT.
I don't know if it's just me but I have not heard anything about reoccurring are the treatments for it
Why is this man downplaying the side effects?!! Would he take this therapy for himself if he had prostate cancer?!!!
Answer me this? If men in their teens- say 40's have very rare instances of prostate cancer, but men say in their 50's and above have prostate cancer, and testosterone is low, wouldnt it make sense to see what their levels are at that age and try to increase them first before cutting their prostate out or doibg any of these barbaric treatments on them.🤔🤷♀️This makes more sense to me! Maybe this should be researched first but then again it wouldnt be profitable for the oncologists and such...😢
Bilateral orchioectomy ..enough...
Later no ADT....
Very bad side effects....
Think..plantbased..diet......n vit D3 n calcium. citrate...continue right from start...after age 35yrs
Yes.
Sulforaphane, wheat grass powder, reduced calorie keto lifestyle...
Beware of side effects! You might get healthy while shrinking your tumors!
Cancer is a metobolic disease. Needs to be treated with diet, exercise, and nutritionals!
Scintillating...sounded like a eulogy.
Chasing cancer cells with chemicals is like herding cats.
Any cell, in any part of the body can be "insulted" by external forces- carcinogens, EMF, hypoxia, etc. Once the cell mitochondria has become compromised, the cell can no longer make ATP through oxidative phosflorylation for it's energy. The cell is relegated to using the process of fermentation, using glocose and glutamine as fuel, sans oxygen. In contrast, normal cells are not confined to using glucose and glutamine, but instead are "flex-fuel" and can still make ATP (with oxygen) thru oxidative phosflorylation, using ketones for their fuel. A ketogenic diet reduces serum glucose, and intermittent fasting helps reduce glutamine, weakening the cancer. Any cancer, any part of the body. If needed, focal ablation can now be used more effectively, without necessarily toxifying the patient.
Note that the mitochondria dictate the DNA of the cell nucleus, and this results in ensuing genetic mutations. But the mutations are not the initial "insult" that damages mitochondria, they follow precipitously, and that cell becomes undifferentiated.
A healthy life always means avoiding known "insults", keeping the BMI well within guidlelines, avoiding sugar and processed flour, eating lots of cruciferous veggies and healthy fats like salmon and avocados, regular strenuous exercise, etc. Following these guidelines will vastly reduce any chance of cell disregluation, and slow or stop the growth of cancer if it has already become a tumor.
After treatment with the SOC, there is often "biochemical recurrence" of cancer. This isn't puzzling, if the metabolic environment of the body has not been addressed- You can cut dead leaves off a tree, but if the root problem is not addressed, the dead leaves will come back. Can't just pull weeds in the garden, they'll just come back. The metabolic environment of the body has to be changed from what it was when the mitochondria first became damaged, otherwise it's just lather, rinse, repeat, like a never-ending groundhog day.
Side effects are worse than the cancer.
Side effects? Hot flashes, weight gain, ed, fatigue? Please elaborate the worse side effects
@@joemaxwell1044 Had 12 months Lupron, 3/20 - 3/21, so off for 3 years. Three years have gone by, and gynecomastica continues to get worse. Severe breast enlargement, with pain just from touching or bumping the nipples. Risk and horrors of gynecomastica are downplayed, and when you get it, the urologists wash their hands of it. I gained 25 pounds on Lupron, and can't lose it. Loss of body hair. Testicles reduced in size. Fatigue, loss of strength and muscle, lack of motivation to do much of anything. Compete change in bodily structure. Complete loss of sexual function, even with Viagra or Levitra, which no longer work. Hot flashes pretty much gone.
@@joemaxwell1044those are all horrible!