Great video! An immature B cell has already undergone vj recombination to produce a light chain. Let’s say v1j1. Aren’t the other segments (v2 onwards and j2 onwards) deleted during this recombination? If so, how does the immature B cell go back to a different light chain combination if it is selected for “receptor editing” ?
Great question ! In case of " receptor editing " ; the immature B cells take advantage of the " allelic exclusion " property of VJ recombination in the coding allele ! Where the excluded allele of the INITIAL VJ recombination is the one that undergoes a NEW recombination of the V & J segments ! Lord knows best !
a clear and comprehensive explanation. thank you so much!
so where is the positive and negative selection of B-Cell :(
I adore you!!!
Great video!
An immature B cell has already undergone vj recombination to produce a light chain. Let’s say v1j1. Aren’t the other segments (v2 onwards and j2 onwards) deleted during this recombination? If so, how does the immature B cell go back to a different light chain combination if it is selected for “receptor editing” ?
Great question !
In case of " receptor editing " ; the immature B cells take advantage of the " allelic exclusion " property of VJ recombination in the coding allele ! Where the excluded allele of the INITIAL VJ recombination is the one that undergoes a NEW recombination of the V & J segments !
Lord knows best !
Very helpful thank you!! :)
Where is the video following this one?
Hi! Why is clonal deletion called "clonal"? Those cells are clones of the same origin cell? Thanks, your video was very helpful and didactic!
Is the receptor editing step negative selection or positive selection given it has to have no affinity to pass through to become mature?
this was very very helpful
Nice
Please,i want lecturer about the avidity and affinity
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