Ep 9: Dave Feldman, Citizen Scientist-What Causes Heart Disease
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- Опубликовано: 7 сен 2024
- Dave Feldman and I discuss the what causes heart disease, specifically focusing on the consensus view and how it differs from what the science actually shows.
Topics:
Basic theory of CVD causation:
• High ApoB/LDL/Cholesterol
• Gradient causes penetration of arterial wall
• Cholesterol/lipid oxidation in wall
• Progression through stages of atherosclerosis
• Blockage/rupture of plaque
• Ischemia of blood to heart
• Death/morbidity via MI
Electro-negative LDL
Aggregated LDL
TG-rich Lipoproteins
Risk and factor models
FH mortality-implications for causality
ApoB48
Albumin
Vasa vasorum
'Atherosclerosis' in veins
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Dave Feldman
Biography:
“I’m a senior software engineer and entrepreneur.
“I began a Low Carb, High Fat diet in April 2015 and have since learned everything I could about it with special emphasis on cholesterol given my lipid numbers spiked substantially after going on the diet. As an engineer, I spotted a pattern in the lipid system that’s very similar to distributed objects in networks.
“I’ve since learned quite a bit on the subject both through research and experimentation which has revealed some very powerful data. With this new general theory, I’ve shifted around my cholesterol substantially without any drugs or special supplements of any kind.
From: cholesterolcod...
Blog: cholesterolcod...
Twitter: / realdavefeldman
Citizen Science Foundation:
Site: citizenscience...
Twitter: / realcsf
DONATE: citizenscience...
Own Your Labs: ownyourlabs.com/
Tucker Goodrich
Blog: yelling-stop.bl...
Substack: tuckergoodrich...
RUclips: / @tuckergoodrich0
Podcast: sites.libsyn.c...
Twitter: / tuckergoodrich
Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
www.seedyapp.com/
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Show Notes
Notes
See the canine LMHR study:
Kronfeld, D. S., Hammel, E. P., Ramberg, C. F., & Dunlap, H. L. (1977). Hematological and metabolic responses to training in racing sled dogs fed diets containing medium, low, or zero carbohydrate. The American Journal of Clinical Nutrition, 30(3), 419-430. doi.org/10.109...
Lipid-Energy Model
Norwitz, N. G., Feldman, D., Soto-Mota, A., Kalayjian, T., & Ludwig, D. S. (2022). Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a “Lean Mass Hyper-Responder” Phenotype. Current Developments in Nutrition, 6(1), nzab144. doi.org/10.109...
Norwitz, N. G., Soto-Mota, A., Kaplan, B., Ludwig, D. S., Budoff, M., Kontush, A., & Feldman, D. (2022). The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets. Metabolites, 12(5), Article 5. doi.org/10.339...
PubMed for Dave's other papers:
pubmed.ncbi.nl...
See Substack for full show notes-They don't fit here
tuckergoodrich...
Great conversation! My layman's understanding of the matter: If you are on a non-inflammatory diet and serum and physical markers point to lack of inflammation, you may not be experiencing endophilic damage. In those cases, elevated Cholesterol and LDL levels don't matter as much. At this point I can deduce that the LDL 'normal' levels everyone gets measured by, were determined by looking at and average of people, most if not all of them on SAD, high sugar and inflammatory diets. Those standards may not be proper for people running on dietetic ketosis. In any case, I feel amazing, I'm the same weight and energy levels as when I was 25 (I'm 57) and I passed CAC, echocardiogram and stress tests with flying colors so I'm not going back to the standard American diet and I'll quit worrying about that. I've been 10 months carnivore btw and continously on ketosis (at least .5 but >=1.5 mmol/L most of the day. I do OMAD and try not to overdo it because, even though I'm not eating carbs, consuming too much meat, will throw me out of ketosis. I'm battling smoldering myeloma (inactive) so staying in ketosis is super important to me as part of my strategy in dealing with my disease.
All diet is fundamentally inflammatory - if you look at the metabolic response to a meal. All kinds of interleukin pathways are activated, for anabolic state. Insulin-related signaling synergizes these inflammatory pathways. We have the science. Start by looking at interleukin signaling activation.
Great discussion! We need more of this in the community.
I'm halfway through. This is all quite complex and interesting. I hope there are some "take home messages" at the end for non specialists.
I'm afraid not. I think I need to do a follow-up...
@TuckerGoodrich0 - yes, this is very dense and tough to synthesize and I have listened to a lot of videos by scientists on this topic. A summary video would be great
Thumbs up even before watching it.
likewise
Me too!!!
Perhaps another factor which can help to mitigate against oxidative chain reaction is for people to start grounding to get enough electrons. Another factor that seems to be missing from discussions is that people would wear leather for the soles of their shoes which would not stop grounding unlike the switch to rubber soles in the 1900s. Great podcast with Dave. I'm excited for the future
Is there experimental proof of some kind, or do you have some other proof for this than the verbal narrative of your #imagination?
This is a banger interview
Brilliant discussion, guys!
It's going to take me a couple of days to get through this entire interview. Do they cover ApoB? Do they cover LDL particle size?
Very informative conversation. This is what the USA needs right now. To be able to talk to each other with active listening skills. Js
Nice one Tucker! Just discovered your newish channel and subscribed before even watching this video!
Awesome, thank you!
Great discussion! Appears Dr. Kendrick is right, you must have an injury to the endothelia layer before athrosclerosis can start.
No, it can start from the inside.
My HDL-C is always 75-85. My triglycerides are always below 50. My BMI is 20-21. Always metabolically healthy by every metric. My CAC was always 0 until it wasn’t. Just test your ApoB. You can order the test yourself and it will cost about $25-30. If it is elevated, then do what you need to do with lifestyle, diet or pharmaceuticals to lower your ApoB. It is causal of cardiovascular disease. It doesn’t matter whether you are metabolically healthy or not. If it is elevated, you are at risk. And don’t listen to these yahoos and think that is not the case based on anything they say. While you’re at it also test your lp(a). You only need to do that one once. If that is elevated, ask your doctor for a statin.
Did he really say “virtually everyone has ApoB? Oh my goodness. That is tantamount to saying virtually everyone has red blood cells.
I really appreciate both of you brining proper thought into this space. My faith in ‘mainstream’ (read corporate funded) science is exactly zero.
I would like to know more about the role of the vascular endothelial glycocalyx.
I believe they act as shields for the endothelium. Shields, down - inflammatory crap gets in.
What wipes out the shields? blood glucose spikes.
Then it takes hours for the glycocalyx to be restored.
The atherosclerotic process requires a one-two punch; it is 2 factor.
So research can be done on sugar and '"Oh, it is fine"
And research on seed oils can say: "Oh it is fine"
thanks for the video
Great discussion!
Brilliant discussion , what about aspirin on heart health and mitochondria ?
Super interesting conversation!! really enjoyed it!
Could you link me that paper about the post mortem heart checks?
"Geographic Pathology of Myocardial Infarction" is in the show notes:
tuckergoodrich.substack.com/p/podcast-ep-9-dave-feldman-citizen
Brilliant discussion would only add Malcolm Kendricks to the mix!!!😅
Here is my NMR after 8 months on Keto
My total cholesterol 442
LDL size 21.7
LDL-C 352
HDL-C 72
Large HDL-P 10.4
HDL size 9.5
TG 93
LDL-P 3500
sm LDL-P 1147
Large VLDL-P < 0.8
VLDL size?
Test not performed. VLDL levels not sufficient for VLDL size
ApoB 234
LP-IR < 25
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Changing game plan:
I will put everything on the menu except junk food. I.e. no refined carbs, no processed food, no sugars.
So I’m T1D and I have high LDL, high HDL and low TG… and my TG/HGL ratio is 0.8… or is it HGL/TG ratio?? Anyway that marker is quite low…. And I stay away from all carbs… am i at risk? Cos based on this discussion the answer is no… and most discussion about diabetes is about type 2, which isn’t me…. BTW I’ve been T1D for over 40 years,…. So there is that….
It's hard for me to say. I'd definitely recommend a CAC scan to see if you have existing CVD.
I have high LDL & TC and also high HDL and low TG. And very low insulin... I lose little sleep over it.
Yeah… planning on a CAC scan before then end in this year… need to referral from my Dr first… our rules are different to US rules (I’m in NZ)…
In part of the video (1 hr 40 mins?), Mr. Goodrich mentioned that eating carbs alone is enough to cause obesity. However, I would beg to differ. That is perhaps why the RICE diet was successful and also maybe even vegan diets in reducing obesity. I think you need both carbs and fats to cause obesity. Sure the body does conversion carbs to fats but if that's all you have, it's not enough to cause obesity.
I hope you guys can also talk about how much fats do we really digest? Just because we are eating lots of fats doesn't mean we absorb all of them. It depends on the bile function. We also know of beginner carnivore doing the toilet runs on the initial stage due to this digestive issue. So what happens when we over consume fats? Does all of them get digested? I also understand that there is a preferential order in oxidizing fats in the body? First it would be the Short/Middle chains fats, then PUFAs and finally mono and then saturated fats. So when we are burning fats but taking in PUFAs, would the PUFAs be oxidized first, with saturated fats being the last in order to oxidize?
And yes, I would like to hear a lot more about the vasa vasorum, even since Ivor last podcast about this, there has not been any more talks about this. Why can't heart disease progress from an outside-in cascade?
If you have too much fat in your poop it floats, I'm carnivore and don't see that.
"In part of the video (1 hr 40 mins?), Mr. Goodrich mentioned that eating carbs alone is enough to cause obesity...."
I didn't say that. I said eating carbs along is NOT enough to cause obesity.
@@TuckerGoodrich0 sorry misheard
interested if anyone has a reference to the nut-eating hunter gatherer study mentioned by Tucker at timestamp 2:05:30. Or the name of the tribe.
Jenkins, T., Lehmann, H., & Nurse, G. T. (1974). Public health and genetic constitution of the San (“Bushmen”): Carbohydrate metabolism and acetylator status of the Kung of Tsumkwe in the North-western Kalahari. British Medical Journal, 2(5909), 23-26. doi.org/10.1136/bmj.2.5909.23
you're the man tg.. @@TuckerGoodrich0
Why not mention Apoa as well as Apob?
Good point.
2hrs? can you reduce this time down to 30 min please?
It's actually 3 hours. LOL. I would like to do a summary...
the Dildo of Enlightenment rarely comes lubed.
It's a sad state when Citizens have to directly fund relevant science on top of funding those for pharma's benefit via taxes.
It is absurd that this video is two hours and 50 minutes long. Nobody’s going to watch it. But the real problem is why they can’t say what needs to be said in a much shorter period of time? Elevated LDL cholesterol does not cause heart disease. Statins are not only worthless, but they have side effects. Heart disease parallels the amount of seed oil (vegetable oil) consumption.
Agreed, cholesterol is not the problem. I was a former vegan now Keto but not religious about it. I'm sure I have my fair share of seed oils , but I'm reversing my heart disease as verified by CAC Score. I'm on the Linus Pauling Heart Protocol. I have to wonder about food influence when I'm reversing my heart disease, though I try and stay surgar and grain free.
😮
At the end of the video Goodrich was saying that LDL cholesterol, when it gets to a certain point, which according to the medical establishment is 100, then we all begin this process of cardiovascular disease because too much concentration of LDL would become too intolerant to the immune system or our body in general, and we would attack our body to defend against this toxic amount of LDL through inflammation and cause this cascade of events that leads to death. So, then that goes back to the overall consensus then that we should all be on statins to get our LDL under 100, or under 70 for some people. Really, we could have just said that in first 5 minutes, considering that LDL above 100 is dangerous and not worry about the rest of this information. All that seems to matter is high LDL.
Can you drop the time code?
Yes, please do. I'm pretty sure I didn't say that.
Thoroughly incorrect, read The Great Cholesterol Con. lowering LDL does not prevent heart disease and below 100 is dangerous. People with very very low LDL still get heart disease and you can include vegans/vegetarians and Olympic level athletes on that list. The new science is HDL/TRG ratio is far far more important
I have to wonder about the HDL/TRG ratio. Mine is about 3, yet I am reversing my heart disease verified by CAC.
I disagree with your reference to yourself as Dr. Goodrich. Your degrees are not in the health field, and that is what you are speaking about here.
I never refer to myself as Dr. Goodrich. I don't have a doctorate. My name is Tucker Goodrich, and people, including physicians, often mishear it as Doctor Goodrich.
@@TuckerGoodrich0 Oops...sorry. Glad to hear I misheard you.
I've met so many doctors who don't deserve to be referred to as doctors, don't measure up to the level of respect once generally merited by the designation.