You are a genius at explaining these biochem concepts!! I was struggling all this week until I found your video!! Seriously thank you so much! I wish you were my professor!
@@bcvanderlinden I agree! I ended up with an A in the course thanks to his videos! I'm also using these to fresh up on the biochem pathways for my MCAT prep! wishing you the best with studies!
You're so much better than my lecturer. Thank you so much. I've been trying to understand these concepts this semester, and you cleared my confusion within 13 minutes.
Finally I found a proper video for differentiation between protein motifs and domains. Thank you so much for this video. It's extremely helpful and you have explained it very nicely. Thank you so much!
DAMN! I've been banging my head trying to differentiate between motif and a Domain, you made sound like A B C D. Greatest Appreciation. Please I have a question however, is there a line that demarcates a motif in the protein or a kind of an amino acid sequence that tells you where a motif starts and ends?
thank u thank u soo much.. i was just about to cry that i was not getting the concept of that what is difference b/w motif n domain........ but u cleared my concept thanks...
Hi Sir, you have explained the difference very well. I still have a question, what is the logic of these two types of active areas of secondary protein.
amazing video! Just had a doubt regarding what interaction binds a beta sheet and an apha helix together or does one secondary structure not interact with another (just with other segments of itself)?
@@thomasmennella5501 Thank you so much for the clarification :) I had another question: what is the difference between an amyloid structure, domain, and protein subunits.
Thank you for this wonderful video.I have a small question.Can I correlate the secondary structure (and also tertiary structure ) from the primary structure (protein sequence)?
Hi X - I believe you're asking about "modular domains". Modular domains are domains that are evolutionarily conserved and found in many different proteins and in many different species. These domains do their job in and for a large number of proteins and seem to be somewhat mobile (i.e., as part of a transposon or hybridized viral genome). A good example of a modular domain would be the HMG (high mobility group) DNA binding domain. HMG domains are found in lots of proteins and across most species and they always allow a protein to bind to DNA. In fact, if you add an HMG domain to a protein that normally does not bind to DNA - using recombinant techniques - that protein will now bind to DNA via the HMG domain. I hope this answered your question and clarified the role of modular domains in proteins.
The best explanation I found for motifs and domains. Thanks for the vid
This is amazing 7 years later and u r still helping med students with these amazing videos
oohhhhh shittttt, brah you were the first person that made me understand wtf a motif was, thank god i found you one day before my biochem exam
Varun Mangal found him the day of my exam
one day before exam🤞
probably 3 hours googling motifs and domains and didn’t understand, this video is so simple and the only thing that explained that clearly, thanks
It's one of the best explanation I've ever listened.
This video is so perfectly simple and clear and visual. I lOVE IT
You are a genius at explaining these biochem concepts!! I was struggling all this week until I found your video!! Seriously thank you so much! I wish you were my professor!
@@thomasmennella5501 you're welcome! Thank you! & I will continue to watch your biochem playlist!
Same here! This doesn’t have to be a mystery, it just needs to be explained well!! So grateful!!
@@bcvanderlinden I agree! I ended up with an A in the course thanks to his videos! I'm also using these to fresh up on the biochem pathways for my MCAT prep! wishing you the best with studies!
The video from 6yrs ago still helps me to understand the concepts best vid!
They age like wine, J. 😉
I cannot thank you enough for this video. You explain very well
Thx dude!. the best explanation EVER about the difference between domain and motifs. ....and the definition of turns too
.
You're so much better than my lecturer. Thank you so much. I've been trying to understand these concepts this semester, and you cleared my confusion within 13 minutes.
Finally a clear explanation, thank you. I felt like a genius when you made it click in my head, but it so simple at the same time.
I've never understood this until now. Thank you!
Finally I found a proper video for differentiation between protein motifs and domains. Thank you so much for this video. It's extremely helpful and you have explained it very nicely. Thank you so much!
Excellent video, very clearly explained. Thanks!
Excellent presentation. Love it
Clear explanation..best so far i have watched!!
Amazing Explanation!!!
I got a whole minute in and realised this isn't talking about a motif within music
So useful
Best explanation I’ve heard yet!! Thank you.
DAMN! I've been banging my head trying to differentiate between motif and a Domain, you made sound like A B C D. Greatest Appreciation. Please I have a question however, is there a line that demarcates a motif in the protein or a kind of an amino acid sequence that tells you where a motif starts and ends?
Your videos are really useful and straight to the point. Thank you. Hope you make more soon.
This was immensely helpful. Thank you.
This is an amazing video, and you are incredible at communicating!
Keep it up sir💝
Thanks, Thomas! 😊
finally understood the concept .... keep up the great work.
Clear concept ✨️ 👌 thanks
Great video!!! Really clear and concise explanation
thanks for great explanation....you are the best
Great video sir!
thank you so much, finally a clear and concise explanation for motifs and domains
You literally just saved me from failing my quiz in the next 30 minutes 😭
Since morning, i was trying to get the difference between motif and domain and then i found this video 👍👌
prasoon kumar me too!
Respect your teaching experience 🙏🙏
This is SO CLEAR and TO THE POINT! THX!!
Thanks god I found this vid, what a legend!
Super accurate explanations
Great video, Very nicely explained . Thank you !!
I was quite lucky to have found your video here.. I wish you were my biochemistry professor
Everything is crystal clear, thank you!
really helped me to understand the motif and domain very clearly...thanks a lot
Made this concept very easy to grasp, thank you very much!
so clear and helpful! much better explained than my profs haha
Wow sir know I understand it fully
This was very helpful. Thanks Siree
Best explaination
A very helpful video
thank u thank u soo much.. i was just about to cry that i was not getting the concept of that what is difference b/w motif n domain........ but u cleared my concept thanks...
Hi Sir, you have explained the difference very well. I still have a question, what is the logic of these two types of active areas of secondary protein.
Hello, Muhammad. Thank you for visiting my videos and for your question. May I ask, what do you mean by “logic”?
My Prof explained this so complex and awful now i can finally understand it
Great video sir
amazing video! Just had a doubt regarding what interaction binds a beta sheet and an apha helix together or does one secondary structure not interact with another (just with other segments of itself)?
@@thomasmennella5501 Thank you so much for the clarification :) I had another question: what is the difference between an amyloid structure, domain, and protein subunits.
big big like straight to the point i didn't waist my time here thank you so much :)
Thank you!! I never understood this until now
thankyou so much sir, cleared concepts 🙏
u are very good man
this video was very helpful and informative, thank you
Thank you for this wonderful video.I have a small question.Can I correlate the secondary structure (and also tertiary structure ) from the primary structure (protein sequence)?
Thank a lot, great video
very good thank you so much sir
Job well done!
Awesome explanation. Thank you very much
that was helpful thanks u sooo much
Excellant
you saved my life thank you 😭♥️
do motifs make up domains?
I love you man!
Blesss your soul
amazing...thank you
Thank you sir for the video.
Thank you so much. So helpful.
Awesome!
very clean explanation and thank you very much !
sir the motif can be found inside domain or not/if it is then can be separating that motif from the domain is able to work?
What is the difference between a domain and a subdomain?
@@thomasmennella5501 Thank you :)
Really helpful
😂😂thank you..i thought i just was so dumb that i couldnt understand it in class
Really well done thank you
thx professeur
Hi thanks for saving my biochem grade
ammmmaaazinnng explanation
OMMGG THANK YOU!!!
What are modular proteins??
Hi X - I believe you're asking about "modular domains". Modular domains are domains that are evolutionarily conserved and found in many different proteins and in many different species. These domains do their job in and for a large number of proteins and seem to be somewhat mobile (i.e., as part of a transposon or hybridized viral genome). A good example of a modular domain would be the HMG (high mobility group) DNA binding domain. HMG domains are found in lots of proteins and across most species and they always allow a protein to bind to DNA. In fact, if you add an HMG domain to a protein that normally does not bind to DNA - using recombinant techniques - that protein will now bind to DNA via the HMG domain. I hope this answered your question and clarified the role of modular domains in proteins.
@@thomasmennella2744 thanks for the answer! It is all clear now.
Thanks, very helpful.
Perfect
Thank you Sir
thank you so so so much
thank you!
I understand everything you said but I stil don't understand the difference between loops and turns
@@thomasmennella5501
Thank you 😊
I love you Thomas
Thank u so much
very helpful
Thank you!
thank you so much
thaks
Thank you
Love this, well explained thank you
wow