Sir, Can you please suggest how can we calculate binding energy or stability of this mutated complex ? I will be very thankful if you can make a video on further analysis of this mutated complex regarding their stability, change in activity after mutation of protein. I am very eager to know how the mutation in one protein affect its interaction to other protein. Thank you
Hii Vijay, Thank you for your comment. Mutations within or near active site of protein may affect their activities and stabilities. If mutation is located at protein-protein interaction(PPI) interface then it can stabilize or destabilize the PPI. SARS-CoV2 RBD-human ACE2 complex is a good example... I will upload a video on it...
Sir, Can you please suggest how can we calculate binding energy or stability of this mutated complex ? I will be very thankful if you can make a video on further analysis of this mutated complex regarding their stability, change in activity after mutation of protein. I am very eager to know how the mutation in one protein affect its interaction to other protein. Thank you
Hii Vijay, Thank you for your comment. Mutations within or near active site of protein may affect their activities and stabilities. If mutation is located at protein-protein interaction(PPI) interface then it can stabilize or destabilize the PPI. SARS-CoV2 RBD-human ACE2 complex is a good example...
I will upload a video on it...