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@@ModernHealthspan Richard- I gleaned the following from his talk: about 1- 1/5 grams of leucine will enhance the effect of NMN. I have reduced my NMN from 1.5 grams to 0.6 grams with 1 gram of leucine. All are easily dissolved in water or juice.
B6 is required for hundreds of different mechanisms in the body. A lot of what happens in the body is rate limited by vitamin B6, but you can't get enough to fulfil your bodies needs if you take the vitamer they fortify most food with. You need the p5p form to not get nerve damage while fulfilling the bodies true needs.
Agreed…what a gem and timely. I have a container of leucine that I was going to give up on. I was aware of leucine’s MTor activation and was using it for my muscle rebuilding cycle when I try and pack muscle on which is ever harder now I’m over 60. But my anecdotal non peer reviewed claim was that the only thing it really increased was my appetite which became voracious after leucine +3 gm dose. But now I’m looking at my furriest faithful companion and noted that she has packed a bit of weight on over CoVid and after hitting her first decade. So she and I are going to do the companion leucine/B6 protocol for 6 weeks. I’ll forward the results to you and some pictures and if you would so kindly act as our peer…perhaps we could all get published in the Journal of Vet medicine or at the very least, the pet shop down the road says they’ll let me post it on their bulliten board if I buy $200 of non gmo bison liver.
I’m serious about testing this and am a keen fan of finding the natural paths to trigger desired outcomes versus letting the pharmaceutical giants come up with something so targeted and expensive that it sucks the wind out of my bank account and likely causes as many side effects as curing the original ailment/target. Thanks for your fine work, Richard.
@@newdata I like individual amino acids including glycine, taurine, and leucine and given they’re all elements of protein I think they are more natural than you suggest
That is the conundrum... doing and funding research on commonly available sources and supplements but finding a way to reap the rewards for the time, effort, and money invested. It becomes clear why big pharma and their lobbyists push their man-made crap medicines that do very little except allow them to charge exorbitant prices. This also explains why regulation is used as a cheap business tactic to prevent others from using common supplements -- e.g. banning sales of NMN and NAC.
Hi Armando, thanks for your comment, and it is indeed a conundrum. But it does seem to be partly solvable, using the model or NR or Rejuvant which use common substances which are not regulated.
@@ModernHealthspan I hope Rejuvant is profitable. It seems the process for making Ca-AKG is patented so I assume they are making money off of it or using it to differentiate themselves from the competition while being the exclusive supplier. I personally do not use Rejuvant but rely on heavy cardio exercise to feel the boost effects of AKG along with other supplements that seem to work well synergistically such as beet root (i.e. betaine or TMG) and black/green tea. I assume getting the boost means the body is absorbing the AKG to some effect.
This guy!!!! Is awesome!!! I'm part of those consumers that want to see data, I am proof of some of that data. The marketing hype is for the sheep. I tell people about NMN, NAC, cofactors, nad+, methylene blue! And they look at me like I'm crazy. And so I've decided to just do what I do. In the last month, I feel like I've changed my whole mind and life around and attitude with some of these supplements, now this is my only opinion. I'm 41 in great shape, no ambition, no enthusiasm, just something was off I mean I did day-to-day stuff but starting something new or just yada yada stress. I've read the data on things, and I started taking those after much research! My energy, focus, mood, just attitude! I feel "young" energy. I was in the Marines, so I'm not at the top of my game as I once was. But I feel pretty close!!! I don't do any of my supplements in abundance, just buy the directions. And consistently at the same. Thank you so much to both of you for sharing your thoughts and brain knowledge!!! I say this for many of us, we are very thankful for your research and your dedication uploading it to RUclips for all of us to learn and enjoy!!!!
If you don't mind posting - what is your current stack of supplements? I'm looking to re-arrange what I'm doing and trying to narrow it all down to the bare minimum paired with the highest quality food I can get access to.
Hold on..new study out claims Leucine triggers Plaque buildup...look it up...I'm having a tub of Leucine powder delivered today and now I'm going to return it...
This shorter clip is a little bit confusing on its own. He starts to talk about Leucine in the first few moments but then he wants to "back up" and then he talks about the B vitamin. But in his description of the studies he conducted, it isn't clear whether he's talking about the B vitamin alone or in combination with other substances. I guess I'll go back and watch the larger video to try to make it make more sense to myself. Because I feel that the least likely correct interpretation is that a common B vitamin, on its own, helps reduce fatty tissue in humans while maintaining lean tissue, but nobody in the world had noticed this before or touted it.
Nope, but do take those for what they're good for. The idea in this video is sirt1 boosting, and fat burning. Protein and multivitamins will just help growth in general.
Start my day with buttered coffee pre-workout...sounds like a gram of leucine and some B6 is in the cards for a self experiment to companion with the Coffee.
Hi Sharon, thanks for the question. In the study they used 2.25g leucine and 30mg of B6 (pyrodoxine). What would be ideal may vary per person and also the goal.
@@ModernHealthspan would that be per meal? I just started striving (with the help of a leucine supplement) to get at least 2.5-3.5 grams of leucine at breakfast & at dinner. I've heard Don Layman talking about that threshold to help with muscle synthesis. I'm a 65-year-old woman and only 4'9.75" and 78 lbs - is it true that leucine's threshold is not based on weight??
Took my first 800mg dose of Leucine last night and had a difficult time sleeping. Turns out I'm allergic to it. It seems to be "fermented from vegetable sources" which is probably why. Can you get Leucine from a meat product base?
Hi Jack, thanks for sharing. I thought that the best sources of leucine are animal based but looking at the pure leucine supplements I could not find the source.
Until I started doing a mostly meat diet, I did not even know I was allergic to so many things. Now, I can tell quickly by the inflammation that I'm allergic to certain things. Nuts, corn, soy etc.. I did find some Leucine that is made from animal (duck feathers??) or bacteria (E-Coli???) It's in powder form and that means making a shake which I was trying to avoid. Thanks for having this fellow on and showing us what Leucine can do.
@GarciaBalonie-dl7fx Great idea. I'll try that today. My friend is taking 1gram Leucine, 200mg Resveratrol twice per day and she loves it. Easy to see her energy level has gone up, can't get a word in edgewise when she's around!!!
I’m on the second episode of leucine benefits and yes it looks like a good idea to add leucine to my list of supplements. However, the question is how much? I would appreciate if in the future you either ask this question directly or post the answer in the comments for those who need to know, ok? For now, I assume it’s around 1g? Keeping in mind that we don’t want to activate mTOR? Or should it be less?
Renue By Science 10% discount: tinyurl.com/3bj65wev For Subscriptions, use code SUBMHS
DoNotAge 10% discount code MODERNHEALTHSPAN donotage.org/products/
NOVOS Core & NOVOS Boost $5 with code MODERNnow5 novoslabs.com/?ref=3957
ProHealth 10% discount code MODERN : prohealth.pxf.io/c/3176409/1541296/17976
InsideTracker 20% discount: insidetracker.sjv.io/DVmqkn with code HEALTHSPAN20
Bulletproof 15% discount code HEALTHSPAN15 tinyurl.com/24hrxt72
If you would like to support our channel, we’d love a coffee ☕…thank you! www.buymeacoffee.com/mhealthspan
Prof Michael Zemel Playlist: tinyurl.com/4d7nw842
Richard- you have found a gem in Dr. Zemel.
Hi David, thank you! It was great talking to him and he does pack a lot of information into a little time!
@@ModernHealthspan Richard- I gleaned the following from his talk: about 1- 1/5 grams of leucine will enhance the effect of NMN. I have reduced my NMN from 1.5 grams to 0.6 grams with 1 gram of leucine. All are easily dissolved in water or juice.
He is very helpful
I wish there was more Zemel on youtube. He's on the cutting edge and is a great science communicator.
B6 is required for hundreds of different mechanisms in the body.
A lot of what happens in the body is rate limited by vitamin B6, but you can't get enough to fulfil your bodies needs if you take the vitamer they fortify most food with.
You need the p5p form to not get nerve damage while fulfilling the bodies true needs.
Agreed…what a gem and timely. I have a container of leucine that I was going to give up on. I was aware of leucine’s MTor activation and was using it for my muscle rebuilding cycle when I try and pack muscle on which is ever harder now I’m over 60. But my anecdotal non peer reviewed claim was that the only thing it really increased was my appetite which became voracious after leucine +3 gm
dose. But now I’m looking at my furriest faithful companion and noted that she has packed a bit of weight on over CoVid and after hitting her first decade. So she and I are going to do the companion leucine/B6 protocol for 6 weeks. I’ll forward the results to you and some pictures and if you would so kindly act as our peer…perhaps we could all get published in the Journal of Vet medicine or at the very least, the pet shop down the road says they’ll let me post it on their bulliten board if I buy $200 of non gmo bison liver.
I’m serious about testing this and am a keen fan of finding the natural paths to trigger desired outcomes versus letting the pharmaceutical giants come up with something so targeted and expensive that it sucks the wind out of my bank account and likely causes as many side effects as curing the original ailment/target. Thanks for your fine work, Richard.
@@ScottChristensenabc ingesting purifed leucine does not sound very natural. any purfied condesced trigger of mtor sounds dangerous
@@newdata I like individual amino acids including glycine, taurine, and leucine and given they’re all elements of protein I think they are more natural than you suggest
Agree! I’m on glynac and creatine. If I add another 17 amino acids I’ll have steak!
That is the conundrum... doing and funding research on commonly available sources and supplements but finding a way to reap the rewards for the time, effort, and money invested. It becomes clear why big pharma and their lobbyists push their man-made crap medicines that do very little except allow them to charge exorbitant prices. This also explains why regulation is used as a cheap business tactic to prevent others from using common supplements -- e.g. banning sales of NMN and NAC.
Hi Armando, thanks for your comment, and it is indeed a conundrum. But it does seem to be partly solvable, using the model or NR or Rejuvant which use common substances which are not regulated.
@@ModernHealthspan I hope Rejuvant is profitable. It seems the process for making Ca-AKG is patented so I assume they are making money off of it or using it to differentiate themselves from the competition while being the exclusive supplier. I personally do not use Rejuvant but rely on heavy cardio exercise to feel the boost effects of AKG along with other supplements that seem to work well synergistically such as beet root (i.e. betaine or TMG) and black/green tea. I assume getting the boost means the body is absorbing the AKG to some effect.
This guy!!!! Is awesome!!! I'm part of those consumers that want to see data, I am proof of some of that data. The marketing hype is for the sheep. I tell people about NMN, NAC, cofactors, nad+, methylene blue! And they look at me like I'm crazy. And so I've decided to just do what I do. In the last month, I feel like I've changed my whole mind and life around and attitude with some of these supplements, now this is my only opinion. I'm 41 in great shape, no ambition, no enthusiasm, just something was off I mean I did day-to-day stuff but starting something new or just yada yada stress. I've read the data on things, and I started taking those after much research! My energy, focus, mood, just attitude! I feel "young" energy. I was in the Marines, so I'm not at the top of my game as I once was. But I feel pretty close!!! I don't do any of my supplements in abundance, just buy the directions. And consistently at the same. Thank you so much to both of you for sharing your thoughts and brain knowledge!!! I say this for many of us, we are very thankful for your research and your dedication uploading it to RUclips for all of us to learn and enjoy!!!!
If you don't mind posting - what is your current stack of supplements? I'm looking to re-arrange what I'm doing and trying to narrow it all down to the bare minimum paired with the highest quality food I can get access to.
From now on, I will take Leucine and Vit B6.
Wow this interview is fascinating. I guess Im adding leucine to my longevity stack!
Hold on..new study out claims Leucine triggers Plaque buildup...look it up...I'm having a tub of Leucine powder delivered today and now I'm going to return it...
This shorter clip is a little bit confusing on its own. He starts to talk about Leucine in the first few moments but then he wants to "back up" and then he talks about the B vitamin. But in his description of the studies he conducted, it isn't clear whether he's talking about the B vitamin alone or in combination with other substances.
I guess I'll go back and watch the larger video to try to make it make more sense to myself. Because I feel that the least likely correct interpretation is that a common B vitamin, on its own, helps reduce fatty tissue in humans while maintaining lean tissue, but nobody in the world had noticed this before or touted it.
Hi Mark thanks for your comment. This is the only section in which we discuss Vitamin B6. Episode 1 does introduce leucine.
Great episode, thank you. I take protein powder and vitamin b complex everyday, hope it counts.
Nope, but do take those for what they're good for. The idea in this video is sirt1 boosting, and fat burning. Protein and multivitamins will just help growth in general.
It won’t
Looking for Leucine on Iherb, but getting L-Leucine. Is it the same, or does the L in front stand for something else?
Start my day with buttered coffee pre-workout...sounds like a gram of leucine and some B6 is in the cards for a self experiment to companion with the Coffee.
Hi Bob, thanks for sharing. I hope that this is working for you.
@@freespiritwithnature4384 The 3 forms of B6 metabolize in both directions, so I stick with 100mg of pyridoxine as sufficient.
What dosing would be ideal for your consumer base?
Hi Sharon, thanks for the question. In the study they used 2.25g leucine and 30mg of B6 (pyrodoxine). What would be ideal may vary per person and also the goal.
@@ModernHealthspan would that be per meal? I just started striving (with the help of a leucine supplement) to get at least 2.5-3.5 grams of leucine at breakfast & at dinner. I've heard Don Layman talking about that threshold to help with muscle synthesis. I'm a 65-year-old woman and only 4'9.75" and 78 lbs - is it true that leucine's threshold is not based on weight??
Thanks Richard.
Hey Ron, Thanks!
Is L-leucine the same as leucine?
yes
YES
Took my first 800mg dose of Leucine last night and had a difficult time sleeping. Turns out I'm allergic to it.
It seems to be "fermented from vegetable sources" which is probably why.
Can you get Leucine from a meat product base?
Animal proteins in general are among the best sources of dietary leucine.
Hi Jack, thanks for sharing. I thought that the best sources of leucine are animal based but looking at the pure leucine supplements I could not find the source.
Until I started doing a mostly meat diet, I did not even know I was allergic to so many things.
Now, I can tell quickly by the inflammation that I'm allergic to certain things. Nuts, corn, soy etc..
I did find some Leucine that is made from animal (duck feathers??) or bacteria (E-Coli???)
It's in powder form and that means making a shake which I was trying to avoid.
Thanks for having this fellow on and showing us what Leucine can do.
@@ModernHealthspan It's my understanding that leucine supplements are usually made from duck feathers or human hair.
@GarciaBalonie-dl7fx Great idea. I'll try that today.
My friend is taking 1gram Leucine, 200mg Resveratrol twice per day and she loves it.
Easy to see her energy level has gone up, can't get a word in edgewise when she's around!!!
Is leucine the same as isoleucine
No, 2 different amino acids
Hi thanks for your question, leucine and isoleucine are different amino acids though both are branch chained.
@@ModernHealthspan thank you. Now I know what to purchase
I’m on the second episode of leucine benefits and yes it looks like a good idea to add leucine to my list of supplements. However, the question is how much? I would appreciate if in the future you either ask this question directly or post the answer in the comments for those who need to know, ok? For now, I assume it’s around 1g? Keeping in mind that we don’t want to activate mTOR? Or should it be less?
Will adding carnitine enhances the effect?
Ok great
I do Not Like leucin i Like valin better