Thanks for the time you've taken to make this excellent LC series! My covid infection was characterized by overwhelming sinus congestion and it continues to be one of my worst symptoms in LC. In January after listening to Gez Medinger's RUclips interview with Laurence Afrin on MCAS, I started 10 mg/day Loratadine for a week, then increased to 20mg/day. Within 2 days of upping to 20mg/day, my sinusitus improved to tolerable levels (though has never cleared completely), but even more exciting is for the first time in 4 months my brain fog COMPLETELY disappeared so I was able to read a book; and my breathing slowed down to normal pace; and my anxiety disappeared. It was an incredible improvement! Alas palpitations & fatigue remain... Based on your explanation I shall now add famotodine H2 blocker (sold otc as Pepcid in North America).
Regarding brain fog: I have quite high anxiety, brain fog, hives, poor sleep. It seems to me that a 1st generation antihistamine that crosses the bbb could be a sleep inducer and antihistamine of brain mast cell activation. Can brain mast cell activation cause some kind of brain hive which could cause the fog? Not itchy of course (thank God!) but still cause inflammation of the brain?
Thanks for the time you've taken to make this excellent LC series! My covid infection was characterized by overwhelming sinus congestion and it continues to be one of my worst symptoms in LC. In January after listening to Gez Medinger's RUclips interview with Laurence Afrin on MCAS, I started 10 mg/day Loratadine for a week, then increased to 20mg/day. Within 2 days of upping to 20mg/day, my sinusitus improved to tolerable levels (though has never cleared completely), but even more exciting is for the first time in 4 months my brain fog COMPLETELY disappeared so I was able to read a book; and my breathing slowed down to normal pace; and my anxiety disappeared. It was an incredible improvement! Alas palpitations & fatigue remain... Based on your explanation I shall now add famotodine H2 blocker (sold otc as Pepcid in North America).
Thank you for making this Long Covid series. I wish you were my doctor
Regarding brain fog: I have quite high anxiety, brain fog, hives, poor sleep. It seems to me that a 1st generation antihistamine that crosses the bbb could be a sleep inducer and antihistamine of brain mast cell activation. Can brain mast cell activation cause some kind of brain hive which could cause the fog? Not itchy of course (thank God!) but still cause inflammation of the brain?