Its really great to not have to deal with all those old diseases. Sometimes old people will be like "I remember being in bed for 3 weeks from djhdkc disease". And its some disease that makes your skin fall off and bones bend sideways!
What a wonderful video. All to often all I ever see on social media is anti-pharma rhetoric so this is a breath of fresh air. Some truly outstanding work, conducting by giants in their fields.
Hope you have a nice day. We've summarized the main points discussed for convenience, but encourage watching the full video to get maximal value from the creator's knowledge. Click the link in my profile if you need summaries. Here is a summary of the key points from the transcript: 0:00 - Introduction. The post-WWII period was one of rebuilding and investment, which benefited the pharmaceutical industry. Leadership in the field shifted to the US. 0:30 - Discovery of cortisone as a treatment for rheumatoid arthritis by Philip Hench, Edward Kendall and Tadeusz Reichstein. Led to the 1950 Nobel Prize. Opened up steroid research and chemistry. 1:15 - Synthesis and production of cortisone by Merck chemists was an immense challenge. This effort established Merck as a top pharma lab. 2:00 - Discovery of NSAIDs like ibuprofen as simpler anti-inflammatory alternatives to steroids. 3:15 - Breakthrough in treating psychotic disorders with chlorpromazine, the first phenothiazine antipsychotic. Marked the beginning of more effective psychiatric treatments. 4:45 - Pioneering antimetabolite research by George Hitchings and Gertrude Elion at Burroughs Wellcome. Led to 6-mercaptopurine for leukemia treatment. 6:30 - The 1950s saw many important new drug discoveries, chemical and biological breakthroughs, and progress in previously untreatable diseases. 7:30 - The 1950s also marked the beginning of "lifestyle drug" research. Overall, the transcript covers key medical innovations in the pharmaceutical industry in the 1950s, including cortisone, NSAIDs, antipsychotics and antimetabolites. It highlights the rebuilding post-WWII and the rising leadership of the US pharma sector.
I love your content, im using it for improving my general knowledge aswell as improving my English skills (im German). I can usually keep up but sometimes I have to rewind and listen to some parts again ^^
It would be awesome to learn about the differences in protein and steroid hormones. Maybe even more broad, like comparing lipid chemistry, protein chemistry, and sugars?
My dad worked in R&D for human and animal pharmaceuticals all my life until he retired a few years ago. He has friends from his time at Pfizer that worked on their Covid vaccine.
The playlist is very good and fantastic I am a pharmacist and i want more details about the history of drug can you give me accurate resources for that ??
Crazy how I literally had a random desire to search "history of drugs" and got your videos. I caught up with the whole series before this one and I'm stoked to see its an ongoing thing. 😁 I hope you get into some non-medicinal drug history such as ayahuasca, mushrooms, marijuana, the dea, timothy Leary, and modern designer drugs
Typical Italian-style pasta: Let’s start with the basics. First, make the sauce: Pour a little olive oil over a finely chopped onion in a pan. Fry the onion until it’s golden and then add chopped tomatoes (about 800 grams) and salt. Simmer the sauce for 10 minutes. Now, for the pasta: Boil a large pot of salted water, and add the pasta (preferably, in order to follow Italian tradition, spaghetti). Remember: the pasta should be added only when the water is already boiling. Doing the opposite is a very common mistake. Stir it to keep the noodles from sticking. Taste the pasta to gauge its readiness (see below for more on how to make sure your pasta is al dente), and drain it when it’s done. Add the sauce and mix. Garnish with a sprinkling of Parmesan cheese or Grana Padano.
On the issue of psychiatric Pharma, you need to look into the work of Robert Whitaker, who wrote Anatomy of an Epidemic. While they can help some, their side effects can be extreme and dangerous, and are largely ignored by psychiatry. There is also the antidepressant merry-go-round that keeps patients on these often-marginally-useful medications for years, switching from one to another when the first proves to be ineffective. The drug companies laugh all the way to the bank.
@@ProfessorDaveExplains Not true. Psych meds do more harm than good. You have a lack of discernment. You can't tell what is true and what isn't when given information. You shouldn't be teaching if you don't have the truth.
Would be interested in hearing your take on Astral Projection, from the cia, the monroe institute, ancient religions from Egypt to India. Also a prominent idea amongst mesoamerican tribes. Do you think 1. People made up stories passed down over time, 2. Certain breathing exercises and sounds can trigger a local psychedelic level experience(my belief), 3. Some stuff about frequencies, earth magnetic resonance, or some other shit they say to justify an subjective brain experience into being real.
@@ProfessorDaveExplains I'm probably going to sound like a moron here but, I suppose I have that belief b/c it appears that the pursuit of profits is the only motivation companies have. It also seems as if many companies will do anything to increase their bottom line. Maybe I should think about the question a bit more though.
@@ProfessorDaveExplains You're not wrong, man. To be more precise, I don't believe the marketing tactics employed by pharmaceutical companies serve society's best interests. Commercials that prompt average people to ask their doctors about a specific drug may not be the most responsible approach; they can lead to unnecessary prescriptions. Additionally, the opioid epidemic offers compelling evidence against the pharmaceutical companies responsible for manufacturing and marketing these drugs-both through TV advertisements aimed at consumers and promotional materials for doctors. We should also consider the pricing of cancer medications, which are prohibitively expensive for many people. While I understand that pharmaceutical companies need to turn a profit and recoup their initial investments, there comes a point when we must ask: is it profits over people? I apologize if I sound uninformed; I'm not as knowledgeable as you, which is why I follow your channel. Thanks Dave, I appreciate you and the work you do.
Advertising is a part of any capitalist society and that people get addicted to opioids does not make the manufacturer accountable nor does it make those drugs less important as pain killers. They're not saints, they don't lift a finger to help solve anything. But it's really not their fault. Drugs being expensive is also not their fault, that is the fault of insurance companies. The government should pay for it, just like in any other civilized nation.
Yeah, nothing in this video is "low hanging fruit". These were monumental targets that earned people Nobel prizes. The rest of what you said is gibberish.
Isn't the body wonderfully complex? Just my undergrad a+p, histology, biochem classes amazed me. NSAIDS have saved the day so many times! Can we get a "future of pharmaceuticals" video. The VA is already actively seeking volunteers so they can eventually use a test to see how an individual will respond to certain drugs and my dr. Tells me they may be able to customize your drugs through a computer program...? Sounds out there!
I've never heard the idea that because the oceans aren't made of soda, therefore the earth is flat. That's some wild unhinged quackery if ever I've come across
Its really great to not have to deal with all those old diseases. Sometimes old people will be like "I remember being in bed for 3 weeks from djhdkc disease". And its some disease that makes your skin fall off and bones bend sideways!
❤❤❤
As long as we take the vaccines that are available. If we don't we may see many of them again. It's happening now
What a wonderful video. All to often all I ever see on social media is anti-pharma rhetoric so this is a breath of fresh air. Some truly outstanding work, conducting by giants in their fields.
Hope you have a nice day. We've summarized the main points discussed for convenience, but encourage watching the full video to get maximal value from the creator's knowledge. Click the link in my profile if you need summaries.
Here is a summary of the key points from the transcript:
0:00 - Introduction. The post-WWII period was one of rebuilding and investment, which benefited the pharmaceutical industry. Leadership in the field shifted to the US.
0:30 - Discovery of cortisone as a treatment for rheumatoid arthritis by Philip Hench, Edward Kendall and Tadeusz Reichstein. Led to the 1950 Nobel Prize. Opened up steroid research and chemistry.
1:15 - Synthesis and production of cortisone by Merck chemists was an immense challenge. This effort established Merck as a top pharma lab.
2:00 - Discovery of NSAIDs like ibuprofen as simpler anti-inflammatory alternatives to steroids.
3:15 - Breakthrough in treating psychotic disorders with chlorpromazine, the first phenothiazine antipsychotic. Marked the beginning of more effective psychiatric treatments.
4:45 - Pioneering antimetabolite research by George Hitchings and Gertrude Elion at Burroughs Wellcome. Led to 6-mercaptopurine for leukemia treatment.
6:30 - The 1950s saw many important new drug discoveries, chemical and biological breakthroughs, and progress in previously untreatable diseases.
7:30 - The 1950s also marked the beginning of "lifestyle drug" research.
Overall, the transcript covers key medical innovations in the pharmaceutical industry in the 1950s, including cortisone, NSAIDs, antipsychotics and antimetabolites. It highlights the rebuilding post-WWII and the rising leadership of the US pharma sector.
Love this type of content thanks professor dave
I love your content, im using it for improving my general knowledge aswell as improving my English skills (im German). I can usually keep up but sometimes I have to rewind and listen to some parts again ^^
Your videos are always so interesting.
A very happy teachers day to you professor!
Thanks so much, I am very happy to see more of this series!
Excellent, Marvelous. ..I m an Ortho, still longed for this for long time....Thanks A Million Ton Dear
It would be awesome to learn about the differences in protein and steroid hormones. Maybe even more broad, like comparing lipid chemistry, protein chemistry, and sugars?
Can't wait for the next installment!!
My dad worked in R&D for human and animal pharmaceuticals all my life until he retired a few years ago. He has friends from his time at Pfizer that worked on their Covid vaccine.
Love the vids bro. Keep them going.
The playlist is very good and fantastic
I am a pharmacist and i want more details about the history of drug can you give me accurate resources for that ??
Don you need to see this, it's an epic series 🎉
Will do, friend
Love this new series! Nice one Dave!
Crazy how I literally had a random desire to search "history of drugs" and got your videos.
I caught up with the whole series before this one and I'm stoked to see its an ongoing thing. 😁
I hope you get into some non-medicinal drug history such as ayahuasca, mushrooms, marijuana, the dea, timothy Leary, and modern designer drugs
I dunno. I'm not like that the golden age is in black and white. What does that imply about today?
Amazing!!!!
Nicely done 👍🏻✅
Super cool
Typical Italian-style pasta: Let’s start with the basics. First, make the sauce: Pour a little olive oil over a finely chopped onion in a pan. Fry the onion until it’s golden and then add chopped tomatoes (about 800 grams) and salt. Simmer the sauce for 10 minutes. Now, for the pasta: Boil a large pot of salted water, and add the pasta (preferably, in order to follow Italian tradition, spaghetti). Remember: the pasta should be added only when the water is already boiling. Doing the opposite is a very common mistake. Stir it to keep the noodles from sticking. Taste the pasta to gauge its readiness (see below for more on how to make sure your pasta is al dente), and drain it when it’s done. Add the sauce and mix. Garnish with a sprinkling of Parmesan cheese or Grana Padano.
what do you think of radio therapy
This was amazing. Could you do one on the history of insulin? Why is it so expensive?
That's what the previous one was on! Check the playlist.
It isn't, most high income countries pay x8 less than US citizens for insulin. What IS expensive is the US healthcare system.
great video
On the issue of psychiatric Pharma, you need to look into the work of Robert Whitaker, who wrote Anatomy of an Epidemic. While they can help some, their side effects can be extreme and dangerous, and are largely ignored by psychiatry. There is also the antidepressant merry-go-round that keeps patients on these often-marginally-useful medications for years, switching from one to another when the first proves to be ineffective. The drug companies laugh all the way to the bank.
Yeah none of that is accurate. Try actually talking to somebody whose psych meds work for them.
@@ProfessorDaveExplains i dont know about robert, but forest whitaker is a great actor.
@@ProfessorDaveExplains
Not true.
Psych meds do more harm than good. You have a lack of discernment. You can't tell what is true and what isn't when given information.
You shouldn't be teaching if you don't have the truth.
Would be interested in hearing your take on Astral Projection, from the cia, the monroe institute, ancient religions from Egypt to India. Also a prominent idea amongst mesoamerican tribes. Do you think 1. People made up stories passed down over time, 2. Certain breathing exercises and sounds can trigger a local psychedelic level experience(my belief), 3. Some stuff about frequencies, earth magnetic resonance, or some other shit they say to justify an subjective brain experience into being real.
Hey Dave
Wish we could get back to making medicines for the betterment of humanity instead of shareholder profits
Why would you presume those are mutually exclusive, champ?
@@ProfessorDaveExplains I'm probably going to sound like a moron here but, I suppose I have that belief b/c it appears that the pursuit of profits is the only motivation companies have. It also seems as if many companies will do anything to increase their bottom line. Maybe I should think about the question a bit more though.
You can say that about literally any company and any industry in the history of mankind.
@@ProfessorDaveExplains You're not wrong, man. To be more precise, I don't believe the marketing tactics employed by pharmaceutical companies serve society's best interests. Commercials that prompt average people to ask their doctors about a specific drug may not be the most responsible approach; they can lead to unnecessary prescriptions. Additionally, the opioid epidemic offers compelling evidence against the pharmaceutical companies responsible for manufacturing and marketing these drugs-both through TV advertisements aimed at consumers and promotional materials for doctors. We should also consider the pricing of cancer medications, which are prohibitively expensive for many people. While I understand that pharmaceutical companies need to turn a profit and recoup their initial investments, there comes a point when we must ask: is it profits over people? I apologize if I sound uninformed; I'm not as knowledgeable as you, which is why I follow your channel. Thanks Dave, I appreciate you and the work you do.
Advertising is a part of any capitalist society and that people get addicted to opioids does not make the manufacturer accountable nor does it make those drugs less important as pain killers. They're not saints, they don't lift a finger to help solve anything. But it's really not their fault. Drugs being expensive is also not their fault, that is the fault of insurance companies. The government should pay for it, just like in any other civilized nation.
This is the best playlist ive listened to every video at least four times now so good especially for a long car ride
Thank you chemistry Jesus
I like to think of him as Nietzsche's Ubermensch or Anti-christ, lol!
❤
The era of low hanging fruit for pharma. Before evergreening, publication bias, and inventing diagnoses.
Yeah, nothing in this video is "low hanging fruit". These were monumental targets that earned people Nobel prizes. The rest of what you said is gibberish.
Isn't the body wonderfully complex? Just my undergrad a+p, histology, biochem classes amazed me. NSAIDS have saved the day so many times! Can we get a "future of pharmaceuticals" video. The VA is already actively seeking volunteers so they can eventually use a test to see how an individual will respond to certain drugs and my dr. Tells me they may be able to customize your drugs through a computer program...? Sounds out there!
slay
Ahhh time for some science jesus
Dave, you preach that the earth is flat but you have to realize that most of the water is uncarbonated, making the earth pretty flat
I've never heard the idea that because the oceans aren't made of soda, therefore the earth is flat. That's some wild unhinged quackery if ever I've come across
2nd defeat in 26 years. Your script is incorrect.
wut
You good champ? Need to talk to someone?
video is too long for me, please make a short out of it.
Come on, bud. Get a longer attention span.
@@ProfessorDaveExplains Or a diagnosis and some adderall, lol!