So you’re right and Hydroxyls are not good leaving groups... based on the high pKa of water, you can infer that it’s conjugate base (hydroxide) is very unstable... I should not have used a hydroxyl as the leaving group.... it can act as a leaving group (and magnitudes better than a hydrogen or carbon leaving group) but nevertheless it was not a good example...
These videos are a God-send. Thank you so much
FORM A BOND BREAK A BOND ✍🏼 ✍🏼
thank you so much
Thank you!!
Bst explanation on the internet
bless your soul
I was under the impression that hydroxides are terrible leaving groups. Is it just a "relatively" stable leaving group in these aldol reactions?
10:04 Also, would the compound with the benzene ring have more resonance stability and therefore more likely be the nucleophile?
So you’re right and Hydroxyls are not good leaving groups... based on the high pKa of water, you can infer that it’s conjugate base (hydroxide) is very unstable... I should not have used a hydroxyl as the leaving group.... it can act as a leaving group (and magnitudes better than a hydrogen or carbon leaving group) but nevertheless it was not a good example...