Gosh ! Thank you so much Dr Neil these videos are amazing and just want i need now in my dedicated . You have no idea how you've helped a lot of people, thank you and God Bless you .Saw your video recommendations on reddit too.
i have been running in circles for weeks trying to find a way to finally understand basic biochem and ACTUALLY ENJOY IT! Thank you so much for what you give to be world may god always bless you! forever grateful from the Dominican Republic.
I appreciate this video immensely. It has helped me grasp a topic that has been a source of nightmares for me. I am grateful for the clarity it provided.
Thank you so much, sir. This really helped me understand what I was struggling doing my UWORLD questions. You are amazing. I hope I can meet you one day in Pensacola.
@@RandyNeilMD I’m KBMS student, final year of my specialty to become a nephrologist, but I’m also studying USMLE meanwhile, your videos are utmost resource I’m using ! Thanks always sir, really appreciate your efforts making all those videos for free…
Whats the difference between DNA polymerase 3 and 1? Always confused when it comes up in questions So 3 has exonuclease. 1 removes RNA primer and adds DNA. Is that it?
DNA polymerase 3 replicates the leading strand and lagging strand from 5' to 3' then proof reads to make sure that there is no wrong bases inserted via exonuclease activity in the opposite direction 3' to 5'. DNA polymerase 1 replicates the lagging strand in just the areas were occupied by the RNA primer so in order to do that it needs to have the same functions of DNA polymerase 3 plus the ability to excise the RNA primer By exonuclease in the direction of 3' to 5'. I like to think about it DNA polymerase 1 cuts RNA primer nucleotide from 3' end( this is the function of 5' to 3 exonuclease) and replace it by adding nucleotide to the 5 end of the previous fragment and so on till done from replacing the entire piece of RNA then it can do the proof reading from 3' to 5' to make sure that every thing is good ( that part is similar to DNA polymerase 3)
@@HassanPoyo DNA Polymerase 1 building DNA in 5'to 3' which is the usual direction and exonuclease activity from 3' to 5' like DNA polymerase 3 plus exonuclease from 5' to 3' to be able to remove the RNA prime
@@HassanPoyo 😂😂😂😂 DNA polymerase 3 and DNA polymerase 1 build DNA from 5' to 3' and proof read read via exonuclease from 3' to 5'. ONLY DNA polymerase 1 has also 5' to 3' exonuclease activity to enable him to remove the RNA primer pieces. try to read my initial comment now and see if it makes sense. Sorry if I confused you more.
KEEP TELLING THE STORY... STUDY HARD. IT WILL PAY OFF.
Hi Dr. Neil. What’s the best way to reach you and send questions?
OH MY GOD THIS VIDEO CAME RIGHT ON TIME!!!!!!!!!!!!!!!!!. I ALWAYS END UP FORGETTING THOSE ENZYMES!!
You rock Dr. Neil!!!!
Umer... PERFECT TIMING.
Gosh ! Thank you so much Dr Neil these videos are amazing and just want i need now in my dedicated . You have no idea how you've helped a lot of people, thank you and God Bless you .Saw your video recommendations on reddit too.
Merocode, Thank you for taking time to comment. I'm glad the videos have been helpful.
i have been running in circles for weeks trying to find a way to finally understand basic biochem and ACTUALLY ENJOY IT! Thank you so much for what you give to be world may god always bless you! forever grateful from the Dominican Republic.
Paloma, Glad it was helpful... I need to keep expanding it... I just got side tracked.
Thank you so much for taking the time to make these videos and helping students like me . I really appreciate it
Sadaf, You are most welcome.
GOSH ! you've really made it easy and understandable , you're simply second to none!
wish i could teach like you , wanna be teacher like you.😀
You have made biochemistry look easy.
Thank you from india🙌
Shiv, Glad it was helpful. Keep studying HARD!!
I appreciate this video immensely. It has helped me grasp a topic that has been a source of nightmares for me. I am grateful for the clarity it provided.
thanks a ton! you have no idea how much time this video saved me
Most underrated channel. Thanks Doc.
Appreciate the comment Youmna.
This video is amazing. I cannot believe how easy you made this topic for me. Thank you so much for telling that story!
PERFECT!!
Thank you so much, sir. This really helped me understand what I was struggling doing my UWORLD questions. You are amazing. I hope I can meet you one day in Pensacola.
Glad it was helpful... Look forward to the day.
Lets get an immunology tell the story!!! This is an amazingly peaceful way to study
Sounds like plan... it just may take a while... plus, I think PATHOMA has the market on that one...
Thank you! had to relearn this 5 years after high school
This should be the last time (hopefully).
Thanks a lot no one ever explained this topic for me like this before 🤩
sir you make a great difference in this world by reaching out to world . i appreciate it
i like you idea of #BACK TO BASICS
Navdeep, You are most welcome. Thank you for taking time to comment.
Your videos are very helpful especially for imgs
Great video! Thanks got to revise very imp concepts
Glad it was helpful.
Oh God, I needed this video! Thanks sir!
Xaaboo, Hope it is helpful. Keep studying hard.
@@RandyNeilMD I’m KBMS student, final year of my specialty to become a nephrologist, but I’m also studying USMLE meanwhile, your videos are utmost resource I’m using ! Thanks always sir, really appreciate your efforts making all those videos for free…
Excellent video and I always struggle with the difference between polymerase 1 and polymerase 3
Its explained wonderfully 👏.
Perfect.
Thank you so much Dr Randy!
You are most welcome
Thank you Dr Neil.. this topic was my nightmare but not anymore. Love from Nepal 🇳🇵
Congratulations! Good job
Thank you Mirley.
It's a very good video. nicely explained
Thank you M
Thank you dr Neil
You are welcome.
Superb , thanks for your great videos
You are most welcome. Glad it was helpful.
You are a genius! ❤️
hardly, but thank you.
Saved my life 😢❤❤❤❤❤❤❤❤
Not a problem... :))
O woooowwww!!!!! Awesome stuff 👏, awesome video though
I have the feeling that Dr Neil got a whip amirightornot?? thx for the good videos much appreciated 🙏🙏
You know it..
🎉🎉🎉 wow 🎉🎉 you made a boring topic super relaxing to understand !
Perfect!!
God bless u❤
Thank you
Hi sir... You are great 👌👍
Thank you.
So helpful thank you 🙏
Nagwan, Glad it was helpful.
Sir it's Fabolous Shift Gear for smooth drive as in life 🧬🌹♥️
Living the dream...
So why do we make okazaki fragments and not continuous in the other strand ?
It's has to be in 5 --> 3 prime direction
@@RandyNeilMD yes but why cant they be continous.
Whats the difference between DNA polymerase 3 and 1? Always confused when it comes up in questions
So 3 has exonuclease. 1 removes RNA primer and adds DNA. Is that it?
DNA polymerase 3 replicates the leading strand and lagging strand from 5' to 3' then proof reads to make sure that there is no wrong bases inserted via exonuclease activity in the opposite direction 3' to 5'.
DNA polymerase 1 replicates the lagging strand in just the areas were occupied by the RNA primer so in order to do that it needs to have the same functions of DNA polymerase 3 plus the ability to excise the RNA primer By exonuclease in the direction of 3' to 5'.
I like to think about it DNA polymerase 1 cuts RNA primer nucleotide from 3' end( this is the function of 5' to 3 exonuclease) and replace it by adding nucleotide to the 5 end of the previous fragment and so on till done from replacing the entire piece of RNA then it can do the proof reading from 3' to 5' to make sure that every thing is good ( that part is similar to DNA polymerase 3)
@@tarekhanna2647 so polymerase 1 can work in both directions. 3 only in 5 to 3 prime?
@@HassanPoyo DNA Polymerase 1 building DNA in 5'to 3' which is the usual direction and exonuclease activity from 3' to 5' like DNA polymerase 3 plus exonuclease from 5' to 3' to be able to remove the RNA prime
@@tarekhanna2647 so both polymerase 1 and 3 can work in 5 to 3 and 3 to 5 direction?
@@HassanPoyo 😂😂😂😂
DNA polymerase 3 and DNA polymerase 1 build DNA from 5' to 3' and proof read read via exonuclease from 3' to 5'.
ONLY DNA polymerase 1 has also 5' to 3' exonuclease activity to enable him to remove the RNA primer pieces.
try to read my initial comment now and see if it makes sense.
Sorry if I confused you more.
THIS IS MAGIC. exam in two hours, if i pass this i’ll owe my grade to you 🪄
CONFIDENCE is KEY!