Biotransformation, Detoxification, Metabolism of Xenobiotics

Phase 1 Reactions
1. Oxidation/ Hydroxylation
involves cytochrome p450
examples- Oxidation of Alcohol, aldehydes, amines, aromatic hydrocarbons, sulfuric compounds, drugs
2. Reduction
examples- nitro compounds, picric acid, Chloral
3. Hydrolysis
examples- Aspirin, atropine, procaine, xylocain, DFP etc

[@prasadhegde7559]

You are the best biochem professor i have seen sir. Your lecture will be crisp and perfect. No requirement of books when heard your lectures.

[@ayushdev007]

That's basically entoxification na?

[@RABPD]

Outstanding sir ....fully detail ...no more question left behind after watching this video

[@Sonu_daily_vlog_mbbs]

Tere ko sab smej aa gya

[@incredulous-]

For questioning you must know extra from before itself

[@divyangsarvaiya9388]

Thank you very much sir.. can't define how important you are for biochem .. gonna suggest all my jrs. About ur channel

[@rikganguly4986]

Dear sir, I really appreciate your reasonable effort in teaching a complex subject like biochemistry so nicely. I have a humble request, most of the textbooks show phase one as consisting of oxidation-reduction and hydrolysis. similarly phase two consists of conjugation pathways. thanking for your great effort and excellence in teaching, my humble regards.

[@sharonpanneerselvam4000]

Thank you so much Sir! You are great! Thank God I discovered your videos on RUclips. I am preparing my Biochemistry Final Examination and thanks to your lectures I can understand the stuff more easily!! Thank you soo much and God Bless you! ❤️

[@Dr.Vyshnavi]

Sir, very good explanation, thank you so much sir, keep going, all the best 👍💯-your lectures are amazing always, even the audio clarity is good 👍

[@jyotikomal9398]

this is life saver video sir thank you for your efforts 🙏🙏🙏

[@harshitapatnaik2115]

Thank u so much Sir 🙏🏻🙏🏻🙏🏻 .. u r the nly teacher for whom now a days i cn cover my chapters 😇😇😇 Thanx a loott Sirr🙏🏻🙏🏻🙏🏻❤️❤️❤️

[@yvsairam7012]

Tq very much sir
I have one doubt sir
Could we take another example for reduction sir that is
Conversion of nitrobenzene to amino benzene
Along with your example
Nitrophenol to aminophenol

[@vaibhavi7718]

Awesome explanation 😊
Please make video on free radicals and antioxidants.

[@sonudesai3310]

Wonderful explianation great time management

[@avinabakarmakar]

14:19 Doubt : Sir, you have told Formic acid is more toxic than ethanol, but in detoxification that is in hydroxylation methanol is converted into formic acid, how ????

[@shanaya6749]

detoxification itself doesnt mean converting into more toxic substance ,its a misnomer as sometimes the detoxified product might be more toxic than original form

[@Prasanth2403]

That is not detoxification it is called entoxification

[@biologyisfun]

Nobody thinks this way mam😅

[@sangramnayak9762]

As methanol converted to formic acid by oxidation which is one of the step of detoxification but result product is more toxic than methanol

[@AYT110]

may I have ur insta id ?

[@manalij8140]

konala shikvaayla challi ahe tu 🤦‍♀️

[@nlnrao123]

U made it very simple and easy to understand sir
Thank you

[@s.h.w.e.t.a.]

Thank u very much sir... Bahut hi behter samjhya apne ... Class me itne ache se clear nhi hua tha .. Bt ab koi doubt nhi h😊😊👍👍👍

[@_WaTeR_793]

Sir your explanation is outstanding

[@Tannyyyyyyyyyyy]

Great Explanation sir.Thank you

[@dhx8452]

Aah ooh thalaivare

[@dr.strange8311]

Nakkuu

[@vishnumohanan947]

Thank you so much sir very good lecture

[@arnavgandhi7620]

outstanding, very helpful

[@SOMERANDOMPREPPY]

From 6:12 the important points are explained… before all are basics

[@radhakrishnanravichandran534]

Awesome explanation sir...tq sir

[@krishnalal9965]

Mast explained kiya sir ji aapne.

[@lordshantel185]

How do we explain the relationship between phase 1 and 2 reactions in xenobiotics?

[@rachelarc8837]

Wow amazing! This is helpful

[@hrijxy]

Sir your lectures are really helpful.✅

[@rajkumarm9829]

Sir pharmaceutical biochemistry notes videos

[@user-jj1ed8hf6e]

Did you know smily didi...? Plz.. You must know...

[@MMIliyas]

It help me alot

[@chichu9521]

This yr we got this question sir 🥴it's a bouncer question for us

[@hardikgangwal6691]

great lecture thanks a lot 😊😊

[@DrRakeshVerma001]

Normally,drug or xenobiotics metabolism occurs in phase 1 followed by phase 2 reactions. My question is there any drug which undergo phase 2 reaction first then to phase 1 reaction for metabolism?

[@harshitapandey2924]

Amazing work sir

[@jyoti2577]

Nice sir 👌👌

[@pradeepmittal7313]

Sir, how you remember all this, great

[@sivagurunaathan5719]

Looking like selvaraghavan❣

[@dr.strange8311]

Oombu

[@dattatreyomitra3906]

thank you sir...it was really helpful

[@alishasayyad5396]

Thank you so much sir 🙏

[@RohitArya-dr6vz]

If your lecture in hindi then we are hindi medium students ka bhi bhala ho jata hai....
Baaki aap likhiye english me hi

[@Ishitajaiswal3449]

Sir it's a biochemistry topic but y it always related with pollutant transformation mean is biotransformation of pollution and biotransformation of xenobiotic is same

[@Acts-4-12]

💜

[@jayanighangas2638]

Thnku soo muchh sir🙏🙏😊😊👍👍

[@srikanth.m5487]

Super sir👌👌👌

[@shrustisoumya2895]

Sir cyt p450 enzymes are located in ER OR MICROSOMES if both option given in mcq

[@pragnithram6130]

microsomes

[@vickimichael255]

Thanks sir this was very helpful

[@Lushbeauty00]

thank you so much for the lecture.

[@fardinqureshi535]

Excellent work sir

[@boddepallijiveeta6597]

Tq so much sir,u saves our time😁

[@patelafifa.9697]

Wooww thank you so much

[@daniyalhaider7883]

bestest

[@chaudharyanshusingh9525]

You are best sir ❣❣💚💚🙏🙏🙏🙏

[@rajayeducation6581]

Thank you sir
It is very helpful for me

[@zaidgauri5236]

Thanku sir 👍🏻👍🏻

[@herusayshaye]

Sir ,Are xenobiotics always undergoing detoxification??????

[@herusayshaye]

Cant they become more toxic on biotransformations ??

[@yogeshwarikhedkar]

In the which lesson, detoxification given ?????

[@Kittupatel089]

Which book u prefer sir ??

[@Rajesh_Jambhulkar]

Vasudevan

[@sonam268]

Thanks ☺️ sir

[@shadilhassan6890]

Respected sir I have completed my bsc MLT I want to go for clinical biochemistry course which course is best for me MSc MLT clinical biochemistry or Msc clinical biochemistry

[@Ankit.malyaj]

Thank you so much sirr ❤❤❤😊😊😊

[@shivanagpal1163]

Thank u sir 🙏

[@shahabuddin6149]

Super lecture Sir thanks alote

[@souravmohanty1200]

Thank you sir 🙏🙂

[@hridoykrishnaborah2438]

Thank you sir❤️

[@nishidwivedi4405]

Sir please upload phase 2 also ASAP 🙏🏻

[@muhammadsulaiman6023]

Phase 2 rxns occurs in mitochondria and cytoplasm of liver cell. They are also called synthetic rxns. Conjugations of xenobiotics takes place. Mostly by UGT...

[@nishidwivedi4405]

MUHAMMAD SULAIMAN
I m not asking for a definition 🙄

[@muhammadsulaiman6023]

@@nishidwivedi4405 it's not definition

[@nishidwivedi4405]

Sukriya Jo bhi tha 😊

[@visualsofautif1233]

Is bilirubin a xenobiotic?

[@nityaupadhyay4823]

Nice sr

[@heenakanwal6777]

Sir plzz video on metabolism of fructose

[@user-nh3hq7cs2d]

thank u!!

[@yuktabodade6942]

Thank u very very much sir.
u listened that

[@abdulhayeekhan9394]

Ey method biodegradation of xynbiotics ky topic pr bhi lokh skty hy....

[@vps5362]

Why bilirubin is foreign compound?

[@sarathgopan3592]

Compounds produced in the body which are to be eliminated, e.g. bilirubin and steroids. Bilirubin is toxic to the brain of newborns and may cause irreversible brain injury. Biotransformation of the lipophilic bilirubin molecule in the liver results in the production of water-soluble (hydrophilic) metabolites excreted into bile.

[@ragnarok9197]

🔥🔥🔥

[@jainilgor3178]

Thank you sir

[@vishnumohanan947]

Thank you so much sir very good lecture

[@Aiming-zw8xo]

Thank you sir 😊🙂

[@ruma7664]

Thank you sir 😊