Activated Charcoal Mechanism of Action in treatment of Poisoning | Charcoal Adsorption Principle

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Activated charcoal adsorbs ingested toxins within the gastrointestinal tract preventing the systemic absorption of that toxin. Activated charcoal only absorbs toxins that are in the dissolved liquid phase via direct contact. Orally administered activated charcoal does not get absorbed through the gastrointestinal lumen and acts within the gastrointestinal (GI) tract in its unchanged form. Ingested toxins come in contact with activated charcoal if the drug has not yet been absorbed from the gastrointestinal lumen, or via recirculation of the toxin into the gut lumen by either enterohepatic recirculation, or entero-enteric recirculation through active secretion, or passive diffusion.
Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from the incomplete combustion of carbonaceous organic matter. It is activated by an oxidizing gas flow at high temperature passed over it. It is used as a gastric decontaminant and emergency medication to treat poisonings following excessive oral ingestion of certain medications or poisons by absorbing most drugs and toxins. Active charcoal acts by binding to pharmaceutical drugs or poisons such as organophosphates and decreasing the systemic absorption of toxic agents. Molecules with a large volume of distribution, thus likely having higher lipid solubility, tends to bind have better absorptive binding to activated charcoal. Following the administration of activated charcoal, cathartics are indicated to evacuate the charcoal-poison bonded complex from the gastrointestinal tract. Activated charcoal may also have an effect on systemic drug levels by lowering the serum levels of already absorbed drugs or toxins. Many absorbed drugs that undergo significant hepatic metabolism and conjugation are eliminated via bile into the small intestines. When they reach the small intestines, drug conjugates can undergo hydrolysis and return to the enterohepatic circulation. Activated charcoal interferes with this process and binds to the conjugated drug before hydrolysis or the free deconjugated drug before reabsorption.
Activated charcoal is used as a gastric decontamination agent in emergency clinical settings in case of poison or medication overdose. Studies show that early administration of one dose of activated charcoal can adsorb poison in the stomach and reduce absorption while it also works long after ingestion, by interrupting of enterohepatic and endovascular cycling of poison.
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[@mohammadshahnawaz2154]

Best explanation sir ❤️

[@Ashish_HB]

Q. Famous/ mostly used antigout drugs are.. ???

[@Ozone-O3w]

Mah_sha_allah sir

[@indianboy8745]

Sir poison bale human ko charcol dry deina hota hai yaa liquid form mai
Or sulphas balei human ko dei saktei hain kiya

[@permijitdunkley1697]