Jurgen Knoblich (IMBA) 2: Modeling Human Brain Development in 3D Organoid Culture

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  • Опубликовано: 18 дек 2024

Комментарии •

  • @Autepify
    @Autepify 7 лет назад +39

    Why is no one talking about how incredibly groundbreaking this is

    • @knockhello2604
      @knockhello2604 3 года назад +5

      Too worried about bullshit

    • @AustinLeeWNSP
      @AustinLeeWNSP 2 года назад

      sorry but the flow of information is dictated by the government who in turn would like you to be less aware of how things work, cause they have plans for you. Fill that head with knowledge before they make it impossible to do so

    • @anmcdd4915
      @anmcdd4915 Год назад

      Because of the HUGE limitations and still ZERO useful practical application. Especially when it comes to mental illness. Not to mention that IPSCs have caused faster death in a number of cancer patients. The potential is one thing, reality check completely something else.

    • @soulbrother12
      @soulbrother12 Год назад

      It takes time, for neurons to process and connect their own development...its like looking into a mirror, without realising, that this information is about US and our own neurons

  • @louiesumrall358
    @louiesumrall358 6 лет назад +3

    Thank you for all the recapitulation...

  • @hraqhraq
    @hraqhraq 3 года назад

    correction at 1:54 "On Apical" not "On Basal"

  • @crazylisi
    @crazylisi 5 лет назад +1

    This right here is why Neuroscience is awesome! Could you enable closed captions [CC] so I can translate the subtitles for other people, please? :))))

  • @kenotmane
    @kenotmane 5 лет назад +1

    Has the study by Magdalena Renner on repairing the mutation in CDK5Rap2 been published yet? I would love to read it for my research project. This was such a helpful video, thank you!

  • @sirranhaal3099
    @sirranhaal3099 6 лет назад +1

    That is some crazy shit. How do you specify ventral v. dorsal organoid programming? I guess I will have to read the paper :)

  • @neuropsych2
    @neuropsych2 4 года назад +1

    "And here on the more basal side is the cortical plate......and here on the more basal side is the ventricular zone.." UGH--HE MISSPOKE!!! So no one screws up with this, the ventricular zone is on the apical side NOT the basal side.

  • @radwanabu-issa4350
    @radwanabu-issa4350 6 лет назад +2

    I think the lack of tissue vascularization would limit the quality of such organoids!

    • @anmcdd4915
      @anmcdd4915 Год назад

      No. Visualisation is actually great. The limitations are of different nature.

  • @catminion1425
    @catminion1425 3 года назад +1

    Using 3D printing nanomaterials that'll allow the arrangement of a scaffolding structure to suffice will give way for circulation of oxygenated water/ nutrients that will in effect allow neural organoids to grow even LARGER to the capacity of engineering an entire brain.

    • @jazzblue7497
      @jazzblue7497 7 месяцев назад

      I wonder how far they have come in this field, for I immediately thought the same

  • @alaahussein6030
    @alaahussein6030 7 лет назад

    think you .....

  • @ShrekReacts
    @ShrekReacts Год назад

    Knob lick

  • @PeterFellin
    @PeterFellin 7 лет назад +1

    I predict that a very significant factor behind migraines and epilepsy is going to be found to be a "conditioned-in" excessive firing of excitatory neurons - a firing that 'forces' a functional deficiency of otherwise normally developed GABA-ergic interneurons.
    I perceive and recognise the enormous significance of that at least one incurred "CURSES" (short for Conditioned-in, {kept} Unconscious, Reverberating State {or states} Effecting Symptoms) has more often than not gotten 'put' (within a migraine or epilepsy *or otherwise* symptom-manifesting person's neural "*actention* selection serving system"); and that in every such case a primarily insidious CURSES was 'put' because of a corresponding, for any reasons ended up *under*, threat of *"traumatizing"* type.
    "Trauma" is a very tacky (i.e. imprecise and meaning-muddled) Freudian term that I've relieved myself of almost always having to use.
    I did so by (ÆPTly) contriving (and defining and justifying), in complementary conjunction with coming up with "CURSES", the 'SEPTIC humored' and 'distinKtly' didactic (deservedly so) ÆPT concept (or concEPT) of "*a threat that implores* (or threats that implore as in demand or require) *Specific/synaptic Hibernation (SH)*". This far from crappily conceived MAD-inspired 'compound concEPT' is of course meant to be allusively expressed/put to use as (e.g.) "a *SH imploring threat*".😎
    P.S. The important topic I'm broaching is naturally so off-putting that I tried to and succeeded at getting excEPTionally explanatory philosophical traction on it through various kinds of facilitating sem_antics (wordplay) and injections of not just MAD-inspired SEPTIC humor but also antiSEPTIC humor (appearing elsewhere within 'ÆPT').

    • @Rolsification
      @Rolsification 5 лет назад +7

      science is still working out how to remove this man's head out of his own ass