**Correction*** Hey Ninja Nerds!! The laryngeal cartilages are actually derived from the 4th and 6th pharyngeal arches NOT the 1st!!! Sorry about that ninja Nerds!!! Hope this video is helpful! Love you ninja Nerds!!!
Hey man can you tell me something I'm a bit confused about it Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?
Development of limbs 1.HOX, TBX4 & TBX5 genes determine the position of formation of limb buds. Once activated, they stimulate release of FGF-10 (fibroblast growth factor). Ectoderm grows off as 4 limb buds. Somatic layer of lateral plate mesoderm moves into limb buds. FBG-10 stimulates a thickening at the tip of the limb buds called apical ectodermal ridge (AER). AER secretes FGF-4 & FGF-8 which causes proliferation of somatic mesoderm. the most distal part keeps proliferating (progress zone) while the proximal part of limb bud starts to differentiate. From cartilage to bone (endochonrdal). Some tissue in AER undergoes apoptosis due to bone morphogenic protein (BMP) & retinoic acid increase. Starts to form fingers. Mesoderm starts to proliferate to make finger bones. AER dies off to stop growth. Tissue called zone of polarizing activity (ZPA) develops on posterior disal limb which causes the asymmetrical growth of the hand. Thumb to pinky.
Hello Zack, I’m a medical student from Iraq, and I just want to thank you for all the work and time you’ve given for everyone who watches your videos. You explain in a such way that is comprehensive yet still fun and enjoyable. Keep going man, wish you the best of luck!
Hey man can you tell me something I'm a bit confused about it Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?
when my med school prof lectures about this subject she just throws it all up on one powerpoint slides and talks through the whole thing at once, which i find very hard to follow and understand. drawing it out step by step like this is immensely helpful, thanks!
Hi Zach. I am Alice, a Nursing Student from Nigeria. I love your energy and enthusiasm while teaching. You also made this topic easier for me. Thank you.
I just wanted to say a most sincere THANK YOU! I really appreciate your work and you must know how much it helps everyone who wants to learn. Thank you again ♡
Brilliant as usual. But what i really want to thank you for is your positive energy. I woke up not in the mood for learning anything about embryology 😂. But the way you explain and the way you seemed so excited is so refreshing! And contagious. So again, thankyouu for making our lives easier
Hey man can you tell me something I'm a bit confused about it Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?
Hi ZACH . I am an Electrical Engineering Student But I'm here to Subscribe you channel because My Brother loves Your Lectures. Keep up the great work! LOVE From PAKISTAN..............
Hey man can you tell me something I'm a bit confused about it Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?
During the first half of the video I was trying to figure out what kind of drug Zach is on. Then I realised it's just embryology. Because damn, embryology is so so cool!!
Thanks ninja nerd, i am a second year medical studen from venezuela, your videos are super easy to understand and it have being keeping me motivated trhough quarantine. I am even thinking about opening my own youtube channel now. thanks
Hey man can you tell me something I'm a bit confused about it Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?
Hey man can you tell me something I'm a bit confused about it Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?
One interesting (important) fact: The nucleus pulposus is the only remnant of the notochord, not sclerotome! Sclerotome gives rise to vertebral bodies, annulus fibrosus of the intervertebral discs and ribs!
Hey man can you tell me something I'm a bit confused about it Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?
He is the best believe me.Anyone who is reading comments to see whether he is good just follow his lectures.Explaining embryology is really difficult but still he is from another planet.
from ninja to nerd and where I'm at? I'm dead in the water mate, and it ain't a pretty sight! But thank you for all the work you've done and are still doing.
Hey man can you tell me something I'm a bit confused about it Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?
Its 3:00 am, i have an end of sem 1 exam and things just escalated quickly from neuroanatomy to embryology to bchem...am glad this made my work 1000 times easier
Thank you so much for the embryology lecture!!! Just want to make sure that does hyoid bone and laryngeal cartilage comes from 2nd~6th pharyngeal arch. thanks a lot
I just got my psychotic preworkout in the mail! Omg!!! I feel the electrons coming out of my membranous neurocranium!!! Thank you Zach!!!! Biochemistry major let’s do this then MCAT!!
Zach, After watching many Ninja Nerd Lectures on RUclips, I've become very impressed with your knowledge. Are you accepting patient? If so, how would someone become a patient of yours?
Hello guys !!!! Omgggg thanks for amazing videos really !!! I swear when ever Zach says " oh man it's so cool " or " isn't that cool ?" I keep rewatching that part 😍😍😍and I swear I learn a lot better he knows how to drag good attention to super important parts !!! And yet keep it so intresting ! Like only by his joy in his face he converts all boaring materials into such a cool one to learn ! Thank you guys ! May God always bless you and get your backs !!! I love youuuuu guys
Hey man can you tell me something I'm a bit confused about it Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?
Limbs 1) Are visible as buds from the body wall during 5th week of development 2) contain bones derived from somatic mesoderm 3) contain bones derived from somatic mesoderm 3) contain bones established by endochoranial oossfication 4) upper limb buds arise 2-3days earlier than lower limb buds Which ones are true? I think all of the above🤷♀️🤷♀️
This topic is very amazing, as many details indicate the existence of a creator for man, and many thanks to you, amazing doctor, for your full discussion of the topic, you are the best doctor 🤍
**Correction*** Hey Ninja Nerds!! The laryngeal cartilages are actually derived from the 4th and 6th pharyngeal arches NOT the 1st!!! Sorry about that ninja Nerds!!! Hope this video is helpful! Love you ninja Nerds!!!
Hey, sorry I think the part where you explained the process of differentiation of fingers got deleted or skipped? Thank you!
I was going to correct this. Good job
Tnx
hyoid bone actually derives from second as you said in pharyngeal apparatus video
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I love it when Zach says things like, "isn't that cool?!" I swear having an excited, passionate teacher makes SUCH a difference. Thanks, Zach!
2:55 he even says "neural crest cells" as if he just met the love of his life for the first time AHHAHA great lecturer!!
Hey man can you tell me something I'm a bit confused about it
Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?
A Pakistani med student here, trying to study embryology from scratch 2 days prior to the exam. Thank you for your energy and explanation!
Same here , used to overestimate it, but it’s such an exciting subject, kudos to Zach sir
A Pakistani Med student here, learning a lot from your videos. Keep up the good work
Development of limbs
1.HOX, TBX4 & TBX5 genes determine the position of formation of limb buds. Once activated, they stimulate release of FGF-10 (fibroblast growth factor).
Ectoderm grows off as 4 limb buds. Somatic layer of lateral plate mesoderm moves into limb buds. FBG-10 stimulates a thickening at the tip of the limb buds called apical ectodermal ridge (AER).
AER secretes FGF-4 & FGF-8 which causes proliferation of somatic mesoderm. the most distal part keeps proliferating (progress zone) while the proximal part of limb bud starts to differentiate. From cartilage to bone (endochonrdal).
Some tissue in AER undergoes apoptosis due to bone morphogenic protein (BMP) & retinoic acid increase. Starts to form fingers. Mesoderm starts to proliferate to make finger bones. AER dies off to stop growth.
Tissue called zone of polarizing activity (ZPA) develops on posterior disal limb which causes the asymmetrical growth of the hand. Thumb to pinky.
sincerely, thank you for this. you have made my exam period at least an hour or two shorter.
Hello Zack, I’m a medical student from Iraq, and I just want to thank you for all the work and time you’ve given for everyone who watches your videos.
You explain in a such way that is comprehensive yet still fun and enjoyable.
Keep going man, wish you the best of luck!
Which book do he follow?
يييي بالقرآن
يامرحله ضلعي ويا كليه
@@Shinzo9567 طب تكريت مرحلة ثانية و انت؟
@@TheMoonlight258 اني هم مرحله ثانبة مستنصريه
Zach you are my mentor and hero. You don't even take Sundays Off! Thank you so much. God Bless you and everyone
We are always in your corner! No days off! 🤓
Hey man can you tell me something I'm a bit confused about it
Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?
i'm an Italian med student and I actually prefer this to may Professors. Thank you for everything you make Zack and crew
I am an Iraqi med student. Definitely, it’s better than what the professors give. It’s well organized and simply explained and understandable
when my med school prof lectures about this subject she just throws it all up on one powerpoint slides and talks through the whole thing at once, which i find very hard to follow and understand. drawing it out step by step like this is immensely helpful, thanks!
Those with ADHD but still fighting, i feel u and im proud of u guys we can be even better …
Thank you!
Hi Zach. I am Alice, a Nursing Student from Nigeria. I love your energy and enthusiasm while teaching.
You also made this topic easier for me.
Thank you.
Am a proud Ninjanerdian 🎉. Thanks buddy 👍
I just wanted to say a most sincere THANK YOU! I really appreciate your work and you must know how much it helps everyone who wants to learn. Thank you again ♡
Brilliant as usual. But what i really want to thank you for is your positive energy. I woke up not in the mood for learning anything about embryology 😂. But the way you explain and the way you seemed so excited is so refreshing! And contagious.
So again, thankyouu for making our lives easier
Hey man can you tell me something I'm a bit confused about it
Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?
I can't stress enough how you actually saved my medschool life 😭
Hi ZACH . I am an Electrical Engineering Student But I'm here to Subscribe you channel because My Brother loves Your Lectures. Keep up the great work!
LOVE From PAKISTAN..............
Thank you so much for providing all these lectures!!! 💕 looking forward to more embryology lectures from you!
Hey man can you tell me something I'm a bit confused about it
Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?
Nerdology : Development of Ninja Nerds
😂😂
That would be the study of ninja nerds. The development would be called Nerdogenesis. 😉
I am very grateful for the support you are giving us ninja nerds you are the most influential man in my medicine career
Zach is a treasure that must be preserved!
In love with his way of teaching 😭❤
During the first half of the video I was trying to figure out what kind of drug Zach is on. Then I realised it's just embryology. Because damn, embryology is so so cool!!
Never have I ever wanted to hit the like button so many times. Thank you so much!
Thanks ninja nerd, i am a second year medical studen from venezuela, your videos are super easy to understand and it have being keeping me motivated trhough quarantine. I am even thinking about opening my own youtube channel now. thanks
Hey man can you tell me something I'm a bit confused about it
Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?
Embryology😻 The greatest gift ever for my upcoming semester. Thank You Mr👍🏻👍🏻👍🏻👍🏻
I swear I have NEVER even considered signing up for Patreon for any other channel except this one. I hope I will in the future.
Thank you, thank you, thank you!
Keep it up with embriology!
Hey man can you tell me something I'm a bit confused about it
Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?
I always hated embryology!! until I found your videos :)) it can be sooo interesting! THANK YOU 😀
One interesting (important) fact: The nucleus pulposus is the only remnant of the notochord, not sclerotome!
Sclerotome gives rise to vertebral bodies, annulus fibrosus of the intervertebral discs and ribs!
Lots of love from Medical School of the University of The Gambia🇬🇲🇬🇲🇬🇲🇬🇲🇬🇲🇬🇲Thank you so much for your videos.. you're just Amazing!
brilliant teaching from you Zach...you're a blessing to us!
Hey man can you tell me something I'm a bit confused about it
Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?
Dear Zach Thank you for this! Explanation for the 44:40 is missing about Retinoic Acid and SHH about how Gremlin-1 is released
Finally, embrio vids, really needed these to jog the memory
I thought you went bold in first few seconds because of the hat lol 😂
I thought his head is distorted and I wad like wtf until I read your comment lol
He is the best believe me.Anyone who is reading comments to see whether he is good just follow his lectures.Explaining embryology is really difficult but still he is from another planet.
from ninja to nerd and where I'm at? I'm dead in the water mate, and it ain't a pretty sight! But thank you for all the work you've done and are still doing.
This video published less than 48 hours before embryology exam. Nothing less of amazing. Thank you guys!
Hey man can you tell me something I'm a bit confused about it
Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?
Holy smokes! 1000 Likes and 0 dislike! Zach you are amazing!
thank u soo much for this video, it's helping me to understand more during my uni class
Its 3:00 am, i have an end of sem 1 exam and things just escalated quickly from neuroanatomy to embryology to bchem...am glad this made my work 1000 times easier
I'm not even learning this yet but I just wanted to comment to voice my support for this channel. Just incredible
Thank you prof Zach..You jus the best ...You make our med school life easy
Hi, from Pakistan...
Watching 2 days before Professional exam
🫡
Your videos are as good as it can get.thankyou so much and please keep them free on youtube
Thank you so much for the embryology lecture!!! Just want to make sure that does hyoid bone and laryngeal cartilage comes from 2nd~6th pharyngeal arch. thanks a lot
I just got my psychotic preworkout in the mail! Omg!!! I feel the electrons coming out of my membranous neurocranium!!! Thank you Zach!!!! Biochemistry major let’s do this then MCAT!!
Watching your videos from somalia 🇸🇴 and thank you for sharing these wonderful videos with us (med students)
I'm in love with this channel, thank you so much
Again excellent explanation of this system.
well done!
youre the best thanking you for helping me through medical school
Now this guy is just exceptional
Your passion really gives it more color and makes it interesting.. very inspiring
thank you
# Ninja Nerd for life. Once you go Ninja Nerd, You don't go back
The way you talk to the audience looks so enjoyable that really attracts us by your lectures.
Love your spirit ❤️ Keep it up 👍
You are SIMPLY THE BEST ZACH!!! thank you thank you for all your hard work and dedication!
Having histo+ embryo in two days and this just came perfectly in time!! THanks!
Zach,
After watching many Ninja Nerd Lectures
on RUclips, I've become very impressed with your knowledge. Are you accepting patient? If so, how would someone become a patient of yours?
Wow! Excellent explanation!
Thank you so so much for putting the time and the effort to make these topics very enjoyable to learn.
Thank you man
Really appreciate it
Med student from Iraq
Hello guys !!!! Omgggg thanks for amazing videos really !!! I swear when ever Zach says " oh man it's so cool " or " isn't that cool ?" I keep rewatching that part 😍😍😍and I swear I learn a lot better he knows how to drag good attention to super important parts !!! And yet keep it so intresting ! Like only by his joy in his face he converts all boaring materials into such a cool one to learn ! Thank you guys ! May God always bless you and get your backs !!! I love youuuuu guys
Hey man can you tell me something I'm a bit confused about it
Is it Thyroid hormone or estrogen which triggers endochondral ossification of epiphyseal cartilage in the long bones during puberty?
Thank you very much 💚. We are waiting for the embryonic formation of the cardiovascular system
You have no idea how easy you’ve made me revision process for exams
Greatest teacher ever ❤
Lucky to have you as my teacher thanks sir for all the beautiful informative videos
Really sir i have no words to explain how you are helping us by your great lectures......amazing sir
I can see how much effort you made when I see your videos
Limbs
1) Are visible as buds from the body wall during 5th week of development
2) contain bones derived from somatic mesoderm
3) contain bones derived from somatic mesoderm
3) contain bones established by endochoranial oossfication
4) upper limb buds arise 2-3days earlier than lower limb buds
Which ones are true?
I think all of the above🤷♀️🤷♀️
This topic is very amazing, as many details indicate the existence of a creator for man, and many thanks to you, amazing doctor, for your full discussion of the topic, you are the best doctor 🤍
bro has rocked my world
I had to stop this video and appreciate this guy 👏
Ayyyyy, let's go! Missed embryo lectures
It is amazing how you are able to make these wonderful educational lectures! I am Rachel from NL and I really love them!
Zach! I see the way you love this beautiful information. It makes me smile. Thank you for getting me through medical school! 🙏🏽
great video~ currently an MD1 and this has helped alot!
I've been waiting for a long time for this! Thanks a lot!
Thank you Sir sooo much
Best Teacher 😊
From Pakistan 🇵🇰
Awesome lecture.
This man is Good
Exceptional lecture
Zack i am so thanking you at my graduation speech !!
HEYY NINJA NERD IT'S KOSAM FROM ZAMBIA, WE LOVE YOU IN AFRICA.
Thank you Zach so understandable and simplified
Hi there. First of all, I love all your videos. Please do make
a short video on the development of the joints. Thank you
omg! finally it all comes together making sense! I am so thankfull for your job and for the fact i had the luck finding you
Thanks a lot from Iraq for providing these videos, keep going!!
Wow ...thank you ...your all videos are interesting...you make me love 😘 the medicine...
Thank you Ninja Nerd.
Man you are literally my career saviour ❤️
I just wanna say thank you very much and keep going in making wonderful videos
finally i got this lecture when only one week is left for my embryology oral exam
Best instructor ever 🫀
Bless y’all 💕
From Zambia. “Isn’t that cool” 😂. Keep it up
The way you expresses the things in lecture
Help me get rid of depression 😂
Thank you for breaking down such difficult topics!!!
Love this. Ur passion really gives me the motivation to learn!
Thank youu soo muchh ninja nerd u make things soo much clear
Thank you very much zach. This is really top notch
The greatest ever
Dude without you my medical journey is sh*ty♥️
The lecture is so nice, understandable and interesting,,add more for us!!!!
Hi , I'm from India . Keep it up Bro...!