Type I Diabetes Mellitus | Mechanism

Type 1 diabetes (T1D), formerly known as juvenile diabetes, is an autoimmune disease that originates when very little or no insulin is produced by the islets of Langerhans (containing beta cells) in the pancreas.[4] Insulin is a hormone required for the cells to use blood sugar for energy and it helps regulate normal glucose levels in the bloodstream.[2] Before treatment this results in high blood sugar levels in the body.[1] The common symptoms of this elevated blood sugar are frequent urination, increased thirst, increased hunger, weight loss.
Type 1 diabetes begins suddenly, typically in childhood or adolescence.[15] The major sign of type 1 diabetes is very high blood sugar, which typically manifests in children as a few days to weeks of polyuria (increased urination), polydipsia (increased thirst), and weight loss.[16][17] Sometimes children can also experience increased appetite, blurred vision, bedwetting, recurrent skin infections, candidiasis of the perineum, irritability, and performance issues at school.[16][17] Adults with type 1 diabetes tend to have more varied symptoms that come on over months rather than days to weeks

[@Flashgirl3D]

Hi! B-cells have GLUT 2 transporters (Not GLUT-4). Glut 4 is insulin-dependent so it wouldn't be logical that they were in B-cells for insulin signaling. Thanks for the explanations, really helpful!

[@alimahmosarwa2671]

It's GLUT 2 Not 4

[@michaeleisenberg7867]

Shabir, Very nice!!
👏👏👏

[@hussainbiology]

Thanks Doc for appreciation...

[@THEMUSLIM11]

Loved it ❤

[@hussainbiology]

thanks for appreciation..Glad it helps....✌️

[@pragtinarang]

Can we get this tested? Which anti-body is affecting us the most?

[@Tejas0017]

Sir kindly explain about the two proteins HLAD3 and HLAD4, if you have any article related to these protiens, kindly share the link of the article, where these proteins got mentioned. please help,
@hussainbiology

[@hussainbiology]

there are number of articles present kn rcsb, ncbi , science direct , jobc,....
Which one to quote here ??? like be specific

[@biology.lectures351]

You said t-cell attack beta cell. But u explain about antibodies which produce by b-cell.

[@hasslo9033]

You are not showing derivation

[@Khana_PakhanawithMehwish]

👍