Thank you, really enjoyed your presentation Nic ! I was an undergraduate major in Biochemistry, you are hitting all the bases in a comprehensible, discrete and humorous manner. Forwarding your good work to concerned parties. Cheers !
Thank you for your work! That's interesting, as a cyclist i typically put in at least 450 minutes of HIIT, including weight training where I am pushing to peak and my heart rate jumps up into the 150s to 180. There was very little hiit in the study from my standpoint.
@@rene-rv6pp Okay well I have very low body fat for a woman 17%. My blood pressure is 108 over 59, My hunger levels are fine and most people think I'm 15 years younger than I am. So I think I'm good. And I did know about cortisol production and I can actually tell when I have high cortisol. I swell up, retain more water. So then I just rest and everything goes back down to normal. Thanks though you're right.
A lot of unknowns here + missed opportunities. The timings of biopsies ideally would have been based on knowledge from previous, specifically focused research. To take many biopsies would likely traumatise the subjects and put a large burden of analysis on the research team. My question is how is "excess" defined? If it were on levels of ROS alone, safer to do no exercise or if you must go "excess". I may have missed the criteria for light, medium and excess
So to repair my mitochondria from oxidative damage over the years I need to use the peptide ss-31 peptase to return the mitochondrial cristi back to it's normal function level. This much information should be good for my 75 year old body to return some energy needed to keep things ticking over.
Please can you do a video on macro ratios for anti aging/longevity when doing OMAD/lower carb. I am confused by the protein recommendations for longevity given its implication for mTOR. However I wonder if a high plant based protein diet supplemented with collagen would still see the negative impacts on autophagy prevention? I also wonder if there is a benefit in carb cycling and if so, what is the optimal frequency? Finally, I would be very interested in you sharing a 'how I implement my research' video featuring what you eat in a day, time restricted eating/eating window, sleep, exercise and supplements for optimal performance.
I would be interested in this as well. My understanding is that protein is good up to the point that your body can use it which is probably 50-70 grams a day, people who are insulin resistant struggle to utilize protein effectively, and excess protein stimulates insulin and fat storage. We need insulin for protein synthesis in the muscles, but we need insulin sensitivity for optimal results. I've also read that different amino acids have different effects; taurine can inhibit mTor and leucine can activate mTor.
@@EhurtAfy I've also seen research that as we age or due to poor diet, our ability to digest protein reduces therefore more is required to compensate for this. Also if you are practicing a diet such as OMAD or on a low carb or plant based diet, then requirements will be more. I for one have around 100g per day from plants based sources and supplement with collagen
THANK YOU for making this learning accessible. I am a former, avid, non-pro cyclist and now I suffer from Chronic Fatigue, I wonder if the excessive cycling and working out caused this fatigue.
Hi, I'm an older hobby cyclist- get your adrenals checked out! (Adrenal fatigue) Also try cycling your carbs and protein. In other words, don't eat carbs for 2 to 3 days, just protein, veggies and fat, then switch and eat your carbs but no protein. And cut back the amount you're eating . The body recycles macros, and they do Houdini tricks and change into one another. We don't need to eat as much as we think we do. Unless you're bulking up for bodybuilding. Cheers!
Thanks for the video. Having recently read Lieberman's book "Exercised..." it has one wondering why ancient ancestors would ever be adapted to HIIT at this level. How did they do the HIIT? Was the HIIT all out maximum effort?
When you watch children play that is basically what they do. They run down the street, then they hang from a branch, then they walk in weird manner and do all kinds of stuff adults never do.
Shearers often get to much exercise leading to injury and often alcoholism. But apart from that finding practical guidelines we can individualise for ourselves is vital for health. Thankyou.
Have you reviewed any studies on your YT channel covering whether the spacing of exercise sets throughout the week/month/any designated time block matters in the long run? For example, say you do 20 sets per week, is it more effective to do 5 sets on a single day and rest in between, or can the sets be dispersed randomly through the same week and achieve the same or even better results? I appreciate the replies. Most tubers can't be bothered to even leave homeboy a thumbs-up.
Thanks for explaining. I always wondered the effects of ⬆️ROS caused by ⬆️exercise. What do you think is the ultimate effect of ⬇️ROS in ET group? Poorer adaptation to increasing load?
I wouldn't subscribe to this guy. He lacks credentials and speaks techno-babble in a high squeeky voice. I mean, oxygen is killing us? That can't be the whole truth. Clearly dis-info.
There may be some truth to that. Oxygen is destructive. In other words, it harms our cells, and without oxygen's effects we would be more healthier, but of course we wouldn't be able to breathe either.
Not true. I only worked out an hour 5 days a week but intense (weight lifting and hiit) and i got hormonal issues, chronic fatigue, insomnia and a host of other issues and i was only in my mid 20s. Reversed it by scaling way back
Thank you, really enjoyed your presentation Nic ! I was an undergraduate major in Biochemistry, you are hitting all the bases in a comprehensible, discrete and humorous manner. Forwarding your good work to concerned parties. Cheers !
ROS: Reactive Oxygen Species.
Not to be confused with,
ROUS: Rodents Of Unusual Size.
Lol!
Does Mythelene Blue really help Mitochondria? How about Red Light Therapy? Would you recommend any of those two, if not, why not?
Thank you for your work! That's interesting, as a cyclist i typically put in at least 450 minutes of HIIT, including weight training where I am pushing to peak and my heart rate jumps up into the 150s to 180. There was very little hiit in the study from my standpoint.
You should have into account that sport is a fountain of cortisol wich is a big burden. And also people who sport a lot us not long living
@@rene-rv6pp Okay well I have very low body fat for a woman 17%. My blood pressure is 108 over 59, My hunger levels are fine and most people think I'm 15 years younger than I am. So I think I'm good.
And I did know about cortisol production and I can actually tell when I have high cortisol. I swell up, retain more water. So then I just rest and everything goes back down to normal. Thanks though you're right.
Is that 45 mins of HIIT, say 3 sessions of 15mins a week, or 450, 7 1/2 hours / week as typed?
@@jonthomas9708yup. Cycling. Did 505 minutes this week.
1055 minutes this week. I am taking serrapeptase and ashwaganda to combat the cortisol.
A lot of unknowns here + missed opportunities. The timings of biopsies ideally would have been based on knowledge from previous, specifically focused research. To take many biopsies would likely traumatise the subjects and put a large burden of analysis on the research team. My question is how is "excess" defined? If it were on levels of ROS alone, safer to do no exercise or if you must go "excess". I may have missed the criteria for light, medium and excess
So to repair my mitochondria from oxidative damage over the years I need to use the peptide ss-31 peptase to return the mitochondrial cristi back to it's normal function level. This much information should be good for my 75 year old body to return some energy needed to keep things ticking over.
Please can you do a video on macro ratios for anti aging/longevity when doing OMAD/lower carb. I am confused by the protein recommendations for longevity given its implication for mTOR. However I wonder if a high plant based protein diet supplemented with collagen would still see the negative impacts on autophagy prevention? I also wonder if there is a benefit in carb cycling and if so, what is the optimal frequency?
Finally, I would be very interested in you sharing a 'how I implement my research' video featuring what you eat in a day, time restricted eating/eating window, sleep, exercise and supplements for optimal performance.
I would be interested in this as well. My understanding is that protein is good up to the point that your body can use it which is probably 50-70 grams a day, people who are insulin resistant struggle to utilize protein effectively, and excess protein stimulates insulin and fat storage. We need insulin for protein synthesis in the muscles, but we need insulin sensitivity for optimal results. I've also read that different amino acids have different effects; taurine can inhibit mTor and leucine can activate mTor.
@@EhurtAfy I've also seen research that as we age or due to poor diet, our ability to digest protein reduces therefore more is required to compensate for this. Also if you are practicing a diet such as OMAD or on a low carb or plant based diet, then requirements will be more. I for one have around 100g per day from plants based sources and supplement with collagen
THANK YOU for making this learning accessible. I am a former, avid, non-pro cyclist and now I suffer from Chronic Fatigue, I wonder if the excessive cycling and working out caused this fatigue.
I doubt it, K R. Exercise tends to be one of the best avenues for fighting fatigue - the literature is pretty clear on that.
Hi, I'm an older hobby cyclist- get your adrenals checked out! (Adrenal fatigue) Also try cycling your carbs and protein. In other words, don't eat carbs for 2 to 3 days, just protein, veggies and fat, then switch and eat your carbs but no protein. And cut back the amount you're eating . The body recycles macros, and they do Houdini tricks and change into one another. We don't need to eat as much as we think we do. Unless you're bulking up for bodybuilding. Cheers!
Intensive training makes cortisol. That make you old
@tracymullane8818 you don't know his diet. You advised is ill advised.
Hi Nicholas, can you do a video on how Thiamine affects the professional athlete's mitochondrial? i.e. tour de france cyclist.
so is it better to overtrain or train at a regular rate with rest days?
Thanks for the video. Having recently read Lieberman's book "Exercised..." it has one wondering why ancient ancestors would ever be adapted to HIIT at this level. How did they do the HIIT? Was the HIIT all out maximum effort?
When you watch children play that is basically what they do. They run down the street, then they hang from a branch, then they walk in weird manner and do all kinds of stuff adults never do.
Shearers often get to much exercise leading to injury and often alcoholism.
But apart from that finding practical guidelines we can individualise for ourselves is vital for health.
Thankyou.
Shearers? Like sheep shavers?
No more like sheep baa baa's
Removing excess wool for fine clothing
Have you reviewed any studies on your YT channel covering whether the spacing of exercise sets throughout the week/month/any designated time block matters in the long run? For example, say you do 20 sets per week, is it more effective to do 5 sets on a single day and rest in between, or can the sets be dispersed randomly through the same week and achieve the same or even better results?
I appreciate the replies. Most tubers can't be bothered to even leave homeboy a thumbs-up.
As in, spreading the volume out or concentrating it on a single day?
@@Physionic That's right. To what degree does the concentration of sets affect muscle growth, strength, etc.
It matters, but not much after splitting one muscle group into two separate days per week.
please, how are mitochondria produced? regards.
Thanks for explaining. I always wondered the effects of ⬆️ROS caused by ⬆️exercise. What do you think is the ultimate effect of ⬇️ROS in ET group? Poorer adaptation to increasing load?
arent humans pretty much endurance hunters?
How much is to much though?
If it's a cellularly expensive process...what is the cell spending to do it...what is the energy currency?
Thank you as always
Thank you for your info. Do you think there is a extra atp output when fusion occurs compared to the amount of atp produced separately?
From my reading, yes. Good thinking, Daniel.
Yes my ATP greedy mind wanted to know the answer to this also. Thanks guys! Knowing this I will view the video again.
Thanks!
Thank you for your generosity, K R. I replied to your last comment, too, btw.
Mitochondria on fasting whoud be a great content❤🔥, if not recorded yet❤🔥
How does 152min HIIT per week count as ET.?
Bo Ho!
I wouldn't subscribe to this guy. He lacks credentials and speaks techno-babble in a high squeeky voice. I mean, oxygen is killing us? That can't be the whole truth. Clearly dis-info.
I’ll be sure not to subscribe. Thanks for watching and dealing with my squeaky* voice.
There may be some truth to that. Oxygen is destructive. In other words, it harms our cells, and without oxygen's effects we would be more healthier, but of course we wouldn't be able to breathe either.
Are you deaf? He does not have a high squeaky voice. You are just salty because you are not as intelligent as this guy
Dude, I’m a regular follower. I was clearly being sarcastic. No one needs to question anyone’s intelligence here. Chill.
All good, everyone - just jokes. I appreciate you guys stopping by.
Unless you are a marathon runner it's tough to get to much exercise
If you train 6 days a week for 2 hours daily you might be getting there tho
Unless you work in a factory. I walk 5hrs a day.
@@kedabro1957You're one of the very few people here who works for a living.
There are people out there addicted to going to the gym.
Not true. I only worked out an hour 5 days a week but intense (weight lifting and hiit) and i got hormonal issues, chronic fatigue, insomnia and a host of other issues and i was only in my mid 20s. Reversed it by scaling way back